Abstract: The present invention provides novel processes for the preparation of N-substituted benzamides having the formula VIc: In some embodiments, the invention provides a process for preparation of roflumilast and other pharmaceutically active species. Novel compounds, including intermediates for the synthesis of roflumilast, are also provided.

Abstract: The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included.

Abstract: The present invention is directed to compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof that are possible useful for treating aldosterone-mediated diseases. The invention furthermore relates to processes for preparing compounds of the Formula (I), to their possible use for the treatment of the above mentioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical compositions which comprise compounds of the Formula (I).

Abstract: The present invention provides novel processes for the preparation of N-substituted benzamides having the formula (VIc). In some embodiments, the invention provides a process for preparation of roflumilast and other pharmaceutically active species. Novel compounds, including intermediates for the synthesis of roflumilast, are also provided.

Abstract: The present invention provides novel processes for the preparation of N-substituted benzamides having the formula (VIc). In some embodiments, the invention provides a process for preparation of roflumilast and other pharmaceutically active species. Novel compounds, including intermediates for the synthesis of roflumilast, are also provided.

Abstract: The present invention is directed to compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof that are possible useful for treating aldosterone-mediated diseases. The invention furthermore relates to processes for preparing compounds of the Formula (I), to their possible use for the treatment of the above mentioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical compositions which comprise compounds of the Formula (I).

Abstract: The present invention is directed to novel substituted aminopiperidines of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-ÏV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

Abstract: The present invention is directed to novel substituted aminopiperidines of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-ÏV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

Abstract: A pin-carrier for a connector has a main panel defining a plane, a secondary panel, a first pin set with multiple first pins and a second pin set with multiple second pins being connected between the main panel and the secondary panel, wherein the first and second pins have connecting segments being raised or lowered relative to the plane. Therefore, manufacturing the pin-carrier requires fewer steps, fewer tools and since the pins are connected to both panels, has higher yields. Therefore, manufacturing the pin-carrier is low cost and convenient.

Abstract: An all-in-one card connector has a insulating case, a first base, a second base, a single card terminal assembly and multiple modular card terminal assemblies. The single card terminal assembly is formed on the first base and is inserted into one end of the insulating case. The modular card terminal assemblies are formed on the second base and are inserted into the other end of the insulating case. After inserting, the bases are cut from the single and modular card terminal assemblies. Because multiple modular card terminal assemblies are all formed on the second base, the material for the base is saved to reduce the cost and the mounting process is also simplified.

Abstract: A drawer-type all-in-one card connector includes a housing defining an insertion chamber; a plurality of card contact terminals; a sliding box slidably mounted in the insertion chamber of the housing and having a card receiving chamber for receiving one of memory cards of different specifications and a plurality of terminal slots accommodating the card contact terminals for contact with the memory card inserted into the card receiving chamber; and a cover covered on the housing, a first ejection spring stopped between the housing and the sliding box, a limiter provided between the housing and the sliding box for guiding movement of the sliding box relatively to the housing in course, and adapter means electrically connected between a circuit board and the card contact terminals of the sliding box.

Abstract: A card connector includes a base having an opening at a front end thereof, two guide channels at bilateral sides inside, and a plurality of terminals mounted at a rear end thereof; at least one movable member movably mounted in the guide channels and having a stopping portion and a bevel formed at upper and lower sides of a front end thereof; a stopping plate pivotably mounted to the base for pivoting movement between a stopping position and a releasing position. While the stopping plate is located at the stopping position, the movable member engages to lock the stopping plate. While the movable member is close to the guide channel, the movable member releases the lock-up status. At least one resilient member is provided for generating resilience keeping movement of the stopping plate toward the stopping position. Therefore, the card connector allows/blocks the normally/erroneously inserted card.

Abstract: A card connector includes a base having an opening at a front end thereof, two guide channels at bilateral sides inside, and a plurality of terminals mounted at a rear end thereof; at least one movable member movably mounted in the guide channels and having a stopping portion and a bevel formed at upper and lower sides of a front end thereof; a stopping plate pivotably mounted to the base for pivoting movement between a stopping position and a releasing position. While the stopping plate is located at the stopping position, the movable member engages to lock the stopping plate. While the movable member is close to the guide channel, the movable member releases the lock-up status. At least one resilient member is provided for generating resilience keeping movement of the stopping plate toward the stopping position. Therefore, the card connector allows/blocks the normally/erroneously inserted card.

Abstract: A drawer-type all-in-one card connector includes a housing defining an insertion chamber; a plurality of card contact terminals; a sliding box slidably mounted in the insertion chamber of the housing and having a card receiving chamber for receiving one of memory cards of different specifications and a plurality of terminal slots accommodating the card contact terminals for contact with the memory card inserted into the card receiving chamber; and a cover covered on the housing, a first ejection spring stopped between the housing and the sliding box, a limiter provided between the housing and the sliding box for guiding movement of the sliding box relatively to the housing in course, and adapter means electrically connected between a circuit board and the card contact terminals of the sliding box.

Abstract: A terminal-protective card connector includes a shell and a pressing member. The shell includes at least two groups of terminals mounted to the shell. The second group of terminals each have a part elastically rising upward and backward. The pressing member includes a plurality for elongated slots formed therein and a plurality of pressing points each defined under a front end of each elongated slot. The pressing member is provided with two ends pivotally mounted in the shell for pivoting movement. One group of terminals extends through bottom sides and then top sides of the elongated slots respectively, having a part contacting against and supporting the pressing points to enable the pressing member to rise for a predetermined height. Thus, a specific group of terminals can be optionally pressed to avoid deformation or short circuit resulted from impact of or contact with uncorresponding cards to be protected.

Abstract: A terminal-protective card connector includes a shell and a pressing member. The shell includes at least two groups of terminals mounted to the shell. The second group of terminals each have a part elastically rising upward and backward. The pressing member includes a plurality for elongated slots formed therein and a plurality of pressing points each defined under a front end of each elongated slot. The pressing member is provided with two ends pivotally mounted in the shell for pivoting movement. One group of terminals [[run]] extends through bottom sides and then top sides of the elongated slots respectively, having a part contacting against and supporting the pressing points to enable the pressing member to rise for a predetermined height. Thus, a specific group of terminals can be optionally pressed to avoid deformation or short circuit resulted from impact of or contact with uncorresponding cards to be protected.

Abstract: A dual-slot card connector includes a flat base having a first insertion slot and a second insertion slots partly overlapping and communicating with each other for receiving different cards, and a pair of the receiving grooves and a pair of the first retaining portions; a movable plate mounted to the overlap of the first and second insertion slots and movably mounted in the receiving grooves and having a main body, a pair of receiving portions mounted to bilateral sides of the main body, a pair of second retaining portions in connection with the first retaining portions, and a plurality of terminal tunnels formed on the main body; a pair of springy strips mounted on the base and contacting against the movable plate; a cover shell covered on the base; and a plurality of contact terminals mounted on the base and partly received in the terminal tunnels.

Abstract: A terminal-protective card connector includes a shell and a pressing member. The shell includes at least two (first and second) groups of terminals mounted thereto, and two upright guiding portions formed at two internal sidewalls thereof. The pressing member includes two guided parts formed at two ends thereof and slidably mounted to the two guiding portions, a plurality of through holes formed therein, and at least one bevel formed at a front end thereof. The second group of terminals has contact portions running through bottom sides and then top sides of the through holes respectively to support the terminals of the second group. Thus, a specific group of terminals can be optionally pressed to avoid deformation or short circuit resulted from impact of or contact with uncorresponding cards to be protected.

Abstract: A variable intake system of a vehicle includes an intake manifold having a runner, an opening/closing part for varying the runner length of the intake manifold, an actuator for driving the opening/closing part, and a vacuum part forming a vacuum chamber for driving the actuator. The vacuum part is disposed on an upper portion of the intake manifold such that noise from the engine may be decreased.

Abstract: Displacement is measured using two overlaid parallel optic gratings as the sensing elements of a sensor head. Optic fibers are employed as the transmission media between the sensor head and a central signal processing unit. The light intensity signals of Moire fringes generated by the overlaid optic gratings are transmitted through optic fibers to the central signal processing unit. By digitally counting the number of Moire fringes, the changes in both direction and magnitude of the displacement are measured. A number of sensor heads employing the overlaid optic gratings as sensing elements are multiplexed through a common optic fiber link to comprise a multipoint sensor system. By similarly modifying the sensor head, this sensor system also measures other physical quantities such as strain, acceleration, and pressure.