Patents by Inventor Dusan Bartsch
Dusan Bartsch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20060088535Abstract: The present invention provides for a method to enhance long-term memory in a subject whose cAMP-responsive gene expression is repressed due to binding of a cAMP-response-element-binding-protein-2 to a protein or a DNA associated with cAMP-responsive gene expression, or both, which comprises administering to the subject a compound capable of interfering with such binding in an amount effective to interfere with binding of the protein or the DNA so as to thereby derepress cAMP-responsive gene expression in the subject and enhance the subject's long-term memory.Type: ApplicationFiled: December 13, 2005Publication date: April 27, 2006Applicant: The Trustees of Columbia UniversityInventors: Dusan Bartsch, Eric Kandel, Mirella Ghirardi
-
Patent number: 7015190Abstract: The present invention provides for a method to enhance long-term memory in a subject whose cAMP-responsive gene expression is repressed due to binding of a cAMP-response-element-binding-protein-2 to a protein or a DNA associated with cAMP-responsive gene expression, or both, which comprises administering to the subject a compound capable of interfering with such binding in an amount effective to interfere with binding of the protein or the DNA so as to thereby derepress cAMP-responsive gene expression in the subject and enhance the subject's long-term memory.Type: GrantFiled: June 3, 1996Date of Patent: March 21, 2006Assignee: The Trustees of Columbia University in the City of New YorkInventors: Dusan Bartsch, Eric R. Kandel, Mirella Ghirardi
-
Publication number: 20050003477Abstract: The present invention provides an isolated nucleic acid molecule encoding a brain cyclic nucleotide gated ion channel (BCNG) protein. An isolated BCNG protein is also provided as is a composition comprising a BCNG encoding nucleic acid or protein or a portion thereof. The present invention also provides a method of identifying an ion channel subunit related protein encoding nucleic acid molecule in a sample. The invention further provides a method for evaluating the ability of a compound to modulate an ion channel associated neurological, cardia, or renal condition. The invention also provides a method for evaluating the ability of a compound to interact with a BCNG-related ion channel subunit protein. Additionally, the present invention provides a method for identifying a compound capable of modulating the activity of a BCNG-related protein. The present invention additionally provides a method of treating a cardiac, renal or neurological condition.Type: ApplicationFiled: March 6, 2003Publication date: January 6, 2005Applicant: The Trustees of Columbia University in the City of New YorkInventors: Eric Kandel, Bina Santoro, Dusan Bartsch, Steven Siegelbaum, Gareth Tibbs, Seth Grant
-
Publication number: 20040142421Abstract: The present invention provides an isolated nucleic acid encoding a BCNG protein or a portion thereof or BCNG-related protein or a portion thereof. The present invention further provides a method for identifying a nucleic acid in a sample which encodes a BCNG protein or a BCNG-related protein. The present invention also provides a method for testing whether a compound affects the expression of a BCNG protein or a BCNG-related protein. In addition, the present invention further provides a method for identifying a compound capable of interacting with a BCNG protein or a BCNG-related protein. Also, the present invention provides a method for identifing a compound capable of modulating BCNG protein or BCNG-related protein activity. Further, the present invention also provides a method of treating a condition in a subject which comprises administering to the subject an amount of the provided compound, effective to treat the condition.Type: ApplicationFiled: January 7, 2004Publication date: July 22, 2004Applicant: The Trustees of Columbia University in the City of New YorkInventors: Eric Kandel, Bina Santoro, Dusan Bartsch, Steven Siegelbaum, Gareth Tibbs, Seth Grant
-
Patent number: 6703485Abstract: The present invention provides an isolated nucleic acid encoding a BCNG protein or a portion thereof or BCNG-related protein or a portion thereof. The present invention further provides a method for identifying a nucleic acid in a sample which encodes a BCNG protein or a BCNG-related protein. The present invention also provides a method for testing whether a compound affects the expression of a BCNG protein or a BCNG-related protein. In addition, the present invention further provides a method for identifying a compound capable of interacting with a BCNG protein or a BCNG-related protein. Also, the present invention provides a method for identifing a compound capable of modulating BCNG protein or BCNG-related protein activity. Further, the present invention also provides a method of treating a condition in a subject which comprises administering to the subject an amount of the provided compound, effective to treat the condition.Type: GrantFiled: May 28, 1998Date of Patent: March 9, 2004Assignee: The Trustees of Columbia University in the City of New YorkInventors: Eric R. Kandel, Bina Santoro, Dusan Bartsch, Steven Siegelbaum, Gareth Tibbs, Seth Grant
-
Publication number: 20030118988Abstract: The present invention provides an isolated nucleic acid encoding a BCNG protein or a portion thereof or BCNG-related protein or a portion thereof. The present invention further provides a method for identifying a nucleic acid in a sample which encodes a BCNG protein or a BCNG-related protein. The present invention also provides a method for testing whether a compound affects the expression of a BCNG protein or a BCNG-related protein. In addition, the present invention further provides a method for identifying a compound capable of interacting with a BCNG protein or a BCNG-related protein. Also, the present invention provides a method for identifing a compound capable of modulating BCNG protein or BCNG-related protein activity. Further, the present invention also provides a method of treating a condition in a subject which comprises administering to the subject an amount of the provided compound, effective to treat the condition.Type: ApplicationFiled: May 28, 1998Publication date: June 26, 2003Inventors: ERIC R. KANDEL, BINA SANTORO, DUSAN BARTSCH, STEVEN SIEGELBAUM, GARETH TIBBS, SETH GRANT
-
Patent number: 6551821Abstract: The present invention provides an isolated nucleic acid molecule encoding a brain cyclic nucleotide gated ion channel (BCNG) protein. An isolated BCNG protein is also provided as is a composition comprising a BCNG encoding nucleic acid or protein or a portion thereof. The present invention also provides a method of identifying an ion channel subunit related protein encoding nucleic acid molecule in a sample. The invention further provides a method for evaluating the ability of a compound to modulate an ion channel associated neurological, cardia, or renal condition. The invention also provides a method for evaluating the ability of a compound to interact with a BCNG-related ion channel subunit protein. Additionally, the present invention provides a method for identifying a compound capable of modulating the activity of a BCNG-related protein. The present invention additionally provides a method of treating a cardiac, renal or neurological condition.Type: GrantFiled: December 23, 1997Date of Patent: April 22, 2003Assignee: The Trustees of Columbia University in the City of New YorkInventors: Eric R. Kandel, Bina Santoro, Dusan Bartsch, Steven Siegelbaum, Gareth Tibbs, Seth Grant
-
Patent number: 5547846Abstract: The invention describes two immunogenic regions of the E7 protein of human papillomavirus type 16 (HPV 16), one immunoreactive region being located downstream from nucleotide 595 and the other being located downstream from nucleotide 667 of the HPV 16 genome.Type: GrantFiled: August 16, 1994Date of Patent: August 20, 1996Assignee: Behringwerke AktiengesellschaftInventors: Dusan Bartsch, Lutz Gissmann, Martin Muller