Abstract: Compounds of general formula (I): wherein R1, R2, R3, R4, R5a, R5b X1, X2, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases and conditions affected by modulation of TMEM16A, particularly respiratory diseases and conditions.

Abstract: A luminaire includes a support positioned in a ceiling. A light module is connected to the support having a base, a light emitter, and an optic. The light modules allow different luminaire configurations to be formed out of similar components.

Abstract: Disclosed are recombinant oncolytic viruses that express one or more reovirus fusion-associated small transmembrane FAST) proteins and uses thereof. The oncolytic activity of the recombinant oncolytic viruses expressing FAST proteins can be used to treat primary and metastatic cancers, especially from breast and colon cancers.

Abstract: A particle accelerator comprises a waveguide configured to accelerate a beam of electrons along an acceleration path. A diversion channel is configured to convey a beam of electrons along a diversion path. A first magnet arrangement is configured to, at a first location, direct electrons from the acceleration path to the diversion path. A second magnet arrangement is configured to, at a second location, direct electrons from the diversion path to the acceleration path.

Abstract: A connection member for connecting a surgical tool to a plurality of different kinds of corresponding connector. A surgical tool including the connection member. A surgical kit including the surgical tool. The connection member includes an elongate shaft having a longitudinal axis, a proximal end and a distal end. The connection member also includes a plurality of connection features located at the proximal end of the shaft. The plurality of connection features includes at least one connection feature for mating with a first kind of corresponding connector. The plurality of connection features also includes at least one connection feature for mating with a second, different kind of corresponding connector. The connection member may be a male connection member and the corresponding connectors may be female. A method including providing the surgical tool and connecting the connection member to a corresponding connector.

Abstract: The invention provides a controller for a wind turbine having three rotor blades, the controller being for controlling activation of individual pitch control of the rotor blades. The controller is configured to receive a flap load signal, from a flap loading sensor of each of the three rotor blades, indicative of flap loading on each of the respective rotor blades. The controller is configured to determine, based on the received flap load signals, a statistical dispersion parameter of flap loading for each of the rotor blades, the statistical dispersion parameters being indicative of a wind event in a wind field in which the wind turbine operates. The controller is configured to control activation of individual pitch control based on the respective statistical dispersion parameters.

Abstract: Apparatuses, methods, and systems for detecting the presence of a beacon are disclosed. An embodiment includes a vehicle that includes a load arm configured to receive a receptacle, a first detector oriented relative to the load arm to receive a first wireless signal when the load arm is in a first position, a second detector oriented relative to the load arm to receive a second wireless signal when the load arm is in a second position, and a controller configured to detect presence of a tag attached to a specific object within the receptacle based on the received signal strengths of the first wireless signal and the second wireless signal.

Abstract: THIS invention relates to a method of constructing a tailings storage facility structure, and to a tailings facility structure. The structure comprises a network of sand channel arteries 10 and permeable capillaries extending through tailings 14. The sand channel arteries 10 are continuous in the vertical and one lateral dimension and connect to a decant point or points. The permeable capillaries 12 are connected at their lowest point to a sand channel artery, and are continuous in one lateral dimension. The capillaries 12 transport water from the tailings 14 to the sand channel arteries 10, and the sand channel arteries transport water from the capillaries 12 and the tailings 14, to the water decant point or points.

Abstract: A light detection and ranging (LIDAR) system includes a transmitter, a first receiver, a second receiver, and one or more processors. The transmitter is configured to output a transmit beam. The first receiver is positioned on a first side of the transmitter and is configured to receive a first component of a return beam from reflection of the transmit beam by an object. The second receiver is positioned on a second side of the transmitter and is configured to receive a second component of the return beam. The one or more processors are configured to determine at least one of a range to the object or a velocity of the object and control operation of the autonomous vehicle based on the at least one of the range or the velocity.

Abstract: In certain embodiments, a method includes identifying, by a NIC of a node where application sender of an application executes, a network data unit for telemetry metadata insertion based on performing a match operation on information associated with the network data unit, wherein the network data unit is being transmitted from the application sender to an application receiver executing on another node; inserting, based on a first success of the first match operation, telemetry metadata into the network data unit, the telemetry metadata comprising network information and application specific information; stripping, by a last hop device along the data flow path, the telemetry metadata from the network data unit; generating, by the last hop device, a telemetry metadata report using the telemetry metadata; and providing the telemetry metadata report to an application collector executing on the second node.

Abstract: Compounds of general formula (I) wherein R1, R2, R3, R4, R5 and X are as defined herein are inhibitors of the epithelial sodium channel (ENaC) and are useful for the treatment or prevention respiratory diseases and conditions, skin conditions and ocular conditions.

Abstract: A durability assessment system may receive a request, from a computing system, for a durability index describing an entity. The durability assessment system may determine the durability index based on information about the resource usage by the entity, such as a resource availability score or a resource allocation score. The durability assessment system may compare the obtained resource availability score and resource allocation score to ranges associated with a set of durability indices. Based on the comparison, the durability assessment system may determine a durability index for the entity. The durability index may indicate an ability of the entity to return accessed resources. In some cases, the durability assessment system may provide the durability index to an allocation computing system that is configured to determine whether to grant access to resources based on the durability index.