Patents by Inventor Eduard V. Denisov
Eduard V. Denisov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9000363Abstract: The present invention provides a radio frequency (RF) power supply in a mass spectrometer. The power supply provides an RF signal to electrodes of a storage device to create a trapping field. The RF field is usually collapsed prior to ion ejection. In an illustrative embodiment the RF power supply includes a RF signal supply; a coil arranged to receive the signal provided by the RF signal supply and to provide an output RF signal for supply to electrodes of an ion storage device; and a shunt including a switch operative to switch between a first open position and a second closed position in which the shunt shorts the coil output.Type: GrantFiled: November 7, 2013Date of Patent: April 7, 2015Assignee: Thermo Finnigan LLCInventors: Alexander A. Makarov, Eduard V. Denisov, Alexander Kholomeev
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Patent number: 8963074Abstract: A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.Type: GrantFiled: August 11, 2014Date of Patent: February 24, 2015Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander Makarov, Eduard V. Denisov, Wilko Balschun, Dirk Nolting, Jens Griep-Raming
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Publication number: 20140346343Abstract: A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.Type: ApplicationFiled: August 11, 2014Publication date: November 27, 2014Inventors: Alexander MAKAROV, Eduard V. DENISOV, Wilko BALSCHUN, Dirk NOLTING, Jens GRIEP-RAMING
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Patent number: 8841604Abstract: A mass analyzer comprises: an electrical field generator, providing a time-varying electric field for injection of ions to be analyzed, excitation of ions to be analyzed or both; first and second detection electrodes, each of which receives a respective voltage pickup due to the time-varying electric field and provides a respective detection signal based on a respective image current at the detection electrode; and a differential amplifier, providing an output based on the difference between the detection signal for the first detection electrode and the detection signal for the second detection electrode. It may also be provided that the electrical field generator comprises at least one field generating electrode without a spatially symmetrical counterpart and the capacitance between each field generating electrode and the first detection electrode is substantially the same as the capacitance between that field generating electrode and the second detection electrode.Type: GrantFiled: May 14, 2012Date of Patent: September 23, 2014Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Eduard V. Denisov, Alexander Kholomeev, Jan-Peter Hauschild, Alexander A. Makarov
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Publication number: 20140239197Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U?(r, ?, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U?(r, ?, z) is the result of a perturbation W to an ideal field U(r, ?, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, ?, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2? radians over an ion detection period Tm.Type: ApplicationFiled: May 5, 2014Publication date: August 28, 2014Applicant: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander A. MAKAROV, Eduard V. DENISOV, Gerhard JUNG, Wilko BALSCHUN, Stevan R. HORNING
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Patent number: 8803082Abstract: A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.Type: GrantFiled: November 15, 2013Date of Patent: August 12, 2014Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander Makarov, Eduard V. Denisov, Wilko Balschun, Dirk Nolting, Jens Griep-Raming
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Patent number: 8791409Abstract: A method for mass analyzing multiply-charged ions is provided as well as a mass analyzer suitable for performing the method, the method comprising: introducing multiply-charged ions into an electrostatic mass analyzer where ions undergo multiple changes of direction of motion; detecting the ions in the analyzer; and determining the mass-to-charge ratio of at least some of the detected ions; wherein the absolute velocity in the analyzer of at least some of the ions whose mass-to-charge ratio is determined is not greater than 8,000 m/s and the average path length over the duration of detection of such ions is longer than required for detecting such ions with a mass-to-charge ratio resolving power of 1,000. High resolution mass spectra of high m/z protein complexes, for example in a native state and with low charge, can be achieved.Type: GrantFiled: July 27, 2012Date of Patent: July 29, 2014Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander Alekseevich Makarov, Eduard V. Denisov, Nicolaie Eugen Damoc
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Publication number: 20140191122Abstract: A mass analyser comprises: an electrical field generator, providing a time-varying electric field for injection of ions to be analysed, excitation of ions to be analysed or both; first and second detection electrodes, each of which receives a respective voltage pickup due to the time-varying electric field and provides a respective detection signal based on a respective image current at the detection electrode; and a differential amplifier, providing an output based on the difference between the detection signal for the first detection electrode and the detection signal for the second detection electrode. It may also be provided that the electrical field generator comprises at least one field generating electrode without a spatially symmetrical counterpart and the capacitance between each field generating electrode and the first detection electrode is substantially the same as the capacitance between that field generating electrode and the second detection electrode.Type: ApplicationFiled: May 14, 2012Publication date: July 10, 2014Applicant: THERMO FISHER SCIENTIFIC (BREMEN) GMBHInventors: Eduard V. Denisov, Alexander Kholomeev, Jan-Peter Hauschild, Alexander A. Makarov
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Publication number: 20140138532Abstract: The present invention provides a radio frequency (RF) power supply in a mass spectrometer. The power supply provides an RF signal to electrodes of a storage device to create a trapping field. The RF field is usually collapsed prior to ion ejection. In an illustrative embodiment the RF power supply includes a RF signal supply; a coil arranged to receive the signal provided by the RF signal supply and to provide an output RF signal for supply to electrodes of an ion storage device; and a shunt including a switch operative to switch between a first open position and a second closed position in which the shunt shorts the coil output.Type: ApplicationFiled: November 7, 2013Publication date: May 22, 2014Applicant: Thermo Finnigan LLCInventors: Alexander A. MAKAROV, Eduard V. DENISOV, Alexander KHOLOMEEV
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Patent number: 8716654Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U? (r, ?, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U?(r, ?, z) is the result of a perturbation W to an ideal field U(r, ?, z) which, for example, is hypologarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, ?, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 ? radians over an ion detection period Tm.Type: GrantFiled: January 9, 2013Date of Patent: May 6, 2014Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander A. Makarov, Eduard V. Denisov, Gerhard Jung, Wilko Balschun, Stevan R. Horning
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Publication number: 20140070091Abstract: A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.Type: ApplicationFiled: November 15, 2013Publication date: March 13, 2014Applicant: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander MAKAROV, Eduard V. DENISOV, Wilko BALSCHUN, Dirk NOLTING, Jens GRIEP-RAMING
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Patent number: 8642948Abstract: A method of changing the kinetic energy of ions is provided, comprising: trapping ions in a trapping region of an ion trap; and directing a beam of gas through the trapping region, so as to change the kinetic energy of the trapped ions thereby. Also provided is a method of separating ions, the method comprising: causing ions to enter a trapping region of an ion trap along a first axis of the trapping region; directing a beam of gas along the first axis and applying an electric potential in the direction of the first axis so as to cause separation of the ions based on their ion mobility. An ion trap and a mass spectrometer for performing the methods are also provided.Type: GrantFiled: September 11, 2009Date of Patent: February 4, 2014Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander A. Makarov, Eduard V. Denisov
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Publication number: 20140027629Abstract: A method for mass analysing multiply-charged ions is provided as well as a mass analyser suitable for performing the method, the method comprising: introducing multiply-charged ions into an electrostatic mass analyser where ions undergo multiple changes of direction of motion; detecting the ions in the analyser; and determining the mass-to-charge ratio of at least some of the detected ions; wherein the absolute velocity in the analyser of at least some of the ions whose mass-to-charge ratio is determined is not greater than 8,000 m/s and the average path length over the duration of detection of such ions is longer than required for detecting such ions with a mass-to-charge ratio resolving power of 1,000. High resolution mass spectra of high m/z protein complexes, for example in a native state and with low charge, can be achieved.Type: ApplicationFiled: July 27, 2012Publication date: January 30, 2014Inventors: Alexander Alekseevich MAKAROV, Eduard V. DENISOV, Nicolaie Eugen DAMOC
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Patent number: 8586914Abstract: A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.Type: GrantFiled: September 14, 2012Date of Patent: November 19, 2013Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander A. Makarov, Eduard V. Denisov, Wilko Balschun, Dirk Nolting, Jens Griep-Raming
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Patent number: 8581185Abstract: The present invention provides a radio frequency (RF) power supply in a mass spectrometer. The power supply provides an RF signal to electrodes of a storage device to create a trapping field. The RF field is usually collapsed prior to ion ejection. In an illustrative embodiment the RF power supply includes a RF signal supply; a coil arranged to receive the signal provided by the RF signal supply and to provide an output RF signal for supply to electrodes of an ion storage device; and a shunt including a switch operative to switch between a first open position and a second closed position in which the shunt shorts the coil output.Type: GrantFiled: September 6, 2011Date of Patent: November 12, 2013Assignee: Thermo Finnigan LLCInventors: Alexander A. Makarov, Eduard V. Denisov, Alexander Kholomeev
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Publication number: 20130126724Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U? (r, ?, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U?(r, ?, z) is the result of a perturbation W to an ideal field U(r, ?, z) which, for example, is hypologarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, ?, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 n radians over an ion detection period Tm.Type: ApplicationFiled: January 9, 2013Publication date: May 23, 2013Inventors: Alexander A. MAKAROV, Eduard V. DENISOV, Gerhard JUNG, Wilko BALSCHUN, Stevan R. HORNING
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Publication number: 20130020481Abstract: A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.Type: ApplicationFiled: September 14, 2012Publication date: January 24, 2013Inventors: Alexander A. MAKAROV, Eduard V. DENISOV, Wilko BALSCHUN, Dirk NOLTING, Jens GRIEP-RAMING
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Patent number: 8288714Abstract: This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.Type: GrantFiled: November 11, 2010Date of Patent: October 16, 2012Assignee: Thermo Finnigan LLCInventors: Alexander A. Makarov, Eduard V. Denisov, Gerhard Jung, Robert Malek, Oliver Lange
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Publication number: 20120248308Abstract: An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U?(r, ?, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U?(r, ?, z) is the result of a perturbation W to an ideal field U(r, ?, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, ?, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 ? radians over an ion detection period Tm.Type: ApplicationFiled: May 17, 2012Publication date: October 4, 2012Inventors: Alexander Makarov, Eduard V. Denisov, Gerhard Jung, Wilko Balschun, Steven Roy Horning
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Patent number: 8278618Abstract: A method of operating a gas-filled collision cell in a mass spectrometer is provided. The collision cell has a longitudinal axis. Ions are caused to enter the collision cell. A trapping field is generated within the collision cell so as to trap the ions within a trapping volume of the collision cell, the trapping volume being defined by the trapping field and extending along the longitudinal axis. Trapped ions are processed in the collision cell and a DC potential gradient is provided, using an electrode arrangement, resulting in a non-zero electric field at all points along the axial length of the trapping volume so as to cause processed ions to exit the collision cell. The electric field along the axial length of the trapping volume has a standard deviation that is no greater than its mean value.Type: GrantFiled: June 3, 2009Date of Patent: October 2, 2012Assignee: Thermo Fisher Scientific (Bremen) GmbHInventors: Alexander A. Makarov, Eduard V. Denisov, Wilko Balschun, Dirk Nolting, Jens Griep-Raming