Patents by Inventor Eckhard Gunther

Eckhard Gunther has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTHRACENE COMPOUNDS AND THEIR USE FOR TREATING BENIGN AND MALIGNANT TUMOR DISORDERS
    Publication number: 20080051463
    Abstract: The present invention provides novel anthracene compounds according to the formulae (I) and (II) and also selected anthracene compound compounds. The present invention furthermore provides a process for preparing such anthracene compounds. Also provided are pharmaceutical formulations comprising these anthracene compounds. The anthracene compounds provided are particularly suitable for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions which can be treated by inhibiting tubulin polymerization and/or by inhibiting microtubuli-based motor proteins, in particular various tumor disorders.
    Type: Application
    Filed: August 3, 2007
    Publication date: February 28, 2008
    Applicant: AETERNA ZENTARIS GmbH
    Inventors: Matthias Gerlach, Eckhard Gunther, Peter Schmidt, Helge Prinz, Konrad Bohm, Eberhard Unger
  • Indolyl-3-glyoxylic acid derivatives having antitumor action
    Publication number: 20080027110
    Abstract: The invention relates to the use of N-substituted indole-3-glyoxylamides of the general formula I as antitumor agents and to a pharmaceutical composition having antitumor action, characterized in that it contains at least one of the compounds of the general formula 1, if appropriate also in the form of the physiologically tolerable acid addition salts or N-oxides. Furthermore, the invention also includes antitumor agents comprising as active compound one or more N-substituted indole-3-glyoxylamides according to the general formula 1 and, if appropriate, their physiologically tolerable acid addition salts and, if possible, N-oxides and a pharmaceutically utilizable carrier and/or diluent or auxiliary substance in the form of tablets, coated tablets, capsules, solutions for infusion or ampoules, suppositories, patches, powder preparations which can be employed by inhalation, suspensions, creams and ointments.
    Type: Application
    Filed: August 20, 2007
    Publication date: January 31, 2008
    Inventors: Bernd Nickel, Istvan Szelenyi, Jurgen Schmidt, Peter Emig, Dietmar Reichert, Eckhard Gunther, Kay Brune, Guillaume Le Baut
  • Pyridopyrazines and the use thereof as kinase inhibitors
    Patent number: 7323468
    Abstract: The invention relates to novel pyrido[2,3-b]pyrazine derivatives of the general Formula I, their preparation and use as medicaments, in particular for the treatment of malignant and other disorders based on pathological cell proliferations.
    Type: Grant
    Filed: May 21, 2004
    Date of Patent: January 29, 2008
    Assignee: AEterna Zentaris GmbH
    Inventors: Eckhard Claus, Eckhard Günther, Irene Seipelt, Ulf R. Rapp, Ludmilla Wixler
  • Pyridopyrazines and the use thereof as kinase inhibitors
    Publication number: 20070275972
    Abstract: The invention relates to novel pyrido[2,3-b]pyrazine derivatives of the general Formula I, their preparation and use as medicaments, in particular for the treatment of malignant and other disorders based on pathological cell proliferations.
    Type: Application
    Filed: July 5, 2007
    Publication date: November 29, 2007
    Inventors: Eckhard Claus, Eckhard Gunther, Irene Speipelt, Ulf Rapp, Ludmilla Wixler
  • Pyridopyrazines and the use thereof as kinase inhibitors
    Patent number: 7276507
    Abstract: The invention relates to novel pyrido[2,3-b]pyrazine derivatives of the general Formula I, their preparation and use as medicaments, in particular for the treatment of malignant and other disorders based on pathological cell proliferations
    Type: Grant
    Filed: May 21, 2004
    Date of Patent: October 2, 2007
    Assignee: AEterna Zentaris GmbH
    Inventors: Eckhard Claus, Eckhard Günther, Irene Seipelt, Ulf R. Rapp, Ludmilla Wixler
  • N-substituted indolyl-3-glyoxylamides, their use as medicaments and process for their preparation
    Patent number: 7211588
    Abstract: The invention relates to novel N-substituted indolyl-3-glyoxylamides of the general formula I, their preparation and use as medicaments, in particular for the treatment of tumors
    Type: Grant
    Filed: July 15, 2004
    Date of Patent: May 1, 2007
    Assignee: Zentaris GmbH
    Inventors: Matthias Gerlach, Tilmann Schuster, Peter Schmidt, Silke Baasner, Eckhard Günther
  • Indole derivatives having an apoptosis-inducing effect
    Patent number: 7205299
    Abstract: The invention relates to indole derivatives which are used as drugs for treating tumor diseases, in particular when there is drug resistance against other active compounds and where there is a metastasizing carcinoma.
    Type: Grant
    Filed: June 2, 2004
    Date of Patent: April 17, 2007
    Assignee: Zentaris GmbH
    Inventors: Matthias Gerlach, Tilmann Schuster, Peter Ernig, Peter Schmidt, Silke Baasner, Eckhard Günther
  • METHODS OF TREATMENT USING NOVEL LHRH ANTAGONISTS HAVING IMPROVED SOLUBILITY PROPERTIES
    Publication number: 20060281685
    Abstract: The invention relates to peptides which contain N-methylated amino acid units and have improved water solubility. The invention also relates methods for treating a hormone-dependent tumor or a non-malignant indication that is treatable by LH-RH suppression, the method comprising administering to a patient in need of the treatment a therapeutically effective amount of a compound of the invention. Hormone-dependent cancers that can be treated with the methods of the invention include prostate cancer, breast cancer, ovarian cancer, endometrial cancer, and pancreatic cancer. Non-malignant indications which can be treated by the methods of the invention include benign prostate hyperplasia (BPH), endometriosis, acne, polycystic ovarian disease, dysmenorrhea, precocious puberty, and uterine fibroids and other leiomyomas.
    Type: Application
    Filed: July 24, 2006
    Publication date: December 14, 2006
    Inventors: Michael Bernd, Bernhard Kutscher, Eckhard Gunther, Peter Romeis, Thomas Reissmann, Thomas Beckers
  • LHRH antagonists having improved solubility properties
    Patent number: 7148195
    Abstract: The invention relates to peptides which contain N-methylated amino acid units and have improved water solubility. Medicaments in which the peptides according to the invention are contained can be used for the treatment of hormone-dependent tumors and hormone-influenced non-malignant disorders.
    Type: Grant
    Filed: September 29, 2003
    Date of Patent: December 12, 2006
    Assignee: Zentaris GmbH
    Inventors: Michael Bernd, Bernhard Kutscher, Eckhard Gunther, Peter Romeis, Thomas Reissmann, Thomas Beckers
  • Heteroaryl derivatives and their use as medicaments
    Patent number: 7056912
    Abstract: The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
    Type: Grant
    Filed: November 14, 2003
    Date of Patent: June 6, 2006
    Assignee: Zentaris GmbH
    Inventors: Peter Emig, Eckhard Günther, Jürgen Schmidt, Bernd Nickel, Bernhard Kutscher
  • Heteroaryl derivatives and their use as medicaments
    Patent number: 7026310
    Abstract: The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
    Type: Grant
    Filed: April 14, 2005
    Date of Patent: April 11, 2006
    Assignee: Zentaris GmbH
    Inventors: Peter Emig, Eckhard Günther, Jürgen Schmidt, Bernd Nickel, Bernhard Kutscher
  • Novel tetrahydrocarbazole derivatives having improved biological action and improved solubility as ligands of G-protein coupled receptors (GPCRs)
    Publication number: 20060014818
    Abstract: The present invention provides novel tetrahydrocarbazole derivatives which have improved properties and which can be employed as inhibitors of GPCRs. This results in the possibility of using the novel compounds to treat pathological conditions whose severity depends on the pathobiochemical effect of GPCRs. The compounds of the invention act in particular via an antagonistic inhibition of the LHRH receptor. The invention further provides medicaments which comprise one or more of the novel compounds as active ingredient. The medicaments are suitable in particular to be employed in an oral dosage form for a mammal, in particular a human.
    Type: Application
    Filed: June 30, 2005
    Publication date: January 19, 2006
    Inventors: Klaus Paulini, Matthias Gerlach, Eckhard Günther, Emmanuel Polymeropoulos, Silke Baasner, Peter Schmidt, Ronald Kühne, Arvid Soderhall
  • Heteroaryl derivatives and their use as medicaments
    Publication number: 20050245523
    Abstract: The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
    Type: Application
    Filed: June 14, 2005
    Publication date: November 3, 2005
    Inventors: Peter Emig, Eckhard Gunther, Jurgen Schmidt, Bernd Nickel, Bernhard Kutscher
  • Heteroaryl derivatives and their use as medicaments
    Patent number: 6936615
    Abstract: The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: August 30, 2005
    Assignee: Zentaris GmbH
    Inventors: Peter Emig, Eckhard Günther, Jürgen Schmidt, Bernd Nickel, Bernhard Kutscher
  • Novel heteroaryl derivatives and their use as medicaments
    Publication number: 20050176744
    Abstract: The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
    Type: Application
    Filed: April 14, 2005
    Publication date: August 11, 2005
    Inventors: Peter Emig, Eckhard Gunther, Jurgen Schmidt, Bernd Nickel, Bernhard Kutscher
  • Heteroaryl derivatives and their use as medicaments
    Patent number: 6890926
    Abstract: The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: May 10, 2005
    Assignee: Zentaris AG
    Inventors: Peter Emig, Eckhard Günther, Jürgen Schmidt, Bernd Nickel, Bernhard Kutscher
  • Pyridopyrazines and the use thereof as kinase inhibitors
    Publication number: 20050032803
    Abstract: The invention relates to novel pyrido[2,3-b]pyrazine derivatives of the general Formula I, their preparation and use as medicaments, in particular for the treatment of malignant and other disorders based on pathological cell proliferations.
    Type: Application
    Filed: May 21, 2004
    Publication date: February 10, 2005
    Inventors: Eckhard Claus, Eckhard Gunther, Irene Seipelt, Ulf Rapp, Ludmilla Wixler
  • N-substituted indolyl-3-glyoxylamides, their use as medicaments and process for their preparation
    Publication number: 20050020636
    Abstract: The invention relates to novel N-substituted indolyl-3-glyoxylamides of the general formula I, their preparation and use as medicaments, in particular for the treatment of tumors.
    Type: Application
    Filed: July 15, 2004
    Publication date: January 27, 2005
    Inventors: Matthias Gerlach, Tilmann Schuster, Peter Schmidt, Silke Baasner, Eckhard Gunther
  • Acridine derivatives and their use as medicaments
    Publication number: 20050009809
    Abstract: The invention relates to novel acridine derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for the treatment of tumors.
    Type: Application
    Filed: June 29, 2004
    Publication date: January 13, 2005
    Inventors: Matthias Gerlach, Peter Emig, Klaus Paulini, Michael Czech, Tilman Schuster, Eckhard Gunther
  • Novel LHRH antagonists having improved solubility properties
    Publication number: 20040266695
    Abstract: The invention relates to peptides which contain N-methylated amino acid units and have improved water solubility. Medicaments in which the peptides according to the invention are contained can be used for the treatment of hormone-dependent tumours and hormone-influenced non-malignant disorders.
    Type: Application
    Filed: September 29, 2003
    Publication date: December 30, 2004
    Inventors: Michael Bernd, Bernhard Kutscher, Eckhard Gunther, Peter Romeis, Thomas Reissmann, Thomas Beckers