Abstract: A method for delivering a biologic to a human with Alzheimer's-related dementia, comprising administering the biologic parenterally into the perispinal space of the human without direct intrathecal injection, and thereafter positioning the human's head below the horizontal. The method further includes delivering a TNF antagonist to the brain of a human for treating mild cognitive impairment, Alzheimer's related dementia, or vascular dementia, comprising administering the TNF antagonist golimumab parenterally into the perispinal space of the human without direct intrathecal injection, and thereafter positioning the human in a Trendelenburg position, for delivery of the golimumab to the brain via the human's vertebral venous system.

Abstract: This application concerns novel methods which enable or improve the ability of molecules, particularly large molecules, to cross the blood-brain barrier, the blood-eye barrier, and/or the blood-nerve barrier and therefore be of improved diagnostic and/or therapeutic use in humans and other mammals. These methods involve perispinal administration of imaging agents without direct intrathecal injection. Perispinal administration is defined as administration of the molecule into the anatomic area within 10 cm of the spine. Perispinal administration results in absorption of the imaging agent into the vertebral venous system.

Abstract: A message tracker having a transfer monitor, a set of registers, and at least one arithmetic unit increases performance and reliability when transmitting or receiving messages within a computer system. A set of message parameters such as a current address, a remaining length, and a communicated length are stored within the set of registers. The transfer monitor observes data transfers on a multi-tenant bus in order to detect data transfers related to the message and provide an update signal. The message parameters within the registers are updated in response to the update signal. The process of detecting and updating is repeated until the entire message is transferred, and the message tracker then informs a control processor or process that communication of the message has occurred. To facilitate message coalescing, several message trackers may share a message queue that is configured to store message parameters corresponding to completed messages.

Abstract: Some embodiments include reception of a first instruction to enter an imaging mode, and, in response to the first instruction, automatic performance of at least one of: reduction of a focal spot size of a radiation beam, movement of a flattening filter out of a path of the radiation beam, replacement of a first target for photon emission with a second target for photon emission, or movement of a scatter-reducing filter into the path of the radiation beam. Embodiments may further include reception of a second instruction to enter a first radiation treatment mode, and, in response to the second instruction, automatic performance at least one of: increase of a focal spot size of the radiation beam, movement of the flattening filter into the path of the radiation beam, replacement of the second target with the first target, or movement of the scatter-reducing filter out of the path of the radiation beam.

Abstract: A method and system for imaging a workstation (or other device) and then associating that image with a specific device are disclosed. The present invention enables an administrator to take an image of a basic workstation (with minimum or no applications) and then when the image is downloaded to the workstation, the service may look into a Directory and download with the image the set of files associated with an Application Object that has been associated with the image in the Directory. Another embodiment of the present invention further provides a method and system for applying an image to a workstation that had never been imported into the tree. A rules-based system may be implemented to enable one or more workstations that are booting to find the image and have it applied.

Abstract: The present invention is an improvement upon the process for the production of 1,3-propanediol wherein an aqueous solution of 3-hydroxy propanal is formed, catalyst, if any, used in said formation is removed from the solution, sodium hydroxide is added to the solution to neutralize any acid therein such that the pH is at least about 5, the neutralized aqueous solution is subjected to hydrogenation to produce a crude 1,3-propanediol mixture which is distilled to produce 1,3-propanediol, water, and reactive heavy components. The improvement on this process comprises replacing the sodium hydroxide with a hydroxide selected from the group consisting of ammonium hydroxide, alkali metal hydroxides other than sodium hydroxide, and alkaline earth metal hydroxides to reduce the viscosity of the reactive heavy components.

Abstract: Some embodiments include a particle source, an RF power source, an accelerator waveguide, and an imaging device. The particle source is to generate a first injector current and a second injector current, the first injector current being less than the second injector current. The RF power source is to generate first RF power at a first pulse rate and second RF power at a second pulse rate, the first pulse rate being greater than the second pulse rate. The accelerator waveguide is to accelerate a first electron beam based on the first injector current and the first RF power and to accelerate a second electron beam based on the second injector current and the second RF power, and the imaging device is to acquire an image based on the first electron beam. The second electron beam may be used to deliver treatment radiation to a patient.

Abstract: A system and method for registering a workstation. The system enables a client to locate an import service for importing workstation information using the domain name system (DNS). A client may send registration information to the import service after locating the import service using the DNS. The import service may then create a workstation object based on at least a portion of the registration information. The import service may then forward the workstation object to the client for registering the workstation.

Abstract: A connector for a spinal alignment system includes a base, a hook, a guide aperture, and a locking portion. The base includes a channel extending therethrough to receive a fixation rod. The hook extends from the base. The guide aperture is adapted to receive a bone fastener and the locking portion is adapted to engage the bone fastener. The guide aperture extends through one of the base and the hook and the locking portion is located in the other of the base and the hook. The locking portion is coaxial with the guide aperture such that the guide aperture guides a shaft of the bone fastener into alignment with the locking portion when the bone fastener is received by the guide aperture. The bone fastener cooperates with the base and hook to form a tension band construct that resists opposing forces acting on the construct. A rod locking fastener engages the channel and the fixation rod to secure the fixation rod in the channel.

Abstract: A spoke-mounted, motion-activated light rod having a transparent column-shaped portion with irregularly spaced voids therein. An end cap has a receiving well for receiving an end of the transparent column and an attachment clip for attachment to a spoke during use. A body providing a component compartment has a rod receiving portion having a second receiving well for receiving an end of the transparent column and an attachment stem extending outwardly from the back having a spoke slot in axial alignment with the attachment clip of the end cap for receiving the spoke. The rod receiving portion has a light source compartment in axial alignment with the second receiving well for receiving an LED within the light source compartment that is cyclically activated by a motion-actuated switch. Illumination from the LED illuminates the transparent column and deflects off the voids therein.

Abstract: Devices including conductometric porous silicon gas sensors, methods of fabricating conductometric porous silicon gas sensors, methods of selecting a device, methods of detecting a concentration of a gas, and methods of analyzing data.

Abstract: The Invention encompasses a system comprising a novel Volume Purchase Rebate Business Method, Volume Purchase Rebate Appliance sub-system, Volume Purchase Rebate Online-Interactive Showroom sub-system, Volume Purchase Rebate Online-Interactive Showcase sub-system, Volume Purchase Rebate Online-Interactive SalesPerson sub-system and Online-Interactive Ordering or Online-Interactive Re-Ordering sub-systems, and methods and processes for purchasing or volume purchasing or excess inventory purchasing or excess capacity purchasing for a plurality of purchasers who are in fact group purchasing yet purchasing individually from merchants for goods, products and services and obtaining and investing rebates while purchasing over the counter or real-time interactive online direct ordering and automatic re-ordering of said goods and services.

Abstract: A liquid-activated lighted ice cube includes a battery-powered electrical circuit and LED housed in a hollow body that resembles an ice cube. The circuit includes electrodes exposed to the exterior of the hollow body that, when in contact with water or other liquid beverage, cause the circuit to turn on the LED and illuminate the beverage.

Abstract: A motion-activated valve stem light comprising a housing adapted to fit securely on a valve stem of a vehicle wheel, and a light circuit contained within the housing, the light circuit including an LED, a battery power source, a control circuit connected to the power source and the LED, and a self-contained motion switch connected to an input of the control circuit, wherein the motion switch includes a sealed case, e.g., a button cell case, having first and second conductive terminal portions, an electrical insulator between the terminal portions, and a BB or other conductive member freely movable within the case and adapted to electrically interconnect the conductive terminal portions at a plurality of spaced points within the case.

Abstract: The present invention provides specific methods of using and administering etanercept to improve cognitive function in a human, for both the treatment and prevention of cognitive impairment, or, alternatively, to enhance cognitive function in three different broad categories of conditions: 4. Cognitive impairment which is characteristic of certain neurological disorders (for example Alzheimer's Disease, Idiopathic Dementia, and Traumatic Brain Injury); 5. Cognitive impairment which accompanies certain systemic or localized non-neurological conditions which are known or suspected to be associated with increased TNF (for example rheumatoid arthritis, psoriasis, and cancer cachexia); and 6. To enhance cognitive function in individuals in whom there is either no brain pathology or in whom the existence of brain pathology is either unknown or undefined, including a human without known disease.

Abstract: Methods for treating neurological or neuropsychiatric diseases or disorders in humans by administering to the human a therapeutically effective dose of specific biologics are presented. The biologics of consideration include antagonists of tumor necrosis factor or of interleukin-1. The administration of these biologics is performed by specific methods, most, but not all of which fall into the category of anatomically localized administration designed for perispinal use. Anatomically localized administration involving perispinal use includes, but is not limited to the subcutaneous, intramuscular, interspinous, epidural, peridural, parenteral or intrathecal routes. Additonally, intranasal administration is discussed as a method to provide therapeutic benefit.

Abstract: A method and apparatus for cache coherency in storage system is disclosed. The invention maintains cache coherency in the controller system of the storage system in a manner to minimize the performance degradation to a host system, and to allow the caches to be coherent without requiring data to be written to the backing disks. Each controller manages an area of memory on the partner controller, but the area is managed dynamically and is done with the information about the partner controller. A first controller determines which mirror cache line on a second controller to copy data into, and then mirrors the data from a first controller cache line to a second controller cache line. A message is sent from the first controller to the second controller informing the second controller of cache meta data associated with the mirror cache line so that the cache line may be added to the second controller's hash table.

Abstract: A system, method, and process that determine and automatically correct registration errors between printed objects and mechanically produced objects using advanced image processing techniques is disclosed. Means are also presented for maintaining all registered functions to within very close tolerances during normal running, with other means for rapidly obtaining initial registration with substantial savings in material waste. The disclosed system and method/process are compatible with the printing and converting industry in which rolls of material are processed by printing a number of colors that require close registration especially in pictorial representation. These roll-fed printing machines are quite versatile and in addition to the printing of any number of colors on both front and back can perform any number of additional operations on the printed web at the same time.