Abstract: A diagnostic and decision support technology is provided for determining the presence, identity, and/or severity of an inherited lysosomal storage disorder. In particular, a mechanism is provided to detect and classify a lysosomal storage disorder in a human patient, which utilizes a logistic regression classifier determined based on a multi-variable-composite-biomarker comprising a specific set of physiological variables of the patient. This multi-variable statistical predictive biomarker approach may be employed for identifying persons whose attributes are consistent with features or glycogen storage diseases, such as late-onset Pompe disease.

Abstract: Methods, systems, and computer-readable media are provided for facilitating mapping of semantically similar terms between and among two or more information systems. In particular, to facilitate automatic discovery, establishment, and/or statistical validation of linkages between a plurality of different nomenclatures employed by a plurality of information systems, such as multiple electronic health record systems. In embodiments, the imputation of latent synonymy in corpora comprised of samples of historical records from each system enables automated terminology mapping between disparate systems' records, thereby establishing reliable linkages that may subsequently be utilized for realtime decision support, data mining-based research, or other valuable purposes.

Abstract: Systems, methods and computer-readable media are provided for facilitating patient health care by providing discovery, validation, and quality assurance of nomenclatural linkages between pairs of terms or combinations of terms in databases extant on multiple different health information systems that do not share a set of unified codesets, nomenclatures, or ontologies, or that may in part rely upon unstructured free-text narrative content instead of codes or standardized tags. Embodiments discover semantic structures existing naturally in documents and records, including relationships of synonymy and polysemy between terms arising from disparate processes, and maintained by different information systems. In some embodiments, this process is facilitated by applying Latent Semantic Analysis in concert with decision-tree induction and similarity metrics.

Abstract: Decision support technology is provided for use with patients who may experience respiratory deterioration. A mechanism is provided to determine an indicator of a patient's probability of deterioration of respiratory functioning, which may include calculating a probability of a respiratory deterioration event in patients from whom serial digital recordings of respiratory sounds are acquired. A forecast or score representing a likelihood of deterioration may be generated and used for pulmonary disease prognosis, diagnosis, and/or determining or implementing an appropriate response action such as automatically issuing an alert or notification to a caregiver associated with the patient.

Abstract: Methods and systems for predicting deterioration of a patient's condition within a future time interval based on a time series of values for monitored physiological variables measured from a patient, and in some instances, providing advanced notice to clinicians or caregivers when deterioration is forecasted or modifying treatment for the patient are provided. In particular, deterioration of a patient's condition is based on a Hopf bifurcation model and is predicted using a ratio of deviations for monitored physiological variables. A ratio of deviations relates the standard deviation and root mean square of successive differences for a set of physiological values measured over time. The RoD for one or more variables, such as heart rate, respiratory rate, and blood pressure, may be used to predict the likelihood of the patient's condition deteriorating into an unstable state as what occurs in a Hopf bifurcation.

Abstract: Systems, methods and computer-readable media are provided for determining a premium for a proposed insurance coverage. In various embodiments, a plurality of context variables can be defined related to proposed coverage. Based on defined context variables, historical claim events are extracted from one or more sources of claims data. Extracted historical claim events may be representative of the proposed coverage. Historical claim events can be aggregated based on a time period to form aggregated claims data per time period. The aggregated data can then be used to determine a historical volatility time series based on differences between logarithms of the aggregated claims data per time period for a plurality of time periods. Additionally or alternately, the aggregated claims data per time period can be used to determine a fit of the aggregated data to one or more distributions. The fit can be evaluated, such as based on a fit parameter, to select a distribution.

Abstract: A catastrophe-theoretic approach is provided for predicting an occurrence of an ischemic myocardial event (e.g., acute myocardial infarction) for a human patient based on a time series of monitored vital signs values measured from a patient, and in some instances, for providing advanced notice to clinicians or caregivers when such an ischemic event is forecasted or modifying treatment for the patient, according to the predicted likelihood. In particular, an ischemic heart disease management system is provided for determining a likelihood of near-term future significant myocardial ischemia in persons with coronary artery disease. Embodiments of the disclosure described herein may provide a forecasted risk for future significant myocardial ischemia within a time horizon comprising a future time interval. In one embodiment, the future time interval is from 30 min to approximately 4 hours into the future, and may be dependent on the frequency of vital signs measurements.

Abstract: Methods, systems, and computer-readable media are provided for facilitating mapping of semantically similar terms between and among two or more information systems. In particular, to facilitate automatic discovery, establishment, and/or statistical validation of linkages between a plurality of different nomenclatures employed by a plurality of information systems, such as multiple electronic health record systems. In embodiments, the imputation of latent synonymy in corpora comprised of samples of historical records from each system enables automated terminology mapping between disparate systems' records, thereby establishing reliable linkages that may subsequently be utilized for realtime decision support, data mining-based research, or other valuable purposes.

Abstract: Systems and methods are provided for injury characterization including detecting matches of an individual subject's record (such as an athlete's record) with collections of other subjects records, based on serial, longitudinal patterns, for facilitating athlete health and training, preventive and rehabilitation medicine, and risk management in athletics.

Abstract: A system, method, and computer-readable media are provided for facilitating clinical decision making, and in particular, decision making based on a third party's clinical situation by determining and providing useful, up-to-date information, such as patient-related information to a decision maker. In one embodiment, a user first identifies an information item concerning a patient. Based on that item, a set of related information items is determined and prioritized, and a reference pointer, which identifies the set of related information, is generated. The reference pointer is communicated to the user's mobile device. Subsequently, the user's mobile device requests information from the set of information items associated with the reference pointer, and provides information authorization information. Following authentication of the user's credentials, updates of information from the set of information items may be communicated to the user's mobile device as they become available.

Abstract: Optimizing psychiatric and physiologic monitoring of a patient having PTSD or anxiety-related mental health condition. According to an embodiment, one or more physiological variables are longitudinally measured; resting heart rate is measured from which a timeseries is constructed; outlier anomalous values are removed from the timeseries, it is de-trended and/or de-meaned; and a serial normal sinus rhythm beats (SDNN) and/or other parameters are determined. Fractal properties of the serial SDNN values are calculated, such as the Hurst exponent alpha via detrended fluctuation analysis (DFA) or spectral regression; and other measures of chaos and nonlinearity are calculated, such as the Shannon entropy of the SDNN or related timeseries. Where such measures indicate a statistically-significant transgression of a context-indexed reference range, a notification is provided to a case management clinician or caregiver so that appropriate additional evaluation and diagnosis and treatment may be undertaken.

Abstract: Technologies are provided for determining deficiencies in narrative textual data that may impact decision-making in a decisional context. A candidate text document and a reference corpus of text may be utilized to generate one or more topic models and document-term matrices, and then to determine a corresponding statistical perplexity and probabilistic coherence. The reference corpus may be known or normatively deemed to be epistemically persuasive and adequate with respect to a particular context. Statistical determinations of a degree to which the candidate deviates from the reference normative corpus are determined, in terms of the statistical perplexity and probabilistic coherence of the candidate as compared to the reference.

Abstract: Systems, methods, and computer-readable storage media are provided for determining and ascribing clinical conditions or diagnoses to patients and provide them to a caregiver, such as attending clinicians or other appropriate health services personnel. In particular, embodiments of the disclosure determine likely phenotypic findings that are salient to the decision-making context for a current human patient, based on anticipative sequence-mining and trajectory-mining. A sequential pattern mining and sequence itemset matching system is provided for determining likely, temporally-relevant concepts that are manifested in the information that is produced during the course of a patient's care. A clinician or caregiver may be provided the sequence itemset matching by generating a list or notice. In addition or alternatively, the results may be stored in an EHR associated with the patient.

Abstract: Systems and methods are provided for the problem of automatic, algorithm-guided estimation of insurance loss ratio, claims frequency, the probability of excess claims, and other insurance policy performance characteristics for an individual insured or for groups of insured individuals. A time-series-derived Bayesian power spectrum weight is calculated from the frequency of temporal pattern-specific values in terms of intensities at various frequencies of the power spectrum computed from credit utilization ratio (CUR; outstanding balance of debt, as a percentage of credit line available) time-series obtained by the insurer by ‘soft pull’ inquiries submitted periodically to credit-rating agencies, and provides an opportunity to capture and measure the relative magnitude of frequent or unexpected changes in consumer liquidity.

Abstract: Systems, methods, and computer-readable media are provided for patient case and care complexity characterization, and detecting matches of an individual patient's record with collections of other patients' records, based on serial, longitudinal patterns, for facilitating efficient health services utilization, implementing programs to reduce complexity, preventive medicine, and risk management in health care.

Abstract: A system, method, and computer-readable media are provided for facilitating clinical decision making, and in particular, decision making based on a third party's clinical situation by determining and providing useful, up-to-date information, such as patient-related information to a decision maker. In one embodiment, a user first identifies an information item concerning a patient. Based on that item, a reference pointer, which identifies the information item, is generated. The reference pointer is communicated to the user's mobile device. Subsequently, the user's mobile device receives updates related to the reference pointer.

Abstract: Methods and systems for enhanced natural language processing of clinical documentation are provided. Using natural language processing, a clinical condition is extracted from unstructured data within a current electronic document. A clinical ontology identifying itemsets associated with the clinical condition is retrieved, and indicators of relevant clinical concepts, as identified from the ontology, are searched from within the patient's longitudinal record, which comprises documentation from at least a prior encounter. Based on the whether the clinical concepts are present in the patent's record, a confidence is assigned to the NLP-extracted clinical condition, and one or more actions may be performed.

Abstract: Systems, methods and computer-readable media are provided for applying Electronic Clinical Quality Measures (eCQM), Pay-for-Performance (P4P) measures, or Meaningful Use (MU) measures in human health care in a fantasy league health exchange. In an embodiment, a Bradley-Terry regression model is utilized to establish performance rankings of healthcare providers during a measurement period. The Bradley-Terry regression model may optionally be parallelized so as to determine statistical associations for factors such as clinician, care venue, and patient attributes. Statistical associations and coefficient values from the regressions are used to forecast or project a future period's performance results for selected individual or group competitors and to provide comparative rankings for purposes of informing decisions regarding draft picks, roster submission, or bets placed in a fantasy league exchange system for health services.

Abstract: A system, method, and computer-readable media are provided for facilitating clinical decision making, and in particular, facilitating treatment of a person having congestive heart failure. The method includes the step of receiving patient information for a patient. The method also includes the steps of determining whether the patient information suggests a trigger event, and upon determining a trigger event, determining at least one goal associated with the trigger event. The method also includes the steps of selecting a first plan, from a library of plans, corresponding to the goal and executing the plan, which further includes determining a solver to determine patient conditions or recommended treatments, receiving parameters for the determined solver, and preparing patient information for the determined solver.

Abstract: Technologies are provided for determining an individual's likelihood of relapsing into prior behavior subsequent to a treatment for a mental health or addiction disorder, and in some instances predicting a likelihood time frame for such a relapse. Target subjects having a risk of addiction relapse, non-adherence to a treatment program, or absconding, may be automatically identified based on a multiplicative-regression model for relative survival (MRS) that is developed for predicting risk or likelihood of relapse or non-adherence. Further, in some embodiments, a leading indicator of near-term future abnormalities may be provided thereby proactively notifying supervisory personnel responsible for the person and providing such personnel with timely notice to enable effective corrective, preventive, or trend-modifying maneuvers to be undertaken.