Patents by Inventor Eduard V. Denisov
Eduard V. Denisov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220293409Abstract: The present invention provides an electrode arrangement 10, 10? for an ion trap, ion filter, an ion guide, a reaction cell or an ion analyser. The electrode arrangement 10, 10? comprises an RF electrode 12a, 12b, 12a?, 12b? mechanically coupled to a dielectric material 11. The RF electrode 12a, 12b, 12a?, 12b? is mechanically coupled to the dielectric material 11 by a plurality of separators 13 that are spaced apart and configured to define a gap between the RF electrode 12a, 12b, 12a?, 12b? and the dielectric material 11. Each of the plurality of separators 13 comprises a projecting portion 13b and the dielectric material 11 comprises corresponding receiving portions 11a such that on coupling of the RF electrode 12a, 12b, 12a?, 12b? to the dielectric material 11, the projecting portion 13b of each separator 13 is received within the corresponding receiving portion 11a of the dielectric material 11.Type: ApplicationFiled: June 2, 2022Publication date: September 15, 2022Inventors: Alexander A. Makarov, Wilko Balschun, Jan-Peter Hauschild, Denis Chernyshev, Eduard V. Denisov
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Patent number: 11387093Abstract: The present invention provides an electrode arrangement 10, 10? for an ion trap, ion filter, an ion guide, a reaction cell or an ion analyser. The electrode arrangement 10, 10? comprises an RF electrode 12a, 12b, 12a?, 12b? mechanically coupled to a dielectric material 11. The RF electrode 12a, 12b, 12a?, 12b? is mechanically coupled to the dielectric material 11 by a plurality of separators 13 that are spaced apart and configured to define a gap between the RF electrode 12a, 12b, 12a?, 12b? and the dielectric material 11. Each of the plurality of separators 13 comprises a projecting portion 13b and the dielectric material 11 comprises corresponding receiving portions 11a such that on coupling of the RF electrode 12a, 12b, 12a?, 12b? to the dielectric material 11, the projecting portion 13b of each separator 13 is received within the corresponding receiving portion 11a of the dielectric material 11.Type: GrantFiled: May 18, 2020Date of Patent: July 12, 2022Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander A. Makarov, Wilko Balschun, Jan-Peter Hauschild, Denis Chernyshev, Eduard V. Denisov
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Publication number: 20200388480Abstract: The present invention provides a mass spectrometer comprising a first ion trap, a second ion trap, a lens stack for directing ions from the first ion trap to the second ion trap and a housing. The first ion trap is arranged to form a linear or curved potential well and the second ion trap is an electrostatic ion trap, for example, an orbital ion trap, arranged to form an annular potential well. The mass spectrometer further comprises a unitary insert comprising a first cavity which holds the lens stack and a second cavity which holds the second ion trap, wherein the insert is inserted within the housing.Type: ApplicationFiled: May 20, 2020Publication date: December 10, 2020Inventors: Alexander A. Makarov, Wilko Balschun, Jan-Peter Hauschild, Aivaras Venckus, Denis Chernyshev, Eduard V. Denisov
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Publication number: 20200373138Abstract: The present invention provides an electrode arrangement 10, 10? for an ion trap, ion filter, an ion guide, a reaction cell or an ion analyser. The electrode arrangement 10, 10? comprises an RF electrode 12a, 12b, 12a?, 12b? mechanically coupled to a dielectric material 11 . The RF electrode 12a, 12b, 12a?, 12b? is mechanically coupled to the dielectric material 11 by a plurality of separators 13 that are spaced apart and configured to define a gap between the RF electrode 12a, 12b, 12a?, 12b? and the dielectric material 11. Each of the plurality of separators 13 comprises a projecting portion 13b and the dielectric material 11 comprises corresponding receiving portions 11a such that on coupling of the RF electrode 12a, 12b, 12a?, 12b? to the dielectric material 11, the projecting portion 13b of each separator 13 is received within the corresponding receiving portion 11a of the dielectric material 11.Type: ApplicationFiled: May 18, 2020Publication date: November 26, 2020Inventors: Alexander A. Makarov, Wilko Balschun, Jan-Peter Hauschild, Denis Chernyshev, Eduard V. Denisov
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Patent number: 10748755Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U?(r, ?, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U?(r, ?, z) is the result of a perturbation W to an ideal field U(r, ?, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, ?, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2? radians over an ion detection period Tm.Type: GrantFiled: January 30, 2019Date of Patent: August 18, 2020Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander A. Makarov, Eduard V. Denisov, Gerhard Jung, Wilko Balschun, Stevan R. Horning
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Publication number: 20190164740Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U?(r, ?, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U?(r, ?, z) is the result of a perturbation W to an ideal field U(r, ?, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, ?, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2? radians over an ion detection period Tm.Type: ApplicationFiled: January 30, 2019Publication date: May 30, 2019Inventors: Alexander A. MAKAROV, Eduard V. DENISOV, Gerhard JUNG, Wilko BALSCHUN, Stevan R. HORNING
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Patent number: 10242860Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U?(r, ?, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U?(r, ?, z) is the result of a perturbation W to an ideal field U(r, ?, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, ?, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 ? radians over an ion detection period Tm.Type: GrantFiled: January 4, 2017Date of Patent: March 26, 2019Assignee: Thermo Fisher Scientifc (Bremen) GmbHInventors: Alexander A. Makarov, Eduard V. Denisov, Gerhard Jung, Wilko Balschun, Stevan R. Horning
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Publication number: 20170117130Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U?(r, ?, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U?(r, ?, z) is the result of a perturbation W to an ideal field U(r, ?, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, ?, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 ? radians over an ion detection period Tm.Type: ApplicationFiled: January 4, 2017Publication date: April 27, 2017Inventors: Alexander A. MAKAROV, Eduard V. DENISOV, Gerhard JUNG, Wilko BALSCHUN, Stevan R. HORNING
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Patent number: 9570283Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U?(r, ?, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U?(r, ?, z) is the result of a perturbation W to an ideal field U(r, ?, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, ?, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 ? radians over an ion detection period Tm.Type: GrantFiled: August 21, 2015Date of Patent: February 14, 2017Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander A. Makarov, Eduard V. Denisov, Gerhard Jung, Wilko Balschun, Stevan R. Horning
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Patent number: 9472385Abstract: The present invention provides a radio frequency (RF) power supply in a mass spectrometer. The power supply provides an RF signal to electrodes of a storage device to create a trapping field. The RF field is usually collapsed prior to ion ejection. In an illustrative embodiment the RF power supply includes a RF signal supply; a coil arranged to receive the signal provided by the RF signal supply and to provide an output RF signal for supply to electrodes of an ion storage device; and a shunt including a switch operative to switch between a first open position and a second closed position in which the shunt shorts the coil output.Type: GrantFiled: April 2, 2015Date of Patent: October 18, 2016Assignee: Thermo Finnigan LLCInventors: Alexander A. Makarov, Eduard V. Denisov, Alexander Kholomeev
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Patent number: 9396919Abstract: A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.Type: GrantFiled: January 25, 2016Date of Patent: July 19, 2016Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander Makarov, Eduard V. Denisov, Wilko Balschun, Dirk Nolting, Jens Griep-Raming
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Publication number: 20160141167Abstract: A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.Type: ApplicationFiled: January 25, 2016Publication date: May 19, 2016Inventors: Alexander MAKAROV, Eduard V. DENISOV, Wilko BALSCHUN, Dirk NOLTING, Jens GRIEP-RAMING
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Patent number: 9245723Abstract: A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.Type: GrantFiled: August 24, 2015Date of Patent: January 26, 2016Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander Makarov, Eduard V. Denisov, Wilko Balschun, Dirk Nolting, Jens Griep-Raming
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Publication number: 20150364316Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U?(r, ?, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U?(r, ?, z) is the result of a perturbation W to an ideal field U(r, ?, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, ?, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 ? radians over an ion detection period Tm.Type: ApplicationFiled: August 21, 2015Publication date: December 17, 2015Inventors: Alexander A. MAKAROV, Eduard V. DENISOV, Gerhard JUNG, Wilko BALSCHUN, Stevan R. HORNING
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Publication number: 20150364308Abstract: A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.Type: ApplicationFiled: August 24, 2015Publication date: December 17, 2015Inventors: Alexander MAKAROV, Eduard V. DENISOV, Wilko BALSCHUN, Dirk NOLTING, Jens GRIEP-RAMING
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Patent number: 9117647Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U?(r, ?, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U?(r, ?, z) is the result of a perturbation W to an ideal field U(r, ?, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, ?, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 ? radians over an ion detection period Tm.Type: GrantFiled: January 13, 2015Date of Patent: August 25, 2015Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander A. Makarov, Eduard V. Denisov, Gerhard Jung, Wilko Balschun, Stevan R. Horning
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Patent number: 9117639Abstract: A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.Type: GrantFiled: February 18, 2015Date of Patent: August 25, 2015Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander Makarov, Eduard V. Denisov, Wilko Balschun, Dirk Nolting, Jens Griep-Raming
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Publication number: 20150214019Abstract: The present invention provides a radio frequency (RF) power supply in a mass spectrometer. The power supply provides an RF signal to electrodes of a storage device to create a trapping field. The RF field is usually collapsed prior to ion ejection. In an illustrative embodiment the RF power supply includes a RF signal supply; a coil arranged to receive the signal provided by the RF signal supply and to provide an output RF signal for supply to electrodes of an ion storage device; and a shunt including a switch operative to switch between a first open position and a second closed position in which the shunt shorts the coil output.Type: ApplicationFiled: April 2, 2015Publication date: July 30, 2015Inventors: Alexander A. MAKAROV, Eduard V. DENISOV, Alexander KHOLOMEEV
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Publication number: 20150170894Abstract: A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.Type: ApplicationFiled: February 18, 2015Publication date: June 18, 2015Inventors: Alexander MAKAROV, Eduard V. DENISOV, Wilko BALSCHUN, Dirk NOLTING, Jens GRIEP-RAMING
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Publication number: 20150122989Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U?(r, ?, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U?(r, ?, z) is the result of a perturbation W to an ideal field U(r, ?, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, ?, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 ? radians over an ion detection period Tm.Type: ApplicationFiled: January 13, 2015Publication date: May 7, 2015Inventors: Alexander A. MAKAROV, Eduard V. DENISOV, Gerhard JUNG, Wilko BALSCHUN, Stevan R. HORNING