Patents by Inventor Edward J. Rebar

Edward J. Rebar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA-binding proteins and uses thereof
    Patent number: 9783827
    Abstract: Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: October 10, 2017
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Philip D. Gregory, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Siyuan Tan, Fyodor Urnov, Lei Zhang
  • Methods and compositions for regulation of transgene expression
    Patent number: 9777281
    Abstract: Nucleases and methods of using these nucleases for expressing a transgene from a safe harbor locus in a secretory tissue, and clones and animals derived therefrom.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: October 3, 2017
    Assignee: Sangamo Therapeutics, Inc.
    Inventor: Edward J. Rebar
  • Methods and compositions for treating hemophilia
    Patent number: 9771403
    Abstract: Disclosed herein are methods and compositions for insertion of transgene sequences encoding proteins involved in clotting into the genome of a cell for treating conditions including hemophilias.
    Type: Grant
    Filed: December 9, 2014
    Date of Patent: September 26, 2017
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Jeffrey C. Miller, David Paschon, Edward J. Rebar
  • COMPOSITIONS FOR LINKING DNA-BINDING DOMAINS AND CLEAVAGE DOMAINS
    Publication number: 20170218349
    Abstract: Disclosed herein are compositions for linking DNA binding domains and cleavage domains (or cleavage half-domains) to form non-naturally occurring nucleases with alternative configurations. Also described are methods of making and using compositions comprising these linkers.
    Type: Application
    Filed: December 15, 2016
    Publication date: August 3, 2017
    Inventors: Jeffrey C. Miller, David Paschon, Edward J. Rebar
  • Methods and compositions for treatment of a genetic condition
    Patent number: 9650648
    Abstract: Methods and compositions for a genetic disease are provided.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: May 16, 2017
    Assignee: SANGAMO BIOSCIENCES, INC.
    Inventors: Gregory J. Cost, Philip D. Gregory, Dmitry Guschin, Michael C. Holmes, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Andreas Reik, Fyodor Urnov, Lei Zhang
  • HTT REPRESSORS AND USES THEREOF
    Publication number: 20170096460
    Abstract: Disclosed herein are Htt repressors and methods and compositions for use of these Htt repressors.
    Type: Application
    Filed: September 23, 2016
    Publication date: April 6, 2017
    Inventors: Steven Froelich, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang
  • METHODS AND COMPOSITIONS FOR TREATING HUNTINGTON'S DISEASE
    Publication number: 20170035839
    Abstract: Disclosed herein are compositions comprising non-naturally occurring zinc finger domains, fusion proteins comprising these zinc finger domains, polynucleotides encoding these proteins, cells expressing these proteins and pharmaceutical compositions comprising these proteins or polynucleotides as well as methods of modifying an Htt gene using these compositions for treating or preventing Huntington's Disease.
    Type: Application
    Filed: October 14, 2016
    Publication date: February 9, 2017
    Inventors: Jeffrey C. Miller, Edward J. Rebar, H. Steve Zhang
  • NOVEL DNA-BINDING PROTEINS AND USES THEREOF
    Publication number: 20170016030
    Abstract: Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
    Type: Application
    Filed: October 3, 2016
    Publication date: January 19, 2017
    Inventors: Philip D. Gregory, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Siyuan Tan, Fyodor Urnov, Lei Zhang
  • Engineered transcription activator like effector (TALE) proteins
    Patent number: 9522936
    Abstract: Disclosed herein are methods and compositions for design and use of engineered TALEs.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: December 20, 2016
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Jeffrey C. Miller, Edward J. Rebar
  • Methods and compositions for treating Huntington's disease
    Patent number: 9499597
    Abstract: Disclosed herein are compositions comprising non-naturally occurring zinc finger domains, fusion proteins comprising these zinc finger domains, polynucleotides encoding these proteins, cells expressing these proteins and pharmaceutical compositions comprising these proteins or polynucleotides as well as methods of modifying an Htt gene using these compositions for treating or preventing Huntington's Disease.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: November 22, 2016
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Jeffrey C. Miller, Edward J. Rebar, H. Steve Zhang
  • DNA-binding proteins and uses thereof
    Patent number: 9493750
    Abstract: Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: November 15, 2016
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Philip D. Gregory, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Siyuan Tan, Fyodor Urnov, Lei Zhang
  • Modified DNA-binding proteins and uses thereof
    Patent number: 9458205
    Abstract: Disclosed herein are enhanced polypeptides, polynucleotides encoding these polypeptides, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: October 4, 2016
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Philip D. Gregory, Jeffrey C Miller, David Paschon, Edward J. Rebar, Siyuan Tan, Fyodor Urnov, Lei Zhang
  • MODIFIED ZINC FINGER BINDING PROTEINS
    Publication number: 20160222364
    Abstract: Disclosed herein are compositions and method comprising non-canonical (e.g., non-C2H2) zinc finger proteins.
    Type: Application
    Filed: January 7, 2016
    Publication date: August 4, 2016
    Inventors: Edward J. Rebar, Andrew Jamieson
  • Methods and compositions for regulation of transgene expression
    Patent number: 9394545
    Abstract: Nucleases and methods of using these nucleases for expressing a transgene from a safe harbor locus in a secretory tissue, and clones and animals derived therefrom.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: July 19, 2016
    Assignee: Sangamo BioSciences, Inc.
    Inventor: Edward J. Rebar
  • DNA-binding proteins and uses thereof
    Patent number: 9322005
    Abstract: Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: April 26, 2016
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Philip D. Gregory, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Siyuan Tan, Fyodor Urnov, Lei Zhang
  • METHODS AND COMPOSITIONS FOR TREATMENT OF A GENETIC CONDITION
    Publication number: 20160090607
    Abstract: Methods and compositions comprising single guide RNAs targeted to endogenous gene for genetic alteration of cells are provided.
    Type: Application
    Filed: December 10, 2015
    Publication date: March 31, 2016
    Inventors: Anthony Conway, Gregory J. Cost, Russell DeKelver, Edward J. Rebar, Andreas Reik, Fyodor Urnov, Jianbin Wang, H. Steve Zhang
  • METHODS AND COMPOSITIONS FOR TREATING TRINUCLEOTIDE REPEAT DISORDERS
    Publication number: 20160082081
    Abstract: Disclosed herein are methods and compositions for treating trinucleotide repeat disorders.
    Type: Application
    Filed: December 4, 2015
    Publication date: March 24, 2016
    Inventors: Philip D. Gregory, Edward J. Rebar, H. Steve Zhang
  • METHODS AND COMPOSITIONS FOR THE TREATMENT OF LYSOSOMAL STORAGE DISEASES
    Publication number: 20160060656
    Abstract: Nucleases and methods of using these nucleases for inserting a sequence encoding a therapeutic protein such as an enzyme into a cell, thereby providing proteins or cell therapeutics for treatment and/or prevention of a lysosomal storage disease.
    Type: Application
    Filed: October 1, 2015
    Publication date: March 3, 2016
    Inventor: Edward J. Rebar
  • Targeted integration and expression on exogenous nucleic acid sequences
    Patent number: 9260726
    Abstract: Disclosed herein are methods and compositions for targeted integration of a exogenous sequence into a predetermined target site in a genome for use, for example, in protein expression and gene inactivation.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: February 16, 2016
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Philip D. Gregory, Michael C. Holmes, Edward J. Rebar, Fyodor Urnov
  • Engineered zinc finger proteins for treating trinucleotide repeat disorders
    Patent number: 9234016
    Abstract: Disclosed herein are methods and compositions for treating trinucleotide repeat disorders.
    Type: Grant
    Filed: July 28, 2010
    Date of Patent: January 12, 2016
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Philip D. Gregory, Edward J. Rebar, H. Steve Zhang