Abstract: The present invention covers heterocyclic compounds of general formula (I) in which T, U, Y, Z, R1 and R3 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer disorders, as a sole agent or in combination with other active ingredients.

Abstract: Embodiments of an expandable sheath can be used in conjunction with a catheter assembly to introduce a prosthetic device, such as a heart valve, into a patient. Such embodiments can minimize trauma to the vessel by allowing for temporary expansion of a portion of the introducer sheath to accommodate the delivery apparatus, followed by a return to the original diameter once the prosthetic device passes through. Some embodiments can include a sheath with inner and outer layers, where a folded portion of the inner layer extends through a slit in the outer layer and a portion of the outer layer overlaps the folded portion of the inner layer. Some embodiments include an elastic outer cover positioned outside the outer layer. Embodiments of the present expandable sheath can avoid the need for multiple insertions for the dilation of the vessel, thus offering advantages over prior art introducer sheaths.

Abstract: A method for ascertaining a time characteristic of a measured variable adjustable by an actuator, wherein a time characteristic of a control variable is applied to the actuator, wherein the ascertaining is effected by means of a Gaussian process state model of the behavior of the actuator, wherein the time characteristic of the measured variable of the actuator is ascertained on the basis of a parameterizable family of functions, wherein in the parameterizable family of functions a time dependency of a later latent state, in particular ascertained using a transfer function, of the actuator on an earlier latent state of the actuator and an earlier control variable of the actuator is the same as the applicable dependency of the Gaussian process state model.

Abstract: A power transmission device outputting torque from a first power source and a second power source to axles, is provided with: a first shaft coupled with the first power source; a differential configured to differentially distribute the torque to the axles; a first gear set configured to drivingly couple the first shaft with the differential; a second shaft coupled with the second power source; a second gear set drivingly coupled with the second shaft; a clutch configured to receive fluid pressure to drivingly and releasably couple the second gear set with the first gear set; and a pump driven by a third power source at least independent of the first power source and the clutch to generate the fluid pressure, the pump being disposed separate from the clutch and in fluid connection with the clutch to supply the fluid pressure.

Abstract: A method for devising an optimum control policy of a controller for controlling a system includes optimizing at least one parameter that characterizes the control policy. A Gaussian process model is used to model expected dynamics of the system. The optimization optimizes a cost function which depends on the control policy and the Gaussian process model with respect to the at least one parameter. The optimization is carried out by evaluating at least one gradient of the cost function with respect to the at least one parameter. For an evaluation of the cost function a temporal evolution of a state of the system is computed using the control policy and the Gaussian process model. The cost function depends on an evaluation of an expectation value of a cost function under a probability density of an augmented state at time steps.

Abstract: A bipolar electrosurgical fusion/sealer and dissector is provided that is arranged to simultaneously fuse and cut tissue captured between jaws of the instrument. The jaws include particularly positioned, shaped and/or oriented electrodes along with a compressible landing pad to perform the simultaneous fusion and cutting of tissue. An electrosurgical generator is arranged to supply RF energy through the instrument and monitors a phase angle of the supplied RF energy and adjusts or terminates the supplied RF energy based on the monitored phase angle to optimally fuse and dissect the tissue.

Abstract: The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: A power transmission device outputting torque from a first power source and a second power source to axles, is provided with: a first shaft coupled with the first power source; a differential configured to differentially distribute the torque to the axles; a first gear set configured to drivingly couple the first shaft with the differential; a second shaft coupled with the second power source; a second gear set drivingly coupled with the second shaft; a clutch configured to receive fluid pressure to drivingly and releasably couple the second gear set with the first gear set; and a pump driven by a third power source at least independent of the first power source and the clutch to generate the fluid pressure, the pump being disposed separate from the clutch and in fluid connection with the clutch to supply the fluid pressure.

Abstract: The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: Partially insulated focused ablation (PIFA) catheters using thermally conductive materials have differential radiofrequency (RF) heating and thereby allow for tailored RF application. Open-irrigated, 4 mm, and 8 mm RF ablation catheters were partially insulated by coating half their surfaces with a layer of vinyl, silicone, vinyl-silicone, polyurethane, or a composite of aluminum oxide/boron nitride (AOBN). RF ablation using catheter tips partially coated with a thermally conductive insulation material such as AOBN results in larger ablation lesion volumes without being limited by standard temperature controls. Partial insulation of the catheter tip is able to protect adjacent critical structures during in vivo ablation.

Abstract: A system and method of implementing distributed metadata checkpointing in a storage device. A storage device is disclosed that includes storage device that employs distributed metadata checkpointing, including: flash memory; and a controller that collects metadata checkpoints and includes: a checkpoint partitioner that partitions a metadata checkpoint into a set of segments; and a segment loader that stores each segment of the set of segments into a spare region of a corresponding different flash memory pages during a write operation of data to flash memory.

Abstract: A bipolar electrosurgical fusion/sealer and dissector is provided that is arranged to simultaneously fuse and cut tissue captured between jaws of the instrument. The jaws include particularly positioned, shaped and/or oriented electrodes along with a compressible landing pad to perform the simultaneous fusion and cutting of tissue. An electrosurgical generator is arranged to supply RF energy through the instrument and monitors a phase angle of the supplied RF energy and adjusts or terminates the supplied RF energy based on the monitored phase angle to optimally fuse and dissect the tissue.

Abstract: Systems, methods, and computer-readable media for flow stitching network traffic flow segments across middleboxes. A method can include collecting flow records of traffic flow segments at a first middlebox and a second middlebox in a network environment including one or more transaction identifiers assigned to the traffic flow segments. Sources and destinations of the traffic flow segments can be identified with respect to the first middlebox and the second middlebox. Corresponding subsets of the traffic flow segments can be stitched together to from a first stitched traffic flow at the first middlebox and a second stitched traffic flow at the second middlebox. The first and second stitched traffic flows can be stitched together to form a cross-middlebox stitched traffic flow across the first middlebox and the second middlebox. The cross-middlebox stitched traffic flow can be incorporated as part of network traffic data for the network environment.

Abstract: Embodiments of an expandable sheath can be used in conjunction with a catheter assembly to introduce a prosthetic device, such as a heart valve, into a patient. Such embodiments can minimize trauma to the vessel by allowing for temporary expansion of a portion of the introducer sheath to accommodate the delivery apparatus, followed by a return to the original diameter once the prosthetic device passes through. Some embodiments can include a sheath with inner and outer layers, where a folded portion of the inner layer extends through a slit in the outer layer and a portion of the outer layer overlaps the folded portion of the inner layer. Some embodiments include an elastic outer cover positioned outside the outer layer. Embodiments of the present expandable sheath can avoid the need for multiple insertions for the dilation of the vessel, thus offering advantages over prior art introducer sheaths.

Abstract: In an embodiment, a pose estimation device obtains an image of an object, and generates a pose estimate of the object. The pose estimate includes a respective heatmap for each of a plurality of pose components of a pose of the object, and the respective heatmap for each of the pose components includes a respective uncertainty indication of an uncertainty of the pose component at each of one or more pixels of the image.

Abstract: An aerial vehicle and methods of use. The aerial vehicle including a central rotor assembly configured to provide vertical thrust. A fuselage having a longitudinal axis mounted to the central rotor assembly. A plurality of rotors smaller than said central rotor mounted to said fuselage by a frame, includes a propeller, an electrical motor, an electronic speed controller, a flight controller (means for controlling the rotation speed of the central rotor and the smaller rotors). A propulsion system for powering said central rotor, said smaller rotors and said flight controller. Together with control and monitoring systems, the aerial vehicle system enables a new agricultural ecosystem for providing small farmer access to global markets.

Abstract: Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (PE), deep vein thrombosis (DVT), cerebrovascular embolism, and other vascular occlusions.

Abstract: Disclosed herein are systems and methods to remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (PE), deep vein thrombosis (DVT), cerebrovascular embolism, and other vascular occlusions.

Abstract: A sealed bearing rock bit has a plurality of legs with journals formed to extend inward and downward at the end of the legs. Each of the legs has a last machined surface located adjacent to the bases of the journals and into which a seal groove is formed which circumscribes the respective journal. Cutters are rotatably mounted to respective ones of the journals, with back faces of the cutters located adjacent to respective ones of the last machined surfaces. The back faces of the cutters have annular-shaped protrusions which extend from said back faces and protrude into the seal grooves beyond the last machined surfaces of said journals extending an annular-shaped seal surface which is engaged by a seal disposed in the seal groove, leaving more of the interface space between the journal and the cutter for larger roller bearings.

Abstract: The invention provides a deflectable catheter capable of forming many variable radius spiral forms from a single, flexible, distal end section. In one aspect, the catheter employs a variable radius control wire to extend or deform a pre-formed loop structure into a three dimensional spiral-like form or geometry. The ability of a single catheter to create a multitude of shapes and sizes allows users to access to a number of anatomical areas without changing the catheter during a procedure or treatment. In another aspect, the invention encompasses methods of producing deflectable variable radius catheters, where two or more regions of the catheter having common control wires are fused or formed onto one another.