Abstract: A system that enables safe cardiac pulsed field ablation by using multiple types of sensors on a patch to detect and cross-check that the heartbeat is in a safe phase to receive an ablation pulse. The patch may contain for example any or all of ECG electrodes, PPG sensors, accelerometers, and microphones. The patch may also contain one or more pulse return electrodes for unipolar ablation. A signal analyzer coupled to a pulse generator may receive sensor data from the patch and may analyze this data to determine the heartbeat phase. If data from different sensors are inconsistent, then pulse generation may be disabled as a safety feature. Otherwise, pulses may be enabled when the heartbeat is in a safe phase; for example, pulses may be excluded during the T wave.

Abstract: The present invention relates to an anti-tipping valve for a pourer of containers which comprises means preventing the tipping or manipulation of the position of the valve, the valve is preferably coupled to the mouth of a container. The present invention is characterized by a valve for a pourer comprising two cavities connected with one another and a valve core arranged in both cavities, such that in a closed position of the valve, the valve core is arranged such that it ensures the sealing between both cavities, and in an open position of the valve, the valve core moves inside the valve to thereby ensure a fluid communication between both cavities.

Abstract: An oral care implement that includes a handle and an oral care refill head. The oral care refill head is alterable between a first state in which it is separated from the handle and a second state in which it is coupled to the handle. The oral care refill head has a proximal edge surface that defines an opening into a sleeve cavity. The proximal edge surface may be inclined in one direction only as it extends from an inner edge surface to an outer edge surface. The handle may have a gripping portion and a stem, with a distal end of the gripping portion forming an annular shoulder surface that surrounds the stem. The annular shoulder surface may be inclined in one direction only as it extends from an inner shoulder edge adjacent to the stem to an outer shoulder edge adjacent to an outer surface of the handle.

Abstract: A computer-implemented method includes receiving an image of an article of interest to be evaluated relative to one or more features of interest, identifying a reference feature of a known size in the received image, identifying two or more extremities of the reference feature in the received image and a number of pixels between the two or more extremities of the reference feature, calculating a pixel size for the selected image based on the reference feature size and the number of pixels between the two or more extremities of the reference feature, annotating the received image to include one or more tolerance lines for the one or more features of interest, and determining whether the one or more features of interest in the image comply with the one or more tolerance lines. A computer program product and computer system corresponding to the method are also disclosed.

Abstract: The present invention relates to a cap-type closure for containers comprising means for showing evidence of a first opening, the closure preferably being coupled to the mouth of a container. The present invention is characterized by a closure comprising an inner cap and an outer cap interconnected to one another so as to allow a spacing to be set between the two once the first opening of the closure takes place.

Abstract: An oral care implement that includes a handle and an oral care refill head. The oral care refill head is alterable between a first state in which it is separated from the handle and a second state in which it is coupled to the handle. The oral care refill head has a proximal edge surface that defines an opening into a sleeve cavity. The proximal edge surface is inclined with radial distance from a cavity axis of the sleeve cavity. Similarly, the handle has a gripping portion that terminates at a distal end and a stem that protrudes from the distal end. The annular shoulder that is inclined downwardly and away from a stem to facilitate mating of the oral care refill head to the handle. The oral care refill head may have features for securing the oral care refill head to the stem of the handle.

Abstract: A catheter having a distal assembly with multiple spines with proximal ends affixed to the catheter and free distal ends. The spines have different lengths so distal ends of the spines trace different circumferences along an inner tissue surface of a tubular region to minimize risk of vein stenosis. The spine lengths can be configured so that the distal ends trace a helical pattern. The distal assembly may have a plunger which deflects the spines when moved longitudinally relative to the distal assembly. The catheter may include a second distal assembly distal of a first distal assembly wherein the first and second distal assemblies are separated by a fixed distanced or an adjustable distance.

Abstract: A catheter having a distal assembly with multiple spines with proximal ends affixed to the catheter and free distal ends. The spines have different lengths so distal ends of the spines trace different circumferences along an inner tissue surface of a tubular region to minimize risk of vein stenosis. The spine lengths can be configured so that the distal ends trace a helical pattern. The distal assembly may have a plunger which deflects the spines when moved longitudinally relative to the distal assembly. The catheter may include a second distal assembly distal of a first distal assembly wherein the first and second distal assemblies are separated by a fixed distanced or an adjustable distance.

Abstract: A personal care implement having a handle which includes a first rigid portion, a second rigid portion, and an elastomeric portion located therebetween. The first and second rigid portions may have end portion with first and second tabs. The elastomeric portion has a front surface, a rear surface, and a peripheral surface that extends between the front and rear surfaces. A first groove may be formed between the first tab of the first rigid portion and the first tab of the second rigid portion. A second groove may be formed between the second tab of the first rigid portion and the second tab of the second rigid portion. A first portion of the peripheral surface of the elastomeric portion may form a floor of the first groove and a second portion of the peripheral surface of the elastomeric portion may form a floor of the second groove.

Abstract: An oral care implement (1000) that includes a handle (100) and an oral care refill head (200). The oral care refill head (200) is alterable between a first state in which it is separated from the handle (100) and a second state in which it is coupled to the handle (100) by inserting a stem (120) of the handle (100) inside of a cavity (221) of the oral care refill head (200). The oral care refill head (200) has at least one alignment groove (250, 260) that receives at least one alignment rib of the stem (120) of the handle (100). Furthermore, the stem (120) and the oral care refill head (200) include snap lock features that form a snap-fit interlock to secure the oral care refill head (200) to the handle (100).

Abstract: The present invention relates to a cap for covering an opening of a container, preferably the opening of a bottle. The present invention is characterized by a cork body having a cylindrical configuration and configured in two portions between which there is arranged an impermeable sheet element according to the longitudinal direction. The presence of an impermeable sheet allows using a conventional closure material preventing permeability in the longitudinal direction both to prevent the liquid from coming out of the container and to prevent bacteria or contaminants from the outside from entering.

Abstract: A personal care implement that uses less plastic by removing material from a handle of the oral care implement while maintaining a comfortable grip which is similar to a normal grip that a user associates with a personal care implement. That is, the handle has a recess in a rear surface thereof, such that the handle or a portion thereof has a U-shaped transverse cross-sectional area. Portions of the handle may be covered with an elastomeric material to increase gripability and comfort. The handle may also include various rib structures elongated along the recess to increase the strength of the handle so that it does not significantly deform during normal use.