Abstract: An electrosurgical system is provided and includes a bipolar electrosurgical instrument and an electrosurgical generator. The bipolar electrosurgical instrument is arranged to seal and cut tissue captured between jaws of the instrument. The jaws include particularly positioned, shaped and/or oriented electrodes to perform the sealing of tissue. The electrosurgical generator is arranged to supply RF energy through the instrument, monitor the supplied RF energy and adjust or terminate the supplied RF energy to optimally seal the tissue.

Abstract: An electrosurgical system is provided and includes a bipolar electrosurgical instrument and an electrosurgical generator. The bipolar electrosurgical instrument is arranged to seal and cut tissue captured between jaws of the bipolar electrosurgical instrument. The electrosurgical generator is arranged to supply RF energy through the bipolar electrosurgical instrument, monitor the supplied RF energy, and adjust or terminate the supplied RF energy to optimally seal the tissue.

Abstract: A method includes receiving relative position data from a laser range finder, where the relative position data includes a distance and a relative angle between a first node and a second node measured by the laser range finder from a first position of the first node. The method may also include computing a second position of the second node based on the relative position data, providing the second position of the second node to a computing device of one or more of the first node and the second node, and computationally reconstructing a route traversed by the first node and the second node from a number of computed positions for the first node and the second node based on data received from the laser range finder.

Abstract: A driving system for a first vehicle comprises a first and second sensor configured to obtain proximity data for one or more vehicles proximate the first vehicle, and a processor in communication with the first and second sensors and programmed to perform the functions of identifying a plurality of vehicles in a first field-of-view instance based on the proximity data, wherein the plurality of vehicles in the first field-of-view has a trajectory to approach a second field-of-view instance based on the proximity data, and adjusting a vehicle maneuver in response to one of the plurality of vehicles being absent from the second field-of-view instance.

Abstract: The present invention provides PRMT5 inhibiting compounds of general formula (I): A compound of general formula (I), in which R1, R2, R3 R4, R5, R6, R7 L1 and L2 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of disorders, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: A system and method for determining an IR image offset and calibrating a depth sensing camera to account for the offset is provided. An RGB-D camera may image a checkerboard pattern at a known distance and location. The checkerboard pattern may be provided on a planar device, such as a board. A three-dimensional primitive shape may be placed at in a known location in relation to the checkerboard. Depth data may be obtained from the checkerboard with the primitive shape. As the system knows the actual depth of the primitive shape, a depth offset may be calculated from the returned depth information from the RGB-D camera. The system may determine the offset between the depth information and the color image. The offset may be taken into account to produce more accurate RGB-D images.

Abstract: Methods and systems for validating intent to actuate an electronic lock are provided, using comparative gesture processing. One method includes obtaining motion signals representative of physical motion of the mobile device detected by a motion sensor of the mobile device and at an electronic lock. The method includes performing a similarity correlation between the first motion signals and the second motion signals, and, based on the similarity correlation determining that the first motion signals and second motion signals are correlated. Based on the correlation and authentication, the wireless electronic lockset is actuated.

Abstract: A computer-implemented method for the safe, active training of a computer-aided model for modeling time series of a physical system using Gaussian processes, including the steps of establishing a safety threshold value ?; initializing by implementing safe initial curves as input values on the system, creating an initial regression model and an initial safety model; repeatedly carrying out the steps of updating the regression model; updating the safety model; determining a new curve section; implementing the determined new curve section on the physical system and measuring output variables; incorporating the new output values in the regression model and the safety model until N passes have been carried out; and outputting the regression model and the safety model.

Abstract: Embodiments are described that relate to methods and systems for growing cells in a hollow fiber bioreactor. In embodiments, the cells may be exposed to an activator for activating expansion of the cells. The cells may in embodiments include T cells, and the activator may be in different forms, including, for example, antigen presenting cells or beads functionalized with antibodies.

Abstract: Systems, methods, and computer-readable media for flow stitching network traffic flow segments at a middlebox in a network environment. In some embodiments, a method can include collecting flow records of traffic flow segments at a middlebox in a network environment including one or more transaction identifiers assigned to the traffic flow segments. The traffic flow segments can correspond to one or more traffic flows passing through the middlebox and flow directions of the traffic flow segments with respect to the middlebox can be identified using the flow records. The traffic flow segments can be stitched together based on the one or more transaction identifiers and the flow directions of the traffic flow segments to form a stitched traffic flow of the one or more traffic flows passing through the middlebox. The stitched traffic flow can be incorporated as part of network traffic data for the network environment.

Abstract: An infrastructure, method and controller card for managing flash memory in a storage infrastructure. A system is provided that includes flash memory; and a controller that includes: an I/O request handler for handling standard read and write (R/W) operations requested from a host; a garbage collection (GC) system that performs a GC process on the flash memory in response to a threshold condition, wherein the GC process includes GC-induced R/W operations; and a scheduler that interleaves standard R/W operations with GC-induced R/W operations, wherein the scheduler calculates minimum and maximum boundaries for GC-induced R/W operations for a GC process based on an estimated GC latency.

Abstract: Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (PE), deep vein thrombosis (DVT), cerebrovascular embolism, and other vascular occlusions.

Abstract: Disclosed herein are expandable introducer sheaths and methods of making and using the same. The sheaths minimize trauma to a patient's vasculature by allowing for temporary expansion of a portion of the sheath to accommodate passage of a delivery system for a cardiovascular device, then return to a non-expanded state after the passage of the device. The sheath includes an elongated annular member through which the cardiovascular device and its delivery system pass. In an embodiment, the annular inner member can be formed by coextruding a first and second material. The first material includes a fold, and the second material radially spaces the different parts of the fold from each other during fabrication and provides support for maintaining the tubular structure. The second material is removed once the coextrusion process is complete.

Abstract: Embodiments of an expandable sheath can be used in conjunction with a catheter assembly to introduce a prosthetic device, such as a heart valve, into a patient. Such embodiments can minimize trauma to the vessel by allowing for temporary expansion of a portion of the introducer sheath to accommodate the delivery apparatus, followed by a return to the original diameter once the prosthetic device passes through. Some embodiments can include a sheath with inner and outer layers, where a folded portion of the inner layer extends through a slit in the outer layer and a portion of the outer layer overlaps the folded portion of the inner layer. Some embodiments include an elastic outer cover positioned outside the outer layer. Embodiments of the present expandable sheath can avoid the need for multiple insertions for the dilation of the vessel, thus offering advantages over prior art introducer sheaths.

Abstract: Embodiments of an expandable sheath can be used in conjunction with a catheter assembly to introduce a prosthetic device, such as a heart valve, into a patient. Such embodiments can minimize trauma to the vessel by allowing for temporary expansion of a portion of the introducer sheath to accommodate the delivery apparatus, followed by a return to the original diameter once the prosthetic device passes through. Some embodiments can include a sheath with inner and outer layers, where a folded portion of the inner layer extends through a slit in the outer layer and a portion of the outer layer overlaps the folded portion of the inner layer. Some embodiments include an elastic outer cover positioned outside the outer layer. Embodiments of the present expandable sheath can avoid the need for multiple insertions for the dilation of the vessel, thus offering advantages over prior art introducer sheaths.

Abstract: Embodiments of an expandable sheath can be used in conjunction with a catheter assembly to introduce a prosthetic device, such as a heart valve, into a patient. Such embodiments can minimize trauma to the vessel by allowing for temporary expansion of a portion of the introducer sheath to accommodate the delivery apparatus, followed by a return to the original diameter once the prosthetic device passes through. Some embodiments can include a sheath with inner and outer layers, where a folded portion of the inner layer extends through a slit in the outer layer and a portion of the outer layer overlaps the folded portion of the inner layer. Some embodiments include an elastic outer cover positioned outside the outer layer. Embodiments of the present expandable sheath can avoid the need for multiple insertions for the dilation of the vessel, thus offering advantages over prior art introducer sheaths.

Abstract: An electric drive system for a vehicle includes a speed/position feedback device coupled to an electric machine and configured to provide an index pulse. The system further includes an inverter having a line voltage sensor. The system includes a controller programmed to, responsive to the electric machine rotating at a generally constant speed without commanding the inverter, generate a resolver offset from a time difference between a zero crossing of a line voltage and the index pulse and operate the inverter according to the resolver offset.

Abstract: Embodiments of an expandable sheath can be used in conjunction with a catheter assembly to introduce a prosthetic device, such as a heart valve, into a patient. Such embodiments can minimize trauma to the vessel by allowing for temporary expansion of a portion of the introducer sheath to accommodate the delivery apparatus, followed by a return to the original diameter once the prosthetic device passes through. Some embodiments can include a sheath with inner and outer layers, where a folded portion of the inner layer extends through a slit in the outer layer and a portion of the outer layer overlaps the folded portion of the inner layer. Some embodiments include an elastic outer cover positioned outside the outer layer. Embodiments of the present expandable sheath can avoid the need for multiple insertions for the dilation of the vessel, thus offering advantages over prior art introducer sheaths.