Abstract: Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL, MER or Tyro3 protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL, MER or Tyro3 and its ligand GAS6.

Abstract: A dynamically balanced, tracked robot, which can switch between dynamically balanced (wheeled) operation and tracked operation, can include a body and at least one wheel rotatably mounted to the body. At least one strut can also be mounted to the body so that it extends therefrom, and an idler wheel can be fixed to the distal end of the strut. A track can be slipped over the wheel and that idler wheel, so that the track frictionally engages both the wheel and the idler wheel. The robot can have a defined vertical reference vector and a processor. The processor can have non-transitory written instructions that, when accomplished, cause the vertical reference vector to be parallel with a vector defined by the robot axis and the revised post-installation center of gravity, to continue to allow for dynamic balancing of the newly-tracked robot.

Abstract: Embodiments relate to polycrystalline diamond compacts (“PDCs”) including a polycrystalline diamond (“PCD”) table in which a metal-solvent catalyst is alloyed with at least one alloying element to improve thermal stability of the PCD table. In an embodiment, a PDC includes a substrate and a PCD table bonded to the substrate. The PCD table includes diamond grains defining interstitial regions. The PCD table includes an alloy comprising at least one Group VIII metal and at least one metallic alloying element that lowers a temperature at which melting of the at least one Group VIII metal begins. The alloy includes one or more solid solution phases comprising the at least one Group VIII metal and the at least one metallic alloying element and one or more intermediate compounds comprising the at least one Group VIII metal and the at least one metallic alloying element.

Abstract: A concealed-shower drain assembly has a rigid vertical flange continuously joined in fixed orientation along one side of a rigid horizontal deck member. An opening in the horizontal deck leads to a sealed drain box on the underside of the deck. A drain pipe at the bottom of the drain box provides egress of waste shower water from the drain box. A removable access panel is supported in the deck opening by a plurality of support posts affixed to the interior wall of the drain box. A continuous gap between the periphery of the access panel and the sides of the opening in the horizontal deck provides a flow path for shower waste water into the drain box. The drain assembly can be securely attached in place in a shower stall by nailing or screwing the rigid vertical flange directly to the framing of the shower stall.

Abstract: A concealed-shower drain assembly has a rigid vertical flange continuously joined in fixed orientation along one side of a rigid horizontal deck member. An opening in the horizontal deck leads to a. sealed drain box on the underside of the deck. A drain pipe at the bottom of the drain box provides egress of waste shower water from the drain box. A removable access panel is supported in the deck opening by a plurality of support posts affixed to the interior wall of the drain box. A continuous gap between the periphery of the access panel and the sides of the opening in the horizontal deck provides a flow path for shower waste water into the drain box. The drain assembly can be securely attached in place in a shower stall by nailing or screwing the rigid vertical flange directly to the framing of the shower stall.

Abstract: In an embodiment, a cell assembly for use in a high-pressure cubic press may include at least one can assembly containing a diamond volume. The at least one can assembly may include an end surface in proximity to the diamond volume. The cell assembly may include at least one heating element including a major surface generally opposing and positioned adjacent to the end surface of the at least one can assembly. The at least one heating element may be positioned and configured to heat the diamond volume. The cell assembly may include at least one pressure transmitting medium extending about the at least one can assembly, and a gasket medium that defines a receiving space configured to receive the at least one can assembly, the one or more heating elements, and the at least one pressure transmitting medium.

Abstract: Embodiments of the invention relate to polycrystalline diamond compacts (“PDCs”) comprising a polycrystalline diamond (“PCD”) table including a thermally-stable region having at least one low-carbon-solubility material disposed interstitially between bonded diamond grains thereof, and methods of fabricating such PDCs. In an embodiment, a PDC includes a substrate, and a PCD table bonded to the substrate. The PCD table includes a plurality of diamond grains exhibiting diamond-to-diamond bonding therebetween and defining a plurality of interstitial regions. The PCD table further includes at least one low-carbon-solubility material disposed in at least a portion of the plurality of interstitial regions. The at least one low-carbon-solubility material exhibits a melting temperature of about 1300° C. or less and a bulk modulus at 20° C. of less than about 150 GPa.

Abstract: System and methods for preventing leakage of exhaust gasses in the segmented manifold of an engine system are disclosed. In an aspect, an assembly includes a first manifold, a flange, and a first carrier and a second carrier having recessed portions configured to accommodate compressions rings to deliver a sealing force.

Abstract: Polypeptides comprising variant vascular endothelial growth factor sequences are provided. The polypeptides are useful in cancer imaging, cancer diagnosis, monitoring and treatment as well as treatment of diseases characterized by excessive neovascularization.

Abstract: Magnesium based cements are provided using one or more slurry precursors. In an embodiment, a method of forming a magnesium-based cement includes providing an aqueous slurry of a magnesium compound. A magnesium cement co-reactant is also provided. The aqueous slurry of the magnesium compound is mixed with the magnesium cement co-reactant to provide the magnesium-based cement.

Abstract: Embodiments of the invention relate to polycrystalline diamond compacts (“PDCs”) comprising a polycrystalline diamond (“PCD”) table including a thermally-stable region having at least one low-carbon-solubility material disposed interstitially between bonded diamond grains thereof, and methods of fabricating such PDCs. In an embodiment, a PDC includes a substrate, and a PCD table bonded to the substrate. The PCD table includes a plurality of diamond grains exhibiting diamond-to-diamond bonding therebetween and defining a plurality of interstitial regions. The PCD table further includes at least one low-carbon-solubility material disposed in at least a portion of the plurality of interstitial regions. The at least one low-carbon-solubility material exhibits a melting temperature of about 1300° C. or less and a bulk modulus at 20° C. of less than about 150 GPa.

Abstract: Polypeptides comprising variant vascular endothelial growth factor sequences are provided. The polypeptides are useful in cancer imaging, cancer diagnosis, monitoring and treatment as well as treatment of diseases characterized by excessive neovascularization.

Abstract: This disclosure relates to bands for wearable devices. In an aspect, the band includes a support structure with an antenna disposed thereon. An electronics unit is coupled to the support structure. The band can include an opening that surrounds the support structure. The band can also include an electronics casing that surrounds the electronics unit. The band can be removed from the support structure and the electronics unit.

Abstract: Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL and its ligand GAS6.

Abstract: Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL and its ligand GAS6.

Abstract: Polypeptides comprising variant vascular endothelial growth factor sequences are provided. The polypeptides are useful in cancer imaging, cancer diagnosis, monitoring and treatment as well as treatment of diseases characterized by excessive neovascularization.

Abstract: Polypeptides comprising variant vascular endothelial growth factor sequences are provided. The polypeptides are useful in cancer imaging, cancer diagnosis, monitoring and treatment as well as treatment of diseases characterized by excessive neovascularization.

Abstract: Polypeptides comprising variant vascular endothelial growth factor sequences are provided. The polypeptides are useful in cancer imaging, cancer diagnosis, monitoring and treatment as well as treatment of diseases characterized by excessive neovascularization.

Abstract: The present disclosure describes apparatuses and techniques for low-power alternate firmware. In some aspects, data packets are received from a network interface via a reduced-feature-set network stack implemented on a subset of hardware. The reduced-feature-set network stack is used to respond to some of the data packets. When a determination is made that the reduced-feature-set network stack is not capable of responding to others of the data packets, an increased-feature-set network stack is implemented via another subset of the hardware.

Abstract: Embodiments of the invention are directed to cutting tool assemblies, material-removing machines that include cutting tool assemblies, and methods of use and operation thereof. In some embodiments, the cutting tool assemblies described herein may be used in material-removing machines that may remove target material. For example, the cutting tool assemblies may include one or more superhard working surfaces and/or one or more shields.