Abstract: A structural support beam for use in buildings, bridges, mechanical frames and the like to resist bending due to gravitational and external forces comprising a top substantially flat flange disposed in fixed spaced relationship relative to a bottom substantially concave flange by an interconnecting web and a lower stabilizing brace disposed to engage the opposite end portions of the bottom substantially concave flange and the opposite end portions of the interconnecting web to reinforce the interconnection therebetween.

Abstract: An inventory system includes a pallet and a base for palletizing or unpalletizing a mobile drive unit. The pallet has a set of openings corresponding with features of the mobile drive unit. The mobile drive unit features may extend into the pallet openings. The base includes protrusions corresponding to the pallet openings. Engaging the pallet and base can position the base protrusions in the pallet openings. Positioning the base protrusions in the pallet openings can displace the mobile drive unit features from the pallet openings and/or provide a surface upon which the mobile drive unit can navigate.

Abstract: The invention provides anti-PCSK9 antibodies, formulations, dosing regimens, and methods of using the same.

Abstract: An inventory system includes a pallet and a base for palletizing or unpalletizing a mobile drive unit. The pallet has a set of openings corresponding with features of the mobile drive unit. The mobile drive unit features may extend into the pallet openings. The base includes protrusions corresponding to the pallet openings. Engaging the pallet and base can position the base protrusions in the pallet openings. Positioning the base protrusions in the pallet openings can displace the mobile drive unit features from the pallet openings and/or provide a surface upon which the mobile drive unit can navigate.

Abstract: An inventory system includes a pallet and a base for palletizing or unpalletizing a mobile drive unit. The pallet has a set of openings corresponding with features of the mobile drive unit. The mobile drive unit features may extend into the pallet openings. The base includes protrusions corresponding to the pallet openings. Engaging the pallet and base can position the base protrusions in the pallet openings. Positioning the base protrusions in the pallet openings can displace the mobile drive unit features from the pallet openings and/or provide a surface upon which the mobile drive unit can navigate.

Abstract: An inventory system includes a pallet and a base for palletizing or unpalletizing a mobile drive unit. The pallet has a set of openings corresponding with features of the mobile drive unit. The mobile drive unit features may extend into the pallet openings. The base includes protrusions corresponding to the pallet openings. Engaging the pallet and base can position the base protrusions in the pallet openings. Positioning the base protrusions in the pallet openings can displace the mobile drive unit features from the pallet openings and/or provide a surface upon which the mobile drive unit can navigate.

Abstract: An approach is provided in which a distributed runtime environment executes a software application that includes isolated runtime constructs corresponding to an isolated runtime environment. During the execution, the distributed runtime environment identifies isolated runtime constructs included in the software application and selects distributed runtime constructs corresponding to the isolated runtime constructs. In turn, the distributed runtime environment executes the distributed runtime constructs in lieu of executing the isolated runtime constructs.

Abstract: An inventory system includes a pallet and a base for palletizing or unpalletizing a mobile drive unit. The pallet has a set of openings corresponding with features of the mobile drive unit. The mobile drive unit features may extend into the pallet openings. The base includes protrusions corresponding to the pallet openings. Engaging the pallet and base can position the base protrusions in the pallet openings. Positioning the base protrusions in the pallet openings can displace the mobile drive unit features from the pallet openings and/or provide a surface upon which the mobile drive unit can navigate.

Abstract: An approach is provided in which a distributed runtime environment executes a software application that includes isolated runtime constructs corresponding to an isolated runtime environment. During the execution, the distributed runtime environment identifies isolated runtime constructs included in the software application and selects distributed runtime constructs corresponding to the isolated runtime constructs. In turn, the distributed runtime environment executes the distributed runtime constructs in lieu of executing the isolated runtime constructs.

Abstract: An approach is provided in in which distributed runtime environment executes a software application that includes isolated runtime constructs corresponding to an isolated runtime environment. During the execution, the distributed runtime environment identifies isolated runtime constructs included in the software application and selects distributed runtime constructs corresponding to the isolated runtime constructs. In turn, the distributed runtime environment executes the distributed runtime constructs in lieu of executing the isolated runtime constructs.

Abstract: An approach is provided in in which distributed runtime environment executes a software application that includes isolated runtime constructs corresponding to an isolated runtime environment. During the execution, the distributed runtime environment identifies isolated runtime constructs included in the software application and selects distributed runtime constructs corresponding to the isolated runtime constructs. In turn, the distributed runtime environment executes the distributed runtime constructs in lieu of executing the isolated runtime constructs.

Abstract: The invention provides anti-PCSK9 antibodies, formulations, dosing regimens, and methods of using the same.

Abstract: A mechanochromic material includes a polymer having a backbone containing a mechanophore.

Abstract: A mechanochromic material includes a polymer having a backbone containing a mechanophore.

Abstract: Methods, systems, and computer program products for improving network operations by dynamically undeploying services (such as web services or other network-accessible services) in a computing network. A process is defined whereby conditions such as usage metrics for incoming client requests (or other network conditions such as load balancing considerations) are monitored, and used to trigger dynamic undeployment of web services from locations in the network. The undeployment may apply to distributed locations of a service, and may also apply to an origin server from which the service was originally deployed. Service requests are dynamically routed to the destination where the service resides, in a manner which is transparent to the client.

Abstract: A method of accessing a remote location on a network using an optical reader. The optical reader has an optical scanning system and a dedicated address memory system. The optical scanning system, in response to the user scanning an encoded indicia therewith, sends to a first computer disposed on the network a scan code indicative of information encoded in the scanned indicia. The dedicated address memory system, in response to the user completing an activation sequence, sends to the first computer a dedicated code indicative of information corresponding to a particular remote location. The information from the dedicated address memory system corresponding to a particular remote location does not originate from the scanning of an encoded indica by the user. One of the scan code and the dedicated code is transmitted from the optical reader to the first computer.

Abstract: The invention provides a controlled-release pharmaceutical formulation for oral administration comprising 4-amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline, or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable adjuvant, diluent or carrier; characterized in that the formulation is adapted to release at least 50% by weight of the 4-amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline, or the pharmaceutically acceptable salt thereof, after 6 hours in Apparatus 1 described in the United States Pharmacopoeia 24 (2000), pp 1941–1943, having 1 litre vessels, baskets of 40 mesh (0.4 mm apertures), a rotation speed of 100 rpm, and a dissolution medium consisting of 900 ml of 0.01 M hydrochloric acid containing 0.7% w/v sodium chloride at 37° C. Formulations according to the invention are suitable for the treatment of BPH.

Abstract: An optical reader is provided for reading a symbol representing information having areas of different light reflectivity. The optical reader comprises a radiant energy source, a photodetector, an optical system and a decoder. The radiant energy source generates a radiant energy for illuminating a target region. The photodetector generates output electrical signals indicative of the radiant energy incident thereon. The optical system includes a projection portion and a collection portion. The projection portion directs the radiant energy along a projection path extending from the radiant energy source to the target region. The collection portion collects the radiant energy reflected from a symbol when the symbol occupies the target region and directs the collected radiant energy along a collection path extending from the target region to the photodetector.

Abstract: Services deployed in a network computing environment (such as a Web services implementation model) are transparently extended. Preferably, handler components in an engine that processes requests and responses provide the extensions. A handler for outgoing messages adds the extensions to a response message that is created responsive to receiving a request message that asks for a service's available operations. A client receiving this response message can then invoke one of the extensions, without knowing that it is an extension. A handler for incoming messages checks received requests: if a request for an extension is received, the handler routes that message to a location other than the service itself; otherwise, incoming requests for operations that are actually available from the service are routed thereto.

Abstract: A method of accessing a remote location on a network using an optical reader. The optical reader includes an optical scanning system, a programmable memory system and an output circuit and is user-switchable between a scan mode, a record mode and a playback mode. The optical reader transmits a code to a first computer disposed on the network. When the optical reader is in the scan mode, the code is indicative of information extracted from an encoded indicia just scanned by the optical scanning system. When the optical reader is in the playback mode, the code is indicative of information retrieved from a user-selectable memory in the programmable memory system. The information in the user-selectable memory was previously stored in the user-selectable memory after being extracted from an encoded indicia scanned by the optical scanning system when the reader was in the record mode. In response to the first computer receiving the code from the optical reader, a second computer disposed on the network is accessed.