Abstract: Methods and systems are disclosed for configurable display of market data. In one embodiment, market data is displayed in a dimensional perspective that emphasizes important aspects of market data while deemphasizing less important aspects. In a graphical user interface (GUI), the displayed market data is presented along a first axis, and a portion of the displayed market data is centered relative to a second axis. In response to receiving a selection of one of multiple controls of the GUI, the displayed market data is configured according to a dimensional perspective associated with the selected control. In some embodiments, the dimensional perspective includes mapping display of the market data to an object, such as an angled surface, a circular object, a flat surface, or a combination of the above. In some embodiments, additional controls of the GUI enable zoomed and rotated perspectives of the displayed market data.

Abstract: Systems and methods for minimally invasive computer-assisted telesurgery are described. For example, this disclosure describes computer-assisted teleoperated surgery instruments with cable-actuated joint mechanisms Some such joint mechanisms include linkages that maintain the joints in operable configurations without relying on cable tension to do so.

Abstract: A disposable absorbent article is disclosed. The absorbent article has a longitudinal centerline and a lateral centerline generally perpendicular to the longitudinal centerline, first and second side edges and first and second end edges disposed at a first end and a second end of the absorbent article, respectively. The absorbent article has a topsheet; a backsheet; an absorbent system disposed between the topsheet and the backsheet. A visual signal visible from a wearer-facing surface, and wherein a difference between a length of the disposable absorbent article and a length of the visual signal is less than 35 mm.

Abstract: Methods and compositions are provided for inhibiting, preventing, ameliorating and/or reducing damage to DNA in non-cancerous cells in a subject undergoing chemotherapeutic treatment and/or radiation treatment of cancer cells in the subject, comprising administering to the subject one or more compounds of arsenic in a therapeutically effective amount prior to chemotherapeutic treatment and/or radiation treatment.

Abstract: Methods and systems are disclosed for configurable display of market data. In one embodiment, market data is displayed in a dimensional perspective that emphasizes important aspects of market data while deemphasizing less important aspects. In a graphical user interface (GUI), the displayed market data is presented along a first axis, and a portion of the displayed market data is centered relative to a second axis. In response to receiving a selection of one of multiple controls of the GUI, the displayed market data is configured according to a dimensional perspective associated with the selected control. In some embodiments, the dimensional perspective includes mapping display of the market data to an object, such as an angled surface, a circular object, a flat surface, or a combination of the above. In some embodiments, additional controls of the GUI enable zoomed and rotated perspectives of the displayed market data.

Abstract: In corneal crosslinking, the anterior surface of the cornea of the eye is maintained in contact with a first liquid having a first concentration of a crosslinking catalyst such as riboflavin, so that the catalyst enters the cornea and forms a first concentration profile (t1) in the corneal stroma. The anterior surface of the cornea is then maintained in contact with one or more additional liquids having concentration of the catalyst lower than the first concentration so that the catalyst forms a second concentration profile (t4, t5, t6) in the stroma. In the second concentration profile, the maximum concentration of the catalyst desirably is posterior to the anterior surface of the cornea. The cornea is irradiated and crosslinked. The second concentration profile facilitates crosslinking deep within the stroma.

Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: Systems and methods for coupling a tag to an item. The methods comprise: dispensing the tag from a tag feeder of a tag applicator; performing first operations by the tag applicator to mechanically move the tag into a nest of the tag applicator; determining if a given criteria is met based on feedback information received from at least one of a user of the tag applicator and a sensor provided with the tag applicator; and performing second operations by the tag applicator to couple the tag to the item, when a determination is made that the given criteria is met.

Abstract: Compound of formula (I): wherein Het, R3, R4, R5, R7, R8, R9, t, p, p?, q, and q? are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic agent.

Abstract: Compounds of formula (1): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.

Abstract: Provided here are therapeutically effective pharmaceutical compositions containing one or more TREX2 inhibitors, and more specifically methods of administering TREX2 inhibitors to increase the effectiveness of a chemotherapeutic agent. Also provided here are methods of identifying agents that inhibit the exonuclease activity of TREX2.

Abstract: A power conveyor circuit for an energy harvesting system includes an input port configured to be electrically coupled to a sensor to receive an input signal from the sensor at an input power level and an output port configured to 5 be electrically coupled to a load. A switch mode power path circuit is coupled to the input port and the output port to receive the input signal from the sensor received at the input port and to provide an output signal to the output port at an output power level equal to the input power level times a transfer efficiency. A method of making the power conveyor circuit and an energy harvesting system including the power conveyor circuit are also disclosed.

Abstract: Validation of a migration task to migrate data from one data store to another may be performed prior to the migration of the data. Parameters associated with the migration may be evaluated according to one or more types of validations for the migration task. In some embodiments, users may specify the validations to perform for the migration task. A determination as to whether the migration task is valid may be performed for the migration task based on the parameter evaluations. A result indicating whether the migration task is valid may be provided to a user.

Abstract: Provided here are methods of assessing prognosis for a patient who has been diagnosed with a type of cancer by measuring TREX2 mRNA expression in a biological sample from the patient, comparing the TREX2 mRNA expression in the biological sample to a reference value, and providing a prognosis based on alterations in the TREX2 mRNA expression and the type of cancer. Also provided here are methods of treating a patient with myelodysplastic syndrome by administering a therapeutically effective amount of a pharmaceutical composition that decreases TREX2 mRNA expression in the patient.

Abstract: This disclosure details mounting systems and associated methods for mounting a battery pack to an electrified vehicle. An exemplary electrified vehicle may include a frame, a battery pack, and a mounting system for mounting the battery pack to the frame. The mounting system may include one or more side rails. Each side rail may include a predefined crush initiator configured to plastically deform for absorbing and transferring energy during vehicle impact loading events.

Abstract: This disclosure details mounting systems and associated methods for mounting a battery pack to an electrified vehicle. An exemplary electrified vehicle may include a frame, a battery pack, and a mounting system for mounting the battery pack to the frame. The mounting system may include one or more side rails. Each side rail may include a predefined crush initiator configured to plastically deform for absorbing and transferring energy during vehicle impact loading events.

Abstract: A hip thrust exercise device includes a main body; a foot mount connected to the first body portion; a grip connected to the second body portion; an extension hingedly connected to the main and an abutment element; and a resistance element connected between the extension and main body. The resistance element provides a resistance force when the abutment element is moved away from the first body portion.

Abstract: Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R13, Ra, Rb, A and n are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.

Abstract: Compounds of formula (I): wherein Het, R3, R4, R5, R7, R8, R9, T, p, p?, q, and q? are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.

Abstract: Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.