Abstract: The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunomers of the invention comprise at least two oligonucleotides linked at their 3? ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunostimulatory oligonucleotide and having an accessible 5? end.

Abstract: Nanostructured layers with 10 nm to 50 nm pores spaced 10-50 nm apart, a method for making such nanostructured layers, optoelectronic devices having such nanostructured layers and uses for such nanostructured layers are disclosed. The nanostructured layer can be formed using precursor sol, which generally includes one or more covalent metal complexes, one or more surfactants, a solvent, one or more optional condensation inhibitors, and (optionally) water. Evaporating the solvent from the precursor sol forms a surfactant-templated film. Covalently crosslinking the surfactant-templated film forms a nanostructured porous layer. Pore size is controlled, e.g., by appropriate solvent concentration, choice of surfactant, use of chelating agents, use of swelling agents or combinations of these.

Abstract: The invention provides an immunostimulatory nucleic acid. In certain embodiments according to this aspect of the invention, the sequence of the immunostimulatory oligonucleotide and/or immunomer is at least partially self-complementary.

Abstract: Described is noise reduction technology generally for speech input in which a noise-suppression related gain value for the frame is determined based upon a noise level associated with that frame in addition to the signal to noise ratios (SNRs). In one implementation, a noise reduction mechanism is based upon minimum mean square error, Mel-frequency cepstra noise reduction technology. A high gain value (e.g., one) is set to accomplish little or no noise suppression when the noise level is below a threshold low level, and a low gain value set or computed to accomplish large noise suppression above a threshold high noise level. A noise-power dependent function, e.g., a log-linear interpolation, is used to compute the gain between the thresholds. Smoothing may be performed by modifying the gain value based upon a prior frame's gain value. Also described is learning parameters used in noise reduction via a step-adaptive discriminative learning algorithm.

Abstract: The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunostimulatory oligonucleotides for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunostimulatory oligonucleotides of the invention preferably comprise novel purines. The immunostimulatory oligonucleotides according to the invention further comprise at least two oligonucleotides linked at their 3? ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunostimulatory oligonucleotide and having an accessible 5? end.

Abstract: A time-asynchronous lattice-constrained search algorithm is developed and used to process a linguistic model of speech that has a long-contextual-span capability. In the algorithm, nodes and links in the lattices developed from the model are expanded via look-ahead. Heuristics as utilized by a search algorithm are estimated. Additionally, pruning strategies can be applied to speed up the search.

Abstract: Disclosed herein are a perfluoroalkyleneoxy group-substituted phenylethylsilane compound and a polymer thereof. The perfluoroalkyleneoxy group-substituted phenylethylsilane compound represented by Formula 1 has excellent thermal and chemical stability to be solution-processed in a monomer state, and the polymer prepared by thermally crosslinking the compound has a high resistance to organic solvents. Moreover, since an insulating layer prepared by applying the same shows improved thermal and physical properties, it is possible to manufacture organic thin-film transistors having a high on/off ratio in a simple process such as a photolithography for a large-size substrate: wherein R1, R2, R3, Z1, Z2, Z3, and n are the same as defined in the detailed description of the invention.

Abstract: Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of TLR2. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding TLR2. The compositions may also comprise antisense oligonucleotides targeted to nucleic acids encoding TLR2 in combination with other therapeutic and/or prophylactic compounds and/or compositions. Methods of using these compounds and compositions for down-regulating TLR2 expression and for prevention or treatment of diseases wherein modulation of TLR2 expression would be beneficial are provided.

Abstract: Provided are a composition for organic thin film transistors including a material including an anthracenyl group and a cross-linker including a maleimide group, an organic thin film transistor formed by using the composition, and a method for manufacturing the same.

Abstract: Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of TLR4. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding TLR4. The compositions may also comprise antisense oligonucleotides targeted to nucleic acids encoding TLR4 in combination with other therapeutic and/or prophylactic compounds and/or compositions. Methods of using these compounds and compositions for down-regulating TLR4 expression and for prevention or treatment of diseases wherein modulation of TLR4 expression would be beneficial are provided.

Abstract: Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of TLR5. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding TLR5. The compositions may also comprise antisense oligonucleotides targeted to nucleic acids encoding TLR5 in combination with other therapeutic and/or prophylactic compounds and/or compositions. Methods of using these compounds and compositions for down-regulating TLR5 expression and for prevention or treatment of diseases wherein modulation of TLR5 expression would be beneficial are provided.

Abstract: Provided is a method of controlling an electronic device by using a remote control device comprising a touch screen, the method including selecting one of a plurality of functions supported by the electronic device via the touch screen, sequentially displaying a plurality of user interfaces, usable for controlling the function selected with an input detected by the touch screen, one-by-one, and controlling the electronic device by using one of the plurality of user interfaces that are sequentially displayed.

Abstract: Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of MyD88. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding MyD88. The compositions may also comprise antisense oligonucleotides targeted to nucleic acids encoding MyD88 in combination with other therapeutic and/or prophylactic compounds and/or compositions. Methods of using these compounds and compositions for down-regulating MyD88 expression and for prevention or treatment of diseases wherein modulation of MyD88 expression would be beneficial are provided.

Abstract: A speech recognition system includes a receiver component that receives a distorted speech utterance. The speech recognition also includes an adaptor component that selectively adapts parameters of a compressed model used to recognize at least a portion of the distorted speech utterance, wherein the adaptor component selectively adapts the parameters of the compressed model based at least in part upon the received distorted speech utterance.

Abstract: A speech recognition system described herein includes a receiver component that receives a distorted speech utterance. The speech recognition also includes an updater component that is in communication with a first model and a second model, wherein the updater component automatically updates parameters of the second model based at least in part upon joint estimates of additive and convolutive distortions output by the first model, wherein the joint estimates of additive and convolutive distortions are estimates of distortions based on a phase-sensitive model in the speech utterance received by the receiver component. Further, distortions other than additive and convolutive distortions, including other stationary and nonstationary sources, can also be estimated used to update the parameters of the second model.

Abstract: A speech recognition system uses Gaussian mixture variable-parameter hidden Markov models (VPHMMs) to recognize speech. The VPHMMs include Gaussian parameters that vary as a function of at least one environmental conditioning parameter. The relationship of each Gaussian parameter to the environmental conditioning parameter(s) is modeled using a piecewise fitting approach, such as by using spline functions. In a training phase, the recognition system can use clustering to identify classes of spline functions, each class grouping together spline functions which are similar to each other based on some distance measure. The recognition system can then store sets of spline parameters that represent respective classes of spline functions. An instance of a spline function that belongs to a class can make reference to an associated shared set of spline parameters. The Gaussian parameters can be represented in an efficient form that accommodates the use of sharing in the above-summarized manner.

Abstract: A speech recognition system uses Gaussian mixture variable-parameter hidden Markov models (VPHMMs) to recognize speech under many different conditions. Each Gaussian mixture component of the VPHMMs is characterized by a mean parameter ? and a variance parameter ?. Each of these Gaussian parameters varies as a function of at least one environmental conditioning parameter, such as, but not limited to, instantaneous signal-to-noise-ratio (SNR). The way in which a Gaussian parameter varies with the environmental conditioning parameter(s) can be approximated as a piecewise function, such as a cubic spline function. Further, the recognition system formulates the mean parameter ? and the variance parameter ? of each Gaussian mixture component in an efficient form that accommodates the use of discriminative training and parameter sharing. Parameter sharing is carried out so that the otherwise very large number of parameters in the VPHMMs can be effectively reduced with practically feasible amounts of training data.

Abstract: Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of TLR8. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding TLR8. The compositions may also comprise antisense oligonucleotides targeted to nucleic acids encoding TLR8 in combination with other therapeutic and/or prophylactic compounds and/or compositions. Methods of using these compounds and compositions for down-regulating TLR8 expression and for prevention or treatment of diseases wherein modulation of TLR8 expression would be beneficial are provided.

Abstract: A method of providing a channel list in an image display system includes receiving a signal mapped to a channel list from an external device; displaying a channel list including one or more channels in response to the received signal; selecting a first channel from the channels included in the channel list; and displaying a tuned first screen of the selected first channel and a second screen, wherein additional information about the first channel is displayed in the second screen.

Abstract: Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of TLR7. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding TLR7. The compositions may also comprise antisense oligonucleotides targeted to nucleic acids encoding TLR7 in combination with other therapeutic and/or prophylactic compounds and/or compositions. Methods of using these compounds and compositions for down-regulating TLR7 expression and for prevention or treatment of diseases wherein modulation of TLR7 expression would be beneficial are provided.