Abstract: The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts thereof, to compositions containing such compounds and to the use of such compounds as inhibitors of HCV replication.

Abstract: The invention relates to isolated polypeptides that include amino acid sequences within botryococcene synthase from different algal species. In another aspect, the invention relates to a method for increasing the production level of a botryococcene hydrocarbon molecule in a cell. The method includes increasing expression of a polynucleotide sequence that encodes botryococcene synthase in the cell. In a further aspect, the invention relates to an algal cell having a polynucleotide sequence that is genetically engineered to express a higher level of botryococcene synthase than a corresponding wild type algal cell, wherein the cell produces an increased level of a botryococcene hydrocarbon molecule than a corresponding wild type algal cell.

Abstract: The invention relates to imidazopyridinones, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. By activating TLRs, it should be possible to induce or stimulate immune cells to mount an immune response. In particular, the TLR7 has been implicated in viral infections (such as HCV or HBV), cancers and tumours, and T2 Helper cell (TH2) mediated diseases, and hence TLR7 agonists are potentially useful in the treatment of such diseases. We have now found a series of imidazopyridinones which are agonists of TLR7. According, there is provided a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is 3- to 8-membered saturated heterocyclic group wherein one ring member is —O—; and R2 is phenyl or pyridinyl, each optionally substituted by C1-C6alkyl.

Abstract: An intraocular lens for insertion into a capsular bag in order to focus incoming light toward a retina and process for manufacturing thereof along with concomitant reduced glare and improved vision provides for a center lens portion of a lens for focusing incoming light toward the retina and the surrounding lens portion for mounting the lens within the capsular bag. A surface roughness disposed on the surrounding lens portion is provided for reducing the glare due to non-focused light directed toward the retina from the intraocular lens with the roughness having a roughness level of between about Ra 45 and about Ra 350.

Abstract: An intraocular lens for insertion into a capsular bag in order to focus incoming light toward a retina and process for manufacturing thereof along with concomitant reduced glare and improved vision provides for a center lens portion of a lens for focusing incoming light toward the retina and the surrounding lens portion for mounting the lens within the capsular bag. A surface roughness disposed on the surrounding lens portion is provided for reducing the glare due to non-focused light directed toward the retina from the intraocular lens with the roughness having a roughness level of between about Ra 45 and about Ra 350.

Abstract: Embodiments of the present invention include a computer-implemented systems and methods for accessing metadata across a network. A metadata server receives requests to access a data source from one or more clients. The metadata server is coupled between one or more backend servers and the clients. The backend servers may be coupled to the data sources of interest. The metadata server provides a metadata service proxy for establishing communications with the backend servers and for signaling the backend servers to establish connections to data sources. Data sources may be stateful or stateless. For stateless data sources, the metadata server may dynamically create reusable metadata service provider proxies that receive metadata from metadata service providers on the backend servers. For stateful data sources, unique metadata service provider proxies may be dynamically created and used to service client requests.

Abstract: The invention is directed to an arrangement for the suppression of unwanted spectral components (‘out-of-band’ radiation, as it is called) in a plasma-based radiation source. The object of the invention is to find a novel possibility for the suppression of unwanted spectral components in radiation exiting from a plasma-based EUV radiation source which permits a simple suppression of out-of-band radiation outside the desired EUV range without requiring costly manufacturing and adjustment of diffraction gratings. This object is met according to the invention in that a filter unit is provided between the plasma and an application location of the EUV radiation, which filter unit has at least one gas curtain comprising at least one rapidly flowing gas whose molecules have no absorption maxima for the desired EUV radiation and intensive absorption maxima for other, unwanted wavelengths that are emitted, at least in the IR region.

Abstract: The invention is directed to a device for generating flows of gas for filtering the radiation emitted in plasma-based radiation sources. It is the object of the invention to find a novel possibility for generating a gas curtain in the immediate vicinity of a radiating plasma so as to permit a simple arrangement and design and a long life of the device for generating the gas curtain under extreme thermal stress. According to the invention, this object is met in that a slit nozzle is formed of a plurality of partial bodies comprising different materials to form a supersonic nozzle profile for the generation of a broad gas curtain in order to accommodate the slit nozzle to different thermal and precision-mechanical requirements in the gas inlet region and in the gas outlet region.

Abstract: The present invention provides a thin film photovoltaic module that has a protective substrate, such as glass, that has been contoured to define a space that allows air to avoid entrapment by a bus bar on the thin film photovoltaic device. The contouring of the protective substrate greatly facilitates the deairing and lamination of the module because it reduces or eliminates the amount of trapped air during lamination. Photovoltaic modules of the present invention can be processed with a minimum of waste caused by deairing and related lamination problems.

Abstract: The present invention relates to immune response modifiers of formula (I), which act selectively through agonism, of Toll-Like Receptors (TLRs), uses thereof, processes for the preparation thereof, intermediates used in the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including the treatment of infectious disease such as Hepatitis (e.g. HCV, HBV), genetically related viral infection and cancer.

Abstract: The present invention provides a thin film photovoltaic module that has a protective substrate, such as glass, that has been contoured to define a space that overlies a bus bar on the thin film photovoltaic device. The contouring of the protective substrate greatly facilitates the deairing and lamination of the module because it reduces or eliminates the amount of trapped air and the degree to which the underlying polymeric material is forced to flow during lamination. Photovoltaic modules of the present invention can be processed with a minimum of waste caused by deairing and related lamination problems.

Abstract: System and methods for manipulating rights expressions for use in connection with a rights management system include one or more tokenized templates. Each tokenized template includes one or more rights expression language statements and one or more tokens associated with at least one of the rights expression language statements. Further, the tokens can be place holders for data items or rights expression elements. The system further includes a license template module that creates the tokenized templates, and a license instance creation module that replaces at least one of the tokens in one or more selected license templates with one or more of the data items or rights expression elements to generate a license instance. Additionally, the system includes a license instance analysis module having sub-modules for validating and interpreting license instances, and a data parsing module for extracting data from created license instances.

Abstract: The invention relates to imidazopyridinones, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. By activating TLRs, it should be possible to induce or stimulate immune cells to mount an immune response. In particular, the TLR7 has been implicated in viral infections (such as HCV or HBV), cancers and tumours, and T2 Helper cell (TH2) mediated diseases, and hence TLR7 agonists are potentially useful in the treatment of such diseases. We have now found a series of imidazopyridinones which are agonists of TLR7. According, there is provided a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is 3- to 8-membered saturated heterocyclic group wherein one ring member is —O—; and R2 is phenyl or pyridinyl, each optionally substituted by C1-C6alkyl.

Abstract: System and methods for manipulating rights expressions for use in connection with a rights management system include one or more tokenized templates. Each tokenized template includes one or more rights expression language statements and one or more tokens associated with at least one of the rights expression language statements. Further, the tokens can be place holders for data items or rights expression elements. The system further includes a license template module that creates the tokenized templates, and a license instance creation module that replaces at least one of the tokens in one or more selected license templates with one or more of the data items or rights expression elements to generate a license instance. Additionally, the system includes a license instance analysis module having sub-modules for validating and interpreting license instances, and a data parsing module for extracting data from created license instances.

Abstract: An intraocular lens for insertion into a capsular bag in order to focus incoming light toward a retina and process for manufacturing thereof along with concomitant reduced glare and improved vision provides for a center lens portion of a lens for focusing incoming light toward the retina and the surrounding lens portion for mounting the lens within the capsular bag. A surface roughness disposed on the surrounding lens portion is provided for reducing the glare due to non-focused light directed toward the retina from the intraocular lens with the roughness having a roughness level of between about Ra 45 and about Ra 350.

Abstract: The invention is directed to a device for generating flows of gas for filtering the radiation emitted in plasma-based radiation sources. It is the object of the invention to find a novel possibility for generating a gas curtain in the immediate vicinity of a radiating plasma so as to permit a simple arrangement and design and a long life of the device for generating the gas curtain under extreme thermal stress. According to the invention, this object is met in that a slit nozzle is formed of a plurality of partial bodies comprising different materials to form a supersonic nozzle profile for the generation of a broad gas curtain in order to accommodate the slit nozzle to different thermal and precision-mechanical requirements in the gas inlet region and in the gas outlet region.

Abstract: The present invention relates to immune response modifiers of formula (I), which act selectively through agonism, of Toll-Like Receptors (TLRs), uses thereof, processes for the preparation thereof, intermediates used in the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including the treatment of infectious disease such as Hepatitis (e.g. HCV, HBV), genetically related viral infection and cancer.

Abstract: The invention is directed to an arrangement for the suppression of unwanted spectral components (‘out-of-band’ radiation, as it is called) in a plasma-based radiation source. The object of the invention is to find a novel possibility for the suppression of unwanted spectral components in radiation exiting from a plasma-based EUV radiation source which permits a simple suppression of out-of-band radiation outside the desired EUV range without requiring costly manufacturing and adjustment of diffraction gratings. This object is met according to the invention in that a filter unit is provided between the plasma and an application location of the EUV radiation, which filter unit has at least one gas curtain comprising at least one rapidly flowing gas whose molecules have no absorption maxima for the desired EUV radiation and intensive absorption maxima for other, unwanted wavelengths that are emitted, at least in the IR region.

Abstract: A rights expression system and method for facilitating creation and/or modification of rights expressions in a rights expression language based on one or more schemas are provided. In one embodiment, the rights expression system comprises selectable layouts corresponding to a rights granting paradigm and comprises type selection components. Each type selection component is adapted to present REL terms and input components. The input components allow input of parameters required by the selected REL term. The rights expression system also includes a data engine that generates rights expressions in proper REL semantics defined by the one or more schemas based on the selected layout and parameter inputted. The type selection components and input components may be type selectors and input forms, respectively, that are implemented in a graphical user interface.

Abstract: The invention is directed to a method and arrangements for the suppression of debris in short-wavelength radiation sources based on a plasma, particularly for EUV sources for semiconductor lithography. The object of the invention is to find a novel possibility for suppressing the particle flow (debris) from a plasma which keeps the debris away from primarily optical components located downstream without excessive attenuation of the desired radiation emitted from the plasma. According to the invention, this object is met in that a buffer gas is injected inside the filter structure of the debris filter lateral to openings that are provided for passing the radiation.