Abstract: The present disclosure provides a method for induced differentiation of an extended pluripotent stem cell (EPSC) into a cardiomyocyte and use thereof, and belongs to the technical field of biomedicine. A reagent used for the induced differentiation is a culture medium having definite chemical components, which can obtain cardiomyocytes having high purity and stable between-batch differentiation efficiency. Compared with cardiomyocytes differentiated from existing pluripotent stem cells, the cardiomyocyte obtained has strong early proliferation ability, and more cell number can be obtained; after extended culture and construction into engineering heart microtissue, maturity is higher, the structure is more regularly arranged, and functional contractility is enhanced. Therefore, the present disclosure is a suitable for mechanism research of heart diseases, drug screening, and cell therapy, and thus has excellent practical application value.

Abstract: A display substrate and a display panel are provided. The display substrate includes a base substrate; the base substrate includes a display region and a peripheral region on at least one side of the display region; the peripheral region includes a first peripheral sub-region and a second peripheral sub-region, the display region includes a first display sub-region corresponding to the first peripheral sub-region and a second display sub-region corresponding to the second peripheral sub-region, and the second display sub-region is different from the first display sub-region; the second peripheral sub-region includes a first gate driving circuit, and the first gate driving circuit is configured to be connected to a plurality of gate scanning signal lines in the first display sub-region through a plurality of connecting lines in the display region, to respectively providing a gate scanning signal to a plurality of rows of pixel units in the first display sub-region.

Abstract: A full-face shaft tunnel boring machine system includes a tunnel boring machine cutterhead device for tunneling downwards in a shaft; a full-hydraulic formwork device for supporting and walling in a wellbore; and an upper muck-discharge system for vertically conveying rock mucks generated by tunneling. The tunnel boring machine cutterhead device comprises a vertical guide frame, a cutter-expanded boring head and an advanced cutterhead that are fixedly connected in a vertical order from top to bottom so as to form an integrated structure. The vertical guide frame is a hollow cylindrical structure and driven to rotate around an axis of the vertical guide frame by a power mechanism, and an outer wall of the vertical guide frame is provided with multiple sets of first guide rollers.

Abstract: The present invention relates to the field of forming technologies for rubber sealing ring blanks, and more particularly to an automatic forming method and device for a rubber sealing ring blank. A cutting blade is fixedly connected to the surface of a blank forming assembly; an equipment body II is fixedly connected to a sliding table die set; a supporting rod II is fixedly connected to the surface of the equipment body II; a blank box is fixedly connected to the inner side surface of the supporting rod II; and a blank spool is fixedly connected to the tail end of a long blank strip. The method and device disclosed by the present invention have the advantages that the automation degree is high, and the long blank strip conveyed from the blank spool passes through guide wheels and a guide groove and is automatically pressed into a ring through the combined action of the blank forming assembly and the cutting blade.

Abstract: The present disclosure provides fully human antibodies that specifically bind the spike (S) protein of the SARS-CoV-2 coronavirus with high affinity, or antigen-binding proteins derived from such antibodies, and uses thereof. Included are anti-spike protein antibodies, antibody fragments, and single-chain antibodies, that are coronavirus neutralizing antibodies, as well as pharmaceutical compositions that include such antibodies and antibody fragments. Methods for using the anti-spike protein antibodies include methods of treating or preventing infection with a coronavirus, such as the SARS-CoV-2 coronavirus, by administering an antibody or antibody fragment as disclosed herein, including by intranasal delivery. Methods and compositions for treating or preventing coronavirus infection by administering a composition that includes a nucleic acid construct that encodes a neutralizing antibody are also provided.

Abstract: A nickel-free LPG marine steel plate and a manufacturing method therefor belong to the technical field of high-strength structural steels; the steel plate consists of the following chemical components by mass percentage: 0.18 to 0.24% of C, 0.10 to 0.19% of Si, 16.1 to 18.9% of Mn, less than or equal to 0.012% of P, 0.15 to 0.35% of Mo, 0.10 to 0.25% of RE, and the balance of Fe and inevitable impurities; the steel plate has a yield strength of ?410 MPa and an impact absorption work of ?66 J at 150° C., has good low-temperature mechanical properties, can replace 5Ni and 9Ni-based steel, and is used for constructing an LPG storage tank and a relevant structural member at low costs.

Abstract: The present disclosure relates to a method of controlling operation state of multi-split air conditioner and system, and a heat pump multi-split. The control method includes: determining a target operation mode of each indoor unit according to an operation mode set by a user for the indoor unit; performing statistics on heat exchange demands of the indoor units corresponding to different target operation modes, and determining a dominant operation mode among the target operation modes according to the heat exchange demands; and using the dominant operation mode as the operation mode of an outdoor unit.

Abstract: The present disclosure discloses a control method for a multi-split air conditioning system and a multi-split air-conditioning system, the multi-split air conditioning system, including a compressor and a plurality of indoor units respectively arranged on a plurality of parallel branches, the indoor unit including a fan and the control method including: in a cooling mode, when the multi-split air conditioning system needs oil return, the multi-split air conditioning system opening a branch where an indoor unit in an off state is located, determining whether the indoor unit has reached a dewing condition, opening the branch on which the indoor unit is located, and controlling the fan of the indoor unit according to a determination result.

Abstract: A monitoring and forewarning method for coal-rock dynamic disasters based on an electromagnetic radiation and an earth-sound monitoring includes the following steps: (1) calculating the weighted average value of research parameter P(t) during a time period according to the monitoring data collected by the electromagnetic radiation and the earth-sound monitoring system in real time; (2) calculating D(t), the deviation value of P(t); (3) calculating |D(t)| as the deviation threshold value, the average value of |D(t)| during period of normal mining of the working surface; (4) calculating DS, the number of times that D(t) is greater than |D(t)| in one day; (5) normalizing DS to obtain the monitoring and forewarning index ?; (6) forewarning the hazard state of dynamic disaster of the working surface in real time according to ? and forewarning method, determining hazard level.

Abstract: The invention relates to the technical field of amorphous soft magnetic material, specifically relating to the field of Fe—Co based amorphous soft magnetic alloy and preparation method thereof. The Fe—Co based amorphous soft magnetic alloy provided in the invention has chemical composition of FeaCobSicBdCue, which possesses merits of highly-saturated magnetic induction, outstanding soft magnetic property and great amorphous forming ability at the same time; the embodiment of Fe—Co based amorphous soft magnetic alloy disclosed in the invention has indicated that its saturation magnetic induction is 1.79˜1.86 T, coercivity 1.4˜4.3 A/m, and permeability 8000˜14000; the invention has advantages of easy treatment process, low annealing temperature, which reduces process cost remarkably and economizes energy, thus having great application prospect.

Abstract: The present disclosure discloses a control method for a multi-split air conditioning system and a multi-split air-conditioning system, the multi-split air conditioning system, including a compressor and a plurality of indoor units respectively arranged on a plurality of parallel branches, the indoor unit including a fan and the control method including: in a cooling mode, when the multi-split air conditioning system needs oil return, the multi-split air conditioning system opening a branch where an indoor unit in an off state is located, determining whether the indoor unit has reached a dewing condition, opening the branch on which the indoor unit is located, and controlling the fan of the indoor unit according to a determination result.

Abstract: The present disclosure relates to a method of controlling operation state of multi-split air conditioner and system, and a heat pump multi-split. The control method includes: determining a target operation mode of each indoor unit according to an operation mode set by a user for the indoor unit; performing statistics on heat exchange demands of the indoor units corresponding to different target operation modes, and determining a dominant operation mode among the target operation modes according to the heat exchange demands; and using the dominant operation mode as the operation mode of an outdoor unit.

Abstract: A device and a method for detecting main acoustic indexes of multi-beam sonar pertaining to the field of hydrographic surveying and charting technology. The device includes a rotating device and a lifting gear installed in an anechoic tank. The bottom of the rotating device is equipped with a multi-beam sonar that has its rotating plane perpendicular to the direction of track line and transmits signals along the horizontal direction. A standard hydrophone is equipped at the bottom of the lifting gear, and is connected with a signal collector. The device utilizes the standard hydrophone to receive the pulse signals transmitted by the multi-beam sonar and employs the multi-beam sonar to receive the standard sound source signals, designs the detection process for data collection for analysis and research, thereby achieving the detection of the frequency, source level and beam angle of multi-beam sonar.

Abstract: Methods and compositions for modulating a target genome are disclosed.

Abstract: A monitoring and forewarning method for coal-rock dynamic disasters based on an electromagnetic radiation and an earth-sound monitoring includes the following steps: (1) calculating the weighted average value of research parameter P(t) during a time period according to the monitoring data collected by the electromagnetic radiation and the earth-sound monitoring system in real time; (2) calculating D(t), the deviation value of P(t); (3) calculating |D(t)| as the deviation threshold value, the average value of |D(t)| during period of normal mining of the working surface; (4) calculating DS, the number of times that D(t) is greater than |D(t)| in one day; (5) normalizing DS to obtain the monitoring and forewarning index ?; (6) forewarning the hazard state of dynamic disaster of the working surface in real time according to ? and forewarning method, determining hazard level.

Abstract: A device and a method for detecting main acoustic indexes of multi-beam sonar pertaining to the field of hydrographic surveying and charting technology. The device includes a rotating device and a lifting gear installed in an anechoic tank. The bottom of the rotating device is equipped with a multi-beam sonar that has its rotating plane perpendicular to the direction of track line and transmits signals along the horizontal direction. A standard hydrophone is equipped at the bottom of the lifting gear, and is connected with a signal collector. The device utilizes the standard hydrophone to receive the pulse signals transmitted by the multi-beam sonar and employs the multi-beam sonar to receive the standard sound source signals, designs the detection process for data collection for analysis and research, thereby achieving the detection of the frequency, source level and beam angle of multi-beam sonar.

Abstract: To comply with a policy for a computing device indicating that data written by the computing device to the storage volume after activation of the policy be encrypted, a sector map is accessed. The sector map identifies one or more sectors of a storage volume and also identifies, for each of the one or more sectors of the storage volume, a signature of the content of the sector. In response to a request to read the content of a sector, the content of the sector is returned without decrypting the content if the sector is one of the one or more sectors and the signature of the content of the sector matches the signature of the sector identified in the sector map. Otherwise, the content of the sector is decrypted and the decrypted content is returned.

Abstract: To comply with a policy for a computing device indicating that data written by the computing device to the storage volume after activation of the policy be encrypted, a sector map is accessed. The sector map identifies one or more sectors of a storage volume and also identifies, for each of the one or more sectors of the storage volume, a signature of the content of the sector. In response to a request to read the content of a sector, the content of the sector is returned without decrypting the content if the sector is one of the one or more sectors and the signature of the content of the sector matches the signature of the sector identified in the sector map. Otherwise, the content of the sector is decrypted and the decrypted content is returned.