Patents by Inventor Edward Walker

Edward Walker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240082410
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP). The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.
    Type: Application
    Filed: May 11, 2023
    Publication date: March 14, 2024
    Inventors: Daniel Paul TEUFEL, Catherine Lucy STACE, Silvia PAVAN, Edward WALKER, Leonardo BALDASSARRE
  • Patent number: 11912794
    Abstract: The invention describes peptide ligands specific for human plasma Kallikrein.
    Type: Grant
    Filed: June 11, 2020
    Date of Patent: February 27, 2024
    Assignee: BicycleRD Limited
    Inventors: John Tite, Edward Walker, Catherine Stace, Daniel Teufel
  • Patent number: 11753444
    Abstract: The invention describes peptide ligands specific for human plasma Kallikrein.
    Type: Grant
    Filed: August 7, 2020
    Date of Patent: September 12, 2023
    Assignee: BicycleRD Limited
    Inventors: Daniel Paul Teufel, Catherine Stace, Edward Walker, John Tite
  • Patent number: 11719592
    Abstract: Systems and methods are provided for non-destructive inspection of an interior of a vessel filled with a liquid.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: August 8, 2023
    Assignee: Sonasearch, Inc.
    Inventors: Stephen Edward Walker, Sheldon Rubin
  • Publication number: 20230184616
    Abstract: Systems and methods are provided for non-destructive inspection of an interior of a vessel filled with a liquid.
    Type: Application
    Filed: October 25, 2019
    Publication date: June 15, 2023
    Applicant: SONASEARCH, INC.
    Inventors: Stephen Edward Walker, Sheldon Rubin
  • Patent number: 11672868
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP). The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.
    Type: Grant
    Filed: July 22, 2021
    Date of Patent: June 13, 2023
    Assignee: BicycleRD Limited
    Inventors: Daniel Paul Teufel, Catherine Lucy Stace, Silvia Pavan, Edward Walker, Leonardo Baldassarre
  • Publication number: 20220362390
    Abstract: The present invention relates to polypeptides which are covalently bound to non-aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP), such as the collagen binding site of MT1-MMP. The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.
    Type: Application
    Filed: December 13, 2019
    Publication date: November 17, 2022
    Inventors: Catherine STACE, Daniel TEUFEL, Edward WALKER
  • Patent number: 11491670
    Abstract: Various systems, apparatuses and methods are disclosed for portioning and/or trimming cooked or pre-cooked bacon slices (or another food product) on a production line at full line speed. An exemplary system may comprise a food conveyor and a portioner. The food conveyor may have at least one transfer mechanism that carries bacon slices over at least one transfer comb. The portioner may have at least one fixed, stationary cutter positioned relative to the transfer comb in the path of the bacon slices. As the transfer mechanism moves the bacon slices across the transfer comb, the bacon slices contact the cutter and are moved by the transfer mechanism over the cutter, which cuts the bacon slices into two or more portions of shorter length.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: November 8, 2022
    Assignee: Fresh Mark, Inc.
    Inventors: Glen Christopher Helman, Mark Edward Walker, Timothy Mark Calvin
  • Publication number: 20220133732
    Abstract: The present invention relates to polypeptides which are covalently bound to aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of carbonic anhydrase IX (CAIX).The invention also includes dmg conjugates comprising said peptides,conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by CAIX.
    Type: Application
    Filed: January 15, 2020
    Publication date: May 5, 2022
    Inventors: Leonardo BALDASSARRE, Liuhong CHEN, Rachid LANI, Catherine STACE, Daniel TEUFEL, Edward WALKER
  • Publication number: 20220119488
    Abstract: The present invention relates to polypeptides which are covalently bound to aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of integrin ?v?3.The invention also includes drug conjugates comprising said peptides,conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and dmg conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by integrin ?v?3.
    Type: Application
    Filed: January 15, 2020
    Publication date: April 21, 2022
    Inventors: Rachid LANI, Catherine STACE, Daniel TEUFEL, Edward WALKER
  • Publication number: 20220098164
    Abstract: Compounds of general formula (I): wherein R1, R2, R3, R4, A, Z1, Z2 and Y are as defined herein are useful for treating respiratory disease and other diseases and conditions modulated by TMEM16A.
    Type: Application
    Filed: December 10, 2021
    Publication date: March 31, 2022
    Inventors: Stephen COLLINGWOOD, Jonathan David HARGRAVE, Duncan Alexander HAY, Edward WALKER
  • Publication number: 20220098167
    Abstract: Compounds of general formula (I) and their tautomeric forms all enantiomers and isotopic variants and salts and solvates thereof: wherein represents a single or a double bond and R1, R2, X1, X2, X3, X4, X5, Y and Z are as defined herein; are useful for treating respiratory disease and other diseases and conditions modulated by TMEM16A.
    Type: Application
    Filed: December 10, 2021
    Publication date: March 31, 2022
    Inventors: Stephen COLLINGWOOD, Clive MCCARTHY, Duncan Alexander HAY, Jonathan David HARGRAVE, Albert MA, Thomas Beauregard SCHOFIELD, Matthew SMITH, Edward WALKER, Naomi WENT, Peter INGRAM, Christopher STIMSON, Someina KHOR
  • Publication number: 20220088118
    Abstract: The present invention relates to polypeptides which are covalently bound to non-aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of carbonic anhydrase IX (CAIX). The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by CAIX.
    Type: Application
    Filed: January 15, 2020
    Publication date: March 24, 2022
    Inventors: Leonardo BALDASSARRE, Liuhong CHEN, Rachid LANI, Catherine STACE, Daniel TEUFEL, Edward WALKER
  • Publication number: 20220072140
    Abstract: The present invention relates to polypeptides which are covalently bound to aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP), such as the collagen binding site of MT1-MMP. The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.
    Type: Application
    Filed: December 13, 2019
    Publication date: March 10, 2022
    Inventors: Catherine STACE, Daniel TEUFEL, Edward WALKER
  • Publication number: 20220064221
    Abstract: The present invention relates to polypeptides which are covalently bound to non-aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of integrin ?v?3. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by integrin ?v?3.
    Type: Application
    Filed: January 15, 2020
    Publication date: March 3, 2022
    Inventors: Rachid LANI, Catherine STACE, Daniel TEUFEL, Edward WALKER
  • Publication number: 20220054646
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of prostrate-specific membrane antigen (PSMA).The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by PSMA.
    Type: Application
    Filed: December 13, 2019
    Publication date: February 24, 2022
    Inventors: Liuhong CHEN, Catherine STACE, Daniel TEUFEL, Punit UPADHYAYA, Edward WALKER
  • Publication number: 20220024983
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of IL-17. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by IL-17.
    Type: Application
    Filed: December 13, 2019
    Publication date: January 27, 2022
    Inventors: Liuhong CHEN, Rachid LANI, Gemma MUDD, Daniel TEUFEL, Edward WALKER
  • Publication number: 20220024982
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP). The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.
    Type: Application
    Filed: December 13, 2019
    Publication date: January 27, 2022
    Inventors: Liuhong CHEN, Euan RICHARDS, Rachid LANI, Gemma MUDD, Catherine STACE, Daniel TEUFEL, Edward WALKER
  • Publication number: 20220023432
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP). The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.
    Type: Application
    Filed: July 22, 2021
    Publication date: January 27, 2022
    Inventors: Daniel Paul TEUFEL, Catherine Lucy Stace, Silvia Pavan, Edward Walker, Leonardo Baldassarre
  • Publication number: 20220008545
    Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of fibroblast activation protein a (FAP?). The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by FAP?.
    Type: Application
    Filed: December 13, 2019
    Publication date: January 13, 2022
    Inventors: Liuhong CHEN, Catherine STACE, Edward WALKER