Abstract: A catheter system for delivering ultrasonic energy to a treatment site within a body lumen, the catheter comprises a tubular body having a proximal end, a distal end and an energy delivery section positioned between the proximal end and the distal end and a plurality of ultrasound radiating members in the energy delivery section. The plurality of ultrasound radiating members are allocated into electrical groups comprising more than one ultrasound radiating member. Members of one electrical group are spatially interdigitated with members of another electrical group.

Abstract: A catheter control system the system can include a control unit having a first connection port. The control unit can have a first visual indicator associated with the first connection port. The system can also include a first catheter interface connector connected to the first connection port of the control unit. The first catheter interface connector can have a first visual indicator corresponding to the first visual indicator on the control unit. The first visual indicator on the first catheter interface connector can be to be active to indicate that the first catheter interface connector is connected to the first connection port on the control unit.

Abstract: A catheter control system the system can include a control unit having a first connection port. The control unit can have a first visual indicator associated with the first connection port. The system can also include a first catheter interface connector connected to the first connection port of the control unit. The first catheter interface connector can have a first visual indicator corresponding to the first visual indicator on the control unit. The first visual indicator on the first catheter interface connector can be to be active to indicate that the first catheter interface connector is connected to the first connection port on the control unit.

Abstract: A catheter control system the system can include a control unit having a first connection port. The control unit can have a first visual indicator associated with the first connection port. The system can also include a first catheter interface connector connected to the first connection port of the control unit. The first catheter interface connector can have a first visual indicator corresponding to the first visual indicator on the control unit. The first visual indicator on the first catheter interface connector can be to be active to indicate that the first catheter interface connector is connected to the first connection port on the control unit.

Abstract: A method of treating an occlusion at a treatment site within a patient's vasculature comprises providing an ultrasonic catheter. The ultrasonic catheter has a distal region, a proximal region opposite the distal region, a fluid delivery lumen having at least one opening in the distal region, and an ultrasound radiating member positioned within the distal region. The method further comprises positioning the ultrasonic catheter at the treatment site, such that at least a portion of the distal region is within the occlusion. The ultrasonic catheter further comprises passing a therapeutic compound through the fluid delivery lumen such that the therapeutic compound is delivered to the treatment site. The ultrasonic catheter further comprises emitting ultrasonic energy from the ultrasound radiating member. The emitted ultrasonic energy has an amplitude that is periodically varied between a low amplitude and a high amplitude.

Abstract: An ultrasound catheter with a lumen for fluid delivery and fluid evacuation, and an ultrasound source is used for the treatment of intracerebral or intraventricular hemorrhages. After the catheter is inserted into a blood clot, a lytic drug can be delivered to the blood clot via the lumen while applying ultrasonic energy to the treatment site. As the blood clot is dissolved, the liquefied blood clot can be removed by evacuation through the lumen.

Abstract: An ultrasound catheter with a lumen for fluid delivery and fluid evacuation, and an ultrasound source is used for the treatment of intracerebral or intraventricular hemorrhages. After the catheter is inserted into a blood clot, a lytic drug can be delivered to the blood clot via the lumen while applying ultrasonic energy to the treatment site. As the blood clot is dissolved, the liquefied blood clot can be removed by evacuation through the lumen.

Abstract: A catheter control system the system can include a control unit having a first connection port. The control unit can have a first visual indicator associated with the first connection port. The system can also include a first catheter interface connector connected to the first connection port of the control unit. The first catheter interface connector can have a first visual indicator corresponding to the first visual indicator on the control unit. The first visual indicator on the first catheter interface connector can be to be active to indicate that the first catheter interface connector is connected to the first connection port on the control unit.

Abstract: An ultrasound catheter with a lumen for fluid delivery and/or fluid evacuation, and ultrasound radiating elements is used for the delivery of therapeutic compounds to a target location. After the catheter is inserted into a cavity, a therapeutic compound can be delivered to the target location via selective activation of the ultrasound radiating elements. Selective activation of the ultrasound radiating elements can be used to cause fluid flow in a direction proximal and/or distal the catheter. Moreover, selective activating can be used to maintain fluid between certain of the ultrasound radiating elements.

Abstract: In one embodiment of the present invention, a method of treating a vascular occlusion located at a treatment site within a patient's vasculature comprises positioning an ultrasound catheter at the treatment site. The method further comprises delivering a microbubble-therapeutic compound from the ultrasound catheter to the vascular occlusion during a first treatment phase.

Abstract: A method for treating an occlusion comprises positioning a catheter at a treatment site in a patient's vasculature. A blockage is located at the treatment site. The method further comprises performing a medical treatment at the treatment site. The medical treatment is configured to reduce the blockage. The method further comprises making a plurality of measurements at the treatment site.

Abstract: In one embodiment of the present invention, a method of treating a vascular occlusion located at a treatment site within a patient's vasculature comprises positioning an ultrasound catheter at the treatment site. The method further comprises delivering a microbubble-therapeutic compound from the ultrasound catheter to the vascular occlusion during a first treatment phase.

Abstract: A method of treating an occlusion at a treatment site within a patient's vasculature comprises providing an ultrasonic catheter. The ultrasonic catheter has a distal region, a proximal region opposite the distal region, a fluid delivery lumen having at least one opening in the distal region, and an ultrasound radiating member positioned within the distal region. The method further comprises positioning the ultrasonic catheter at the treatment site, such that at least a portion of the distal region is within the occlusion. The ultrasonic catheter further comprises passing a therapeutic compound through the fluid delivery lumen such that the therapeutic compound is delivered to the treatment site. The ultrasonic catheter further comprises emitting ultrasonic energy from the ultrasound radiating member. The emitted ultrasonic energy has an amplitude that is periodically varied between a low amplitude and a high amplitude.

Abstract: An ultrasound catheter with a lumen for fluid delivery and fluid evacuation, and an ultrasound source is used for the treatment of intracerebral or intraventricular hemorrhages. After the catheter is inserted into a blood clot, a lytic drug can be delivered to the blood clot via the lumen while applying ultrasonic energy to the treatment site. As the blood clot is dissolved, the liquefied blood clot can be removed by evacuation through the lumen.

Abstract: In one embodiment of the present invention, a method of treating a vascular occlusion located at a treatment site within a patient's vasculature comprises positioning an ultrasound catheter at the treatment site. The method further comprises delivering a microbubble-therapeutic compound from the ultrasound catheter to the vascular occlusion during a first treatment phase.

Abstract: An ultrasound catheter system can be configured to provide therapeutic ultrasound and imaging. An ultrasound catheter system can comprise a catheter having a distal portion. In several embodiments, a first ultrasonic element can be disposed in the distal portion of the catheter and can be configured to emit a first ultrasonic energy to enhance delivery of a therapeutic compound. In some embodiments, a second ultrasonic element can be disposed in the distal portion of the catheter and can be configured to convert a second ultrasonic energy that is reflected from an imaging site into an electrical signal.

Abstract: A catheter system for delivering ultrasonic energy to a treatment site within a body lumen, the catheter comprises a tubular body having a proximal end, a distal end and an energy delivery section positioned between the proximal end and the distal end and a plurality of ultrasound radiating members in the energy delivery section. The plurality of ultrasound radiating members are allocated into electrical groups comprising more than one ultrasound radiating member. Members of one electrical group are spatially interdigitated with members of another electrical group.

Abstract: A method of treating an occlusion at a treatment site within a patient's vasculature comprises providing an ultrasonic catheter. The ultrasonic catheter has a distal region, a proximal region opposite the distal region, a fluid delivery lumen having at least one opening in the distal region, and an ultrasound radiating member positioned within the distal region. The method further comprises positioning the ultrasonic catheter at the treatment site, such that at least a portion of the distal region is within the occlusion. The ultrasonic catheter further comprises passing a therapeutic compound through the fluid delivery lumen such that the therapeutic compound is delivered to the treatment site. The ultrasonic catheter further comprises emitting ultrasonic energy from the ultrasound radiating member. The emitted ultrasonic energy has an amplitude that is periodically varied between a low amplitude and a high amplitude.

Abstract: In one embodiment of the present invention, a method of treating a vascular occlusion located at a treatment site within a patient's vasculature comprises positioning an ultrasound catheter at the treatment site. The method further comprises delivering a microbubble-therapeutic compound from the ultrasound catheter to the vascular occlusion during a first treatment phase.

Abstract: A central venous catheter comprises an ultrasound assembly. In one arrangement, the radiating member is used to remove a blockage from the central venous catheter. In another arrangement, inserting an ultrasound assembly into a central venous catheter. The ultrasound assembly comprises an ultrasound radiating member mounted on an elongate support structure. The method further comprises positioning the ultrasound assembly within the central venous catheter such that the ultrasound radiating member is adjacent to a deposited material formed on a portion of the central venous catheter. The method further comprises supplying an electrical current to the ultrasound radiating member to expose the deposited material to ultrasonic energy. The method further comprises passing a therapeutic compound through the central venous catheter to expose the deposited material to the therapeutic compound simultaneously with ultrasonic energy.