Patents by Inventor Edward J. Rebar

Edward J. Rebar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • REGULATION OF GENE EXPRESSION USING ENGINEERED NUCLEASES
    Publication number: 20200131490
    Abstract: The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a hematopoietic cell.
    Type: Application
    Filed: January 9, 2020
    Publication date: April 30, 2020
    Inventors: Jeffrey C. Miller, Edward J. Rebar
  • Regulation of gene expression using engineered nucleases
    Patent number: 10563184
    Abstract: The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a hematopoietic cell.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: February 18, 2020
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Jeffrey C. Miller, Edward J. Rebar
  • METHODS AND COMPOSITIONS FOR TREATING HUNTINGTON'S DISEASE
    Publication number: 20200030408
    Abstract: Disclosed herein are compositions comprising non-naturally occurring zinc finger domains, fusion proteins comprising these zinc finger domains, polynucleotides encoding these proteins, cells expressing these proteins and pharmaceutical compositions comprising these proteins or polynucleotides as well as methods of modifying an Htt gene using these compositions for treating or preventing Huntington's Disease.
    Type: Application
    Filed: September 30, 2019
    Publication date: January 30, 2020
    Inventors: Jeffrey C. Miller, Edward J. Rebar, H. Steve Zhang
  • HTT REPRESSORS AND USES THEREOF
    Publication number: 20200002390
    Abstract: Disclosed herein are Htt repressors and methods and compositions for use of these Htt repressors.
    Type: Application
    Filed: August 26, 2019
    Publication date: January 2, 2020
    Inventors: Steven Froelich, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang
  • METHODS AND COMPOSITIONS FOR TREATING HEMOPHILIA
    Publication number: 20190345208
    Abstract: Disclosed herein are methods and compositions for insertion of transgene sequences encoding proteins involved in clotting into the genome of a cell for treating conditions including hemophilias.
    Type: Application
    Filed: July 26, 2019
    Publication date: November 14, 2019
    Inventors: Jeffrey C. Miller, David Paschon, Edward J. Rebar
  • Methods and compositions for treating Huntington's disease
    Patent number: 10471123
    Abstract: Disclosed herein are compositions comprising non-naturally occurring zinc finger domains, fusion proteins comprising these zinc finger domains, polynucleotides encoding these proteins, cells expressing these proteins and pharmaceutical compositions comprising these proteins or polynucleotides as well as methods of modifying an Htt gene using these compositions for treating or preventing Huntington's Disease.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: November 12, 2019
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Jeffrey C. Miller, Edward J. Rebar, H. Steve Zhang
  • ZINC FINGER PROTEIN COMPOSITIONS FOR MODULATION OF HUNTINGTIN (HTT)
    Publication number: 20190322711
    Abstract: The present disclosure is in the field of modulation of Htt gene expression and HTT protein levels.
    Type: Application
    Filed: April 17, 2019
    Publication date: October 24, 2019
    Inventors: Steven Froelich, Ignacio Munoz-Sanjuan, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang
  • HTT repressors and uses thereof
    Patent number: 10435441
    Abstract: Disclosed herein are Htt repressors and methods and compositions for use of these Htt repressors.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: October 8, 2019
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Steven Froelich, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang
  • Methods and compositions for treating hemophilia
    Patent number: 10407476
    Abstract: Disclosed herein are methods and compositions for insertion of transgene sequences encoding proteins involved in clotting into the genome of a cell for treating conditions including hemophilias.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: September 10, 2019
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Jeffrey C. Miller, David Paschon, Edward J. Rebar
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF LYSOSOMAL STORAGE DISEASES
    Publication number: 20190224246
    Abstract: Nucleases and methods of using these nucleases for inserting a sequence encoding a therapeutic protein such as an enzyme into a cell, thereby providing proteins or cell therapeutics for treatment and/or prevention of a lysosomal storage disease.
    Type: Application
    Filed: April 2, 2019
    Publication date: July 25, 2019
    Inventor: Edward J. Rebar
  • METHODS AND COMPOSITIONS FOR REGULATION OF TRANSGENE EXPRESSION
    Publication number: 20190218560
    Abstract: Nucleases and methods of using these nucleases for expressing a transgene from a safe harbor locus in a secretory tissue, and clones and animals derived therefrom.
    Type: Application
    Filed: April 3, 2019
    Publication date: July 18, 2019
    Inventor: Edward J. Rebar
  • Modified zinc finger binding proteins
    Patent number: 10344271
    Abstract: Disclosed herein are compositions and method comprising non-canonical (e.g., non-C2H2) zinc finger proteins.
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: July 9, 2019
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Edward J. Rebar, Andrew Jamieson
  • METHODS AND COMPOSITIONS FOR TREATING HUNTINGTON'S DISEASE
    Publication number: 20190183970
    Abstract: Disclosed herein are compositions comprising non-naturally occurring zinc finger domains, fusion proteins comprising these zinc finger domains, polynucleotides encoding these proteins, cells expressing these proteins and pharmaceutical compositions comprising these proteins or polynucleotides as well as methods of modifying an Htt gene using these compositions for treating or preventing Huntington's Disease.
    Type: Application
    Filed: March 4, 2019
    Publication date: June 20, 2019
    Inventors: Jeffrey C. Miller, Edward J. Rebar, H. Steve Zhang
  • REGULATION OF GENE EXPRESSION USING ENGINEERED NUCLEASES
    Publication number: 20190177709
    Abstract: The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a hematopoietic cell.
    Type: Application
    Filed: February 21, 2019
    Publication date: June 13, 2019
    Inventors: Jeffrey C. Miller, Edward J. Rebar
  • NOVEL DNA-BINDING PROTEINS AND USES THEREOF
    Publication number: 20190169640
    Abstract: Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
    Type: Application
    Filed: February 12, 2019
    Publication date: June 6, 2019
    Inventors: Philip D. Gregory, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Siyuan Tan, Fyodor Urnov, Lei Zhang
  • Methods and compositions for the treatment of lysosomal storage diseases
    Patent number: 10293000
    Abstract: Nucleases and methods of using these nucleases for inserting a sequence encoding a therapeutic protein such as an enzyme into a cell, thereby providing proteins or cell therapeutics for treatment and/or prevention of a lysosomal storage disease.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: May 21, 2019
    Assignee: Sangamo Therapeutics, Inc.
    Inventor: Edward J. Rebar
  • Methods and compositions for treating Huntington's Disease
    Patent number: 10265377
    Abstract: Disclosed herein are compositions comprising non-naturally occurring zinc finger domains, fusion proteins comprising these zinc finger domains, polynucleotides encoding these proteins, cells expressing these proteins and pharmaceutical compositions comprising these proteins or polynucleotides as well as methods of modifying an Htt gene using these compositions for treating or preventing Huntington's Disease.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: April 23, 2019
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Jeffrey C. Miller, Edward J. Rebar, H. Steve Zhang
  • DNA-binding proteins and uses thereof
    Patent number: 10253333
    Abstract: Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: April 9, 2019
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Philip D. Gregory, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Siyuan Tan, Fyodor Urnov, Lei Zhang
  • Methods and compositions for treatment of a genetic condition
    Patent number: 10196652
    Abstract: Methods and compositions comprising a CRISPR/Cas nuclease that cleaves a T cell receptor (TCR) gene and/or human leukocyte (HLA) gene, the nuclease comprising a cleavage domain and a single guide RNA that binds to a target site in the TCR and/or HLA gene.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: February 5, 2019
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Anthony Conway, Gregory J. Cost, Russell Dekelver, Edward J. Rebar, Andreas Reik, Fyodor Urnov, Jianbin Wang, H. Steve Zhang
  • Methods and compositions for treatment of a genetic condition
    Patent number: 10196651
    Abstract: Methods and compositions comprising a CRISPR/Cas nuclease that cleaves a BCL11A gene for the modification of the BCL11A gene and for modification of globin expression.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: February 5, 2019
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Anthony Conway, Gregory J. Cost, Russell Dekelver, Edward J. Rebar, Andreas Reik, Fyodor Urnov, Jianbin Wang, H. Steve Zhang