Abstract: Methods of treating patients diagnosed with AML or MDS harboring mutant IDH-1 include detecting an IDH1 mutation and the therapeutic administration of an inhibitor of a mutant IDH-1 as a single agent, or in combination with azacitidine (AZA) or cytarabine.

Abstract: Methods of treating patients diagnosed with cancer harboring an IDH-1 mutation are provided, including the therapeutic administration of a certain inhibitor of a mutant IDH-1 as a single agent, or in combination with azacitidine (AZA).

Abstract: Methods of treating patients diagnosed with cancer harboring an IDH-1 mutation are provided, including the therapeutic administration of a certain inhibitor of a mutant IDH-1 as a single agent, or in combination with azacitidine (AZA).

Abstract: Methods of treating patients diagnosed with AML or MDS harboring mutant IDH-1 include detecting an IDH1 mutation and the therapeutic administration of an inhibitor of a mutant IDH-1 as a single agent, or in combination with azacitidine (AZA) or cytarabine.

Abstract: The present invention relates to SNS-595 and methods of treating cancer using the same.

Abstract: Payment systems allowing credit and/or points to fund financial transactions are provided. In one example, a payment system comprises a credit device issued to a consumer enabling the consumer to purchase products or services from a plurality of merchants using funds from a credit account associated with the consumer. The payment system comprises a payment network enabling the plurality of merchants to receive payment from an issuer that issues the credit device to the consumer. A funding device is configured to access information regarding credit available from the credit account, the funding device further configured to access information regarding points available to the consumer. The funding device is configured to use pre-established rules to determine the use of available credit and available points for completing a transaction with a first merchant of the plurality of merchants. The transaction appears to the first merchant as a regular credit card transaction.

Abstract: The present invention relates to SNS-595 and methods of treating cancer using the same.

Abstract: Methods of treating, preventing or managing cancer, including certain leukemias are disclosed. The methods encompass the administration of enantiomerically pure (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid. Also provided are methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods are also disclosed.

Abstract: The present invention relates to SNS-595 and methods of treating cancer using the same.

Abstract: An airblast fuel injector is provided for a fuel spray nozzle of a gas turbine engine. The injector has an annular air passage for the passage of a swirling air flow therethrough. The swirling air flow is used by the injector to produce an atomized fuel spray. The air passage contains a swirler for producing the swirling air flow, the swirler comprising a circumferential row of vanes which span inner and outer side walls of the air passage. Viewed on a longitudinal section through the injector, the air passage has a bend downstream of the swirler, the bend changing the direction of the air passage. The vanes are configured to introduce a radial component to the air flow exiting the swirler, the radial component guiding the air flow around the bend.

Abstract: A gas turbine engine lean burn fuel injector includes a fuel injector head which has a first air swirler, a second air swirler arranged around the first air swirler, a pilot fuel injector arranged radially between the first air swirler and the second air swirler. A third air swirler arranged around the second air swirler, a fourth air swirler arranged around the third air swirler and a main fuel injector arranged radially between the third air swirler and the fourth air swirler. A shroud is arranged around the fourth air swirler. A downstream end of the shroud is generally circular in cross-section in a plane perpendicular to the axis (Y) of the fuel injector head and an upstream end of the shroud is generally elliptical in cross-section in a plane perpendicular to the axis (Y) of the fuel injector head.

Abstract: The present invention relates to SNS-595 and methods of treating cancer using the same.

Abstract: An airblast fuel injector is provided for a fuel spray nozzle of a gas turbine engine. The injector has an annular air passage for the passage of a swirling air flow therethrough. The swirling air flow is used by the injector to produce an atomised fuel spray. The air passage contains a swirler for producing the swirling air flow, the swirler comprising a circumferential row of vanes which span inner and outer side walls of the air passage. Viewed on a longitudinal section through the injector, the air passage has a bend downstream of the swirler, the bend changing the direction of the air passage. The vanes are configured to introduce a radial component to the air flow exiting the swirler, the radial component guiding the air flow around the bend.

Abstract: The present invention relates to SNS-595 and methods of treating cancer using the same.

Abstract: Methods of treating, preventing or managing cancer, including certain leukemias are disclosed. The methods encompass the administration of enantiomerically pure (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid. Also provided are methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods are also disclosed.

Abstract: A gas turbine engine lean burn fuel injector includes a fuel injector head which has a first air swirler, a second air swirler arranged around the first air swirler, a pilot fuel injector arranged radially between the first air swirler and the second air swirler. A third air swirler arranged around the second air swirler, a fourth air swirler arranged around the third air swirler and a main fuel injector arranged radially between the third air swirler and the fourth air swirler. A shroud is arranged around the fourth air swirler. A downstream end of the shroud is generally circular in cross-section in a plane perpendicular to the axis (Y) of the fuel injector head and an upstream end of the shroud is generally elliptical in cross-section in a plane perpendicular to the axis (Y) of the fuel injector head.

Abstract: The present invention relates to SNS-595 and methods of treating cancer using the same.

Abstract: The present invention relates to SNS-595 and methods of treating cancer using the same.

Abstract: The present invention relates to SNS-595 and methods of treating cancer using the same.

Abstract: Apparatus is disclosed for optically steering an optical beam, the apparatus comprising a pair of optical prism components arranged together with a diffraction grating so as to allow efficient coupling of an array of spectrally and spatially offset laser diodes to a common optical fiber. A method of optically steering at least one of a series of optical beams is disclosed, the method comprising providing a pair of optical prism components comprising a thermo-optic material; actuating at least one of the components so as to steer at least one of the series of optical beams received from an array of spatially and spectrally offset lasers.