Abstract: The present invention provides a method of screening for compounds which affect the processing of EphA4 by ?-secretase, which includes the following steps: (i) contacting a first biological composition containing ?-secretase or a biologically active fragment thereof with a second biological composition containing EphA4 in the presence and absence of a candidate compound; (ii) measuring the cleavage of the EphA4 in the presence and absence of the candidate compound; (iii) selecting those candidate compounds which affect the cleavage of the EphA4 by ?-secretase; and (iv) identifying the candidate compounds selected in step (iii) as compounds which affect the processing of EphA4 by ?-secretase.

Abstract: The present invention provides EphA4 polypeptides which encode EphA4 fragments cleaved by ?-secretase, especially intracellular fragments of such cleaved fragments, polynucleotides which encode such polypeptides, and antibodies specific to such polypeptides. Also disclosed is a method of screening for compounds which affect the processing of EphA4 by ?-secretase; a method of screening for compounds which affect dendritic spine formation by EphA4 processed by ?-secretase (?-secretase-processed EphA4); and a method of screening for compounds which affect Rac activity mediated by ?-secretase-processed EphA4.

Abstract: The present invention provides a method of screening for compounds which affect the processing of EphA7 by ?-secretase, comprising the following steps: (i) contacting a first biological composition containing ?-secretase or a biologically active fragment thereof with a second biological composition containing EphA7 in the presence and absence of a candidate compound; (ii) measuring the cleavage of the EphA7 in the presence and absence of the candidate compound; (iii) selecting those candidate compounds which affect the cleavage of the EphA7 by ?-secretase; and (iv) identifying the candidate compounds selected in step (iii) as compounds which affect the processing of EphA7 by ?-secretase.

Abstract: A method for controlling air intake into an air conditioned enclosure includes generating a plurality of sensor output voltages using a NOx sensor. A NOx voltage ratio is calculated from the sensor output voltages. A determination is made when the NOx voltage ratio one of equals and exceeds a NOx threshold. The NOx voltage ratio is reset to a unitary value for a predetermined length of time.

Abstract: The present invention provides a method of screening for compounds which affect the processing of c-Ret by ?-secretase. The method involves contacting a first biological composition containing ?-secretase or a biologically active fragment thereof with a second biological composition containing c-Ret in the presence and absence of a candidate compound; measuring the cleavage of the c-Ret in the presence and absence of the candidate compound; selecting those candidate compounds which affect the cleavage of the c-Ret by ?-secretase; and identifying the candidate compounds selected in the previous step as compounds which affect the processing of c-Ret by ?-secretase.

Abstract: The present invention enabled the detection and quantification of CAST, which is localized to synapses and tightly bound to the cytomatrix, and of the mRNA encoding the CAST. Furthermore, it was revealed that CAST functions as a protein scaffold for localizing RIM1 to synapses, contributing as a molecular basis for active zone formation.

Abstract: In this toroidal continuously variable transmission unit, a carrier 100 and a disc 2 is brought into direct friction contact with each other, and power transmission between the carrier 100 and the disc 2 is implemented by friction force. Because of this, the necessity of machining a gear or claw on the disc or carrier, which has conventionally be done, is obviated, whereby a manufacturing process can be shortened and manufacturing costs can largely be reduced.

Abstract: The present invention provides a polynucleotide which consists of a partial sequence of a polynucleotide encoding the amino acid sequence as shown in SEQ ID NO: 2, wherein the former polynucleotide encodes a polypeptide consisting of a partial amino acid sequence of SEQ ID NO: 2 whose N-terminus starts between positions 564 and 621 of SEQ ID NO: 2.

Abstract: A control unit is imparted a function in which the engagement of a high-speed clutch which had been in disengagement until then is started (or the energization of a high-speed clutch solenoid switch valve is put to ON) before a change-speed of a toroidal continuously variable transmission has reached an optimal value for performance of a mode switch (a point A, for example, 0.46 in a speed increasing ratio) or at a point B (for example, 0.6 in the speed increasing ratio). As a result of this, the problem can be solved.

Abstract: The present invention relates to a method of screening for compounds which affect the processing of c-Met by ?-secretase, comprising the following steps: (i) contacting a first biological composition containing ?-secretase or a biologically active fragment thereof with a second biological composition containing c-Met in the presence of a candidate compound and c-Met in the absence of a candidate compound; (ii) measuring cleavage of the c-Met in the presence of the candidate compound and cleavage of c-Met in the absence of the candidate compound; (iii) selecting those candidate compounds which affect the cleavage of the c-Met by ?-secretase; and (iv) identifying the candidate compounds selected in step (iii) as compounds which affect the processing of c-Met by ?-secretase.

Abstract: A vehicle having a sensor apparatus includes a first mounting portion and a second mounting portion disposed on a side surface of a vehicle frame, wherein the first and second mounting portions are spaced apart in a vehicle length direction, wherein the first and second mounting portions configured to receive a load platform of the vehicle, a wheel assembly comprising a sensor transmitter, and a receiver mounted to the side surface between the first and the second mounting portions, the receiver configured to receive a signal from the sensor transmitter.

Abstract: The present invention provides a method of screening for compounds which affect the processing of EphA4 by ?-secretase, comprising the following steps: (i) contacting a first biological composition containing ?-secretase or a biologically active fragment thereof with a second biological composition containing EphA4 in the presence and absence of a candidate compound; (ii) measuring the cleavage of the EphA4 in the presence and absence of the candidate compound; (iii) selecting those candidate compounds which affect the cleavage of the EphA4 by ?-secretase; and (iv) identifying the candidate compounds selected in step (iii) as compounds which affect the processing of EphA4 by ?-secretase.

Abstract: A sleeve 28 making up a gear ratio control valve 21 is driven by not only a stepping motor 29 but also a secondary actuator 47. Pressure oil is made free to be introduced into the secondary actuator 47 through a manual oil pressure switching valve 37 which is switched over by a gearshift. Then, when the gearshift is operated from a non-running state to a running state, a gear ratio of a toroidal type continuously variable transmission is corrected by a predetermined amount by driving the sleeve 28 by the secondary actuator 47. As a result, while improving characteristic of a vehicle when starting from rest, the vehicle can be prevented from being reduced in speed unintentionally excessively even when the gearshift is operated while running.

Abstract: The present invention enabled the detection and quantification of CAST, which is localized to synapses and tightly bound to the cytomatrix, and of the mRNA encoding the CAST. Furthermore, it was revealed that CAST functions as a protein scaffold for localizing RIM1 to synapses, contributing as a molecular basis for active zone formation.

Abstract: A toroidal type continuously variable transmission has an input shaft to which a rotation torque is input, an input side disk and an output side disk that are concentrically and rotatably supported by the input shaft in a state that an inner peripheral surface of the input side disk opposes to an inner peripheral surface of the output side disk, a power roller held between the input side disk and the output side disk and a hydraulic loading device applying predetermined pressing force so that the power roller is pressed between the input and output side disks. Fine grooves are formed on at least a radially inner part of the inner peripheral surface of the input side disk and at least radially outer part of the inner peripheral surface of the output side disk, respectively.

Abstract: A toroidal-type continuously variable transmission includes an input shaft, an input disk and an output disk, plural power rollers, a power roller bearing, an oil passage, and a mesh filter. The input and output disks are supported mutually concentrically with the input shaft and mutually independently rotatably. The plural power rollers are sandwiched between the input disk and the output disks. The power roller bearing rotatably supports the power rollers. The oil passage for leading lubricating oil to the power roller bearing. The mesh filter is provided in the oil passage. Accordingly, the toroidal-type continuously variable transmission can prevent an occurrence of biting-in of foreign substances at a power roller bearing, to thereby increase the life of the power roller bearing.

Abstract: A toroidal-type continuously variable transmission has a casing; an input disk and an output disk rotatably supported concentrically with each other; a plurality of power rollers each held between the input and output disks; a plurality of trunnions disposed at position twisted with respect to a center axis; a drive device for shifting the trunnions in the axial directions or the pivot shafts; a pair of yokes for supporting the pivot shafts of each of the trunnions so as to be swung and shifted in the axial direction thereof, the yokes being swingable according to the shifting movement of the associated trunnion; and, a pair of opposing members each disposed to be opposed to the associated yoke, wherein the yokes each includes projection portion contacted with the associated opposing member, the projection portion being the fulcrum of the swinging movements of the yokes.

Abstract: A toroidal-type continuously variable transmission has a casing; a rotary shaft; a pair of outside disks each including an axial-direction one-side surface and supported on the rotary shaft so as to be rotated in synchronization with the rotary shaft; an inside disk including axial-direction two-side surfaces and rotatably supported on the periphery of the middle portion of the rotary shaft so as to be rotated with respect to the rotary shaft; support members disposed between the one side axial-direction surface and the axial-direction one-side surface so as to be swung and shifted about pivot shafts thereof; power rollers rotatably supported on the support members, the peripheral surface of the power rollers being contacted with the axial-direction two-side surface and the axial-direction one-side surface; and ball bearings for supporting the inside disk in such a manner that the inside disk is rotated with respect to the casing.

Abstract: A continuously variable transmission apparatus includes a toroidal continuously variable transmission, a planetary gear transmission and a clutch apparatus that connects the toroidal continuously variable transmission and the planetary gear transmission. The clutch apparatus includes: a low speed clutch a high speed clutch and a controller. The controller controls the transmission ratio of the toroidal continuously variable transmission so that rotational speeds of members connected via the clutch apparatus equals with each other, and then disengages the one of the low speed clutch and the high speed clutch after engaging the other, whereby an instance of simultaneously transmitting the power by the two clutches is set during a time period until disconnecting the other clutch after starting to transmit the power by the one clutch.

Abstract: The support beam 34 having the cylindrical convex surface 33 is provided at the intermediate portion of the trunnion 9b. The recess 38 of the partial cylindrical surface formed on the outside of the outer ring 37 on the thrust ball bearing 36 supporting the power rollers 8b and the cylindrical convex surface 33 of the support beam are engaged. The outer ring and the power rollers 8b are supported swingably in the axial direction of the input and output discs in respect to the trunnions 9b.