Abstract: The present invention relates to a pharmaceutical composition comprising a compound of the present invention, an isomer thereof, a hydrate thereof, a solvate thereof, or a pharmaceutically acceptable salt thereof as an active ingredient for prevention or treatment of cancer. The compound exhibits high inhibitory activity against epidermal growth factor receptor (EGFR) mutants or at least one of the wild-type or mutant ErbB2 and ErbB4 and as such, can be advantageously used for treatment of the cancer expressing same.

Abstract: Provided are a chemiresistor and a method of manufacturing the same, a chemiresistive sensor, and a device. The chemiresistor includes a conductive porous nanocomposite of a three-dimensional metal-organic framework and a two-dimensional metal-organic framework, wherein the two-dimensional metal-organic framework is chemically bound to the three-dimensional metal-organic framework on a surface of the three-dimensional metal-organic framework, and the three-dimensional metal-organic framework and the two-dimensional metal-organic framework form a core-shell structure in the conductive porous nanocomposite.

Abstract: The present application relates to a method for producing a substrate which includes a step of exposing and developing a photosensitive resin composition layer formed on a surface of a substrate base layer to produce spacers. The method for producing a substrate of the present application can uniformly form spacers having a height according to a desired cell gap and can also freely control the height of the spacers.

Abstract: Disclosed is a pharmaceutical composition for the prevention or treatment of brain cancer, containing a compound capable of penetrating the blood-brain barrier as an active ingredient, the pharmaceutical composition for the prevention or treatment of brain cancer is capable of efficiently penetrating the blood-brain barrier of the brain to thereby effectively inhibit LRRK2 protein expression, and is thus useful in the prevention or treatment of brain cancer.

Abstract: Disclosed is a pharmaceutical composition for the prevention or treatment of brain cancer, containing a compound capable of penetrating the blood-brain barrier as an active ingredient, the pharmaceutical composition for the prevention or treatment of brain cancer is capable of efficiently penetrating the blood-brain barrier of the brain to thereby effectively inhibit LRRK2 protein expression, and is thus useful in the prevention or treatment of brain cancer.

Abstract: The present invention relates to a heteroaryl derivative and a pharmaceutical composition for the prevention or treatment of cancer comprising the same as an active ingredient, and a compound according to an aspect of the present invention, a stereoisomer thereof, a hydrate thereof, or a pharmaceutically acceptable salt thereof suppresses kinases, particularly, a TTK kinase, and thus can remarkably suppress the proliferation of cancer cells, and accordingly, can be effectively used as a pharmaceutical composition for the prevention or treatment of cancer.

Abstract: A member for a metal oxide nanofiber based gas sensor can include a metal nanoparticle catalyst and can be formed to be functionalized by binding the metal nanoparticle catalyst and an alkali or alkaline earth metal through electrospinning and heat treatment processes. The member can detect a trace amount of a gas with high selectivity and ultra-high sensitivity by uniformly binding the alkali or alkaline earth metal and the metal nanoparticle catalyst through electrospinning and high-temperature heat treatment.

Abstract: The present invention relates to the radiant artificial lunar light system that contains effective elements for the growth of plants. To explain more specifically, the radiant artificial lunar light system emits lights containing the main mineral materials distributed on the oceanic region of the moon, such as Si, Ti, Fe, Mg, Ca, Na, K, P, Mn, Cr, etc. each doped with a doner by the plural PN bond-type semiconductors' photon device modules; and plural PN bond-type semiconductors' photon device modules; and plural PN bond-type semiconductors' LED modules emitting lights of certain intensity, in order to form the radiant artificial lunar light system.

Abstract: The present invention relates to a method of producing an ADM collagen fiber, an ADM collagen fiber produced using the method, and an apparatus for producing the ADM collagen fiber. More particularly, the present invention relates to a method of producing an ADM collagen fiber including a step of extruding an acidic ADM collagen solution into a basic solution to form filaments. The present invention has an effect of providing a method of producing an ADM collagen fiber, an ADM collagen fiber produced using the method, and an apparatus for producing the ADM collagen fiber. According to the present invention, since a collagen solution raw material having a required concentration may be prepared by immediately pulverizing ADM collagen shells, economic efficiency and productivity may be increased through reduction in production cost and time. In addition, mass production is possible by using a continuous process apparatus with a simple structure.

Abstract: Embodiments of the present disclosure relate to a violacein-polymer composite nanofibrous antimicrobial membrane and a method for manufacturing same, wherein the membrane comprises violacein having antimicrobial efficacy against methicillin-resistant Staphylococcus aureus (MRSA) caused by resistance to antibiotics and is formed such that one-dimensional nanofibers are three-dimensionally entangled, and can be used as an antimicrobial membrane for preventing and treating MRSA infections. Specifically, a solution in which violacein is uniformly mixed is prepared by dissolving a large amount of violacein in a solution with a polymer dissolved therein, and the solution is subjected to an electrospinning process to synthesize a nanofibrous membrane in which violacein is uniformly included inside/outside nanofibers without agglomeration. Thus, this is different from existing methods for applying a material to the surface of fibers.

Abstract: Provided are a composite structure, in which metal nanoparticle-perovskite oxide is bound to metal oxide supports (i.e., sensing materials), and a preparation method thereof. The composite structure has improved durability, in which metal nanoparticles uniform in size are evenly distributed on the surface of perovskite oxide. Provided is also a high-performance gas sensor having excellent target gas detection performances by including the composite structure.

Abstract: Provided is a dish washer having an enhanced structure for usability. A dish washer may be installed in a built-in type in a system kitchen including a cabinet having a storage room and a counter arranged on the cabinet to have an opening. The dish washer includes a tub having a front opening, a front door provided to open or close the front opening, a cover frame mounted on the opening of the counter to be separated from the tub in a vertical direction of the dish washer, a top door installed on the cover frame to open or close the opening of the counter, and a coupling member coupling the cover frame to the tub to be expanded or contracted in the vertical direction of the dish washer.

Abstract: The present invention relates to an N-containing heteroaryl derivative and a pharmaceutical composition comprising same as an active ingredient for the prevention or treatment of cancer. The derivative exhibits high inhibitory activity against various protein kinases, particularly excellent ret proto-oncogene (RET) enzyme inhibitory ability, and has an excellent effect of inhibiting the proliferation of medullary thyroid cancer cells and lung cancer cells, which express RET fusion genes, and thus the derivative can be effectively used in the treatment of cancer, for example, medullary thyroid cancer or lung cancer, and particularly, can be effectively used in the treatment of cancer in which RET fusion genes are expressed.

Abstract: The present invention relates to a 6-(isooxazolidin-2-yl)-N-phenylpyrimidin-4-amine derivative, and a pharmaceutical composition for preventing or treating cancer comprising the compound as an effective component. The compound exhibits high inhibitory activity against an epidermal growth factor receptor (EGFR) variant, or wild-type or variants of one or more of ERBB2 and ERBB4, and thus may be usefully used in the treatment of cancers in which same are expressed. In particular, the compound exhibits excellent inhibitory activity on proliferation of lung cancer cell lines, and thus can be usefully used in the treatment of lung cancer.

Abstract: The present invention relates to a 6-(isooxazolidin-2-yl)-N-phenylpyrimidin-4-amine derivative, and a pharmaceutical composition for preventing or treating cancer comprising the compound as an effective component. The compound exhibits high inhibitory activity against an epidermal growth factor receptor (EGFR) variant, or wild-type or variants of one or more of ERBB2 and ERBB4, and thus may be usefully used in the treatment of cancers in which same are expressed. In particular, the compound exhibits excellent inhibitory activity on proliferation of lung cancer cell lines, and thus can be usefully used in the treatment of lung cancer.

Abstract: Disclosed are a member for a gas sensor, a gas sensor using the member, and a method of fabricating the same. Specifically, disclosed are a member for a gas sensor using a metal oxide nanofiber material in which nanocatalysts have been uniformly bound and functionalized using chitosans with which nanoparticle catalysts have been combined, a gas sensor using the member, and a method of fabricating the same.

Abstract: The present invention relates to a heterocycle-fused pyrimidine derivative compound or a pharmaceutically acceptable salt thereof, a pharmaceutical composition for preventing or treating diseases related to one or more protein kinases of FLT3, CDK4, CDK6 and HPK1, comprising the same as an active ingredient, and a method for preventing or treating diseases related to one or more protein kinases of FLT3, CDK4, CDK6 and using the same.

Abstract: Disclosed herein is a complex generator including a hydrophilic fiber membrane coated with an adsorption material. Electrical energy is generated in such a manner that the adsorption material is adsorbed onto a polar solvent in some region of the hydrophilic fiber membrane by asymmetrical wetting of the polar solvent for the hydrophilic fiber membrane.

Abstract: The present invention relates to the radiant artificial lunar light system that contains effective elements for the growth of plants. To explain more specifically, the radiant artificial lunar light system emits lights containing the main mineral materials distributed on the oceanic region of the moon, such as Si, Ti, Fe, Mg, Ca, Na, K, P, Mn, Cr, etc. each doped with a doner by the plural PN bond-type semiconductors' photon device modules; and plural PN bond-type semiconductors' photon device modules; and plural PN bond-type semiconductors' LED modules emitting lights of certain intensity, in order to form the radiant artificial lunar light system.