Abstract: The disclosure provides EP2 receptor agonist compounds and methods for using the compounds for treating conditions which can be alleviated by agonism of an EP2 receptor.

Abstract: Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

Abstract: A launch vehicle comprising a casing, a solid propellant, a channel, a geometric feature, and a suppression structure. The solid propellant is located within the casing. The channel is through the solid propellant, and the geometric feature is in the channel. The suppression structure is located around a centerline for the channel and located upstream in a flow path from the geometric feature.

Abstract: Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

Abstract: A compound of formula (III): or a salt, solvate and chemically protected form thereof, wherein: R5 is an optionally substituted C5-20 aryl or C4-20alkyl group; L? is a single bond, —O— or —C(?O)—; A is selected from the group consisting of: formulae (i) (ii) (iii) wherein X and Y are selected from the group consisting of: O and CR3; S and CR3; NH and CR3; NH and N; O and N; S and N; N and S; and N and O, and where the dotted lines indicate a double bond in the appropriate location, and where Q is either N or CH; D is selected from: formulae (i) (ii) (iii) (iv) (v) (vii) (viii) (ix) B is selected from the group consisting of: formulae (A) (B) where RP6 is selected from fluoro and chloro; and R2 is either: (i) —CO2H; (ii) —CONH2; (iii) —CH2—OH; or (iv) tetrazol-5-yl.

Abstract: The invention relates to a microcrystalline form of a compound which is an inhibitor of PGD2 at the CRTH2 receptor. The microcrystalline form is obtained from a simple chemical reaction without the need for a milling process.

Abstract: A compound of formula (I): or a salt, or chemically protected form thereof, wherein: R5 is an optionally substituted phenyl; A is ?wherein Q is N; R3 is selected from H, F, Cl and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl, and C5-7 aryl-C1-4 alkyl groups; R4 is selected from H, F, Cl and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl, and C5-7 aryl-C1-4 alkyl groups; R6 is selected from H, F, Cl, and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl, and C5-7 aryl-C1-4 alkyl groups; D is selected from: B is selected from the group consisting of: Where RN? is selected from H and C1-4 alkyl; where one of RP3 and RP4 is —Cm-alkylene-R2 and the other of RP3 and RP4 is H, m and n can be 0 or 1, and m+n=1 or 2; and additionally, when RP3 is —Cm-alkylene-R2, m can also be 2 or 3, and m+n=1, 2, 3 or 4, and when R2 is tetrazol-5-yl, m+n may be 0; or where one of RP3 and RP4 is —O—CH2—R2, and the other of RP3 and RP4 is H, n is 0; RN is H or optional

Abstract: Aspects of the present invention are directed to using surface acoustic wave (SAW) sensors mounted on a disc coupling component in a powertrain to measure the torque generated by an automobile engine. The sensor may be positioned and oriented on the disc coupling component so that the phase velocities of SAWs propagating through active elements of the SAW sensors are aligned with principal strain components due to torque in the disc coupling component. The torque may be calculated by determining the difference between resonant frequencies of the active elements to suppress common-mode interference factors. In addition, SAW resonant frequencies may be communicated in a non-contacting manner by utilizing rotary and stationary couplers employing radio frequency (RF) signals. Moreover, SAW sensors may be activated and interrogated by employing targeted RF pulses having different carrier frequencies at or near respective resonant frequencies of each resonator in a SAW sensor.

Abstract: A device for securing a rear seat within a cab of a vehicle, comprising a crossmember configured for attachment to a floor pan of the vehicle, the crossmember cooperating with the floor pan to provide a cavity for storing items within the cab. When the crossmember is attached to the floor pan and the rear seat is attached to the crossmember, the crossmember is contained within the space between the seat and the floor pan without extending into a passenger leg room area.

Abstract: The disclosure provides EP2 receptor agonist compounds and methods for using the compounds for treating conditions which can be alleviated by agonism of an EP2 receptor.

Abstract: The present invention provides indole derivatives that antagonize prostaglandin D2, and that can be used to treat inflammatory diseases mediated by prostaglandin D2.

Abstract: Disclosed herein is a portable apparatus for accessing an elevated area on an automobile. The portable apparatus comprises a central element, a hook plate, and load supporting members. The central element comprises an upper section and a lower section. The hook plate is affixed to the upper end of the upper section of the central element. The hook plate secures the central element to the automobile. The load supporting members are positioned laterally on the lower section of the central element. The load supporting members enable a user to access the elevated area on the automobile and to ascend and descend the automobile. Adjustment wings may be provided on the hook plate and extended on both sides of the hook plate for fitting the hook plate in stake pockets of different sizes provided on the automobile. The portable apparatus is lightweight and easy to use, store, and install.

Abstract: A mounting system for mounting a body to a tailgate having first and second latch assemblies that engage a pair of striker plates. The mounting system includes a first mounting bracket having a first striker plate to engage the first latch assembly and a second mounting bracket having a second striker plate to engage the second latch assembly. The first and second mounting brackets mount the body on the tailgate when the first and the second mounting brackets are attached to the body and when the first and second striker plates are engaged with the first and second latch assemblies.

Abstract: The present invention provides indole derivatives that antagonize prostaglandin D2, and that can be used to treat inflammatory diseases mediated by prostaglandin D2.

Abstract: The present invention provides indole derivatives that antagonize prostaglandin D2, and that can be used to treat inflammatory diseases mediated by prostaglandin D2.

Abstract: The present invention provides indole derivatives that antagonize prostaglandin D2, and that can be used to treat inflammatory diseases mediated by prostaglandin D2.

Abstract: The present invention provides indole derivatives that antagonize prostaglandin D2, and that can be used to treat inflammatory diseases mediated by prostaglandin D2.

Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.

Abstract: A method of processing a signal in a wireless digital communications system, wherein a source of disturbance affects differently at least first and second portions of a received signal carrying user data and/or control data, the method comprising: identifying the second portion of the received signal, most affected by the source of disturbance; generating a first estimate of the disturbance (PI) for received samples in the first, less affected portion of the received signal; generating a second estimate of the disturbance (PI(SCH)) for received samples in the second portion of the received signal; and using the first and second disturbance estimates to generate reliability information for the data bits corresponding to the received signal samples, for use in a decoding process to estimate the transmitted data bits.

Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.