Abstract: Provided herein is an ionizable, cationic amino lipid or a pharmaceutically acceptable salt thereof. The ionizable, cationic amino lipid has: a protonatable amino head group; two lipophilic chains, wherein the protonatable amino head group has a central carbon atom to which each of the two lipophilic chains are directly bonded; at least one of the two lipophilic chains has a structure of Formula C: wherein E is an ester in either orientation. The compounds may be formulated in a lipid nanoparticle for use in the delivery of charged cargo such as nucleic acid.

Abstract: A method for quoting and booking aircraft services via text messaging includes receiving an initial message from a mobile device; authenticating the user based on the mobile device, the authentication resulting in identification of a user record corresponding to the user; receiving a plurality of booking messages; extracting booking data selected from the group consisting of departure airport information, arrival airport information, departure date information, departure time information, passenger count information, and combinations thereof; generating one or more quotes; transmitting a quote message including the one or more quotes; receiving a quote choice message corresponding to a selected one of the one or more quotes; booking aircraft services corresponding to the booking data and the selected one of the one or more quotes, the booking resulting in a booking record having a booking record identifier; transmitting the booking record identifier.

Abstract: A system includes a plurality of computing nodes that form a blockchain network, wherein one or more of the computing nodes is a metaverse computing node configured to generate a mixed reality environment. A processor of at least one computing node is configured to record a plurality of data interactions performed by a user using a metaverse computing node, determine, based on the plurality of data interactions, a data interaction behavior of the user in relation to the data file, detect that a data interaction performed in relation to the data file of the user is not in accordance with the data interaction behavior of the user, determine that the data interaction is a suspicious data interaction, assign an alert level to the suspicious data interaction, determine at least one action to be performed based on the alert level and perform the at least one action.

Abstract: Systems, methods, and apparatus are provided for developing and applying a metaverse enabled digital cognitive twin. Customer communications may be secured at a data layer using multi-cloud object storage. A first multi-modal AI system may generate segmented customer activity data from the customer communications and output the segmented customer activity data to a set of decentralized streaming caches. At an extended reality platform, a second multi-modal AI system may generate immersive content from a real time customer input and the segmented customer activity data for viewing in an XR environment. The system may train an XR avatar based at least in part on the customer communications. The XR avatar may interact with customers and agents and may present a video together with customized supplementary information. The immersive video and the XR avatar may be generated by a plug-in application configured to adapt a variety of XR platforms.

Abstract: Systems, methods, and computer-readable media are described herein which utilizes and controls an electromagnetic energy beam steering apparatus. The electromagnetic energy beam steering apparatus uses directional properties of a Luneburg lens to receive RF energy from one or more points of the Luneburg lens and re-transmits the RF energy from a different point of the Luneburg lens to focus the RF energy in a desired direction. The electromagnetic energy beam steering apparatus may take a form of a passive repeater, an active repeater, or a multipath active repeater.

Abstract: Provided are bearing assemblies including one or more substrate assemblies, such as thrust bearing assemblies. The substrate assemblies include a bearing element fixed to a substrate. The bearing elements are formed from a thermally stable material such as a ceramic-bonded diamond composite. Methods for manufacturing the bearing assemblies are also provided.

Abstract: An apparatus for audio communication includes a memory configured to receive audio data from a user of a voice communication, and one or more processors in communication with the memory. The one or more processors are configured to receive the audio data for the voice communication, which includes voice data of the user and background audio data. The processors are further configured to classify the background audio data into a plurality of types of background audio data, determine to not suppress a subset of the plurality of types of background audio data, process the audio data to not suppress the subset of the plurality of types of background audio data to generate output audio data, and transmit the output audio data.

Abstract: A system includes a memory and a processor coupled to the memory. The processor receives a voice command from a first user to transfer a first amount of data objects from a first data file of the first user to a second data file of a second user. The processor generates a voice signature of the first user and further generates a virtual device in the virtual environment, wherein the virtual device comprises metadata relating to the transfer of the data objects. The processor presents the virtual device and the voice signature to the second user in the virtual environment. The processor receives a selection from the second user of the voice signature and plays the voice signature on a second user device of the second user. The processor receives an acknowledgement from the second user and initiates the requested transfer of data objects to the second user.

Abstract: The present invention relates to stable pharmaceutical compositions comprising apixaban or its pharmaceutically acceptable salts thereof. The present invention further relates to a capsule composition comprising a therapeutically effective amount of apixaban solubilized or dispersed in a pharmaceutically acceptable carrier, wherein the therapeutically effective amount of apixaban ranges from about 0.5 mg/unit dosage form to about 50 mg/unit dosage form. The present invention also provides manufacturing processes thereof and use of the said compositions for prevention, treatment or prophylaxis of disorders in human patients in need thereof.

Abstract: Systems, computer program products, and methods are described herein for processing resources and associated metadata in the metaverse using knowledge graphs. The invention relates to a method for processing and converting documents from a digital data source, involving the following steps: receiving one or more documents from the data source; storing the documents in a network attached storage using a file transfer protocol; converting the documents into an extensible markup language (XML) format; storing the converted documents in an API-accessible document database; generating a downstream process API for accessing the document database; creating an abstract document delineation for the converted documents based on data extracted via the downstream process API; and finally, transforming the abstract document delineation and associated metadata into a semantic, immersive, actionable ontological modeling language, facilitating enhanced document representation and interaction.

Abstract: Aspects of the present invention relate to wireless communications by a user equipment (UE), comprising, identifying resources in a narrowband region, the narrowband region spanning no more than a single resource block in a transmission time interval (TTI) and communicating with a base station using the identified resources.

Abstract: The present invention relates to stable liquid oral compositions of cyclophosphamide having extended stability, methods for their administration, processes for their production, and use of these compositions for treatment of diseases treatable by cyclophosphamide. The invention also relates to a kit comprising stable liquid oral compositions of cyclophosphamide.

Abstract: Aspects of the disclosure describe methods and systems involving separate, parent (e.g., public) and child (e.g., private) metaverses with varying confidentiality and access privileges for auditor users, financial analyst users, regulatory users, and other virtual reality/metaverse users to interact in a fully immersive, real-time manner (e.g., using an immersive query modulation engine) to fulfill audit and regulatory reporting requirements, including extracting information from heterogeneous data stores, recordkeeping of audit responses for regulatory purposes, and maintaining access privileges of varying user profiles.

Abstract: Systems, computer program products, and methods are described herein for intelligent exception handling within a distributed network environment. The present disclosure is configured to receive an incidence of a first exception associated with a network interaction; extract information associated with the first exception; determine, via a machine learning (ML) subsystem, a first exception category associated with the first exception based on at least the information associated with the exception; retrieve, from a repository, a first set of actions associated with the first exception category, wherein the first set of actions are configured to resolve the first exception; and in response, execute the first set of actions.

Abstract: Aspects of the disclosure relate to a distributed evaluation platform. The distributed evaluation platform may train a machine learning model based on historical nonfungible tokens. The distributed evaluation platform may receive client information from a client device. The distributed evaluation platform may generate NFTs corresponding to the client information. The distributed evaluation platform may generate soft tokens corresponding to each NFT. The distributed evaluation platform may apply test cases to the soft tokens. The distributed evaluation platform may generate remedial tokens based on the soft tokens and remediation actions. The distributed evaluation platform may apply the test cases to the remedial tokens. The distributed evaluation platform may overwrite the NFTs using the remedial tokens. The distributed evaluation platform may send an event processing request to an event processing system. The distributed evaluation platform may refine the machine learning model based on the NFTs.

Abstract: The systems and methods described herein optimize the retrieval of missed content by playing back cached content to enable tuners with limited capacity to retrieve the missed content. A content presentation system may receive, with a tuner, a transmission of content comprising media content and advertisements. The content presentation system may cache the advertisements. The content presentation system may determine whether an interruption during the transmission resulted in a missed portion of content and, in response, determine whether an advertisement upcoming at a time period in the transmission of content is cached. If the upcoming advertisement is cached, the content presentation system may play back the cached advertisement at the time period and release the tuner previously receiving the transmission of content to retrieve the missed portion of the content during the time period.

Abstract: Systems, methods, and computer-readable media are described herein which utilizes and controls an electromagnetic energy beam steering apparatus. The electromagnetic energy beam steering apparatus uses directional properties of a Luneburg lens to receive RF energy from one or more points of the Luneburg lens and re-transmits the RF energy from a different point of the Luneburg lens to focus the RF energy in a desired direction. The electromagnetic energy beam steering apparatus may take a form of a passive repeater, an active repeater, or a multipath active repeater.

Abstract: An electronic universal shared utility board (EUSUB) that is implemented as an application configured to provide a fully-integrated and all-in-one multi-user collaboration product which enhances share board use is disclosed. The EUSUB combines features and functionality of an electronic shared notice board, an electronic shared whiteboard, a proctoring board, a schedulable electronic e-meeting board, and a productivity utility board. The EUSUB allows users to pin reference documents to shared meeting boards for all users current access and export for later use, annotate audio/video of the session, provide playback of the audio/video to better understand content, and collaborate both synchronously in meeting style and asynchronously in noticeboard style, while at the same time providing more integrations to capture/record and attach the whole discussion in all aspects in one place to be more productive.

Abstract: In response to receiving a tagging request to map a first non-fungible token (NFT) to a first user device, a processor transmits an authorization request to a second user device to map the first NFT to the first user device. In response to receiving an approval of the request, the processor transmits a request to a minting server of an NFT blockchain network to generate the first NFT for the first user device. The processor stores a token ID of the generated first NFT in a memory. In response to receiving a second authorization from the first user device to perform a data interaction, the processor requests the NFT blockchain network based on the token ID, verification of the first user device. In response to receiving an indication that the first user device is verified, the processor processes the data interaction.

Abstract: The present invention relates to stable liquid oral compositions of cyclophosphamide having extended stability, methods for their administration, processes for their production, and use of these compositions for treatment of diseases treatable by cyclophosphamide. The invention also relates to a kit comprising stable liquid oral compositions of cyclophosphamide.