Abstract: Methods of reforming rib geometry of a stopper having a seal surface configured for engagement with an interior bore of a barrel of an injector device after formation of the rib include reforming a first edge of the rib.

Abstract: A diametrically adjustable endoprosthesis includes a controlled expansion element extending along at least a portion of a graft and is supported by a stent. The controlled expansion element diametrically constrains and limits expansion of the endoprosthesis. Upon deployment from a smaller, delivery configuration, the endoprosthesis can expand to the initial diameter set by the controlled expansion element. Thereafter, the endoprosthesis can be further diametrically expanded (e.g., using balloon dilation) by mechanically altering the controlled expansion element.

Abstract: The present disclosure relates to implantable encapsulation devices for housing a biological moiety or a therapeutic device that contains a biological moiety. Particularly, aspects of the present disclosure are directed to an implantable apparatus that includes a distal end, a proximal end, a manifold including at least one access port positioned either at the distal end or the proximal end, and a plurality of containment tubes affixed to the manifold and in fluid communication with the at least one access port. Additionally, the encapsulation device may contain a flush port and a tube that are fluidly connected to the manifold. The containment tubes may contain therein a biological moiety (e.g., cells) or a therapeutic device (e.g. a cell encapsulation member).

Abstract: A sorbent article is described including a sorbent region, a desorbing media region, and a selective barrier layer positioned at least between the two regions. Also described are methods of forming the sorbent article and methods of using the sorbent article for the purpose of swing adsorption, including for direct air capture (DAC) of carbon dioxide. The selective barrier layer may be impermeable to water and water vapor to protect the sorbent region. The sorbent article may be collapsible, wherein the selective barrier layer collapses into an adsorptive configuration to maximize access to the sorbent region during adsorption and expand into a desorptive configuration to maximize access to the desorbing media region during desorption.

Abstract: Embodiments of the present disclosure comprise occlusion and drug delivery devices and methods. One aspect of the disclosure comprises a drug delivery device comprising an inner expansion member and an outer drug delivery component. Another aspect of the disclosure comprises bioabsorbable, lumen-occluding implants.

Abstract: The invention relates to a medical device and a method of using it. The device is a stent which can be percutaneously deliverable with (or on) an endovascular catheter or via other surgical or other techniques and then expanded. The stent is configured to have a central portion defined by “open” cells and at least two end portions, defined by “closed” cells, spaced apart and directly connected to the distal and proximal ends of the central portion of the stent. The stent may also optionally have a covering or a lattice with openings.

Abstract: The invention relates to medical devices and methods of using them. The devices are prostheses which can be percutaneously deliverable with (or on) an endovascular catheter or via other surgical or other techniques and then expanded. The prostheses are configured to have a lattice resistant to dilation and creep, which is defined by a plurality of openings. The prosthesis may also optionally have a stent disposed proximal to the lattice. In exemplary embodiments, the fluoropolymer is expanded polytetrafluoroethylene. The composite materials exhibit high elongation while substantially retaining the strength properties of the fluoropolymer membrane. In at least one embodiment, the lattice is made of a composite material that includes a least one fluoropolymer membrane including serpentine fibrils and an elastomer. A lattice including a generally tubular member formed of a composite material including a least one fluoropolymer membrane containing serpentine fibrils and an elastomer is also provided.

Abstract: Sorbent polymer composite articles are disclosed herein. The article includes a polymer region having a constant volume, a plurality of expandable particles disposed within the polymer region, and a plurality of compressible particles disposed within the polymer region. The expandable particles and the compressible particles have a first configuration with a first total volume of the respective particles and a second configuration with a second total volume of the respective particles greater than the first total volume. The expandable particles impart a force to the compressible particles when the expandable particles transition from the first configuration to the second configuration to compress the compressible particles from the second configuration to the first configuration to maintain the constant volume of the polymer region.

Abstract: Methods for manufacturing an injector device including a barrel having a wall defining an inner surface and a stopper that is slidably received in the barrel, the stopper having an outer side engaged with the inner surface of the wall of the barrel. The methods may include modifying a stopper by directing energy through the wall of the barrel to the stopper.

Abstract: Embodiments of the present disclosure comprise occlusion and drug delivery devices and methods. One aspect of the disclosure comprises a drug delivery device comprising an inner expansion member and an outer drug delivery component. Another aspect of the disclosure comprises bioabsorbable, lumen-occluding implants.

Abstract: The invention relates to medical devices and methods of using them. The devices are prostheses which can be percutaneously deliverable with (or on) an endovascular catheter or via other surgical or other techniques and then expanded. The prostheses are configured to have a lattice resistant to dilation and creep, which is defined by a plurality of openings. The prosthesis may also optionally have a stent disposed proximal to the lattice. In exemplary embodiments, the fluoropolymer is expanded polytetrafluoroethylene. The composite materials exhibit high elongation while substantially retaining the strength properties of the fluoropolymer membrane. In at least one embodiment, the lattice is made of a composite material that includes a least one fluoropolymer membrane including serpentine fibrils and an elastomer. A lattice including a generally tubular member formed of a composite material including a least one fluoropolymer membrane containing serpentine fibrils and an elastomer is also provided.

Abstract: An occlusive device includes a covering component configured to modulate passage of blood or thrombus therethrough, and an occlusion frame that includes a plurality of elongate occlusion frame members. The elongate occlusion frame members are arranged to form a generally disc-shaped member. The occlusion frame is at least partially covered by the covering component. The device further includes an anchor frame that includes a plurality of elongate anchor frame members. The device further includes a first hub component from which the elongate frame members extend, and a second hub component from which the elongate frame members extend.

Abstract: Methods for manufacturing injector devices, including positioning a stopper of the injector device in a tubular member such that an outer side of the stopper is engaged with an inner surface of the tubular member and modifying the outer side of a stopper by causing relative motion between the stopper and the tubular member, the relative motion including one or both of rotational motion and vibrational motion.

Abstract: A stopper for use in injector devices, where the stopper having an outer side configured for engagement with an interior bore of a barrel of the injector device. The stoppers may include an elastomer body, a multi-layer barrier coupled to the elastomer body, the multi-layer barrier having an inner surface oriented toward the elastomer body and an outer surface oriented away from the elastomer body, the multi-layer barrier including a first layer and a second layer, the first layer defining the inner surface and the second layer defining the outer surface, and the multi-layer barrier having at least one micro feature formed by the first layer, the at least one micro feature including one or both of a micro groove and/or a micro rib.

Abstract: Carbon dioxide sorbent article assemblies and methods of manufacturing the same include: separable sheets of sorbent article disposed adjacent to each other to define a gap between adjacent separable sheets, the gap being maintained uniformly between opposing surfaces of adjacent separable sheets to define a passage extending between adjacent separable sheets from an inlet of the separable sheets to an outlet of the separable sheets; and a support framework supporting the separable sheets to maintain the gap, the support framework having a gap-maintaining component extending from the support framework along at least one separable sheet to maintain an initial position of the separable sheet.

Abstract: A stopper for use in an injector device, the stopper having an outer side configured for engagement with an interior bore of an injector device barrel, includes an elastomer body and a barrier coupled to the elastomer body, the barrier having an inner surface oriented toward the elastomer body and an outer surface oriented away from the elastomer body, the barrier including a first layer of a first material and a second layer of a second material, the first layer being configured to be activatable by an energy source and the second layer configured to be less activatable by the energy source than the first layer.

Abstract: An implantable containment apparatus for receiving and retaining a plurality of cells for insertion into a patient, such as into a tissue bed, is disclosed. The device includes a chamber having structural spacers therein to maintain an average distance between the first interior surface and the second interior surface of the chamber and to define at least one reservoir space for the placement of cells within the chamber.

Abstract: An additive manufacturing process is provided to produce integral 3-dimensional (3D) articles by laminating together a plurality of expanded polytetrafluoroethylene (ePTFE) membranes. The process includes repetitive cycles of ePTFE membrane lamination paired with laser cutting/bonding to produce a desired geometry based on a predefined pattern. The process may be practiced manually or may be configured to work with commercially available LOM machines/systems developed for use with other roll-to-roll processible materials, such as paper.

Abstract: Embodiments of the present disclosure relate to apparatuses, systems, and methods for percutaneous delivery of neurostimulation arrays. In an embodiment, neurostimulation lead comprises a body portion configured to transition from a collapsed delivery configuration to an expanded deployed configuration. In aspects, the expanded deployed configuration is wider than the collapsed delivery configuration. Additionally, in some embodiments, transitioning the neurostimulation lead from the collapsed delivery configuration to the expanded deployed configuration comprises unfolding or unwrapping motions that are not perpendicular to the central axis of the delivery system. In certain embodiments, the neurostimulation lead includes an array of electrodes arranged on the body portion, wherein the array of electrodes is electrically coupled to an implantable pulse generator (IPG).

Abstract: A direct air capture (DAC) device includes a shelving unit to support at least one sorbent article therein and having an upstream location and a downstream location for transporting steam. The shelving unit includes a set of support members forming a plurality of housing portions in which the sorbent article is housed. The support members include first support members extending parallel to each other in a first orientation, and second support members extending parallel to each other in a second orientation different from the first orientation.