Abstract: The present invention is directed to the anti-LAG-3 antibodies, LAG-3 mAb 1, LAG-3 mAb 2, LAG-3 mAb 4, LAG-3 mAb 5, and LAG-3 mAb 6, and to humanized and chimeric versions of such antibodies. The invention additionally pertains to LAG-3-binding molecules that comprise LAG-3 binding fragments of such anti-LAG-3 antibodies, immunocongugates, and to bispecific molecules, including diabodies, BiTEs, bispecific antibodies, etc., that comprise (i) such LAG-3-binding fragments, and (ii) a domain capable of binding an epitope of a molecule involved in regulating an immune check point present on the surface of an immune cells. The present invention also pertains to methods of detecting LAG-3, as well as methods of using molecules that bind LAG-3 for stimulating immune responses.

Abstract: A packet-filtering system configured to filter packets in accordance with packet-filtering rules may receive data indicating network-threat indicators and may configure the packet-filtering rules to cause the packet-filtering system to identify packets comprising unencrypted data, and packets comprising encrypted data. A portion of the unencrypted data may correspond to one or more of the network-threat indicators, and the packet-filtering rules may be configured to cause the packet-filtering system to determine, based on the portion of the unencrypted data, that the packets comprising encrypted data correspond to the one or more network-threat indicators.

Abstract: A wheelchair armrest storage system may include a housing for a wheelchair, where: the housing includes a proximal portion, a distal portion, a first lateral side, and a second lateral side, the housing extends longitudinally between the proximal portion and the distal portion, and at least one cover receiving cavity is defined in each of the first lateral side and the second lateral side. The wheelchair armrest storage system may further include a storage area defined within the housing, and a cover configured to translate within each of the at least one cover receiving cavity defined in each of the first lateral side and the second lateral side.

Abstract: Systems and methods of wheelchair systems having a companion control mode are disclosed. The wheelchair system includes a companion and a wheelchair. The wheelchair includes one or more wheels, at least one actuator coupled to the one or more wheels, a processing device, and a non-transitory, processor-readable storage medium in communication with the processing device. The non-transitory, processor-readable storage medium includes one or more programming instructions that, when executed, cause the processing device to determine the companion, generate a companion profile based on the determined companion, determine a movement of the companion, and actuate the at least one actuator to drive the one or more wheels to follow the movement of the companion. The actuation of the at least one actuator to drive the one or more wheels to follow the movement of the companion is an autonomous control.

Abstract: An omni-wheel may include a shaft, a plurality of rollers, and a braking device. The plurality of rollers may be circumferentially arranged about the shaft and arranged radially outward from the shaft. The braking device may include a fluid-filled bladder and a plurality of braking pads. The fluid-filled bladder may be circumferentially arranged about the shaft. The plurality of braking pads may be arranged between the fluid-filled bladder and the plurality of rollers. The fluid-filled bladder may expand radially outward when pressurized, displacing the plurality of braking pads radially outward to contact the plurality of rollers, preventing rotation of the rollers.

Abstract: A powered wheelchair apparatus includes a chair component, a power base component and a wheelchair control system. The wheelchair control system includes a processor and a user input device communicatively coupled to the processor. A display is communicatively coupled to the processor. A memory module is communicatively coupled to the processor that stores logic that, when executed by the processor, causes the system to receive user instructions from the user input device and display a message on the display based on the user instructions. The display is on a back of the chair component.

Abstract: Embodiments herein are directed to a mobility device. The mobility device includes a frame, a pair of foot plates, and a base. The frame has a pair of side rails. The pair of foot plates are pivotally attached to the pair of side rails. Each of the pair of foot plates have a transport surface. The base has an upper surface and an opposite lower surface. The lower surface of the base includes at least one receiving cavity that corresponds to a shape of the pair of foot plates. The base is positioned on the transport surface to receive the pair of foot plates within the at least one receiving cavity and is configured to receive a plurality of cargo containers on the upper surface.

Abstract: A window covering system that includes an elongated tube configured for a window covering to be wound around the tube, a clutch assembly that includes a pulley and a power spring having a first end engaging the pulley and a second end that is stationary, a limiter assembly, a booster assembly arranged between the clutch assembly and the limiter assembly, a cord arranged at least partially within the clutch assembly, and a wand fixed to the cord to selectively raise and lower the window covering.

Abstract: Pharmaceutical compositions comprising 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of manufacturing, methods of administering, and kits thereof are disclosed.

Abstract: An exoskeleton wheelchair system includes a base, one or more wheels coupled to the base, a body support connected to the base comprising: a back support; and one or more leg supports pivotally coupled to the back support, and a gait wheel linked with the one or more leg supports via one or more gait linkages and configured to rotate the one or more leg supports. The one or more leg supports are configured to pivot about a first axis when the back support is in a standing position mode. The back support is maintained at a fixed position relative to a location of the base when the one or more leg supports pivot about the first axis while the back support is in the standing position mode.

Abstract: A wheelchair system comprises a wheelchair comprising a seat, one or more first sensors disposed on or within the seat, one or more second sensors configured to communicate with the one or more first sensors and configured to be associated with a user to determine if the user is falling out of the wheelchair, wherein, upon detection that the user is falling out of the wheelchair, the wheelchair is configured to automatically stop.

Abstract: A partition key format for allocating partitions to data items in a single table database, where the data items are owned by different entities. The partition key format including a sequence of a plurality of frames, wherein a first of said frames is an identifier of the requesting entity (EID), and a second one of said frames is an identifier of the type of data item (TID).

Abstract: A mobility device positionable between a powered transport position and a powered wheelchair position is provided. The mobility device includes a frame including a pair of side rails, a pair of wheels on each side rail, a distance between each wheel on a corresponding side rail defining a length of the mobility device, a pair of arms coupled to an end of the pair of side rails, and a seat member positioned between the pair of arms. A pair of foot plates is pivotally attached to the pair of side rails and rotatable between an unfolded position in which the foot plate is horizontal and a folded position in which the foot plate is vertical. Each foot plate having a length at least substantially equal to the length of the mobility device.

Abstract: A multifunctional mobility device includes a frame that is configurable between a plurality of modes corresponding to at least a power wheelchair mode, a power scooter mode, and a power walker mode, a plurality of motorized wheels mounted to the frame, and handles pivotally coupled to the frame and communicatively coupled to the plurality of motorized wheels. Pivoting the handles operates the plurality of motorized wheels, wherein each handle is independently pivotable to independently drive rotation of a motorized wheel of the plurality of motorized wheels.

Abstract: A support device includes a wheel, a base member, a leg coupled to the wheel and the base member, the leg including an upper leg segment, a lower leg segment positioned below the upper leg segment, a joint positioned between the upper leg segment and the lower leg segment, and an actuator engaged with the upper leg segment and the lower leg segment, where the actuator includes a linear engagement member that is engaged with one of the upper leg segment and the lower leg segment, a cammed member defining a non-circular perimeter engaged with the linear engagement member, and a motor engaged with the linear engagement member through the cammed member.

Abstract: Systems and methods of wheelchair systems herein provide a wheelchair capable of providing a brace system that moves between retracted and deployed positions to provide a physical support to the legs of the user to assist the user in transition between a plurality of user positions. Embodiments determine a user request for such assistance and then either deploys and/or retracts the brace system. Embodiments provide for assistance independent of additional people, such as aides, to assist the user in moving or transitioning between the plurality of user positions while also allowing or permitting the wheelchair to function normally when the brace system is in the retracted position.

Abstract: Embodiments herein are directed to a system that includes a powered wheelchair, a user-worn exoskeleton, and a master controller. The master controller monitors the independent movements of the powered wheelchair and the user-worn exoskeleton. The master controller prioritizes the movement of the powered wheelchair and the user-worn exoskeleton such that only one of the powered wheelchair or the user-worn exoskeleton will have the priority to complete the intended movement. The master controller may coordinate movements between the powered wheelchair and the user-worn exoskeleton so to perform a plurality of predetermined programs. For example, assisting a user to sit within the powered wheelchair, to assist a user to stand from a seating position when outside of the powered wheelchair, and/or use the powered wheelchair as a guide for walking.

Abstract: A support device includes a wheel, a base member, a leg coupled to the wheel and the base member, the leg including an upper leg segment, a lower leg segment positioned below the upper leg segment, a joint positioned between the upper leg segment and the lower leg segment, the joint including a cam defining a non-circular perimeter, and an actuator coupled to one of the upper leg segment and the lower leg segment, the actuator including an engagement member that is engaged with the non-circular perimeter of the of the cam of the joint, where the actuator selectively moves the engagement member to move the cam and the upper leg segment and the lower leg segment about the joint.

Abstract: A modular seat apparatus includes a base cushion and a back cushion that includes a plurality of segments defining a longitudinal length of the back cushion. The back cushion is pivotably coupled to the base cushion such that the back cushion is oriented at an angle relative to the base cushion. The plurality of segments is configured to translate in response to the back cushion pivoting relative to the base cushion such that the longitudinal length of the back cushion decreases as the angle increases and the longitudinal length of the back cushion increases as the angle decreases.

Abstract: A system for controlling a wheelchair is disclosed. The system includes an input device that includes a shaft element, a base element, and one or more annular elements. A lower distal end of the shaft element is coupled to the base element, and the shaft element is configured to pivotally move about the lower distal end of the shaft element. A first annular element of the one or more annular elements is circumferentially disposed around the shaft element. The first annular element is coupled to the base element, and the first annular element is configured to rotate about the shaft element. The input device is configured to generate one or more input signals based on a position of the first annular element and a pivotal movement of the shaft element. The one or more input signals are configured to cause a controller to set an operation mode of the wheelchair.