Abstract: A lens blocking device is disclosed that includes a frame, a light source mounted on the frame, a carriage having a first end and a second end mounted on the frame for sliding movement between first and second positions, a first mirror mounted on the carriage first end and a lens block holder mounted on the carriage second end and shiftable between third and fourth positions with respect to the carriage, a stage disposed between the light source and the carriage, and including an opening, for supporting an object, an at least partially translucent screen generating a display image operably connected to the support frame, at least one second mirror arranged to reflect an image of an object on the stage from the first mirror, when the carriage is in the first position, onto the screen, and an actuator operably connected to the carriage.

Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.

Abstract: The present invention makes available methods and reagents for inducing activation of a hedgehog pathway in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as a small molecule, in a sufficient amount to achieve a therapeutic result. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.

Abstract: A compound represented in general formula (X) and (XI):

Abstract: An adaptor for receiving a fluidic device (12) and facilitating connection of the device (12) to a similar device or other object, the device having defined therein at least one fluid pathway (24), the adaptor being capable of receiving fluid from said at least one pathway (24) and having connecting means (28) for connecting to the, or each fluid pathway (24), so as to substantially immobilise the pathway(s) with respect to the device, thereby preventing damage to the pathway(s), the means for connecting each pathway provides a fluid tight seal, so that in use fluid passes to/from the device, without leakage, to a similar device.

Abstract: An uncooled, through-hole configured laser module adapted to receive and transmit RF signals to a laser at bandwidths from direct current (DC) to about ten gigahertz. The laser module incorporates an option for two pin-out configurations. One pin-out configuration has one ground pin and one signal pin for operation at about one gigabit/second or one gigahertz. The second high performance pin-out uses two ground pins and one signal pin for operation up to about ten gigabit/second or ten gigahertz.

Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.

Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.

Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.

Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function by contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize hedgehog activity.

Abstract: A semiconductor component that receives incoming light includes an integrated circuit, a package and an optics unit. The optics unit may provide a pathway, either generally or selectively, for the incoming light to the photodetector circuitry of the integrated circuit and may modify the incoming light, as well. The optics unit may be either electrically active or passive. When active, the optics unit is coupled to the integrated circuit with a conductor. The optics unit may also include a liquid crystal device, a beamsplitter assembly, a lensing assembly or other filters, and/or apertures. The liquid crystal device can act as a shutter or a display and the optics unit may be a single module or a plurality of modules. The integrated circuit may also include shutter drive circuitry and image processing circuitry.

Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.

Abstract: The invention is an imaging device having a high fill factor. The high fill factor is achieved by constructing the light sensors in a vertical fashion in the imaging device. The control circuitry of the light sensor is then contained inside the integrated circuit chip, rather than taking up area that could otherwise be used for light collection. The majority of the area on the surface of the IC chip is made up of light sensing elements, since the control circuitry is embedded in the IC chip. The control circuitry is connected to the light sensing devices through vias in the IC chip. The control circuitry of the chip is mainly contained within the die, rather than on it.

Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.

Abstract: This invention includes systems and methods for cleaning ventilation ducts using a dry ice blasting system that is adapted to blast debris from the interior surfaces of ventilation ducts. This invention employs either existing or artificial duct ventilation airflow to evacuate dislodged debris and a filter or filtration system attached to the ventilation system to capture the dislodged debris.

Abstract: An integrated bed side step assembly is provided for a pick-up truck having a bed. The integrated bed side step assembly includes a body opening assembly forming one side of the bed and having an opening extending therethrough above a floor of the bed to allow access to an interior of the bed. The integrated bed side step assembly also includes a door assembly operatively cooperating with the body opening assembly to open and close the opening and having at least one step to allow an operator to step up into and access the interior of the bed.

Abstract: A gas sensor is described which is particularly well suited as a carbon monoxide (CO) sensor in a self test gas sensor. The sensor includes a number of aspects which may or may not be used in conjunction with one another. A first aspect is an embodiment which reduces electrical interference (or cross-talk) between a test or gas generating cell and a sensing cell. In one embodiment, baffles are provided to prevent cross-talk. In another embodiment a switching circuit ensures that a test gas generator is operational only when the gas sensor is disconnected from a current source. A second aspect is an embodiment which includes an improved wick which is in close proximity with an electrode and ensures electrolyte is always in contact with the electrode. In an alternate embodiment a solid polymer electrolyte is used between the electrodes. A third aspect is an improved catalyst which reduces the reaction energy and thereby renders the sensor more sensitive. The catalyst is also cheaper than platinum.

Abstract: Apparatus for dispensing a predetermined volume of a liquid (18) comprises a reservoir (12) for the liquid, a channel (13) provided with an outlet (16) for conveying the liquid (18) from the reservoir to the outlet, and means for generating a pulse of gas. The apparatus is arranged such that the flow of gas causes a predetermined volume of liquid to be ejected from the outlet. The outlet comprises a pair of openings in the channel which face one another, the liquid being retained between the openings by surface tension in the absence of a flow of gas. The gas flow is directed towards one of said openings in use. The apparatus may be used to dispense volumes of a liquid reagent in the range 1 nl to 2 &mgr;l. The apparatus avoids contamination of the liquid, and dispensing head construction allows devices to be low cost disposable units. The apparatus is less sensitive to liquid viscosity than existing devices.

Abstract: A camera system employs an electronic imager such as a Charged Couple Device (CCD) or a Complementary Metal Oxide Semiconductor (CMOS) array that captures a first portion of light and reflects a second portion of light reflected from a target subject. The light reflected by the electronic imager may be reflected towards film media or a color filter, for example. The electronic imager may include an integrated circuit, or a dielectric reflecting coating that acts to partially reflect incoming light reflected from the target subject. A display, such as an LCD (Liquid Crystal Display), may be utilized to determine which images are desirable or to identify which films to develop. Film writing circuitry that allows various types of information to be written may be utilized. The camera system further features an electronic imager shutter, and a film shutter for shuttering purposes. The film shutter can provide exposure control.