Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.

Abstract: Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

Abstract: A device for securing a rear seat within a cab of a vehicle, comprising a crossmember configured for attachment to a floor pan of the vehicle, the crossmember cooperating with the floor pan to provide a cavity for storing items within the cab. When the crossmember is attached to the floor pan and the rear seat is attached to the crossmember, the crossmember is contained within the space between the seat and the floor pan without extending into a passenger leg room area.

Abstract: A compound of formula (III): or a salt, solvate and chemically protected form thereof, wherein: R5 is an optionally substituted C5-20 aryl or C4-20alkyl group; L? is a single bond, —O— or —C(?O)—; A is selected from the group consisting of: formula (i) (ii) (iii) wherein X and Y are selected from the group consisting of: O and CR3; S and CR3; NH and CR3; NH and N; O and N; S and N; N and S; and N and O, and where the dotted lines indicate a double bond in the appropriate location, and where Q is either N or CH; D is selected from: formula (i) (ii) (iii) (iv) (v) (vii) (viii) (ix) B is selected from the group consisting of: formula (A) (B) where RP6 is selected from fluoro and chloro; and R2 is either: (i) —CO2H; (ii) —CONH2; (iii) —CH2—OH; or (iv) tetrazol-5-yl.

Abstract: Compounds of general formula (I) wherein R1 is halo or cyano; R2 is C1-C4 alkyl; and R3 is phenyl substituted with one or more substituents chosen from C1-C6 alkyl, halo or —SO2(C1-C6 alkyl); or a pharmaceutically acceptable salt, hydrate, solvate, complex or prodrug thereof; are useful in the treatment of diseases and conditions mediated by the action of PGD2 at the CRTH2 receptor.

Abstract: One or more embodiments may include a method for remotely obtaining information about an energy source of a vehicle. Information identifying one or more vehicles and one or more drivers of the vehicles may be received at one or more computing devices remote from a vehicle. Instructions from the one or more remote computing devices may be transmitted requesting information from the identified vehicle(s) about a status of an energy source for the identified vehicle(s). The status information may be received at the remote computing device(s). Based on the energy source status information and the driver identifying information, a vehicle energy source status with respect to one or more attributes of the vehicle drivers may be calculated. Additionally, the vehicle energy source status may be displayed at the one or more devices.

Abstract: One or more embodiments may include a method for selectively charging a vehicle. The method may include receiving at one or more computers one or more periods for charging a vehicle. The vehicle charging periods may be stored in memory. Further, pricing rates for charging the vehicle during the one or more vehicle charging periods may be received at the computer(s). Based on the one or more pricing rates and the vehicle charging periods, one or more low cost charging periods may be determined. The one or more low cost charging periods may be automatically adjusted if the one or more pricing rates change. The vehicle may be charged during at least part of the one or more low cost charging periods.

Abstract: Aspects of the present invention are directed to using surface acoustic wave (SAW) sensors mounted on a disc coupling component in a powertrain to measure the torque generated by an automobile engine. The sensor may be positioned and oriented on the disc coupling component so that the phase velocities of SAWs propagating through active elements of the SAW sensors are aligned with principal strain components due to torque in the disc coupling component. The torque may be calculated by determining the difference between resonant frequencies of the active elements to suppress common-mode interference factors. In addition, SAW resonant frequencies may be communicated in a non-contacting manner by utilizing rotary and stationary couplers employing radio frequency (RF) signals. Moreover, SAW sensors may be activated and interrogated by employing targeted RF pulses having different carrier frequencies at or near respective resonant frequencies of each resonator in a SAW sensor.

Abstract: A method of processing a signal in a wireless digital communications system, wherein a source of disturbance affects differently at least first and second portions of a received signal carrying user data and/or control data, the method comprising: identifying the second portion of the received signal, most affected by the source of disturbance; generating a first estimate of the disturbance (PI) for received samples in the first, less affected portion of the received signal; generating a second estimate of the disturbance (PI(SCH)) for received samples in the second portion of the received signal; and using the first and second disturbance estimates to generate reliability information for the data bits corresponding to the received signal samples, for use in a decoding process to estimate the transmitted data bits.

Abstract: A mounting system for mounting a body to a tailgate having first and second latch assemblies that engage a pair of striker plates. The mounting system includes a first mounting bracket having a first striker plate to engage the first latch assembly and a second mounting bracket having a second striker plate to engage the second latch assembly. The first and second mounting brackets mount the body on the tailgate when the first and the second mounting brackets are attached to the body and when the first and second striker plates are engaged with the first and second latch assemblies.

Abstract: Concepts and technologies described herein provide for the creation of an actuating fluid flow utilizing a multi-stage actuator. According to one aspect of the disclosure provided herein, a fluid actuation system includes at least two stages, each stage having a plenum and one or two diaphragms acting on the plenum to create an actuating fluid flow. The diaphragms of each stage may be substantially aligned along an axis. The actuating flow is aggregated between stages and expelled into a fluid flow to be controlled. According to various aspects, the diaphragms may include piezoelectric discs.

Abstract: Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

Abstract: Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

Abstract: A system and method for processing digital samples from a signal received via a wireless transmission channel in a wireless communications system. The method comprises: comparing a target signal quality value with an estimated received signal quality value; detecting if the estimated received signal quality value exceeds the target signal quality value for a period; and selecting one of a plurality of processing routines of differing sensitivities for processing the digital samples.

Abstract: A method of power control in a wireless communication system wherein blocks are transmitted from a transmitter to a receiver on multiple wireless transport channels. The method comprises comparing a target signal quality value with a received signal quality value and providing the results of the comparing step to the transmitter to adjust transmit power, and a mechanism for controlling the target signal quality for transport channels that have been inactive for a predefined period. A corresponding receiver is also provided.

Abstract: Compounds of general formula (I) wherein R1 is halo or cyano; R2 is C1-C4 alkyl; and R3 is phenyl substituted with one or more substituents chosen from C1-C6 alkyl, halo or —SO2(C1-C6 alkyl); or a pharmaceutically acceptable salt, hydrate, solvate, complex or prodrug thereof; are useful in the treatment of diseases and conditions mediated by the action of PGD2 at the CRTH2 receptor.

Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist of formula (I) in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.

Abstract: A method of power control in a wireless communications system wherein blocks are transmitted from a transmitter to a receiver via a wireless transmission channel. The method comprises comparing a target signal quality value with a received signal quality value and providing the results of the comparing step to the transmitter to adjust transmit power based on the comparing step. The target signal quality value is set by the following steps: determining an initial target value; determining if received blocks have been successfully decoded; identifying the received blocks as pass or fail blocks; when pass blocks are received, comparing the target signal quality value with the received signal quality value and decreasing the target value only if the target value is greater than the received signal quality value less a margin.

Abstract: A method of power control in a wireless communication system, wherein blocks are transmitted from a transmitter to a receiver via a wireless transport channel. The method comprises comparing a target signal quality value with a received signal quality value and providing the results of the comparing step to the transmitter to adjust transmit power based on the comparing step. The target signal quality value is set by the following steps: determining an initial target value; detecting if a data block has been received; detecting if received blocks have been successfully decoded; and decreasing the target value when pass blocks are received and increasing the target value when failed blocks are received subject to monitoring a period of inactivity on the transport channel in which no blocks are received.

Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.