Abstract: A method is directed to continuously, non-invasively, and directly measuring blood pressure, and includes providing a calibrated measurement device having a blood-flow control balloon and a sensor array. The method further includes placing the sensor array in a non-invasive manner over the surface of a patch of skin connected to an artery by adjoining soft tissues and inflating the blood-flow control balloon with a controlled amount of pressure. In response to the inflating of the blood-flow control balloon, changes in the artery geometry and forces are detected, via the sensor array, during a heartbeat cycle. The changes correspond to spatio-temporal signals from the artery or in the adjoining soft tissues. The spatio-temporal signals are measured and processed, via a controller, to determine blood-pressure parameters.

Abstract: Provided are compounds of Formula (I?): or pharmaceutically acceptable salts thereof, wherein the variables in the formula are as defined herein; and methods for their use and production.

Abstract: A method is directed to continuously, non-invasively, and directly measuring blood pressure, and includes providing a calibrated measurement device having a blood-flow control balloon and a sensor array. The method further includes placing the sensor array in a non-invasive manner over the surface of a patch of skin connected to an artery by adjoining soft tissues and inflating the blood-flow control balloon with a controlled amount of pressure. In response to the inflating of the blood-flow control balloon, changes in the artery geometry and forces are detected, via the sensor array, during a heartbeat cycle. The changes correspond to spatio-temporal signals from the artery or in the adjoining soft tissues. The spatio-temporal signals are measured and processed, via a controller, to determine blood-pressure parameters.

Abstract: A small to mid-scale liquefied natural gas production system and method is provided. The disclosed liquefied natural gas production system employs at least one heat exchanger, three turbine/expanders and at least three refrigerant compression stages. The expansion ratio of one turbine/expander is appreciably lower than the expansion ratio of the other turbine/expanders such that the temperature of the exhaust stream from the turbine/expander with the lower expansion ratio is above the critical point temperature of the compressed natural gas containing feed stream but colder than about ?15° C. The present system and method may be configured using either a single nitrogen-based expansion refrigerant circuit or two separate refrigerant circuits wherein the turbine/expander with the lowest expansion ratio is contained within a separate refrigeration circuit from the other two turbine/expanders with the higher expansion ratios.

Abstract: A small to mid-scale liquefied natural gas production system and method is provided. The disclosed liquefied natural gas production system employs a nitrogen-based refrigerant, at least one heat exchanger, three turbine/expanders and two or more refrigerant compression stages. The expansion ratio of one turbine/expander is appreciably lower than the expansion ratio of the other turbine/expanders such that the temperature of the exhaust stream from the turbine/expander with the lower expansion ratio is above the critical point temperature of the compressed natural gas containing feed stream but colder than ?15° C.

Abstract: A small to mid-scale liquefied natural gas production system and method is provided. The disclosed liquefied natural gas production system employs a nitrogen-based refrigerant, at least one heat exchanger, three turbine/expanders and two or more refrigerant compression stages. The expansion ratio of one turbine/expander is appreciably lower than the expansion ratio of the other turbine/expanders such that the temperature of the exhaust stream from the turbine/expander with the lower expansion ratio is above the critical point temperature of the compressed natural gas containing feed stream but colder than -15° C.

Abstract: A small to mid-scale liquefied natural gas production system and method is provided. The disclosed liquefied natural gas production system employs a nitrogen-based refrigerant, at least one heat exchanger, three turbine/expanders and two or more refrigerant compression stages. The expansion ratio of one turbine/expander is appreciably lower than the expansion ratio of the other turbine/expanders such that the temperature of the exhaust stream from the turbine/expander with the lower expansion ratio is above the critical point temperature of the compressed natural gas feed stream but colder than ?15° C.

Abstract: A system and method for liquefaction of natural gas using two distinct refrigeration circuits having compositionally different working fluids and operating at different temperature levels is provided. The turbomachinery associated with the liquefaction system are driven by a single three-pinion or four-pinion integral gear machine with customized pairing arrangements. The system and method of natural gas liquefaction further includes the conditioning of a lower pressure natural gas containing feed stream to produce a purified, compressed natural gas containing stream at a pressure equal to or above the critical pressure of natural gas and substantially free of heavy hydrocarbons to be liquefied.

Abstract: A system and method for liquefaction of natural gas using two distinct refrigeration circuits having compositionally different working fluids and operating at different temperature levels is provided. The turbomachinery associated with the liquefaction system are driven by a single three-pinion or four-pinion integral gear machine with customized pairing arrangements. The system and method of natural gas liquefaction further includes the conditioning of a lower pressure natural gas containing feed stream to produce a purified, compressed natural gas stream at a pressure equal to or above the critical pressure of natural gas and substantially free of heavy hydrocarbons to be liquefied.

Abstract: A system and method for liquefaction of natural gas using two distinct refrigeration circuits having compositionally different working fluids and operating at different temperature levels is provided. The turbomachinery associated with the liquefaction system are driven by a single three-pinion or four-pinion integral gear machine with customized pairing arrangements. The system and method of natural gas liquefaction further includes the conditioning of a lower pressure natural gas containing feed stream to produce a purified, compressed natural gas stream at a pressure equal to or above the critical pressure of natural gas and substantially free of heavy hydrocarbons to be liquefied.

Abstract: A system and method for liquefaction of natural gas using two distinct refrigeration circuits having compositionally different working fluids and operating at different temperature levels is provided. The turbomachinery associated with the liquefaction system are driven by a single three-pinion, three-turbine integral gear machine with customized pairing arrangements. The system and method of natural gas liquefaction further includes the conditioning of a lower pressure natural gas containing feed stream to produce a purified, compressed natural gas stream at a pressure equal to or above the critical pressure of natural gas and substantially free of heavy hydrocarbons to be liquefied.

Abstract: A system and method for liquefaction of natural gas containing feed stream using two distinct refrigeration circuits having compositionally different working fluids and operating at different temperature levels is provided. The turbomachinery associated with the liquefaction system are driven by a single three-pinion or four-pinion integral gear machine with customized pairing arrangements. The system and method of natural gas liquefaction further includes the conditioning of a lower pressure natural gas containing feed stream to produce a purified, compressed natural gas containing stream at a pressure equal to or above the critical pressure of natural gas and substantially free of heavy hydrocarbons to be liquefied.

Abstract: A system and method for liquefaction of natural gas using two distinct refrigeration circuits having compositionally different working fluids and operating at different temperature levels is provided. The turbomachinery associated with the liquefaction system are driven by a single three-pinion, three-turbine integral gear machine with customized pairing arrangements. The system and method of natural gas liquefaction further includes the conditioning of a lower pressure natural gas feed stream to produce a purified, compressed natural gas stream at a pressure equal to or above the critical pressure of natural gas and substantially free of heavy hydrocarbons to be liquefied.

Abstract: An example adaptive tooling system is provided that includes an adaptive base plate assembly and a tool base assembly selectively engageable with each other. The adaptive base plate assembly includes a base plate with holes formed therein, and location pins attached to the base plate via the holes. The tool base assembly includes a central support member, first and second lock plates, and a latch pivotably disposed relative to the central support member. The first and second lock plates include an opening formed therein. The opening of the lock plates is configured to at least partially receive first and second location pins of the location pins of the adaptive base plate assembly. The latch is configured to releasably engage with a third location pin of the location pins of the adaptive base plate assembly to releasably engage the tool base assembly with the adaptive base plate assembly.

Abstract: Methods and systems for estimating recall while screening an ordered list of bibliographic references are provided. According to one embodiment, a method includes: sorting a list of bibliographic references according to a sorting algorithm to produce a first list in order from most to least relevant; selecting, from the list, the most relevant reference, and displaying, to a human screener, information associated with the selected reference; and receiving the screener's judgment of the relevance of the selected reference. If sufficiently relevant, the selected reference is moved from the first list to a second list. The received indication is used to re-sort the remaining references in the first list. A statistical model is used to estimate the number of relevant references remaining. That estimate is displayed to the screener. The process ends when the screener determines, based on the displayed estimate, that a sufficient number of relevant references has been found.

Abstract: A method is directed to continuously, non-invasively, and directly measuring blood pressure, and includes providing a calibrated measurement device having a blood-flow control balloon and a sensor array. The method further includes placing the sensor array in a non-invasive manner over the surface of a patch of skin connected to an artery by adjoining soft tissues and inflating the blood-flow control balloon with a controlled amount of pressure. In response to the inflating of the blood-flow control balloon, changes in the artery geometry and forces are detected, via the sensor array, during a heartbeat cycle. The changes correspond to spatio-temporal signals from the artery or in the adjoining soft tissues. The spatio-temporal signals are measured and processed, via a controller, to determine blood-pressure parameters.

Abstract: An example adaptive tooling system is provided that includes an adaptive base plate assembly and a tool base assembly selectively engageable with each other. The adaptive base plate assembly includes a base plate with holes formed therein, and location pins attached to the base plate via the holes. The tool base assembly includes a central support member, first and second lock plates, and a latch pivotably disposed relative to the central support member. The first and second lock plates include an opening formed therein. The opening of the lock plates is configured to at least partially receive first and second location pins of the location pins of the adaptive base plate assembly. The latch is configured to releasably engage with a third location pin of the location pins of the adaptive base plate assembly to releasably engage the tool base assembly with the adaptive base plate assembly.

Abstract: A system of a leading locomotive with a reduced complement of onboard Positive Train Control (PTC) equipment leveraging a full complement of PTC equipment in a trailing locomotive, while operating in a PTC territory. The system can be applied to a push-pull passenger train, wherein the cab car has the reduced complement of onboard PTC equipment and the locomotive has the full complement, whereby the train is operable in both directions in a PTC territory. The system can also serve as an expedient repair of a leading locomotive with failed onboard PTC equipment by leveraging the functional PTC equipment in another locomotive in the consist. The same leveraging principle can allow a PTC-equipped locomotive to operate in a non-interoperable PTC territory. Considerable cost savings are achieved compared to the prior art practice of fully equipping all locomotives and cab cars with a full PTC installation.

Abstract: The present disclosure relates to a system and method for linking GUI plug-ins with multiple data providers. Embodiments may include allowing, via one or more computing devices, at least one data provider access to a data abstraction layer. Embodiments may further include allowing at least one GUI plug-in access to the data abstraction layer and receiving, at the data abstraction layer, a query from the at least one GUI plug-in. In response to the query, embodiments may include retrieving one or more data sets from the at least one data provider and aggregating a subset of the one or more data sets from the at least one data provider. Embodiments may further include providing the subset of the one or more data sets to the at least one GUI plug-in.

Abstract: A method of quantizing a floating point machine learning network to obtain a fixed point machine learning network using a quantizer may include selecting at least one moment of an input distribution of the floating point machine learning network. The method may also include determining quantizer parameters for quantizing values of the floating point machine learning network based at least in part on the at least one selected moment of the input distribution of the floating point machine learning network to obtain corresponding values of the fixed point machine learning network.