Abstract: The disclosed invention relates to a system and method for aligning reference marks defining the optical center or major reference point on a lens blank with a series of alignment marks, or “fiducials”. The fiducials comprise first and second alignment bars displayed on a display operably associated with a computer, and overlay the reference marks, also displayed on the display. The fiducials may be adjusted to accurately precisely align the lens blank.

Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.

Abstract: A compound represented in general formula (X) and (XI):

Abstract: The present invention makes available methods and reagents for inducing activation of a hedgehog pathway in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as a small molecule, in a sufficient amount to achieve a therapeutic result. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.

Abstract: An adaptor for receiving a fluidic device (12) and facilitating connection of the device (12) to a similar device or other object, the device having defined therein at least one fluid pathway (24), the adaptor being capable of receiving fluid from said at least one pathway (24) and having connecting means (28) for connecting to the, or each fluid pathway (24), so as to substantially immobilise the pathway(s) with respect to the device, thereby preventing damage to the pathway(s), the means for connecting each pathway provides a fluid tight seal, so that in use fluid passes to/from the device, without leakage, to a similar device.

Abstract: An uncooled, through-hole configured laser module adapted to receive and transmit RF signals to a laser at bandwidths from direct current (DC) to about ten gigahertz. The laser module incorporates an option for two pin-out configurations. One pin-out configuration has one ground pin and one signal pin for operation at about one gigabit/second or one gigahertz. The second high performance pin-out uses two ground pins and one signal pin for operation up to about ten gigabit/second or ten gigahertz.

Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.

Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.

Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.

Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function by contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize hedgehog activity.

Abstract: A semiconductor component that receives incoming light includes an integrated circuit, a package and an optics unit. The optics unit may provide a pathway, either generally or selectively, for the incoming light to the photodetector circuitry of the integrated circuit and may modify the incoming light, as well. The optics unit may be either electrically active or passive. When active, the optics unit is coupled to the integrated circuit with a conductor. The optics unit may also include a liquid crystal device, a beamsplitter assembly, a lensing assembly or other filters, and/or apertures. The liquid crystal device can act as a shutter or a display and the optics unit may be a single module or a plurality of modules. The integrated circuit may also include shutter drive circuitry and image processing circuitry.

Abstract: A manually operated, finger-manipulatable non-electric hair trimming device for shaving nostril hair, ear hair or the like, includes a head structure sized to fit within a small body cavity, such as a person's nostril or ear cavity, which includes a flexible razor blade strip. The head structure has a base portion and a curved guard portion, which preferably has first and second ends which are attached to the base portion. A finger grip portion is connected to the base portion to allow precise manual manipulation of the hair trimming device. The head structure further has a thin, elongated narrow razor blade strip with a razor sharp first edge portion, which may be a serrated edge with razor-sharp notches such as V-slots or may be a conventional straight edge. Alternatively, two razor-sharp edges, one serrated and one straight, may be provided.

Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.

Abstract: The invention is an imaging device having a high fill factor. The high fill factor is achieved by constructing the light sensors in a vertical fashion in the imaging device. The control circuitry of the light sensor is then contained inside the integrated circuit chip, rather than taking up area that could otherwise be used for light collection. The majority of the area on the surface of the IC chip is made up of light sensing elements, since the control circuitry is embedded in the IC chip. The control circuitry is connected to the light sensing devices through vias in the IC chip. The control circuitry of the chip is mainly contained within the die, rather than on it.

Abstract: The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity.

Abstract: This invention includes systems and methods for cleaning ventilation ducts using a dry ice blasting system that is adapted to blast debris from the interior surfaces of ventilation ducts. This invention employs either existing or artificial duct ventilation airflow to evacuate dislodged debris and a filter or filtration system attached to the ventilation system to capture the dislodged debris.

Abstract: An integrated bed side step assembly is provided for a pick-up truck having a bed. The integrated bed side step assembly includes a body opening assembly forming one side of the bed and having an opening extending therethrough above a floor of the bed to allow access to an interior of the bed. The integrated bed side step assembly also includes a door assembly operatively cooperating with the body opening assembly to open and close the opening and having at least one step to allow an operator to step up into and access the interior of the bed.

Abstract: A gas sensor is described which is particularly well suited as a carbon monoxide (CO) sensor in a self test gas sensor. The sensor includes a number of aspects which may or may not be used in conjunction with one another. A first aspect is an embodiment which reduces electrical interference (or cross-talk) between a test or gas generating cell and a sensing cell. In one embodiment, baffles are provided to prevent cross-talk. In another embodiment a switching circuit ensures that a test gas generator is operational only when the gas sensor is disconnected from a current source. A second aspect is an embodiment which includes an improved wick which is in close proximity with an electrode and ensures electrolyte is always in contact with the electrode. In an alternate embodiment a solid polymer electrolyte is used between the electrodes. A third aspect is an improved catalyst which reduces the reaction energy and thereby renders the sensor more sensitive. The catalyst is also cheaper than platinum.

Abstract: In-line razor-blade shaving devices feature two sets of razor blade strips pointing inwardly in opposite directions. The devices are designed for safely and rapidly shaving hair from large body portions such as legs and arms. Each device features an elongated handle arranged in line with an elongated bi-directional razor blade head. Each set of razor blade strips in the head may be provided with one or more straight razor-sharp edges, which point in the same direction, while the blade edges of the two sets point inwardly toward from one another, generally in opposite directions. The edges of blade strips of the two sets may be arranged in one common working plane, or each set may be in its own working plane, with the planes at an angle to one another. The working planes are defined by the elongated front and rear guard surfaces of the blade-edge guarding system on the face of the razor head. These guard surfaces contact a user's skin before and after the razor-sharp edges to help ensure safe shaving.