Patent number: 5458805
Abstract: Novel phenylcyclohexanes of the formula I ##STR1## in which n is 0 to 7, Q.sup.1 and Q.sup.2 are H, or one of these radicals is alternatively CH.sub.3, r is 0, 1, 2, 3, 4 or 5, A is trans-1,4-cyclohexylene, 1,4-phenylene, 3-fluoro-1,4-phenylene or a single bond, X is F, Cl, --CF.sub.3, --CN, --OCF.sub.3 or --OCHF.sub.2, and Y and Z are each, independently of one another, H or F, with the proviso that, in the case where A is a single bond, Q.sup.1 =Q.sup.2 =H and simultaneously X=CN, Y and/or Z are F.
Type:
Grant
Filed:
April 15, 1993
Date of Patent:
October 17, 1995
Assignee:
Merck Patent Gesellschaft mit beschrankter Haftung
Inventors:
Andreas Wachtler, Reinhard Hittich, Eike Poetsch, Herbert Plach, David Coates, Bernhard Rieger, Joachim Krause
Patent number: 5393459
Abstract: The invention relates to optically active compounds of the formula I ##STR1## in which R is an alkyl or alkenyl radical having up to 15 carbon atoms which is unsubstituted, monosubstituted by --CN or at least monosubstituted by fluorine or chlorine, it also being possible for a CH.sub.2 group in these radicals to be replaced by --O--, --CO--, --O--CO--, --CO--O-- or --O--CO--O--,A.sup.1 and A.sup.2 are each, independently of one another, a 1,4-phenylene radical, pyridine-2,5-diyl radical, pyrimidine-2,5-diyl radical, pyrazine-2,5-diyl radical, pyridazine-3,6-diyl radical, 1,3,4-thiadiazole-2,5-diyl radical, 1,2,4-thiadiazole-3,5-diyl radical or trans-1,4-cyclohexylene radical, each of which is unsubstituted or substituted by one or two fluorine atoms, and in which, in addition, one or two non-adjacent CH.sub.2 groups may be replaced by --O-- and/or --S--, and/or a CH group,Z.sup.1, Z.sup.2 and Z.sup.3 are each, independently of one another, --CO--O--, --O--CO--, --CH.sub.2 O--, --OCH.sub.2 --, --CH.sub.2 CH.
Type:
Grant
Filed:
October 5, 1992
Date of Patent:
February 28, 1995
Assignee:
Merck Patent Gesellschaft Mit Beschrankter Haftung
Inventors:
Andreas Wachtler, Thomas Geelhaar, Reinhard Hittich, Ekkehard Bartmann, Joachim Krause, Eike Poetsch