Patents by Inventor E. Jacobsen

E. Jacobsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TEMPERATURE REGULATED CRISPR-CAS SYSTEMS AND METHODS OF USE THEREOF
    Publication number: 20250129388
    Abstract: The present disclosure relates to CRISPR-Cas systems that utilize Cas12L for binding to and modifying nucleic acids in eukaryotic cells in a temperature regulated manner. Methods and compositions for using these CRISPR-Cas systems for editing nucleic acids for use in disease treatment and prevention in eukaryotic cells are provided herein.
    Type: Application
    Filed: August 31, 2022
    Publication date: April 24, 2025
    Inventors: Jennifer A. Doudna, Steven E. Jacobsen, Zheng Li, Basem Al-Shayeb
  • TOOLS FOR GENE SILENCING
    Publication number: 20250042956
    Abstract: The present disclosure relates to recombinant transcriptional repressor polypeptides that are capable of being targeted to specific loci, as well as methods of using these recombinant polypeptides for reducing expression of a target nucleic acid in plants.
    Type: Application
    Filed: December 2, 2022
    Publication date: February 6, 2025
    Applicant: The Regents of the University of California
    Inventors: Steve E. JACOBSEN, Ming WANG
  • Methods and compositions for targeting RNA polymerases and non-coding RNA biogenesis to specific loci
    Patent number: 12043839
    Abstract: The present disclosure relates to the use of recombinant proteins for inducing epigenetic modifications at specific loci, as well as to methods of using these recombinant proteins for reducing the expression of genes in plants.
    Type: Grant
    Filed: February 14, 2022
    Date of Patent: July 23, 2024
    Assignee: The Regents of the University of California
    Inventors: Steve E. Jacobsen, Javier Gallego-Bartolomé, Ashot Papikian
  • TARGETED GENE DEMETHYLATION IN PLANTS
    Publication number: 20240141367
    Abstract: The present disclosure relates to the use of recombinant proteins for inducing epigenetic modifications at specific loci, as well as to methods of using these recombinant proteins for modulating the expression of genes in plants.
    Type: Application
    Filed: January 5, 2024
    Publication date: May 2, 2024
    Applicant: The Regents of the University of California
    Inventors: Steve E. JACOBSEN, Javier GALLEGO-BARTOLOMÉ, Ashot PAPIKIAN, Jason GARDINER
  • CRISPR-CAS EFFECTOR POLYPEPTIDES AND METHODS OF USE THEREOF
    Publication number: 20240102032
    Abstract: The present disclosure provides CRISPR-Cas effector polypeptides that exhibit enhanced gene editing and/or trans cleavage activity, compared to a wild-type CasPhi polypeptide. The present disclosure provides systems and kits comprising such CRISPR-Cas effector polypeptides. The present disclosure provides methods, including gene editing and diagnostic methods, using a CRISPR-Cas effector polypeptide of the present disclosure.
    Type: Application
    Filed: January 24, 2022
    Publication date: March 28, 2024
    Inventors: Jennifer A. Doudna, Patrick Pausch, Katarzyna Soczek, Steven E. Jacobsen, Zheng Li
  • TARGETED GENE DEMETHYLATION IN PLANTS
    Publication number: 20230235343
    Abstract: The present disclosure relates to the use of recombinant proteins for inducing epigenetic modifications at specific loci, as well as to methods of using these recombinant proteins for modulating the expression of genes in plants.
    Type: Application
    Filed: September 29, 2022
    Publication date: July 27, 2023
    Applicant: The Regents of the University of California
    Inventors: Steve E. JACOBSEN, Javier GALLEGO-BARTOLOMÉ, Ashot PAPIKIAN, Jason GARDINER
  • Targeted gene activation in plants
    Patent number: 11692198
    Abstract: The present disclosure relates to the targeting of transcriptional activators to specific loci in plants to activate transcription of the targeted loci. Specifically, the present disclosure provides methods and compositions for using guided (e.g. RNA-guided) transcriptional activators to activate transcription of specific loci in plants.
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: July 4, 2023
    Assignee: The Regents of the University of California
    Inventors: Steve E. Jacobsen, Ashot Papikian
  • CRISPR SYSTEMS IN PLANTS
    Publication number: 20230159943
    Abstract: The present disclosure relates to CRISPR-Cas systems that utilize Cas 12J for editing nucleic acids in plants. Methods and compositions for using these systems for editing nucleic acids in plants are provided herein.
    Type: Application
    Filed: April 20, 2021
    Publication date: May 25, 2023
    Applicant: The Regents of the University of California
    Inventors: Steve E. JACOBSEN, Zheng LI, Jennifer DOUDNA, Patrick PAUSH, Basem AL-SHAYEB
  • Targeted gene demethylation in plants
    Patent number: 11566253
    Abstract: The present disclosure relates to the use of recombinant proteins for inducing epigenetic modifications at specific loci, as well as to methods of using these recombinant proteins for modulating the expression of genes in plants.
    Type: Grant
    Filed: January 22, 2018
    Date of Patent: January 31, 2023
    Assignee: The Regents of the University of California
    Inventors: Steve E. Jacobsen, Javier Gallego-Bartolomé, Ashot Papikian, Jason Gardiner
  • Methods and compositions for targeting RNA polymerases and non-coding RNA biogenesis to specific loci
    Patent number: 11479781
    Abstract: The present disclosure relates to recombinant proteins that induce epigenetic gene silencing and to methods of using such proteins for reducing the expression of genes in plants.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: October 25, 2022
    Assignee: The Regents of the University of California
    Inventors: Steve E. Jacobsen, Javier Gallego-Bartolomé
  • METHODS AND COMPOSITIONS FOR TARGETING RNA POLYMERASES AND NON-CODING RNA BIOGENESIS TO SPECIFIC LOCI
    Publication number: 20220275386
    Abstract: The present disclosure relates to the use of recombinant proteins for inducing epigenetic modifications at specific loci, as well as to methods of using these recombinant proteins for reducing the expression of genes in plants.
    Type: Application
    Filed: February 14, 2022
    Publication date: September 1, 2022
    Applicant: The Regents of the University of California
    Inventors: Steve E. JACOBSEN, Javier GALLEGO-BARTOLOMÉ, Ashot PAPIKIAN
  • Methods and compositions for targeting RNA polymerases and non-coding RNA biogenesis to specific loci
    Patent number: 11286493
    Abstract: The present disclosure relates to the use of recombinant proteins for inducing epigenetic modifications at specific loci, as well as to methods of using these recombinant proteins for reducing the expression of genes in plants.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: March 29, 2022
    Assignee: The Regents of the University of California
    Inventors: Steve E. Jacobsen, Javier Gallego-Bartolomé, Ashot Papikian
  • HERBICIDAL COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20200037609
    Abstract: The present disclosure relates generally to herbicidal compositions and methods of use thereof, and more specifically to herbicidal compositions containing aspterric acid or a derivative thereof for use in inhibiting vegetative growth in plants.
    Type: Application
    Filed: March 21, 2018
    Publication date: February 6, 2020
    Applicant: The Regents of the University of California
    Inventors: Yan YAN, Yi TANG, Steve E. JACOBSEN, Qikun LIU
  • TARGETED GENE ACTIVATION IN PLANTS
    Publication number: 20200017869
    Abstract: The present disclosure relates to the targeting of transcriptional activators to specific loci in plants to activate transcription of the targeted loci. Specifically, the present disclosure provides methods and compositions for using guided (e.g. RNA-guided) transcriptional activators to activate transcription of specific loci in plants.
    Type: Application
    Filed: July 18, 2019
    Publication date: January 16, 2020
    Applicant: The Regents of the University of California
    Inventors: Steve E. JACOBSEN, Ashot PAPIKIAN
  • METHODS AND COMPOSITIONS FOR TARGETING RNA POLYMERASES AND NON-CODING RNA BIOGENESIS TO SPECIFIC LOCI
    Publication number: 20190390211
    Abstract: The present disclosure relates to recombinant proteins that induce epigenetic gene silencing and to methods of using such proteins for reducing the expression of genes in plants.
    Type: Application
    Filed: July 3, 2019
    Publication date: December 26, 2019
    Applicant: The Regents of the University of California
    Inventors: Steve E. JACOBSEN, Javier GALLEGO-BARTOLOMÉ
  • TARGETED GENE DEMETHYLATION IN PLANTS
    Publication number: 20190352654
    Abstract: The present disclosure relates to the use of recombinant proteins for inducing epigenetic modifications at specific loci, as well as to methods of using these recombinant proteins for modulating the expression of genes in plants.
    Type: Application
    Filed: January 22, 2018
    Publication date: November 21, 2019
    Applicant: The Regents of the University of California
    Inventors: Steve E. JACOBSEN, Javier GALLEGO-BARTOLOMÉ, Ashot PAPIKIAN, Jason GARDINER
  • Methods and compositions for targeting RNA polymerases and non-coding RNA biogenesis to specific loci
    Patent number: 10351867
    Abstract: The present disclosure relates to recombinant proteins that induce epigenetic gene silencing and to methods of using such proteins for reducing the expression of genes in plants.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: July 16, 2019
    Assignee: The Regents of the University of California
    Inventors: Steve E. Jacobsen, Javier Gallego-Bartolomé
  • METHODS AND COMPOSITIONS FOR TARGETING RNA POLYMERASES AND NON-CODING RNA BIOGENESIS TO SPECIFIC LOCI
    Publication number: 20190203216
    Abstract: The present disclosure relates to the use of recombinant proteins for inducing epigenetic modifications at specific loci, as well as to methods of using these recombinant proteins for reducing the expression of genes in plants.
    Type: Application
    Filed: May 26, 2017
    Publication date: July 4, 2019
    Applicant: The Regents of the University of California
    Inventors: Steve E. JACOBSEN, Javier GALLEGO-BARTOLOMÉ, Ashot PAPIKIAN
  • Titanium alloy
    Patent number: 9630251
    Abstract: A titanium base alloy powder is formed by subsurface reduction of a chloride vapor with a molten alkali metal or molten alkaline earth metal to form reaction products comprising pre-alloy particles and a salt of the alkali metal or the alkaline earth metal. A majority of the pre-alloy particles have a composition of at least 50% by weight of titanium, about 5.38% to 6.95% by weight of aluminum, and about 3% to 5% by weight of vanadium. The pre-alloy particles are recovered from the reaction products to produce a titanium base alloy powder containing less than about 200 ppm alkali or alkaline earth metal.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: April 25, 2017
    Assignee: Cristal Metals Inc.
    Inventors: Lance E. Jacobsen, Adam Benish
  • METHODS AND COMPOSITIONS FOR TARGETING RNA POLYMERASES AND NON-CODING RNA BIOGENESIS TO SPECIFIC LOCI
    Publication number: 20160017348
    Abstract: The present disclosure relates to recombinant proteins that induce epigenetic gene silencing and to methods of using such proteins for reducing the expression of genes in plants.
    Type: Application
    Filed: February 28, 2014
    Publication date: January 21, 2016
    Applicant: The Regents of the University of California
    Inventors: Steve E. Jacobsen, Julie Law, Lianna Johnson