Abstract: The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more inorganic ion receptor activities, preferably the molecule can mimic or block an effect of an extracellular ion on a cell having an inorganic ion receptor, more preferably the extracellular ion is Ca2+ and the effect is on a cell having a calcium receptor; (2) inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (3) nucleic acids encoding inorganic ion receptor proteins and fragments thereof, preferably calcium receptor proteins and fragments thereof; (4) antibodies and fragments thereof, targeted to inorganic ion receptor proteins, preferably calcium receptor protein; and (5) uses of such molecules, proteins, nucleic acids and antibodies.

Abstract: Novel methods of treating bone diseases or disorders are provided.

Abstract: A wire insertion guide may be used with a wide variety of closed barrel electrical contacts. The wire insertion guide includes a housing, a movable funnel located within the housing, a fixed funnel nested within the movable funnel, and a contact holder mounted in spaced relation with the movable funnel.The wire insertion guide is used in concert with a crimper assembly, but is a separate apparatus, and may be used with a wide variety of crimper assemblies either of the manual or automatic type.