Abstract: The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating certain protein kinases such as mTor, tyrosine kinases, and/or lipid kinases such as PI3 kinase. Also provided in the present invention are methods of using these compositions to modulate activities of one or more of these kinases, especially for therapeutic applications.

Abstract: The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating lipid kinases such PB kinases, tryosine kinases and protein kinases such as mTOR. Also provided in the present invention are methods of using these compositions to modulate these kinases especially for therapeutic applications.

Abstract: Chemical entities that modulate PI3 kinase activity, pharmaceutical compositions containing the chemical entities, and methods of using these chemical entities for treating diseases and conditions associated with PI3 kinase activity are described herein.

Abstract: A system for restricting operation of wireless devices, for example cell phones, comprises a controller and a plurality of sensors. The system restricts device usage, while permitting emergency phone calls, for example 911 calls. The sensors receive transmissions from devices, and use the transmissions for identification and determining whether a device is within a restricted zone. One disclosed method is triangulation, using time of arrival of transmissions at the sensors. If the device is within the zone, the controller sends device identification, and possibly a customized restriction request, to a remote node, for example a control node of a cell phone network operator. The operator then uses its network resources to implement the requested restrictions. Communication between the controller and the remote node is secure, possibly encrypted, to minimize malicious interference. A wireless control can define vertices of the zone and exempt certain devices from restrictions. Jamming is not required.

Abstract: A process is described for reducing the thiophene content in a synthesis gas mixture, comprising comprises the steps of (i) passing a synthesis gas mixture comprising hydrogen and carbon oxides and containing thiophene over a copper-containing sorbent disposed in a sorbent vessel at an inlet temperature in the range 200-280 oC, (ii) withdrawing a thiophene depleted synthesis gas containing methanol from the sorbent vessel, and (iii) adjusting the temperature of the methanol-containing thiophene-depleted synthesis gas mixture. The resulting gas mixture may be used for production of chemicals, e.g. methanol production or for the Fischer-Tropsch synthesis of liquid hydrocarbons, for hydrogen production by using water gas shift, or for the production of synthetic natural gas.

Abstract: Chemical entities that modulate PI3 kinase activity, pharmaceutical compositions containing the chemical entities, and methods of using these chemical entities for treating diseases and conditions associated with PI3 kinase activity are described herein.

Abstract: A hand held exfoliation device suitable for repeated use on a facial skin surface is provided. The exfoliation device includes a body and an exfoliating material attached thereto that is sized for application to a facial skin surface. The exfoliating material includes a substrate and an exfoliating surface. The exfoliating surface is formed from a plurality of particles, wherein the plurality of particles are attached to the substrate to form peaks and valleys thereon. The exfoliating material has a surface roughness Sa from about 2 ?m to about 16 ?m and the particles have an average Mohs hardness from about 4 to about 8.

Abstract: The proposed innovation provides methods and systems for measuring the interpupillary distance. The proposed innovation provides a fitting pad (102) having two detection points (104 and 106). The fitting pad is placed on the forehead of the user and an image is captured. The image is uploaded and pupil distance calculator software locates the fitting detection points and calculates the distance in pixels of the left and right X, Y coordinates. The software creates an image scale by dividing the pixel counts between the detection points. The software automatically locates the X, Y coordinates between the center of the left and right pupils and calculates the distance in pixels. The resulting pixel distance divided by the image scale provides the interpupillary distance in millimeter. In embodiments, segment height is calculated based upon an image imported by the user and the combined scaled images of the user and the frame.

Abstract: Heterocyclic entities that modulate PI3 kinase activity, pharmaceutical compositions containing the heterocyclic entities, and methods of using these chemical entities for treating diseases and conditions associated with PI3 kinase activity are described herein.

Abstract: A surface treating head assembly for an appliance such as a vacuum cleaner includes a head and a piston assembly operable to apply a force to the head. The piston assembly is connected to the main motor of the vacuum cleaner by a valve. When the valve is opened, suction airflow flows through tubes connecting the motor to the piston assembly. The resulting suction force causes the piston assembly to contract, thereby drawing the cleaner head downwards. Thus, the head is urged towards the floor surface so as to improve the efficiency of a cleaning operation.

Abstract: A cosmetic applicator includes a handle, a drive coupled to the handle, an applicator head coupled to the drive, and a torque limiter. The torque limiter includes a magnetic coupling, the magnetic coupling being coupled to at least one of the drive and the applicator head such that the torque applied via the applicator head does not exceed a predetermined allowable torque.

Abstract: A heart valve implant may include a shaft and an anchor configured to be coupled to an end of the shaft. A spacer may be coupled to a portion of the shaft and comprise a plurality of individual segments including a first and at least a second individual segment. The first segment may be coupled to the shaft. The second segment may be coupled to at least a portion of an exterior surface of the first segment and may have at least one cross-section dimension which is greater than an internal cross-sectional dimension of a delivery lumen. Additional segments may be coupled to an inner, adjacent segment. The segments may include a collapsible body portion to facilitate percutaneously delivery through a lumen. The segments may define an outer surface of the spacer configured to interact with at least a portion of at least one cusp of a heart valve to at least partially restrict a flow of blood through the heart valve in a closed position.

Abstract: The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating certain protein kinases such as mTor, tyrosine kinases, and/or lipid kinases such as PI3 kinase. For example, the invention provides compounds of Formula: Also provided in the present invention are methods of using such compounds or compositions, and methods of using these compositions to modulate activities of one or more of these kinases, especially for therapeutic applications such as treatment of cancer.

Abstract: The present invention provides chemical entities, compounds and pharmaceutical compositions thereof that are capable of modulating certain protein kinases such as mTor, tyrosine kinases, and/or lipid kinases such as PI3 kinase. For example, the invention provides compounds of Formula: Also provided in the present invention are methods of making such compounds or compositions, and methods of using these compositions to modulate activities of one or more of these kinases, especially for therapeutic applications such as treatment of cancer.

Abstract: The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating certain protein kinases such as mTor, tyrosine kinases, and/or lipid kinases such as PI3 kinase. For example, the invention provides compounds of Formula: Also provided in the present invention are methods of using such compounds or compositions, and methods of using these compositions to modulate activities of one or more of these kinases, especially for therapeutic applications such as treatment of cancer.

Abstract: The present invention provides chemical entities, compounds and pharmaceutical compositions thereof that are capable of modulating certain protein kinases such as mTor, tyrosine kinases, and/or lipid kinases such as PI3 kinase. For example, the invention provides compounds of Formula: Also provided in the present invention are methods of making such compounds or compositions, and methods of using these compositions to modulate activities of one or more of these kinases, especially for therapeutic applications such as treatment of cancer.

Abstract: A cosmetic applicator includes a handle, a drive coupled to the handle, an applicator head coupled to the drive, and a torque limiter coupled to or within at least one of the drive and the applicator head such that the torque applied via the applicator head does not exceed a predetermined allowable torque.

Abstract: A multi-functional, multi-compositional cosmetic applicator is disclosed. The applicator includes an application surface in liquid communication with a reservoir. The reservoir includes a first personal care composition and a second personal care composition stored therein, and the applicator is actuatable between a first and second functional configuration wherein the application surface of the applicator exhibits a first frictional force when in the first functional configuration and a second frictional force that is less than the first frictional force when in the second functional configuration. The applicator includes an actuatable delivery system that allows a user to selectively dispense the first and second compositions.

Abstract: A multi-functional, multi-compositional cosmetic applicator is disclosed. The applicator includes an application surface in liquid communication with a reservoir. The reservoir includes a first personal care composition and a second personal care composition stored therein, and the applicator is actuatable between a first and second functional configuration wherein the application surface of the applicator exhibits a first frictional force when in the first functional configuration and a second frictional force that is less than the first frictional force when in the second functional configuration. The applicator includes an actuatable delivery system that allows a user to selectively dispense the first and second compositions.

Abstract: A multi-functional, multi-compositional cosmetic applicator is disclosed. The applicator includes an application surface in liquid communication with a reservoir. The reservoir includes a first personal care composition and a second personal care composition stored therein, and the applicator is actuatable between a first and second functional configuration wherein the application surface of the applicator exhibits a first frictional force when in the first functional configuration and a second frictional force that is less than the first frictional force when in the second functional configuration. The applicator includes an actuatable delivery system that allows a user to selectively dispense the first and second compositions.