Patents by Inventor Edward Semple

Edward Semple has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Non-covalent inhibitors of urokinase and blood vessel formation
    Patent number: 6586405
    Abstract: Novel compounds having activity as non-covalent inhibitors of urokinase and having activity in reducing or inhibiting blood vessel formation are provided. These compounds have P1 a group having an amidino or guanidino moiety or derivative thereof. These compounds are useful in vitro for monitoring plasminogen activator levels and in vivo in treatment of conditions which are ameliorated by inhibition of or decreased activity of urokinase and in treating pathologic conditions wherein blood vessel formation is related to a pathologic condition.
    Type: Grant
    Filed: December 7, 2000
    Date of Patent: July 1, 2003
    Assignee: Corvas International, Inc.
    Inventors: Joseph Edward Semple, Michael I. Weinhouse, Odile Esther Levy, Edwin L. Madison, Amir P. Tamiz
  • Novel non-convalent thrombin inhibitors
    Publication number: 20030092679
    Abstract: The present invention provides compounds which have a pyrazinone or pyridinone ring at P3 and an optionally substituted heteroaryl group at P1. These compounds have biological activity as active and potent inhibitors of thrombin. Their pharmaceutically acceptable salts, pharmaceutical compositions thereof and methods of using these compounds and pharmaceutical compositions comprising these compounds as therapeutic agents for treatment of disease states in mammals which are characterized by abnormal thrombosis are also described.
    Type: Application
    Filed: July 13, 2001
    Publication date: May 15, 2003
    Inventors: Daniel Vanna Siev, Joseph Edward Semple, Mallareddy Komandla, John Eugene Reiner, Scott Jeffrey Kemp
  • Thrombin inhibitors having a lactam at P3
    Patent number: 6541467
    Abstract: The present invention provides compounds having a lactam ring at P3 and at P1 have a six-membered heterocyclic ring having two ring nitrogen ring atoms and the remainder of the ring atoms carbon atoms. These compounds have biological activity as active and potent inhibitors of thrombin. Their pharmaceutically acceptable salts, pharmaceutical compositions thereof and methods of using these compounds and pharmaceutical compositions comprising these compounds as therapeutic agents for treatment of disease states in mammals which are characterized by abnormal thrombosis are also described.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: April 1, 2003
    Assignee: Corvas International, Inc.
    Inventors: Jonathan Zhanqi Ho, Joseph Edward Semple
  • Substituted hydrazinyl heteroaromatic inhibitors of thrombin
    Patent number: 6506761
    Abstract: Compound of the invention are active as inhibitors of Thrombin and are useful in treating disease states in mammals which are characterized by abnormal thrombosis and have the following structure: as described herein.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: January 14, 2003
    Assignee: Corvas International, Inc.
    Inventors: Gian Luca Araldi, Joseph Edward Semple
  • Non-covalent thrombin inhibitors
    Patent number: 6506754
    Abstract: The present invention provides compounds which have a pyrazinone or pyridinone ring at P3 and which feature a six member heterocyclic ring having two ring nitrogen atoms and the remainder of the ring atoms carbon atoms at P1. These compounds have biological activity as active and potent inhibitors of thrombin. Their pharmaceutically acceptable salts, pharmaceutical compositions thereof and methods of using these compounds and pharmaceutical compositions comprising these compounds as therapeutic agents for treatment of disease states in mammals which are characterized by abnormal thrombosis are also described.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: January 14, 2003
    Assignee: Corvas International, Inc.
    Inventors: Daniel Vanna Siev, Gian Luca Araldi, Jonathan Zhanqi Ho, John Eugene Reiner, Joseph Edward Semple
  • Substituted hydrazinyl heteroaromatic inhibitors of thrombin
    Patent number: 6506760
    Abstract: Compounds of the invention are active as inhibitors of Thrombin and are useful in treating disease states in mammals which are characterized by abnormal thrombosis and have the following structure: as described herein.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: January 14, 2003
    Assignee: Corvas International, Inc.
    Inventors: Gian Luca Araldi, Joseph Edward Semple
  • Compounds, compositions and methods for treatment of parasitic infections
    Publication number: 20020107266
    Abstract: Compounds and pharmaceutical compositions useful as anti-parasitic agents agents, particularly in the treatment, prevention or amelioration of one or more symptoms of malaria or Chagas' disease, are provided. In particular, methods of modulating the activity of falcipain or cruzain, preferably inhibiting falcipain or cruzain, with the compounds and compositions are provided.
    Type: Application
    Filed: December 11, 2001
    Publication date: August 8, 2002
    Inventors: Marguerita Lim-Wilby, Joseph Edward Semple, Michael I. Weinhouse, Erick A. Goldman, Gian L. Araldi
  • Non-covalent inhibitors of urokinase and blood vessel formation
    Publication number: 20020037857
    Abstract: Novel compounds having activity as non-covalent inhibitors of urokinase and having activity in reducing or inhibiting blood vessel formation are provided. These compounds have Pi a group having an amidino or guanidino moiety or derivative thereof. These compounds are useful in vitro for monitoring plasminogen activator levels and in vivo in treatment of conditions which are ameliorated by inhibition of or decreased activity of urokinase and in treating pathologic conditions wherein blood vessel formation is related to a pathologic condition.
    Type: Application
    Filed: December 7, 2000
    Publication date: March 28, 2002
    Applicant: Corvas International, Inc.
    Inventors: Joseph Edward Semple, Michael I. Weinhouse, Odile Esther Levy, Edwin L. Madison, Amir P. Tamiz
  • Aromatic heterocyclic derivatives as enzyme inhibitors
    Patent number: 6342504
    Abstract: The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.
    Type: Grant
    Filed: December 21, 1999
    Date of Patent: January 29, 2002
    Assignee: Corvas International, Inc.
    Inventors: Terence Kevin Brunck, Susan Y. Tamura, Joseph Edward Semple, Robert John Ardecky, Yu Ge, William Charles Ripka
  • Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors (II)
    Patent number: 6204384
    Abstract: The present invention provides peptide aldehydes having an 3-amino-2-hydro yenyl acetamide group as part of the peptide backbone d an arginine group or analog at P1. These compounds e potent and specific or inhibitors of thrombin. Ther pharmaceutically acceptable salts, pharmaceutic ly acceptable compositions thereof, and methods of using t as therapeutic agents for disease states in mammals charachterized by abnormal thrombosis are also described. Also described are 3-amino-2-hydroxyphenyl-acetamide derivatives having in history activity towards proteases of the trypsin/chymotrypsin class.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: March 20, 2001
    Assignee: Corvas International, Inc.
    Inventors: Joseph Edward Semple, Marguerita S. Lim-Wilby, Terence K. Brunck
  • 3-amino-2-oxo-1-piperidnercetic derivatives as enzyme inhibitors
    Patent number: 6034215
    Abstract: The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: March 7, 2000
    Assignee: Corvas International, Inc.
    Inventors: Joseph Edward Semple, Robert John Ardecky, Ruth Foelsche Nutt, William Charles Ripka, David C. Rowley, Marguerita S. L. Lim-Wilby, Terence Kevin Brunck
  • Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors
    Patent number: 6011047
    Abstract: The present invention provides peptide aldehydes having a 3-amino-2-hydroxyphyenyl-acetamide group as part of the peptide backbone and an arginine mimic group such as an amidinopiperidine or amidinophenyl tail. These compounds are potent and specific inhibitors of thrombin. Their pharmaceutically salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis are also described. Also described are 3-amino-2-hydroxyphenyl-acetamide derivatives having inhibitory activity toward proteases of the trypsin/chymotrypsin class.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: January 4, 2000
    Assignee: Corvas International Inc.
    Inventors: Joseph Edward Semple, Marguerita S. Lim-Wilby, Terence K. Brunck
  • Aromatic heterocyclic derivatives as enzyme inhibitors
    Patent number: 6011158
    Abstract: The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.
    Type: Grant
    Filed: June 7, 1996
    Date of Patent: January 4, 2000
    Assignee: Corvas International, Inc.
    Inventors: Susan Yoshiko Tamura, Joseph Edward Semple, William Charles Ripka, Robert John Ardecky, Yu Ge, Stephen H. Carpenter, Terence K. Brunck, Marguerita S. L. Lim-Wilby, Ruth F. Nutt, Matthew M. Abelman
  • Aromatic hetherocyclic derivatives as enzyme inhibitors
    Patent number: 6008351
    Abstract: The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.
    Type: Grant
    Filed: December 18, 1995
    Date of Patent: December 28, 1999
    Assignee: Corvas International, Inc.
    Inventors: Susan Yoshiko Tamura, Joseph Edward Semple, William Charles Ripka, Robert John Ardecky, Yu Ge, Stephen H. Carpenter, Terence K. Brunck, Marguerita S. L. Lim-Wilby, Ruth F. Nutt, Matthew M. Abelman
  • 3-amino-2-oxo-1-piperidineacetic derivatives as enzyme inhibitors
    Patent number: 5703208
    Abstract: The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 30, 1997
    Assignee: Corvas International, Inc.
    Inventors: Joseph Edward Semple, Robert John Ardecky, Ruth Foelsche Nutt, William Charles Ripka, David C. Rowley, Marguerita S. L. Lim-Wilby, Terence Kevin Brunck
  • Aromatic heterocyclic derivatives as enzyme inhibitors
    Patent number: 5658930
    Abstract: The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 19, 1997
    Assignee: Corvas International, Inc.
    Inventors: Susan Yoshiko Tamura, Joseph Edward Semple, William Charles Ripka, Robert John Ardecky, Yu Ge, Stephen H. Carpenter, Terence K. Brunck
  • Aromatic heterocyclic derivatives as enzyme inhibitors
    Patent number: 5656645
    Abstract: The present invention discloses heterocyclic aromatic peptide aldehydes which have an oxopyrimidine or oxopyridine group and an argininal tail which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 12, 1997
    Assignee: Corvas International, Inc.
    Inventors: Susan Yoshiko Tamura, Joseph Edward Semple, William Charles Ripka, Robert John Ardecky, Yu Ge, Stephen H. Carpenter, Terence K. Brunck
  • N-L-seryl-3-azetidinecarboxylic acid
    Patent number: 4534787
    Abstract: N-L-seryl-3-azetidinecarboxylic acid, useful for sterilizing the male parts of plants.
    Type: Grant
    Filed: May 24, 1984
    Date of Patent: August 13, 1985
    Assignee: Shell Oil Company
    Inventors: Gary M. Gardner, J. Edward Semple