Abstract: This application discloses compositions, devices, and methods for the prevention and treatment of osteolysis and osteoporosis. Treatment or prevention of osteolysis or osteoporosis is carried out by targeting the enzyme, Shp2 (a Src homology 2 (SH2) domain containing non-transmembrane Protein Tyrosine Phosphatase (PTP)), or proteins involved in the Shp2 signaling pathway by administering a Shp2 pathway inhibitor that inhibits fusion of pre-osteoclasts.

Abstract: Disclosed are systems, apparatuses, and methods for implementing a competitive BCM learning rule used in a neural network. Such a method includes identifying a maximally responding neuron with respect to a feature of an input signal. The maximally responding neuron is the neuron in a group that has a response with respect to the feature of the input signal that is greater than a response of each other neuron in the group. Such a method also includes applying a learning rule to weaken the response of each other neuron with respect to the feature of the input signal. The learning rule may also strengthen the response of the maximally responding neuron with respect to the feature of the input signal.

Abstract: Packaging for visually impaired and blind user is disclosed. In one embodiment, a package includes an exterior surface, a first sub-component package, and a second sub-component package. The first sub-component package and the second sub-component package are enclosed by the exterior surface in an interior region of the package. The package further includes a first non-visual message element associated with the first sub-component package, and a second non-visual message element associated with the second sub-component package. The non-visual message elements may be configured as tactile and/or audio non-visual message elements. In some embodiments, wireless signal emitter devices are provided within the package to actuate one or more speaker devices to thereby play auditory signals.

Abstract: Methods and systems are disclosed for calibrating a camera using a calibration target apparatus that contains at least one fiducial marking on a planar surface. The set of all planar markings on the apparatus are distinguishable. Parameters of the camera are inferred from at least one image of the calibration target apparatus. In some embodiments, pixel coordinates of identified fiducial markings in an image are used with geometric knowledge of the apparatus to calculate camera parameters.

Abstract: An apparatus is disclosed which may serve as a target for calibrating a camera. The apparatus comprises one or more planar surfaces. The apparatus includes at least one fiducial marking on a planar surface. The set of all planar markings on the apparatus are distinguishable.

Abstract: The systems and methods are directed to mechanical arms and manipulators, and more particularly, to optical distance sensors in use for approach, grasping and manipulation. The system may include a manipulator having an arm and a multi fingered end-effector coupled to the distal end of the arm. The end-effector may include an optical proximity sensor configured to detect the distance to an object prior to contact with the object. The end-effector may include an optical proximity sensor configured detect a measurement of force applied to the object by the manipulator post contact with the object. The measurement of force may be a range of force measurements including a minimum, a maximum and a measurement between or within the minimum and the maximum.

Abstract: In one aspect, a method is performed by one or more processors. The method includes receiving a primary view image showing a scene from a view of a primary camera; depth values for one or more objects in the scene; and a camera offset between the primary camera and a secondary camera. The method further includes determining disparities for each pixel in the primary view image. The method further includes generating a secondary view image using the primary view image, the depth values, and the camera offset. At least some of the pixels are repositioned according to the determined disparities.

Abstract: An electronics module includes a module housing having a base structure and a plurality of side walls. A module cover contacts the side walls and is connected to the module housing via at least one fastener. The module housing includes at least one fastener boss for receiving the at least one fastener. Each of the fastener bosses includes a fastener hole protruding partially into the fastener boss and a vent hole connecting the fastener hole to an opening on a surface of the fastener boss exterior to the module housing, and a sealant disposed in the fastener boss, thereby preventing external air from entering the electronics module through a fastener connection.

Abstract: A wearable neck device includes an IMU coupled to the wearable neck device and adapted to detect inertial measurement data and a GPS coupled to the device and adapted to detect location data. The wearable neck device further includes a camera adapted to detect image data and a memory adapted to store data. The wearable neck device further includes a processor adapted to recognize an object in the surrounding environment by analyzing the data. The processor can determine a desirable action based on the data and a current time or day. The processor can determine a destination based on the determined desirable action. The processor can determine a navigation path based on the determined destination and the data. The processor is further adapted to determine output based on the navigation path. The wearable neck device further includes a speaker adapted to provide audio information to the user.

Abstract: A wearable neck device and a method of operating the wearable neck device are provided for outputting optical character recognition information to a user. The wearable neck device has at least one camera, and a memory storing optical character or image recognition processing data. A processor detects a document in the surrounding environment and adjusts the field of view of the at least one camera such that the detected document is within the adjusted field of view. The processor analyzes the image data within the adjusted field of view using the optical character or image recognition processing data. The processor determines output data based on the analyzed image data. A speaker of the wearable neck device provides audio information to the user based on the output data.

Abstract: A wearable neck device for providing environmental awareness to a user, the wearable neck device includes a flexible tube. A first stereo pair of cameras is encased in a left portion of the flexible tube and a second stereo pair of cameras is encased in a right portion of the flexible tube. A vibration motor within the flexible tube provides haptic and audio feedback to the user. A processor in the flexible tube recognizes objects from the first stereo pair of cameras and the second stereo pair of cameras. The vibration motor provides haptic and audio feedback of the items or points of interest to the user.

Abstract: A smart necklace includes a body defining at least one cavity and having a neck portion and first and a second side portions. The necklace includes a pair of stereo cameras that is configured to detect image data including depth information corresponding to a surrounding environment of the smart necklace. The necklace further includes a positioning sensor configured to detect positioning data corresponding to a positioning of the smart necklace. The necklace includes a non-transitory memory positioned in the at least one cavity and configured to store map data and object data. The smart necklace also includes a processor positioned in the at least one cavity, coupled to the pair of stereo cameras, the positioning sensor and the non-transitory memory. The processor is configured to determine output data based on the image data, the positioning data, the map data and the object data.

Abstract: A computer-implemented method for configuring stereo cameras includes detecting, in a computer system, a relocation of a manipulator in a virtual set. The manipulator defined in the computer system to specify an aspect of the virtual set. The method includes receiving an input in the computer system, the input specifying an aspect of a projection environment. The method includes configuring, using the relocation and the input, first and second cameras to capture a stereo view of a scene such that the stereo view is compatible for being projected in the projection environment.

Abstract: Methods and systems for providing navigation assistance to a user are disclosed. A method for providing navigation assistance to a user includes defining at least one virtual wall along at least a portion of a path for navigation through an environment. The at least one virtual wall is offset from the path by an offset distance. The method further includes determining a location of the user and providing tactile feedback to the user, automatically by a processor, when the location of the user is within a threshold distance of the at least one virtual wall.

Abstract: The present invention relates to maintaining bioactive molecules in their native or substantially near-native form and preventing or reduce aggregation. In particular, the present invention relates to precipitation-protective or stabilizing additives and a method of using said precipitation-protective/stabilizing additives to protect and maintain the bioactive molecules in a native or substantially near-native form and to prevent or reduce aggregation during or following precipitation to form particles.

Abstract: The present invention relates to the provision of a novel method for preparing dry amorphous precipitated protein particles. In particular to a method provides amorphous precipitated protein particles suitable for use in dry protein formulations which can be reconstituted to provide clear, foam free concentrated protein solutions.

Abstract: A system and method for providing a touch sensor disposed in a vehicle, wherein the touch sensor may be a portable device that is removable from the vehicle such as a tablet computer or it may be a built-in device, wherein the touch sensor may store account information in a secure element in order to make a secure payment by wirelessly communicating with a merchant terminal from within the vehicle in order to make a financial transaction without giving a physical credit or debit card to the merchant.

Abstract: A method performed by one or more processors includes: receiving model data defining a three-dimensional scene; rendering the three-dimensional scene into a primary view image showing the three-dimensional scene from a view of a primary camera; and generating, for each of at least some pixels in the primary view image, a disparity value that defines a disparity between a location of the pixel in the primary view image and an indicated location of the pixel in a secondary view image showing the three-dimensional scene from a view of a secondary camera.

Abstract: An electronics module includes a module housing having a base structure and a plurality of side walls. A module cover contacts the side walls and is connected to the module housing via at least one fastener. The module housing includes at least one fastener boss for receiving the at least one fastener. Each of the fastener bosses includes a fastener hole protruding partially into the fastener boss and a vent hole connecting the fastener hole to an opening on a surface of the fastener boss exterior to the module housing, and a sealant disposed in the fastener boss, thereby preventing external air from entering the electronics module through a fastener connection.

Abstract: An electronics housing includes a first enclosure portion defining an internal cavity, a second enclosure portion sealing the internal cavity, at least one vent positioned in one of the first enclosure portion and the second enclosure portion, the vent comprising a through hole protruding from an exterior edge of the vent to an interior edge of the vent, a malleable sealing member disposed in the vent, and a rigid retaining member disposed in the vent.