Abstract: Methods of treating, preventing or managing cancer, including certain leukemias are disclosed. The methods encompass the administration of enantiomerically pure (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid. Also provided are methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods are also disclosed.

Abstract: An optical communication system which has an optical signal source adapted to receive a base binary signal and produce a first signal, said first signal being frequency modulated; and an optical spectrum reshaper adapted to reshape the first signal into a second signal, said second signal being amplitude modulated and frequency modulated in which the frequency characteristics of said first signal, and the optical characteristics of said optical spectrum reshaper, being such that the frequency characteristics of said second signal are configured so as to increase the tolerance of the second signal to dispersion in a transmission fiber.

Abstract: A fiber optic communication system, comprising: an optical signal source adapted to produce a frequency modulated signal; and an optical spectrum reshaper adapted to receive the frequency modulated signal and output a substantially amplitude modulated signal; wherein the optical spectrum reshaper limits the bandwidth of the frequency modulated signal.

Abstract: A fiber optic transmitter comprising a digital driver adapted to adjust the crossing point of a digital base signal, an optical source adapted to receive the digital base signal and produce a frequency modulated optical signal, and an optical spectrum reshaper adapted to convert the frequency modulated optical signal to an amplitude modulated optical signal. A method for transmitting a signal, comprising: adjusting the crossing point of a digital base signal; providing the adjusted signal to an optical source to produce a frequency modulated optical signal; and providing the frequency modulated optical signal to an optical spectrum reshaper to convert the frequency modulated optical signal to an amplitude modulated optical signal.

Abstract: This invention provides a flat dispersion frequency discriminator (FDFD) capable of having a substantially flat dispersion with either a positive or negative dispersion along the spectrum region of the discriminator. This way, a FDFD may not cause substantial distortion of the intensity patter of its output to minimize the occurrence distortion due to overshooting or undershooting of the intensity pattern depending on the relative spectral alignment of the laser output relative to the filter transmission.

Abstract: The present invention relates to SNS-595 and methods of treating cancer using the same.

Abstract: In one form of the present invention, there is provided a fiber optic communication system comprising: an optical signal source adapted to receive a base binary signal and produce a first signal, said first signal being frequency modulated; and an optical spectrum reshaper adapted to reshape the first signal into a second signal, said second signal being amplitude modulated and frequency modulated; characterized in that: the frequency characteristics of said first signal, and the optical characteristics of said optical spectrum reshaper, being such that the frequency characteristics of said second signal are configured so as to increase the tolerance of the second signal to dispersion in a transmission fiber.

Abstract: A fiber optic communication system, comprising: an optical signal source adapted to produce a frequency modulated signal; and an optical spectrum reshaper adapted to receive the frequency modulated signal and output a substantially amplitude modulated signal; wherein the optical spectrum reshaper limits the bandwidth of the frequency modulated signal.

Abstract: The present invention relates to SNS-595 and methods of treating cancer using the same.

Abstract: Apparatus is disclosed for optically steering an optical beam, the apparatus comprising a pair of optical prism components arranged together with a diffraction grating so as to allow efficient coupling of an array of spectrally and spatially offset laser diodes to a common optical fiber. A method of optically steering at least one of a series of optical beams is disclosed, the method comprising providing a pair of optical prism components comprising a thermo-optic material; actuating at least one of the components so as to steer at least one of the series of optical beams received from an array of spatially and spectrally offset lasers.

Abstract: A fiber optic transmitter comprising a digital driver adapted to adjust the crossing point of a digital base signal, an optical source adapted to receive the digital base signal and produce a frequency modulated optical signal, and an optical spectrum reshaper adapted to convert the frequency modulated optical signal to an amplitude modulated optical signal. A method for transmitting a signal, comprising: adjusting the crossing point of a digital base signal; providing the adjusted signal to an optical source to produce a frequency modulated optical signal; and providing the frequency modulated optical signal to an optical spectrum reshaper to convert the frequency modulated optical signal to an amplitude modulated optical signal.