Abstract: Provided are antibody-cytokine fusion proteins comprising an anti-PD-L1 antibody and an Interleukin 21, and methods for preparing the same, as well as applications of the fusion proteins for therapeutic purpose.

Abstract: The present disclosure provides compositions and methods of inactivating a lipid enveloped virus in a product feedstream in a manufacturing process of a therapeutic protein using environmentally compatible detergents. The present disclosure provides a detergent mixture comprising two environmentally sustainable detergents: n-Octyl-?-D-Glucopyranoside (OG) and n-Dodecyl-?-D-Maltopyranoside (DDM). The performance of this OG:DDM detergent combination is superior to that of Lauryldimethylamine Oxide (LDAO), ECOSURF™ EH9, or Triton X-100 in the purification of therapeutic proteins such as abatacept and belatacept. OG:DDM combinations are highly effective for viral inactivation, while having essentially no impact on protein stability, protein charge distribution (e.g., sialic acid levels), impurity clearance, protein deamination, or protein oxidation. Accordingly, combinations of OG and DDM can be used as substitutes of Triton X-100 for viral inactivation steps in the production of biologics.

Abstract: A coenzyme Q10 slow-release drug includes an isolation layer and a drug layer, where the drug layer is composed of coenzyme Q10 and a pharmaceutically acceptable carrier; the isolation layer is composed of a degradable gel; a diameter of the drug layer is not larger than that of the isolation layer. The coenzyme Q10 slow-release drug is prepared as follows. (S1) The degradable gel is laid on a mold for casting into a film to form the isolation layer. (S2) Coenzyme Q10 and the pharmaceutically acceptable carrier are mixed and laid on the mold in step (S1) for casting to form the drug layer on the isolation layer. (S3) Steps (S1) and (S2) are repeated, and then edges of adjacent controlled-release layers are bonded to obtain the coenzyme Q10 slow-release drug.

Abstract: A cigarette filter which includes lyocell tow made of a plurality of lyocell fibers and a binder configured to bond the lyocell fibers to each other is provided. The cigarette filter according to one embodiment of the present disclosure reduces each of tar and nicotine, which are delivered through cigarette smoke, by 70% to 95%. The cigarette filter according to one embodiment of the present disclosure has a resistance to draw of 80 mmWG to 200 mmWG. The cigarette filter according to one embodiment of the present disclosure is filled with the lyocell tow at a packing density of 0.2 g/mL to 0.6 g/mL. The cigarette filter according to one embodiment of the present disclosure addresses basic material-related problems, such as low hardness, of the lyocell tow and, further, has excellent filtration functionality as a filter.

Abstract: The present disclosure provides a smoking article filter which includes lyocell tow including lyocell fibers, a binder solution, and filter wrapping paper, and has 90% or higher biodegradation within 6 months according to the American Society for Testing and Materials (ASTM) D6691 under marine conditions at 30° C., and a smoking article including the smoking article filter.

Abstract: A cordycepin-based derived compound with an anti-tumor effect, and a structure of the compound is as shown in formula I; a cordycepin derivative and a pharmaceutical composition thereof provided by the invention have a good anti-tumor proliferation effect; compared with a parent drug, the cordycepin derivative has better affinity to cell membranes, so that a half-life period of in-vivo metabolism of the drug is longer, and in-vivo remaining time of the drug is longer; compared with other nucleoside anti-tumor drugs, the cordycepin derivative and the pharmaceutical composition thereof provided by the invention have wider types and action ranges of tumors, have excellent inhibition effects on a gastric cancer, a pancreatic cancer, a liver cancer, a small cell lung cancer, a colorectal cancer, melanoma, an ovarian cancer and the like, and have lower side effects and better curative effects.

Abstract: A display device includes: a display panel including a plurality of pixels connected to a plurality of scan lines; a scan driving circuit, which drives the plurality of scan lines in synchronization with a clock signal; and a driving controller, which outputs the clock signal. While an operating mode is a multi-frequency mode, the driving controller comparts the display panel into a first display area and a second display area. A hold frame of the multi-frequency mode includes a first section during which the first display area is driven, and a second section during which the second display area is driven. The driving controller outputs the clock signal of a normal power mode during the first section and outputs the clock signal of a low-power mode during the second section.

Abstract: A voice recognition method, apparatus, electronic device, storage medium, and computer program product are provided herein The method includes performing a sliding window interception on a voice signal to obtain at least a first sub-voice signal and a second sub-voice signal, performing voice feature extractions on the first sub-voice signal and the second sub-voice signal to obtain a first sub-voice embedded representation feature of the first sub-voice signal and a second sub-voice embedded representation feature of the second sub-voice signal, obtaining an embedded representation feature of each contrastive word in a preset contrastive word library, performing a first voice recognition on the first sub-voice signal to obtain a first sub-voice recognition result, performing a second voice recognition on the second sub-voice signal to obtain a second sub-voice recognition result, and determining a voice recognition result based on the first and second sub-voice recognition results.

Abstract: An off-road travel assistive device includes a receiver configured to receive travel data of a vehicle, and an estimator. The estimator includes a road surface severity estimator configured to estimate road surface severity data based on the travel data of the vehicle. The device also includes a stuck probability determiner configured to determine probability of a stuck state of the vehicle occurring using the travel data and the road surface severity data. The stuck probability determiner determines stuck probability using a meta-model.

Abstract: One example blood pressure measurement device includes a body, a wrist strap, an airbag, an air supply and exhaust apparatus, a first sensor, and a second sensor. The airbag has an air cavity, and the airbag is connected to the body. The body includes a cavity, and the air supply and exhaust apparatus is disposed in the cavity. The air supply and exhaust apparatus includes an air intake path and an air exhaust path, and the air supply and exhaust apparatus communicates with the air cavity of the air bag. The first sensor is configured to measure an air pressure value in the air cavity. The second sensor is located on a same side of the wrist strap as the airbag, and is configured to measure a pulse wave signal.

Abstract: The present invention relates to the technical field of leakage protection, in particular to a leakage current detection circuit and a device thereof. The connected S1 inductive terminal and the S2 inductive terminal can be signal-connected, and the driving module detects whether the S1 inductive terminal and the S2 inductive terminal are connected by a signal. There is a connection signal to judge whether there is leakage, and the drive module turns the switch module on or off to control whether the circuit breaker generates a circuit breaker signal, and then the main switch S can be disconnected when leakage occurs to ensure the safety of electricity use. There is no need to set up a transformer. Reduced volume, simple circuit structure, and easier production.

Abstract: The present invention relates to a neural network-based high-resolution image restoration method and system, including: performing feature extraction on a target frame in a network input to obtain a first feature, performing feature extraction on a first frame and an adjacent frame and an optical flow between the first frame and the adjacent frame to obtain a second feature, and concatenating the first feature and the second feature to obtain a shallow layer feature; performing feature extraction and refinement on the shallow layer feature to obtain a plurality of output first features and a plurality of output second features; performing feature decoding on the plurality of output second features, and concatenating decoded features along channel dimensionality to obtain features; and performing weight distribution on the features to obtain final features, and restoring an image. The present invention can effectively help to improve image quality.

Abstract: A pixel arrangement structure includes two first sub-pixels and two second sub-pixels which are connected as a first virtual quadrilateral. The two first sub-pixels are located at two first vertices of the first virtual quadrilateral. The two second sub-pixels are located at two second vertices of the first virtual quadrilateral. The two first vertices and the two second vertices are alternately arranged and spaced apart from each other. A third sub-pixel is located within the first virtual quadrilateral, and a center of the third sub-pixel deviates from a center of the first virtual quadrilateral. In a row direction or a column direction, the first virtual quadrilateral includes a first side and a second side facing to each other, and a length of the first side is smaller than a length of the second side.

Abstract: A heterocyclic compound represented by Chemical Formula 1 and an organic light emitting device including the same, and the heterocyclic compound which is used as a material of an organic material layer of the organic light emitting device and provides improved efficiency, low driving voltage and improved lifetime characteristics of the organic light emitting device.

Abstract: A refrigerator includes a box body, a door body, a hinge assembly, and a mounting block. The door body is connected to the box body. The hinge assembly includes a first hinge shaft and a second hinge shaft. The mounting block includes a first trajectory groove and a second trajectory groove. During a process of the door body being rotated to open or close, the first hinge shaft moves relative to the first trajectory groove, and the second hinge shaft moves relative to the second trajectory groove. The first trajectory groove includes a curved groove segment. An end of the curved groove segment extends in a direction proximate to a first side edge, and a distance between the curved groove segment and the door side wall is decreased along a direction from a door rear wall to a door front wall.

Abstract: Provided is a device for spraying an ammoniacal gas in an automatically-adjustable manner based on a flow rate

Abstract: In a search and tracking method for full time-domain laser detection of space debris, a set of latest precision orbital parameters of a debris object and start and end moments of a current transit of the object are first obtained. Search-specific guidance data is generated based on the above information and in combination with estimation of a maximum along-track error of the orbital parameters of the object during the current transit. A DLR system performs multi-elevation search on the object based on the search-specific guidance data, obtains a plurality of pieces of detection data of the object after detecting the object during the search, determines an along-track error of the orbital parameters of the object based on the detection data, and corrects the orbital parameters of the object in real time based on the along-track error, so as to guide the DLR system to subsequently track and detect the object.

Abstract: The present disclosure provides TrkA antibodies, compositions comprising such antibodies, and methods of using such antibodies for the prevention and/or treatment of a disease or disorder associated with an inappropriate expression or function of TrkA, such as pain.

Abstract: Provided is a disconnector apparatus including a casing having therein a support ring and one side gear, one side gear engaging with a pinion gear in the support ring, a first clutch ring connected to a sleeve and having a first clutch part provided at one side directed toward the support ring, and a second clutch ring inserted into the first clutch ring and having a second clutch part provided at one side directed toward one side gear, the second clutch ring having the other side outer-diameter portion to which the sleeve is coupled.

Abstract: Volumetric quantification can be performed for various parameters of an object represented in volumetric data. Multiple views of the object can be generated, and those views provided to a set of neural networks that can generate inferences in parallel. The inferences from the different networks can be used to generate pseudo-labels for the data, for comparison purposes, which enables a co-training loss to be determined for the unlabeled data. The co-training loss can then be used to update the relevant network parameters for the overall data analysis network. If supervised data is also available then the network parameters can further be updated using the supervised loss.