Abstract: A cordycepin-based derived compound with an anti-tumor effect, and a structure of the compound is as shown in formula I; a cordycepin derivative and a pharmaceutical composition thereof provided by the invention have a good anti-tumor proliferation effect; compared with a parent drug, the cordycepin derivative has better affinity to cell membranes, so that a half-life period of in-vivo metabolism of the drug is longer, and in-vivo remaining time of the drug is longer; compared with other nucleoside anti-tumor drugs, the cordycepin derivative and the pharmaceutical composition thereof provided by the invention have wider types and action ranges of tumors, have excellent inhibition effects on a gastric cancer, a pancreatic cancer, a liver cancer, a small cell lung cancer, a colorectal cancer, melanoma, an ovarian cancer and the like, and have lower side effects and better curative effects.

Abstract: An antenna apparatus used in an electronic device having a flexible display, the flexible display can be bent at a rotating shaft, the flexible display includes a primary screen and a secondary screen respectively configured on two sides of the rotating shaft. The antenna apparatus may include a first metal strip disposed on the primary screen frame close to one end of the rotating shaft, and a second metal strip disposed on the secondary screen frame close to the same end of the rotating shaft. The first metal strip may be implemented as a plurality of antennas through dual-feed design. When the flexible display is in a folded state, the second metal strip may be coupled to the first metal strip to generate radiation. In this case, the second metal strip may be used as a parasitic antenna of the first metal strip.

Abstract: A two-component polyurethane composition comprising: an aqueous dispersion comprising an emulsion polymer and a specific sulphate and/or sulfonate surfactant, and a water-dispersible polyisocyanate; the emulsion polymer with a weight average molecular weight of 70,000 g/mol or less comprising, by weight based on the weight of the emulsion polymer, greater than 0.25% of structural units of a phosphorous-containing acid monomer and/or salts thereof, greater than 15% of structural units of a hydroxy-functional alkyl (meth)acrylate, structural units of an monoethylenically unsaturated nonionic monomer, and from zero to 10% of structural units of an additional acid monomer and/or salts thereof; and a process of preparing the two-component polyurethane composition.

Abstract: The present invention provides PD-1 monoclonal antibodies, particularly human monoclonal antibodies of PD-1, which specifically bind to PD-1 with high affinity and comprise a heavy chain and a light chain. The present invention further provides nucleic acid sequence encoding the antibodies of the invention, cloning or expression vectors, host cells and methods for expressing or isolating the antibodies. Immunoconjugates, therapeutic compositions comprising the antibodies of the invention are also provided. The invention also provides methods for treating various cancers with anti-PD-1 antibodies.

Abstract: A packaged device includes a circuit board, an electronic component, and a heat storage portion. The electronic component is electrically coupled to the circuit board; and the heat storage portion is disposed on the circuit board or embedded in the circuit board, and the heat storage portion is adjacent to the electronic component, where a specific heat capacity of the heat storage portion is higher than a specific heat capacity of the circuit board, and the heat storage portion is configured to store and release heat. A heat storage material with a relatively high specific heat capacity is introduced into the packaged device, and the heat storage portion is disposed on the circuit board around the electronic component where a large amount of heat generated by the electronic component in a short time can be quickly stored in the heat storage portion and then released to the outside.

Abstract: A gene sequencing reaction device, a gene sequencing system and a gene sequencing reaction method. The gene sequencing reaction device includes: a supporting platform; a dipping container disposed on the supporting platform, wherein the dipping container has a dipping reaction area, and the dipping reaction area is configured to hold a chemical reagent for gene sequencing reaction, so as to dip a sequencing chip having a DNA sample loading structure on the surface and having a DNA sample loaded thereon in the chemical reagent to perform a gene sequencing reaction; a temperature control apparatus, configured to control the temperature of the chemical reagent in the dipping reaction area; and a transfer apparatus, configured to insert the sequencing chip into the dipping reaction area or pull out the sequencing chip from the dipping reaction area.

Abstract: A disclosed method for implementing containers in an information handling system generates, with a first non-privileged container, a request that is sent to a RESTful API. Whenever the API identifies a request requiring host access the API launches a second container, which is configured to operate in a privileged execution mode. The second container accesses the host and executes the requested actions. When the request completes, the first container resumes non-privileged execution, thereby confining privileged mode execution to a container that is only active during host interaction. The host access can be access required to: exchange data with the host, query the host for hardware information, and modify host configuration. The host may be implanted within a device featuring an HCI infrastructure. In one configuration, the host resides of one of multiple distinct nodes of an HCI appliance.

Abstract: The present disclosure relates to lamp unit, lamp system and method for mounting the lamp system. The lamp unit includes: a lamp panel having a cavity formed by a light-emitting surface and a back surface, is provided with light-emitting elements and a plurality of electrical contact points that are electrically connected to the light-emitting elements, and a plurality of openings to expose the electrical contact points; and a mounting unit configured to be detachably mounted on a back surface center portion of the back surface and used for mounting the lamp unit on a predetermined position, and the mounting unit is provided with a plurality of connection positions for forming an electrical connection with another lamp unit. By means of the above manner, the operation of mounting a connector on the lamp unit is easier.

Abstract: The present disclosure provides a membrane electrode assembly (MEA) with high-efficiency water and heat management for a direct ethanol fuel cell (DEFC), and a fabrication method therefor, and belongs to the technical field of fuel cells. In the MEA for a DEFC in the present disclosure, a cathode catalyst layer is designed to be convex and ordered and an anode catalyst layer is designed to be concave and ordered, which is conducive to the timely discharge of the generated heat. The MEA for a DEFC can be fabricated by gradually fabricating each layer of the MEA on an inner surface and an outer surface of a proton-exchange membrane (PEM) or by step-by-step dip coating on an anode support tube. The present disclosure can effectively improve the working capacity of the cell.

Abstract: ?-lactamase inhibitors, pharmaceutical compositions including the same, methods of preparing the same, and methods of treating bacterial infections in combination with ?-lactam antibiotics, including infection caused by drug resistant organisms and especially multi-drug resistant organisms. The present invention includes compounds according to formula (I) or pharmaceutically acceptable salts thereof, wherein M and R are as defined herein.

Abstract: A monobactam compound of formula (I), a preparation thereof, and a use thereof as antibiotic agents for the treatment of bacterial infections are provided. In the formula (I), M is hydrogen or a pharmaceutically acceptable salt forming cation, R1 and R2 represent independently of one another hydrogen or methyl, W represents a bond or O, X represents CR4 or N, R4 represents halogen, R3 represents hydrogen, amino, hydroxy, (C1-C6)-alkyl, or a 4-, 5- or 6-membered nitrogen-containing heterocycle.

Abstract: The present disclosure provides a membrane electrode assembly (MEA) with high-efficiency water and heat management for a direct ethanol fuel cell (DEFC), and a fabrication method therefor, and belongs to the technical field of fuel cells. In the MEA for a DEFC in the present disclosure, a cathode catalyst layer is designed to be convex and ordered and an anode catalyst layer is designed to be concave and ordered, which is conducive to the timely discharge of the generated heat. The MEA for a DEFC can be fabricated by gradually fabricating each layer of the MEA on an inner surface and an outer surface of a proton-exchange membrane (PEM) or by step-by-step dip coating on an anode support tube. The present disclosure can effectively improve the working capacity of the cell.

Abstract: Provided are ?-lactam compounds of formula (I), their preparation and use as antibiotic agents for the treatment of bacterial infections: Wherein X, W, R1, R2 and R3 are defined herein.

Abstract: The present disclosure provides an oscillating circuit and an electronic device; the oscillating circuit includes a capacitor charging and discharging circuit unit, a voltage comparison circuit unit and a threshold voltage generation circuit unit; the oscillating circuit uses the capacitor charging and discharging and the hysteresis effect of the capacitor charging and discharging circuit unit to achieve oscillation based on the negative feedback regulation constituted by the voltage comparison circuit unit and the threshold voltage generation circuit unit, which is different from the traditional oscillating circuit based on capacitance and inductance; the oscillating circuit does not adopts inductors, has relatively low power consumption, and outputs oscillation signals with frequencies that vary with currents, and when the oscillating circuit is used to provide clock signals for the sensor, it can be integrated with a sensor signal processing circuit to realize the miniaturization and integration of the sen

Abstract: The present disclosure provides an oscillating circuit and an electronic device; the oscillating circuit includes a capacitor charging and discharging circuit unit, a voltage comparison circuit unit and a threshold voltage generation circuit unit; the oscillating circuit uses the capacitor charging and discharging and the hysteresis effect of the capacitor charging and discharging circuit unit to achieve oscillation based on the negative feedback regulation constituted by the voltage comparison circuit unit and the threshold voltage generation circuit unit, which is different from the traditional oscillating circuit based on capacitance and inductance; the oscillating circuit does not adopts inductors, has relatively low power consumption, and outputs oscillation signals with frequencies that vary with currents.

Abstract: A bag breaking device for garbage bags, which includes a horizontal moving mechanism, a vertical moving mechanism mounted on the horizontal moving mechanism, and a bag breaking mechanism mounted on the vertical moving mechanism; the bag breaking mechanism includes a first motor on the vertical moving mechanism, a first housing fixedly connected to an output end of the first motor, a second housing fixed on the first housing, a second motor fixed in the first housing, a first screw rod fixedly connected to an output end of the second motor, a screw block scraper rotatably mounted on the first screw rod, and a cylindrical knife fixed on the second housing.

Abstract: A camera module includes a circuit board; a photosensitive chip located on the circuit board and electrically coupled to the circuit board, a package material body arranged on the circuit board, a support member arranged on one end of the package material body away from the circuit board, and a filter having a first and a second surfaces. The package material body includes a top end bearing surface. The support member includes a support body and an extension structure, and the extension structure includes a bottom surface, the bottom surface is connected to the bearing surface, and the second surface is connected to the bottom surface. The camera module is a three-stage structure of a package material body plus a support member plus a plurality of lenses.

Abstract: A photosensitive assembly includes a circuit board, photosensitive chip coupled to the circuit board, the photosensitive chip includes a photosensitive area on an upper surface thereof and a non-photosensitive area surrounding the photosensitive area, and a package body packaged on the circuit board and covering a portion of the non-photosensitive area of the photosensitive chip, the package body includes an inner surface, and the inner surface has a curved surface on an edge thereof contacting the non-photosensitive area.

Abstract: The present disclosure relates to a camera module and a photosensitive assembly thereof. The photosensitive assembly comprises includes a circuit board, a photosensitive chip, and a packaging body. The photosensitive chip is connected to the circuit board. The packaging body is formed on the circuit board. A through hole is formed in the packaging body. The through hole is opposite to the photosensitive chip to provide a light channel of for the photosensitive chip. An inner side surface of the through hole comprises includes a first cambered surface, a connection surface, and a second cambered surface, and the first cambered surface and the second cambered surface are respectively connected to two ends of the connection surface.

Abstract: A camera module includes a circuit board; a photosensitive chip coupled to the circuit board, a package material body attached on the circuit board, and a support member mounted on the package material body. The package material body has a photosensitive surface, which includes a photosensitive region. The support member includes a support body and an extension structure. A side of the support body away from the package material body is coplanar with the extension structure. An orthographic projection of the extension structure on the photosensitive surface is spaced apart from the photosensitive region.