Abstract: Compositions and methods that can increase or stimulate hair growth, as well as novel chemicals that affect hair growth and hair loss.

Abstract: A computer system displays a representation of a camera field of view and receives one or more inputs corresponding to a request to display the representation of the field of view based on a physical object at a first pose, a virtual object at a simulated second pose, and the one or more cameras at a third pose in a physical environment. In response, if a first portion of the virtual object corresponds to physical space that is occluded by the physical object, the system: displays the representation of the physical object; forgoes displaying the first portion of the virtual object; and, if a second portion of the virtual object corresponds to physical space that is not occluded, displays the second portion, including visually deemphasizing a displayed first region of the second portion relative to a displayed second region of the second portion of the virtual object.

Abstract: The present disclosure provides compounds of Formula (I), (II), and (III). The provided compounds are able to bind protein kinases (e.g., SIK) and may be useful in modulating (e.g., inhibiting) the activity of a protein kinase (e.g., SIK, (e.g., SIK1, SIK2, or SIK3)) in a subject or cell. The provided compounds may be useful in treating or preventing a disease (e.g., proliferative disease, musculoskeletal disease, genetic disease, hematological disease, neurological disease, painful condition, psychiatric disorder, or metabolic disorder) in a subject in need thereof. Also provided are pharmaceutical compositions, kits, methods, and uses that include or involve a compound described herein.

Abstract: The present disclosure provides compounds of Formula (I), (II), and (III). The provided compounds are able to bind protein kinases (e.g., SIK) and may be useful in modulating (e.g., inhibiting) the activity of a protein kinase (e.g., SIK, (e.g., SIK1, SIK2, or SIK3)) in a subject or cell. The provided compounds may be useful in treating or preventing a disease (e.g., proliferative disease, musculoskeletal disease, genetic disease, hematological disease, neurological disease, painful condition, psychiatric disorder, or metabolic disorder) in a subject in need thereof. Also provided are pharmaceutical compositions, kits, methods, and uses that include or involve a compound described herein.

Abstract: Systems and techniques are provided for detecting gaze direction of subjects in an area of real space. The system receives a plurality of sequences of frames of corresponding fields of view in the real space. The system uses sequences of frames in a plurality of sequences of frames to identify locations of an identified subject and gaze directions of the subject in the area of real space over time. The system includes logic having access to a database identifying locations of items in the area of real space. The system identifies items in the area of real space matching the identified gaze directions of the identified subject.

Abstract: Systems and techniques are provided for linking subjects in an area of real space with user accounts. The user accounts are linked with client applications executable on mobile computing devices. A plurality of cameras are disposed above the area. The cameras in the plurality of cameras produce respective sequences of images in corresponding fields of view in the real space. A processing system is coupled to the plurality of cameras. The processing system includes logic to determine locations of subjects represented in the images. The processing system further includes logic to match the identified subjects with user accounts by identifying locations of the mobile computing devices executing client applications in the area of real space and matching locations of the mobile computing devices with locations of the subjects.

Abstract: In one aspect, a mounting assembly for mounting an architectural covering to a support structure may include a bracket configured to be coupled to the support structure and a bracket adapter configured to be coupled to the bracket. In addition, the mounting assembly may include an end mount configured to be coupled to both an adjacent end of the covering and the bracket adapter. In accordance with aspects of the present subject matter, the various components of the mounting assembly may be configured or adapted to provide one or more advantages over known mounting assemblies.

Abstract: Disclosed herein are methods and compositions for reducing and/or preventing hair greying in a subject.

Abstract: Systems and techniques are provided for detecting gaze direction of subjects in an area of real space. The system receives a plurality of sequences of frames of corresponding fields of view in the real space. The system uses sequences of frames in a plurality of sequences of frames to identify locations of an identified subject and gaze directions of the subject in the area of real space over time. The system includes logic having access to a database identifying locations of items in the area of real space. The system identifies items in the area of real space matching the identified gaze directions of the identified subject.

Abstract: Systems and techniques are provided for linking subjects in an area of real space with user accounts. The user accounts are linked with client applications executable on mobile computing devices. A plurality of cameras are disposed above the area. The cameras in the plurality of cameras produce respective sequences of images in corresponding fields of view in the real space. A processing system is coupled to the plurality of cameras. The processing system includes logic to determine locations of subjects represented in the images. The processing system further includes logic to match the identified subjects with user accounts by identifying locations of the mobile computing devices executing client applications in the area of real space and matching locations of the mobile computing devices with locations of the subjects.

Abstract: In one aspect, a mounting assembly for mounting an architectural covering to a support structure may include a bracket configured to be coupled to the support structure and a bracket adapter configured to be coupled to the bracket. In addition, the mounting assembly may include an end mount configured to be coupled to both an adjacent end of the covering and the bracket adapter. In accordance with aspects of the present subject matter, the various components of the mounting assembly may be configured or adapted to provide one or more advantages over known mounting assemblies.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for receiving data related to a first flight risk factor and a second flight risk factor where the first and second risk factors include one of: a proficiency risk factor, an equipment risk factor, an environmental risk factor, or a performance risk factor. Applying a first weighting to the first flight risk factor to generate a first weighted flight risk factor, and applying a second weighting to the second flight risk factor to generate a second weighted flight risk factor. Assessing a flight risk level for a flight based on the first weighted flight risk factor and the second weighted flight risk factor. Providing data indicating the assessed flight risk level for the flight for display to a user.

Abstract: This disclosure provides compositions and methods of treating cancer by inhibiting histone methyltransferases alone or in combination by synergistically inhibiting a histone demethylase, or a histone deacetylase (HDAC), or a bromodomain (BRD)-containing protein, or a B-Raf kinase. In particular, the cancers have deficient of SWI/SNF chromatin remodeling complexes because of mutations in one or more of the complex's subunit members.

Abstract: A method of unmanned aerial vehicle (UAV) flight includes providing horizontal thrust in-line with the direction of forward flight of the UAV using at least one electric motor, providing primary vertical lift for the UAV during the forward flight using a fixed and non-rotating wing, repositioning the at least one electric motor to provide vertical thrust during transition of the UAV to vertical flight for descent, landing the UAV on a surface using a vertical approach after the motor repositioning, and deploying an anchor to secure the UAV to a surface.

Abstract: A method for tracking inventory items is provided. The method includes using sensors to produce respective sequences of images of corresponding fields of view, the field of view of each sensor overlapping with the field of view of at least one other sensor. The method includes dividing the area of real space into cells having volume and coordinates in a real space, and identifying inventory items and their locations in three dimensions using the sequences of images produced by at least two sensors having overlapping fields of view. The method includes, in response to the identification of the inventory items: (i) matching locations in three dimensions of identified inventory items with cells in the plurality of cells, and (ii) determining, for a particular inventory item matched with a particular cell, whether a count of the particular inventory item is below a threshold for re-stocking the particular inventory item.

Abstract: Compositions and methods for stimulating proliferation and/or migration of melanocytes in order to re-pigment skin regions, using ROCK inhibitors and optionally SIK inhibitors.

Abstract: A method for identifying an inventory item is provided. The method includes using first one or more sensors to produce first one or more outputs indicative of an inventory item, using second one or more sensors to produce second one or more outputs indicative of the inventory item, generating, based on the first one or more outputs and independent of the second one or more outputs, a first confidence level of the inventory item being a first inventory item, generating, based on the second one or more outputs and independent of the first one or more outputs, a second confidence level of the inventory item being a second inventory item, and identifying, based on the first confidence level and the second confidence level, the inventory item as one of the first inventory item or the second inventory item.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for receiving data related to a first flight risk factor and a second flight risk factor where the first and second risk factors include one of: a proficiency risk factor, an equipment risk factor, an environmental risk factor, or a performance risk factor. Applying a first weighting to the first flight risk factor to generate a first weighted flight risk factor, and applying a second weighting to the second flight risk factor to generate a second weighted flight risk factor. Assessing a flight risk level for a flight based on the first weighted flight risk factor and the second weighted flight risk factor. Providing data indicating the assessed flight risk level for the flight for display to a user.

Abstract: A method for identifying gestures in an area of real space is provided. The method including using a plurality of sensors to produce respective sequences of frames of corresponding fields of view in the area of real space, detecting subjects in the area of real space, using a sequence of frames produced by a corresponding sensor in the plurality of sensors in a first inference engine to identify inventory items carried by the detected subjects in the sequence of frames, using outputs of the first inference engine over a period of time in a second inference engine to identify gestures of the detected subjects, and storing the identified gestures in a database.

Abstract: The present disclosure provides methods of increasing skin pigmentation in a subject in need thereof using salt-inducible kinase (SIK) inhibitors, such as macrocyclic compounds of Formula (I), bicyclic urea compounds of Formula (II), (III), and (IV), and compounds of Formula (V), (VI), (VI-A), or (VII). Also provided are pharmaceutical compositions, methods, and uses that include or involve a compound described herein.