Patents by Inventor Dorothea Reilly

Dorothea Reilly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for secretion of heterologous polypeptides
    Patent number: 11390872
    Abstract: The present invention relates generally to the fields of molecular biology and protein technology. More specifically, the invention concerns signal sequences for the secretion of heterologous polypeptide from bacteria. The invention also concerns re-combinant polypeptides and uses thereof.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: July 19, 2022
    Assignee: Genentech, Inc.
    Inventors: Dorothea Reilly, Yizhou Zhou
  • METHODS AND COMPOSITIONS FOR SECRETION OF HETEROLOGOUS POLYPEPTIDES
    Publication number: 20200181625
    Abstract: The present invention relates generally to the fields of molecular biology and protein technology. More specifically, the invention concerns signal sequences for the secretion of heterologous polypeptide from bacteria.
    Type: Application
    Filed: August 22, 2019
    Publication date: June 11, 2020
    Applicant: Genentech, Inc.
    Inventors: Dorothea REILLY, Yizhou ZHOU
  • Methods and compositions for secretion of heterologous polypeptides
    Patent number: 10435694
    Abstract: The present invention relates generally to the fields of molecular biology and protein technology. More specifically, the invention concerns signal sequences for the secretion of heterologous polypeptide from bacteria. The invention also concerns recombinant polypeptides and uses thereof.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: October 8, 2019
    Assignee: Genentech, Inc.
    Inventors: Dorothea Reilly, Yizhou Zhou
  • Methods of producing two chain proteins in bacteria
    Patent number: 10112994
    Abstract: Provided herein are methods of producing a polypeptide containing two chains, such as an antibody including a light chain and a heavy chain. In particular, methods are provided for producing heterologous secretory proteins in bacteria through utilization of optimized expression vectors and culture processes.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: October 30, 2018
    Assignee: GENENTECH, INC.
    Inventors: James Giulianotti, Dorothea Reilly
  • Methods of producing two chain proteins in bacteria
    Patent number: 10066002
    Abstract: Provided herein are methods of producing a recombinant polypeptide containing two chains, such as an immune mobilizing monoclonal T-cell receptor against cancer (ImmTAC) protein including an alpha chain and a beta chain. In particular, methods are provided for producing heterologous secretory proteins in bacteria through utilization of optimized expression vectors and culture processes.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: September 4, 2018
    Assignee: GENENTECH, INC.
    Inventors: James Giulianotti, Dorothea Reilly, Kieran Aurori, Laura C. Simmons
  • METHODS AND COMPOSITIONS FOR SECRETION OF HETEROLOGOUS POLYPEPTIDES
    Publication number: 20170029825
    Abstract: The present invention relates generally to the fields of molecular biology and protein technology. More specifically, the invention concerns signal sequences for the secretion of heterologous polypeptide from bacteria. The invention also concerns recombinant polypeptides and uses thereof.
    Type: Application
    Filed: March 16, 2015
    Publication date: February 2, 2017
    Applicant: GENENTECH, INC.
    Inventors: Dorothea REILLY, Yizhou ZHOU
  • METHODS OF PRODUCING TWO CHAIN PROTEINS IN BACTERIA
    Publication number: 20160159880
    Abstract: Provided herein are methods of producing a recombinant polypeptide containing two chains, such as an immune mobilizing monoclonal T-cell receptor against cancer (ImmTAC) protein including an alpha chain and a beta chain. In particular, methods are provided for producing heterologous secretory proteins in bacteria through utilization of optimized expression vectors and culture processes.
    Type: Application
    Filed: November 5, 2015
    Publication date: June 9, 2016
    Applicant: GENENTECH, INC.
    Inventors: James GIULIANOTTI, Dorothea REILLY, Kieran Aurori, Laura C. Simmons
  • METHODS OF PRODUCING TWO CHAIN PROTEINS IN BACTERIA
    Publication number: 20160159898
    Abstract: Provided herein are methods of producing a polypeptide containing two chains, such as an antibody including a light chain and a heavy chain. In particular, methods are provided for producing heterologous secretory proteins in bacteria through utilization of optimized expression vectors and culture processes.
    Type: Application
    Filed: November 5, 2015
    Publication date: June 9, 2016
    Applicant: GENENTECH, INC.
    Inventors: James GIULIANOTTI, Dorothea REILLY
  • ALTERED BR-3 BINDING POLYPEPTIDES
    Publication number: 20100166741
    Abstract: The present invention relates to novel BR3 binding antibodies having altered Fc effector function and/or having a mature core carbohydrate structure in the Fc region which lacks fiicose. The present invention also relates to the use of those BR3 binding antibodies and polypeptides in, e.g., methods of treatment, screening methods, diagnostic methods, assays and protein purification methods.
    Type: Application
    Filed: July 12, 2007
    Publication date: July 1, 2010
    Applicants: Genentech , Inc., Biogen Idec Ma Inc.
    Inventors: Robert F. Kelley, Amy Yijuan Shen, Dorothea Reilly, Mark S. Dennis, Germaine Fuh, Chingwei V. Lee, Christine M. Ambrose, Jeffrey S. Thompson
  • Methods and compositions for increasing antibody production
    Patent number: 7655783
    Abstract: The invention provides methods and compositions for improved expression and production of recombinant antibodies in host cell expression systems. In particular, prokaryotic expression and production of antibodies with modified hinge cysteine residues are provided. The invention further provides compositions, kits and articles of manufacture for practicing methods of the present invention.
    Type: Grant
    Filed: May 22, 2006
    Date of Patent: February 2, 2010
    Assignee: Genentech, Inc.
    Inventors: Dorothea Reilly, Daniel Yansura
  • Methods and compositions for increasing antibody production
    Patent number: 7608429
    Abstract: The invention provides methods and compositions for improved expression and production of recombinant antibodies in host cell expression systems. In particular, prokaryotic expression and production of antibodies with modified hinge cysteine residues are provided. The invention further provides compositions, kits and articles of manufacture for practicing methods of the present invention.
    Type: Grant
    Filed: October 30, 2003
    Date of Patent: October 27, 2009
    Assignee: Genentech, Inc.
    Inventors: Dorothea Reilly, Daniel Yansura
  • Antibodies with altered effector functions
    Publication number: 20070269371
    Abstract: The invention provides antibodies with altered effector functions, and methods of using these antibodies in the treatment of various diseases. The invention further provides compositions, kits and articles of manufacture for practicing methods of the invention.
    Type: Application
    Filed: February 28, 2007
    Publication date: November 22, 2007
    Inventors: Lynne Krummen, Dorothea Reilly, Stefanie Weikert
  • Methods and compositions for increasing antibody production
    Publication number: 20070128111
    Abstract: The invention provides methods and compositions for improved expression and production of recombinant antibodies in host cell expression systems. In particular, prokaryotic expression and production of antibodies with modified hinge cysteine residues are provided. The invention further provides compositions, kits and articles of manufacture for practicing methods of the present invention.
    Type: Application
    Filed: May 22, 2006
    Publication date: June 7, 2007
    Applicant: GENENTECH, INC.
    Inventors: Dorothea Reilly, Daniel Yansura
  • Prokaryotically produced antibodies and uses thereof
    Publication number: 20070065909
    Abstract: The present invention provides methods and compositions for improved expression and production of recombinant antibodies in prokaryotic expression systems. Particularly contemplated are prokaryotic expression and production of full length aglycosylated antibodies. The antibody products of the invention can be used in various aspects of biological research, diagnosis and medical treatment.
    Type: Application
    Filed: February 9, 2006
    Publication date: March 22, 2007
    Applicant: GENENTECH, INC.
    Inventors: Laura Simmons, Laura Klimowski, Dorothea Reilly, Daniel Yansura
  • Prokaryotically produced antibodies and uses thereof
    Publication number: 20070020725
    Abstract: The present invention provides methods and compositions for improved expression and production of recombinant antibodies in prokaryotic expression systems. Particularly contemplated are prokaryotic expression and production of full length aglycosylated antibodies. The antibody products of the invention can be used in various aspects of biological research, diagnosis and medical treatment.
    Type: Application
    Filed: May 22, 2006
    Publication date: January 25, 2007
    Applicant: GENENTECH, INC.
    Inventors: Laura Simmons, Laura Klimowski, Dorothea Reilly, Daniel Yansura
  • Process for production of polypeptides
    Publication number: 20060286640
    Abstract: Vectors for producing polypeptides heterologous to prokaryotes are described comprising, along with the polypeptide-encoding nucleic acid, anti-termination nucleic acid that inhibits intragenic transcription termination with a non-lambda promoter therefor and/or nucleic acid encoding a GreA or GreB protein and a promoter therefor. Also described are processes for producing a heterologous polypeptide in prokaryotic host cells utilizing such elements to improve the quality and/or quantity of heterologous polypeptide produced.
    Type: Application
    Filed: August 16, 2006
    Publication date: December 21, 2006
    Inventors: Eriks Paegle, Dorothea Reilly, Daniel Yansura
  • Process for production of polypeptides
    Publication number: 20060216784
    Abstract: Vectors for producing polypeptides heterologous to prokaryotes are described comprising, along with the polypeptide-encoding nucleic acid, anti-termination nucleic acid that inhibits intragenic transcription termination with a non-lambda promoter therefor and/or nucleic acid encoding a GreA or GreB protein and a promoter therefor. Also described are processes for producing a heterologous polypeptide in prokaryotic host cells utilizing such elements to improve the quality and/or quantity of heterologous polypeptide produced.
    Type: Application
    Filed: January 26, 2006
    Publication date: September 28, 2006
    Inventors: Eriks Paegle, Dorothea Reilly, Daniel Yansura
  • Process for production of polypeptides
    Patent number: 7029876
    Abstract: Vectors for producing polypeptides heterologous to prokaryotes are described comprising, along with the polypeptide-encoding nucleic acid, anti-termination nucleic acid that inhibits intragenic transcription termination with a non-lambda promoter therefor and/or nucleic acid encoding a GreA or GreB protein and a promoter therefor. Also described are processes for producing a heterologous polypeptide in prokaryotic host cells utilizing such elements to improve the quality and/or quantity of heterologous polypeptide produced.
    Type: Grant
    Filed: February 22, 2002
    Date of Patent: April 18, 2006
    Assignee: Genentech, Inc.
    Inventors: Eriks Sasha Paegle, Dorothea Reilly, Daniel G. Yansura
  • Separate-cistron contructs for secretion of aglycosylated antibodies from prokaryotes
    Patent number: 6979556
    Abstract: The present invention provides methods and compositions for improved expression and production of recombinant antibodies in prokaryotic expression systems. Particularly contemplated are prokaryotic expression and production of full length aglycosylated antibodies. The antibody products of the invention can be used in various aspects of biological research, diagnosis and medical treatment.
    Type: Grant
    Filed: December 13, 2001
    Date of Patent: December 27, 2005
    Assignee: Genentech, Inc.
    Inventors: Laura C. Simmons, Laura Klimowski, Dorothea Reilly, Daniel G. Yansura
  • Prokaryotically produced antibodies and use thereof
    Publication number: 20050170464
    Abstract: The present invention provides methods and compositions for improved expression and production of recombinant antibodies in prokaryotic expression systems. Particularly contemplated are prokaryotic expression and production of full length aglycosylated antibodies. The antibody products of the invention can be used in various aspects of biological research, diagnosis and medical treatment.
    Type: Application
    Filed: March 2, 2005
    Publication date: August 4, 2005
    Applicant: GENENTECH, INC.
    Inventors: Laura Simmons, Laura Klimowski, Dorothea Reilly, Daniel Yansura