Abstract: The present disclosure relates to the technical field of biotechnology, and discloses a nucleic acid targeting proprotein convertase subtilisin/kexin 9 and uses thereof. The nucleic acid provided by the present disclosure can effectively inhibit the expression of PCSK9, thereby being capable of treating and/or preventing hyperlipidemia related diseases.

Abstract: The present disclosure relates to the technical field of small nucleic acid drug delivery, and particularly discloses a compound, a conjugate and uses thereof. The present disclosure provides a nucleic acid drug targeted delivery monomer and conjugate and a preparation method thereof, the monomer and the conjugate which is formed by the monomer and has a specific design structure can specifically deliver an active drug (or small nucleic acid) to a cell receptor (or surface) in a targeted manner and can be combined with the receptor. The conjugate connected with the active drug (or small nucleic acid) can improve the cell penetration capability of the nucleic acid drug and enhance the stability of the nucleic acid drug in cells owing to the structural characteristics of the conjugate, and can effectively solve the problem of directional delivery of the drug.

Abstract: A foldable electronic device includes a first device body, a second device body, an earpiece, an antenna, and a first switch control circuit. The antenna includes a main radiator and a first parasitic radiator. The main radiator is disposed on the first device body, and the first parasitic radiator and the earpiece are disposed on the second device body. When the foldable electronic device is in a folded state, the main radiator is disposed relative to the first parasitic radiator at a first interval and is coupled to the first parasitic radiator through the first interval. The first switch control circuit includes a first switch component and a plurality of different first matching branches disposed in parallel connection. One end of the first switch control circuit is connected to a ground of the second device body, and the other end is connected to the first parasitic radiator.

Abstract: The present invention relates to a composition for inhibiting the inflammation or aging of stem cells, comprising, as an active ingredient, a compound of Chemical Formula 1 or a pharmaceutically acceptable salt thereof; a method for inhibiting the inflammation or aging of stem cells by using the same; and a method for preparing stem cells having inhibited inflammation or aging; and a pharmaceutical composition for preventing or treating inflammatory diseases, comprising the stem cells, wherein when stem cells are treated with the compound of Chemical Formula 1, the inflammation or aging of stem cells can be inhibited so that the function and morphology of stem cells and intracellular mitochondria damaged in an inflammatory environment can be restored, and the stem cells treated with the compound of Chemical Formula 1 can be effectively used in the prevention or treatment of inflammatory diseases.

Abstract: The present disclosure relates to the technical field of small nucleic acid drug delivery, and particularly discloses a compound, a conjugate and uses thereof. The present disclosure provides a nucleic acid drug targeted delivery monomer and conjugate and a preparation method thereof, the monomer and the conjugate which is formed by the monomer and has a specific design structure can specifically deliver an active drug (or small nucleic acid) to a cell receptor (or surface) in a targeted manner and can be combined with the receptor. The conjugate connected with the active drug (or small nucleic acid) can improve the cell penetration capability of the nucleic acid drug and enhance the stability of the nucleic acid drug in cells owing to the structural characteristics of the conjugate, and can effectively solve the problem of directional delivery of the drug.

Abstract: The present disclosure relates to the technical field of biotechnology, and discloses a nucleic acid targeting angiotensinogen and uses thereof. The nucleic acid provided by the present disclosure can effectively inhibit the expression of AGT, thereby being capable of treating and/or preventing disease related to elevated AGT expression such as hypertension.

Abstract: An example system includes an electronic device and a server. The electronic device includes a display; a first communicator; and a first controller configured to: control to transmit, to the server, location data identifying locations of the electronic device. The server includes a second communicator; and a second controller configured to: control to receive the location data; identify a course of travel; link photograph images to locations on the course of travel; and control to transmit to the electronic device the course of travel and the photograph images. The first controller of the electronic device is configured to control to receive the course of travel and the photograph images and to control to display on the display, at the same time, a map image, the course of travel, and one or more of the photograph images linked to a selected location on the course of travel.

Abstract: There is included a method and apparatus comprising computer code for generating enhanced target speech from audio data, performed by a computing device, the method comprising: receiving audio data corresponding to one or more speakers; generating estimated an target speech, an estimated noise, and an estimated echo simultaneously based on the audio data using a jointly trained complex ratio mask; predicting frame-level multi-tap time-frequency (T-F) spatio-temporal-echo filter weights based on the estimated target speech, the estimated noise, and the estimated echo using a trained neural network model; and predicting enhanced target speech based on the frame-level multi-tap T-F spatio-temporal-echo filter weights.

Abstract: Embodiments of this application provide an electronic device, including a first decoupling member, a first radiator, a second radiator, a first feed unit, a second feed unit, and a rear cover. A first gap is formed between the first radiator and the second radiator. The first radiator includes a first feed point. The second radiator includes a second feed point. The first decoupling member is indirectly coupled to the first radiator and the second radiator, and the first decoupling member is disposed on a surface of the rear cover.

Abstract: Compounds useful as components of immunogenic compositions for the induction of an immunogenic response in a subject against infection, methods for their use in treatment, and processes for their manufacture are provided herein. The compounds comprise a nucleic acid construct comprising a sequence which encodes an interferon effector.

Abstract: An image processing method is performed by a processor. The image processing method includes following operations: generating an average brightness value of each of a plurality windows in image data; generating a pixel ratio value according to the image data; generating a weight value of the each of the windows according to the pixel ratio value, a first brightness weight, and a second brightness weight; generating an adjusted brightness value according to the average brightness values of the windows and the weight values of the windows; and performing an auto exposure process according to the adjusted brightness value to generate final image data. The final image data is for a display panel to display.

Abstract: The disclosure relates to a staggered electrode bio-electro-Fenton groundwater circulation well system, including a groundwater circulation well, a water pumping and injecting assembly and an in-well bio-electro-Fenton assembly. The water pumping and injecting assembly is configured to realize water pumping and injection between different screening sections of the groundwater circulation well. The bio-electro-Fenton assembly arranged in a first screening section of the groundwater circulation well includes at least one electrode device. A cathode and an anode of the electrode device form a spatially staggered arrangement according to different distribution areas.

Abstract: An antenna assembly and a mobile terminal include a first grounding part and a second grounding part and a slot, the first grounding part and the second grounding part are separated by the slot; at least a part of a first feed line is located in the slot or is located in a directly opposite position of the slot, the first feed line is configured to feed the first grounding part and electrically connected to the first grounding part; at least a part of a second feed line is located in the slot or is located in a directly opposite position of the slot, the second feed line is configured to feed one of the first grounding part and the second grounding part, and electrically connected to the other of the first grounding part and the second grounding part.

Abstract: A method and apparatus that identifies one or more characters within a text; determines one or more informative sections within the text, the one or more informative sections providing information regarding a gender of the one or more characters within the text; selects a most informative section from the one or more informative sections; extracts unlabeled instances corresponding to the gender of the one or more characters from the most informative section; iteratively trains a multi-task model using unlabeled corpora, the multi-task model performing both speaker identification and gender identification; and labels the gender of the one or more characters based on the extracted unlabeled instances and the multi-task model.

Abstract: The disclosure relates to a staggered electrode bio-electro-Fenton groundwater circulation well system, including a groundwater circulation well, a water pumping and injecting assembly and an in-well bio-electro-Fenton assembly. The water pumping and injecting assembly is configured to realize water pumping and injection between different screening sections of the groundwater circulation well. The bio-electro-Fenton assembly arranged in a first screening section of the groundwater circulation well includes at least one electrode device. A cathode and an anode of the electrode device form a spatially staggered arrangement according to different distribution areas.

Abstract: An apparatus includes logic circuitry that selects a retag transaction identifier for an original transaction identifier of an incoming transaction request, based on a plurality of sub-groups of retag tracking data. Each sub-group of retag tracking data is associated with a corresponding sub-group of retag transaction identifiers in a group of retag transaction identifiers. The logic circuitry retags the incoming transaction request with the selected retag transaction identifier (ID) by replacing the original transaction identifier associated with the incoming transaction request and sends the retagged incoming transaction request to a target. A returned response is received from the target. The retag transaction ID in the returned response is removed and replaced with the original transaction ID before being sent as a reply to the requesting unit. Associated methods are also presented.

Abstract: A method including receiving an input comprising natural language texts; segmenting the natural language texts into sections; summarizing the natural language texts; developing a first model based on the plurality of sections and the summary of the natural language texts; identifying one or more salient sentences within the natural language texts using the first model; determining a sentence quality score based on how informative a salient sentence is; determining a sentence similarity score based on a salient sentence's similarity to another salient sentence; developing a second model based on the sentence quality score and the sentence similarity score; combining the first model and the second model into a final model; selecting sentences based on the final model; and generating an extractive summarization using the selected sentences.

Abstract: A method, computer program, and computer system is provided for identifying a speaker in at text based work. Labeled and unlabeled instances corresponding to one or more speakers are extracted. Pseudo-labels are inferred for the extracted unlabeled instances based on the labeled instances. One or more of the unlabeled instances are labeled based on the inferred pseudo-labels.

Abstract: A method including: receiving an input comprising natural language texts; selecting, via a knowledge selector, one of a plurality of knowledge categories from an external memory based on a context of the input; retrieving one or more helpful knowledge pieces from the selected knowledge category; augmenting the input using the one or more helpful knowledge pieces; feeding the augmented input into a text-to-text model; and generating an output answer based on the text-to-text model.

Abstract: There is included a method and apparatus comprising computer code for instance-wise adaptive knowledge injection in a pre-trained language model (PTLM) including determining a necessity of external knowledge in a plurality of queries of a first dataset based on a likelihood that a respective query is solved by internal knowledge of a target model. Then, the one or more queries determined to need external knowledge may be augmented with pieces of external knowledge. A combined dataset may be generated by combining the first dataset and the one or more augmented queries, and the combined dataset may be applied to the target model.