Abstract: Disclosed are methods, systems, and a non-transitory computer-readable medium for regenerating at least a portion of a flight plan of a vehicle. The method may include generating an adjustment to a speed, an altitude, and/or a heading for one or more locations along a flight path within at least one of a predetermined distance of the vehicle and a predetermined window of time, based on received speed data, altitude data, and flight path data, including a subset of points along each boom footprint included in the flight path data, and a permissible threshold boom value for each of the one or more locations. The method may also include regenerating a portion of a flight plan corresponding to the one or more locations, based on the generated adjustment to the speed, altitude, and/or heading for the one or more locations.

Abstract: Disclosed are methods, systems, and a non-transitory computer-readable medium for modifying a flight plan of a vehicle. The method may include identifying a maneuver of a flight path that will generate a focus boom, based on received flight path data and permissible threshold boom values for locations along a boom footprint of the maneuver, and generating an adjustment to at least one of a speed, an altitude, an attitude, a location, and a turn radius of the maneuver based on the received data and the permissible threshold boom values. In addition, the method may include updating the flight plan based on the generated adjustment to the at least one of the speed, the altitude, the attitude, the location, and the turn radius of the at least one maneuver.

Abstract: A technique facilitates hydrocarbon fluid production. A well is formed in a subterranean region by drilling a borehole, e.g. a generally vertical wellbore. At least one tunnel is formed and oriented to extend outwardly from the borehole at least 10 feet into a formation surrounding the borehole. The orientation of the at least one tunnel is selected such that it extends at a desired angle with respect to a direction of horizontal stress in the formation. A fracture stimulation of the at least one tunnel is performed to create a network of fractures. The orientation of the at least one tunnel ensures that the network of fractures extends through a target zone in a hydrocarbon bearing region of the formation.

Abstract: Downhole fluid volumes of a geological formation may be estimated using nuclear magnetic resonance (NMR) measurements, even in organic shale reservoirs. Multi-dimensional NMR measurements, such as two-dimensional NMR measurements and/or, in some cases, one or more well-logging measurements relating to total organic carbon may be used to estimate downhole fluid volumes of hydrocarbons such as bitumen, light hydrocarbon, kerogen, and/or water. Having identified the fluid volumes in this manner or any other suitable manner from the NMR measurements, a reservoir producibility index (RPI) may be generated. The downhole fluid volumes and/or the RPI may be output on a well log to enable an operator to make operational and strategic decisions for well production.

Abstract: The present invention relates to methods of treating pancreatic cancer with particular dosage regimes of antibodies that bind colony stimulating factor 1 receptor (CSF1R) (e.g. cabiralizumab) in combination with antibodies that bind programmed cell death 1 (PD-1) (e.g. nivolumab).

Abstract: A lighting device, such as a light-emitting diode (LED) light source, may operate in an interim operable state to avoid and/or prevent undesirable characteristics in the light emitted by the lighting device (e.g., strobing and/or flickering of a brightness of the light and/or shifting or change of a color of the light). When operating in a normal state, the control circuit may determine if a measured value of a first operational characteristic (e.g., a forward voltage of an emitter of the lighting device) is outside of a range and operate in the interim operable state if the measured value of the first operational characteristic is outside of the range. When operating in the interim operable state, the control circuit may adjust a drive current for the emitter in response to a measured value of a second operational characteristic (e.g., a forward voltage of a detector of the lighting device).

Abstract: A method in an aircraft for the validation of variable data is provided. The method comprises: receiving a request from an application program to retrieve data attributes for at least one data item to be entered via a GUI provided by the application program; requesting, from the flight management engine using an API, the data attributes for the at least one data item, wherein the data attributes identify at least one limit for data entry for the at least one data item including a minimum and/or maximum value for the at least one data item; receiving the requested data attributes from the flight management engine; and transmitting the data attributes to the application program; wherein the application program restricts data entry for the at least one data item in conformance with each limit provided by the data attributes for the at least one data item.

Abstract: An illumination device and method are provided herein for calibrating individual LEDs in the illumination device to obtain a desired luminous flux and a desired chromaticity of the device over changes in drive current, temperature, and over time as the LEDs age. The calibration method may include subjecting the illumination device to a first ambient temperature, successively applying at least three different drive currents to a first LED to produce illumination at three or more different levels of brightness, obtaining a plurality of optical measurements from the illumination produced by the first LED at each of the at least three different drive currents, obtaining a plurality of electrical measurements from the photodetector and storing results of the obtaining steps within the illumination device to calibrate the first LED at the first ambient temperature.

Abstract: Methods and systems are provided for assisting operation of a vehicle deviating from a desired manner of operation, such as an aircraft deviating from a planned trajectory. One method involves identifying a current aircraft altitude, identifying a current aircraft configuration, determining a recommended flight path from the current aircraft altitude for satisfying an upcoming constraint associated with a reference descent strategy based at least in part on the current aircraft configuration in response to a deviation between the current aircraft altitude a target altitude according to the reference descent strategy, and providing an output influenced by the recommended flight path. The recommended flight path includes a recommended vertical profile and a recommended speed profile, and the recommended flight path is configured to vary at least one of a kinetic energy or a potential energy of the aircraft along the recommended flight path en route to the upcoming constraint.

Abstract: The present invention provides methods of enhancing immune response to a vaccine using variant forms of anti-CTLA-4 antibodies having enhanced ADCC activity. Variant anti-CTLA-4 antibodies for use in the present invention include nonfucosylated ipilimumab.

Abstract: An illumination device, system, and method are provided herein for emulating sunlight along a daytime or nighttime locus. Color temperature is determined using a first color temperature curve that includes data representative of a first color temperature as a function of a time of day. In response to a request to a change in brightness of one or more LED chains, a target color temperature output as a function of the current time of day is determined using a second color temperature curve based on the requested change in brightness. The second color temperature curve includes the target color temperature corresponding to the determined current time of day. The target color temperature output includes a lesser change in color temperature at solar noon than the change in color temperature at sunrise and sunset.

Abstract: An LED lamp and method are provided for autonomously changing the output brightness and color temperature of a plurality of LED strings to follow a first dimcurve in temporal synchronization with at least one other LED lamp. Synchronization is achieved based on a time of day determined using a clock signal. The output brightness and color temperature can transition from the first dimcurve to a second dimcurve over a predetermined number of scenes. The number of scenes is a function of a difference between the first dimcurve and the second dimcurve in at least one of the output brightness and the color temperature.

Abstract: A lighting device, such a controllable light-emitting diode (LED) light source, may execute a self calibration procedure to compensate for changes to an optical system of the lighting device that may have occurred after an initial factory calibration procedure. The lighting device may include an emitter, a detector that generates a detector signal in response to detected light, a memory that stores a curve defining an optical compensation value with respect to a measured forward voltage of the detector, and a control circuit configured to receive a measured value of a luminous flux of the light emitted by the emitter that may be determined in response to the detector signal and based the optical compensation value. The control circuit may adjust the curve defining the optical compensation value in response to a difference between the measured value and an expected value of the luminous flux.

Abstract: An illumination device and method is provided herein for calibrating individual LEDs in the illumination device, so as to obtain a desired luminous flux and a desired chromaticity of the device over changes in drive current, temperature, and over time as the LEDs age. The calibration method may include subjecting the illumination device to a first ambient temperature, successively applying at least three different drive currents to a first LED to produce illumination at three or more different levels of brightness, obtaining a plurality of optical measurements from the illumination produced by the first LED at each of the at least three different drive currents, obtaining a plurality of electrical measurements from the photodetector and storing results of the obtaining steps within the illumination device to calibrate the first LED at the first ambient temperature.

Abstract: Provided are mammalian cells devoid of lactate dehydrogenase activity.

Abstract: An illumination system and method is provided for readily mapping a plurality of scenes along a dimcurve form a natural show for one or more groups of LED illumination devices. Mapping can be performed using a graphical user interface on a remote controller wirelessly linked to the illumination devices. A keypad is preferably configured for button control of changes to color temperature as a function of brightness along each of the various dimcurves for each of the various groups of illumination devices controlled by a corresponding keypad to allow momentary or persistent override and reprogram of the natural show. Modification to a scene further comprises modifications to scenes before and after the currently modified scene to provide a smoothing dimcurve modification. Global keypad can be used to control multiple zones arranged throughout a structure to switch between a natural show that emulates outdoor sunlight conditions to a panic show when an intruder is detected.

Abstract: An illumination device, system and method are provided herein for emulating sunlight along a daytime or nighttime locus. Sunlight is emulated depending on the path length of the sun relative to a structure containing the illumination device and system. One or more illumination devices can be grouped together and perform the sunlight emulation along the locus by producing different color temperatures throughout the day by all illumination devices within that group producing the same color temperature changes throughout the day. Moreover, a particular advantage of the preferred embodiments is the ability to manually change at any time the emulated natural sunlight output from the one or more groups of illumination devices and advantageously change the color output more so at certain times than at other times by simply actuating a trigger on a dimmer associated with a virtual or physical keypad.

Abstract: An improved device and process for the production of oxides of nitrogen (NOx) having a novel plasma reactor assembly (105) with a gas and water injector (104) that mixes gas (10) and water (103) to produce gas and micro-fine water droplets (106) and injects same into a plasm reactor vessel (125) between electric diodes (128, 129) to yield a nitrous-rich plasma product (107) which is useful in a variety of commercial, agriculture, medical and industrial arenas.

Abstract: The invention comprises an apparatus, method and system used to treat various liquids, seeds, and soil or other growth media used in cultivating plants by exposure to a plasma discharge. The system comprises a novel electrode structure which utilizes a tapered inner electrode and a porous outer electrode to create a three-dimensional plasma discharge, which is applied to liquid, seeds or growth media through removably attachable sub-assemblies. When used to treat water or seeds, highly-concentrated plasma activated water (PAW) and disease and drought resistant plasma activated seeds (PAS), respectively, are produced, which improve germination rate and efficiency, and eliminate the need for ammonia-based chemical fertilizers.

Abstract: An illumination device and method is provided herein for controlling an LED illumination device, so that a desired luminous flux and a desired chromaticity of the device can be maintained over time as the LEDs age. According to one embodiment, the method determines an expected wavelength value and an expected intensity value for each emission LED included within the illumination device at the drive current currently applied to the emission LED and the present emitter forward voltage. In addition, the method determines a photodetector responsivity for each emission LED at the expected wavelength value and the present photodetector forward voltage. The photodetector responsivity calculated for each emission LED is used as a reference for adjusting the lumen output of the emission LED to account for LED aging affects.