Abstract: A process for reducing the thiophene content in a synthesis gas mixture, comprises the steps of (i) passing a synthesis gas mixture comprising hydrogen and carbon oxides and containing thiophene over a copper-containing sorbent disposed in a sorbent vessel at an inlet temperature in the range 200-280° C., (ii) withdrawing a thiophene depleted synthesis gas containing methanol from the sorbent vessel, and (iii) adjusting the temperature of the methanol-containing thiophene-depleted synthesis gas mixture. The resulting gas mixture may be used for production of chemicals, e.g. methanol production or for the Fischer-Tropsch synthesis of liquid hydrocarbons, for hydrogen production by using water gas shift, or for the production of synthetic natural gas.

Abstract: Heterocyclic entities that modulate PI3 kinase activity, pharmaceutical compositions containing the heterocyclic entities, and methods of using these chemical entities for treating diseases and conditions associated with PI3 kinase activity are described herein.

Abstract: A hat configured to secure a pair of eyeglasses or any other stem is provided with a crown portion having an exterior surface and an interior surface, a band attached to the interior surface of the crown portion thereby forming a pocket between the interior surface of the crown portion and the band, and at least one opening that extends through the exterior surface and interior surface of the crown portion wherein the at least one opening is positioned such that the pocket between the interior surface of the crown portion and the band is accessible from the exterior surface of the crown portion through the opening, whereby an item may be inserted through the at least one opening and into the pocket formed between the interior surface of the crown portion and the band to secure the item to the hat.

Abstract: Certain chemical entities that modulate PI3 kinase activity, and chemical entities, pharmaceutical compositions, and methods of treatments of diseases and conditions associated with PB kinase activity are described.

Abstract: Disclosed teem are display systems comprising light-emitting, diodes (LEDs), suitably blue light LEDs, which demonstrate increased optical power output. In embodiments, the display systems include compositions comprising phosphors, including luminescent nanocrystals.

Abstract: The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating lipid kinases such PI3 kinases, tyrosine kinases and protein kinases such as mTOR. For example, the invention provides compounds of Formula: Also provided in the present invention are methods of using these compositions to modulate these kinases especially for therapeutic applications.

Abstract: The present invention provides for a method for treating a disease condition associated with PI3-kinase ? and/or mTOR in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3-kinase ? and/or mTOR in a subject. In yet another aspect, a method of inhibiting phosphorylation of both Akt (S473) and Akt (T308) in a cell is set forth. The present invention also provides a pharmaceutical kit effective for treating a disease condition associated with PI3-kinase ? and/or mTOR in a subject.

Abstract: A cosmetic applicator comprising a handle having a proximal end and a distal end, wherein the handle comprises a drive; an applicator head operatively associated with the drive to move at least part of the applicator head relative to the handle; and a control surface disposed at the proximal end of the handle and operatively associated with the drive. The control surface may be rotatable about a control surface axis through a plurality of positions and the control surface axis may be aligned with the longitudinal axis of the handle. The control surface may be moveable through a plurality of positions. The applicator may comprise an additional control surface, such as a second control surface or temporary control surface, which may be operated independently or in combination with the first control surface.

Abstract: A heart valve implant according to one embodiment may include a shaft and an anchor disposed on one end of the shaft, the anchor configured to engage tissue. The heart valve implant may further include an expandable member disposed over at least part of the shaft, the expandable member comprising a resiliently deformable internal layer and a resiliently deformable external layer disposed over the internal layer, the expandable member defining a chamber and being configured to receive an inflation medium in the chamber to expand the expandable member, the expandable member further configured to deform upon contact with at least a portion of at least one leaflet of a heart valve to at least partially conform to the shape of the leaflet.

Abstract: A package for applying a liquid personal care product. the package including a body for storing and dispensing a personal care product and an applicator with a skin-contacting portion for applying the personal care product to the skin of a user. The body of the package and the skin-contacting portion both have first and second cross-sectional shapes with major and minor dimensions aligned with one another. The major dimension being greater than the minor dimension. The skin contacting portion includes a patterned surface. The patterned surface produces a corresponding pattern on skin when the personal care product is applied thereto. The pattern may be configured to deliver a discontinuous film of product to the skin, resulting in natural looking coverage.

Abstract: A system for restricting operation of wireless devices, for example cell phones, comprises a controller and a plurality of sensors. The system restricts device usage, while permitting emergency phone calls, for example 911 calls. The sensors receive transmissions from devices, and use the transmissions for identification and determining whether a device is within a restricted zone. One disclosed method is triangulation, using time of arrival of transmissions at the sensors. If the device is within the zone, the controller sends device identification, and possibly a customized restriction request, to a remote node, for example a control node of a cell phone network operator. The operator then uses its network resources to implement the requested restrictions. Communication between the controller and the remote node is secure, possibly encrypted, to minimize malicious interference. A wireless control can define vertices of the zone and exempt certain devices from restrictions. Jamming is not required.

Abstract: A skin smoothing film made from a skin smoothing composition that comprises sodium silicate, polyvalent silicate and water. Moreover, the film may be made from a composition that has a contraction value of from about 30% to about 160%. The film thickness is from about 5 microns to about 50 microns, preferably from about 10 microns to about 40 microns, when applied. The standard deviation of the film over the area covered is less than about 30, preferably less than about 25.

Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

Abstract: An applicator for applying a skin smoothing composition comprising a head and a body, the head having a portion of its surface coated with flock fibers, bristles, cloth, sponge, polymeric mesh, nonwovens, and mixtures thereof, the skin smoothing composition comprises sodium silicate, polyvalent silicate and water, or the skin smoothing composition comprises a contraction value of from about 30% to about 160%, or both. The applicator can have a portion of its head coated with flock fibers, wherein the flock fibers have a Denier from about 10.0 dtex to about 0.1 dtex and a flock fiber length of from about 5.0 mm to about 0.3 mm. The applicator head may have a Shore A Durometer softness of from about 25 to about 140.

Abstract: An implant delivery system may comprise a catheter including at least one lumen, a guide wire configured to be received in the lumen, and an implant. The guide wire may comprise a clamping mechanism disposed about a distal end of the guide wire. The clamping mechanism may include a first and at least a second jaw wherein at least one of the jaws is configured to pivot between a closed position wherein the jaws define at least one internal cavity between the jaws configured to receive at least a portion of the implant and an open position configured to release the implant. The implant may be configured to be received in the lumen and may comprise a driver configured to be releasably received in the cavity of the clamping mechanism.

Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

Abstract: Certain chemical entities that modulate PI3 kinase activity, and chemical entities, pharmaceutical compositions, and methods of treatments of diseases and conditions associated with PB kinase activity are described.

Abstract: A heart valve implant according to one embodiment may include a shaft and an anchor disposed on one end of the shaft, the anchor configured to engage tissue. The heart valve implant may further include an expandable member disposed over at least part of the shaft, the expandable member comprising a resiliently deformable internal layer and a resiliently deformable external layer disposed over the internal layer, the expandable member defining a chamber and being configured to receive an inflation medium in the chamber to expand the expandable member, the expandable member further configured to deform upon contact with at least a portion of at least one leaflet of a heart valve to at least partially conform to the shape of the leaflet.

Abstract: Chemical entities that modulate PI3 kinase activity, pharmaceutical compositions containing the chemical entities, and methods of using these chemical entities for treating diseases and conditions associated with P13 kinase activity are described herein.

Abstract: A system for restricting operation of wireless devices, for example cell phones, comprises a controller and a plurality of sensors. The system restricts device usage, while permitting emergency phone calls, for example 911 calls. The sensors receive transmissions from devices, and use the transmissions for identification and determining whether a device is within a restricted zone. One disclosed method is triangulation, using time of arrival of transmissions at the sensors. If the device is within the zone, the controller sends device identification, and possibly a customized restriction request, to a remote node, for example a control node of a cell phone network operator. The operator then uses its network resources to implement the requested restrictions. Communication between the controller and the remote node is secure, possibly encrypted, to minimize malicious interference. A wireless control can define vertices of the zone and exempt certain devices from restrictions. Jamming is not required.