Abstract: The present teachings relate to improved methods, kits, and compositions for making nucleic acid libraries and sequencing nucleic acids. In some embodiments, directionally defined concatamers are generated, facilitating sequencing efforts.

Abstract: A weighted training bat formed of wood and having a handle and a barrel. The barrel has an elongated hollow cavity formed into a distal end thereof and an outer cavity portion having internal threads. Lead which has been poured or cast-in-place into and filling the proximal portion of the cavity, when solidified, adheres to the interior surface of the cavity to resist loosening, the lead adding weight at and evenly astride the sweet spot of the bat. An elongated wooden screw having external threads is tightly engaged into internal threads in the cavity so the screw bears against the lead to further prevent loosening of the lead. The threads are permanently glued and an outer end of the screw is formed to blend with the contour of the end of the barrel.

Abstract: A system for machining a component with complex contour. The machining system includes a coolant flow nozzle with an interior passage with a first portion having a first cross-sectional shape, and a second portion having a second cross-sectional shape, with the second cross-sectional shape selected so that fluid discharged from the nozzle has a selected cross-sectional shape. A method of fabricating a coolant flow nozzle with an interior passage that has a varying cross sectional shape.

Abstract: A system for machining a component with complex contour. The machining system includes a coolant flow nozzle with an interior passage with a first portion having a first cross-sectional shape, and a second portion having a second cross-sectional shape, with the second cross-sectional shape selected so that fluid discharged from the nozzle has a selected cross-sectional shape. A method of fabricating a coolant flow nozzle with an interior passage that has a varying cross sectional shape.

Abstract: The present invention discloses a method for coating nanoelectrospray emitters. The method involves providing a nanoelectrospray emitter body and evaporating an electrically conductive material under conditions effective to form a thin layer of the electrically conductive material onto the nanoelectrospray emitter body.

Abstract: A computer-implemented method and system for determining colimits of hereditary diagrams. A user specifies a diagram of diagram and specifies performance of a colimit operation. Once the colimit is performed, the name of the colimit is added to the hereditary diagram. The described embodiment supports diagrams of diagrams, also called hierarchical diagrams.

Abstract: The present invention discloses a method for coating nanoelectrospray emitters. The method involves providing a nanoelectrospray emitter body and evaporating an electrically conductive material under conditions effective to form a thin layer of the electrically conductive material onto the nanoelectrospray emitter body.

Abstract: A microtiter plate having at least one well and a lid having at least one insert which seals and reduces the volume of the well and methods of using the combination of the well and insert are described herein.

Abstract: A dual roof rail air bag is provided with an integrated fill system. The air bag system has an inflatable curtain attached to the roof rail of the vehicle, and an inflatable tube structure attached to the bottom end of the inflatable curtain. A single manifold simultaneously provides gas from an inflator to the inflatable curtain and the inflatable tube structure in an integrated manner.

Abstract: A dual roof rail air bag is provided with an integrated fill system. The air bag system has an inflatable curtain attached to the roof rail of the vehicle, and an inflatable tube structure attached to the bottom end of the inflatable curtain. A single manifold simultaneously provides gas from an inflator to the inflatable curtain and the inflatable tube structure in an integrated manner.

Abstract: Embodiments of the present invention feature nucleic acid and proteins derived from Mycobacterium tuberculosis and leprae. The proteins and nucleic acid of the present invention have applications in diagnostics and therapeutics.

Abstract: Novel methods for determining the existence or nonexistence of a test nucleotide on a strand of DNA are provided. The methods involve the use of a proofreading polymerase that is capable of incorporating a labeled nucleotide in a primer into and extension product if there is a match between the test nucleotide on the strand of DNA and the complementary nucleotide on the primer, but which excises the labeled nucleotide and does not incorporate it into an extension product if there is a mismatch. The presence or absence of the test nucleotide then may be established by determining whether the label is preserved or lost following the reaction. Methods involving the use of a quencher-chromophore pair are also provided.

Abstract: A computer-implemented method and system for allowing software to carry its own specification.

Abstract: A fluid distribution system for transporting pressurized fluid. The system includes a plate having a first face and a slot extending along the face between opposite first and second ends of the slot. In addition, the system includes a body having a surface sealingly engaging the first face of the plate and overlying the slot so that a portion of the surface and the slot at least partially define a passage for transporting pressurized fluid between the first and second ends of the slot. A method of making the system is also disclosed.

Abstract: Tool extension and stability in milling machines is enhanced by providing a spindle extension having a housing attached to the mill head and an arbor rotatively mounted in a bore formed in the housing. The arbor, which is significantly longer than conventional arbors, is supported by first and second bearing assemblies and includes a substantially cylindrical body portion with an integral shank formed on one end thereof for connecting the arbor to a machine tool spindle. A cutting tool is attached to the other end of the arbor.

Abstract: A simulated panel door structure formed from a flat surface door utilizing an endless groove formed along the flat surface and etched to a uniform depth. The endless groove possesses a base surface and first and second side walls extending outwardly from the base surface. The second side wall of the groove is positioned outside the first side wall toward the periphery of the door. An insert having a lower surface and first and second side walls positions within the endless groove such that the lower surface of the insert lies adjacent the base surface of the groove. The first side wall of the insert lies adjacent a beveled surface of the veneer and extends no further outwardly than the flat surface of the door. The second side wall of the insert lies adjacent the second side wall of the groove. The insert further includes a lateral surface spanning the first and second side walls with a depression therealong.

Abstract: A modular shelving system has a pair of vertical supports for a central stack of shelves. Each shelf is supported by a pair of shelf support brackets extending between the vertical supports and the back wall of a closet, for example. Each shelf has a plurality of sheet metal planks of generally trapezoidal cross section which elastically snap into complementary bosses along the tops of the shelf support brackets. Similar shelves extend from the central stack to side walls of the closet and are supported there by side wall brackets which also have bosses along the top complementary to the cross section of the planks. Some of the brackets have sockets for receiving the ends of hanger bars beneath the shelves.