Patents by Inventor Ejner Knud Moltzen

Ejner Knud Moltzen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Serotonin 5-HT1A and dopamin D2 receptor ligands
    Patent number: 6514993
    Abstract: The present invention relates to a novel series of 4-phenylpiperazines, 4-phenylpiperidines and 4-phenyl-1,2,3,6-tetrahydropyridines compounds of general formula (I) wherein A is alkylene, alkenylene, alkynylene, and C3-7 cycloalkylene; R1 is a C3-10 alkyl, alkenyl, or alkynyl group, cycloalk(en)yl, cycloalk(en)yl-alk(en/yn)yl, trifluoromethylsulfonyl, or alkylsulfonyl, R2-R5 are optional substituents; R9 and R10 are hydrogen, alkyl or together form an ethylene or propylene bridge; W is O or S; V is O, S, CR6R7, or NR8 wherein R6, R7, and R8 are hydrogen or alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, optionally substituted arylalkyl or aryl, or R6 and R7 constitute a 3-7 membered spiro ring; Z is —(CH2)m—, m being 2 or 3 or Z is —CH═CH—; X is N, C or CH; show effects on central serotonin 5-HT1A and dopamine D2 receptors. Thus the novel compounds are useful in the treatment of certain psychic and neurologic disorders, in particular psychosis.
    Type: Grant
    Filed: December 9, 1996
    Date of Patent: February 4, 2003
    Assignee: H. Lundbeck A/S
    Inventors: Jens Kristian Perregaard, Ejner Knud Moltzen
  • Indole and 2,3-dihydroindole derivatives, their preparation and use
    Publication number: 20030018050
    Abstract: The present invention relates to indole and 2,3-dihydroindole derivatives having formula (I) 1
    Type: Application
    Filed: August 16, 2002
    Publication date: January 23, 2003
    Applicant: H. Lundbeck A/S
    Inventors: Ejner Knud Moltzen, Jens Kristian Perregaard, Ivan Mikkelsen, Garrick Paul Smith
  • Piperidine, tetrahydropyridine and piperazine derivatives, their preparation and use
    Publication number: 20020173512
    Abstract: A piperidine, tetrahydropyridine or piperazine derivative having formula (I), 1
    Type: Application
    Filed: May 16, 2002
    Publication date: November 21, 2002
    Applicant: H. Lundbeck A/S
    Inventors: Ejner Knud Moltzen, Christian Krog-Jensen, Berith Bjornholm
  • Indole and 2,3-dihydroindole derivatives, their preparation and use
    Patent number: 6476035
    Abstract: The present invention relates to indole and 2,3-dihydroindole derivatives having formula (I) or any of its any of its enantiometers or any mixture thereof, or an acid addition salt thereof, wherein A, R1, R2, R3, W, X, Y and Z are as described in the description. The compounds are potent serotonin reuptake inhibitors and have 5-HT1A receptor antagonistic activity.
    Type: Grant
    Filed: January 25, 2000
    Date of Patent: November 5, 2002
    Inventors: Ejner Knud Moltzen, Jens Kristian Perregaard, Ivan Mikkelsen, Garrick Paul Smith
  • 4,5,6, and 7-indole and indoline derivatives, their preparation and use
    Publication number: 20020128272
    Abstract: A substituted 4-, 5-, 6-, and 7-indole derivative of Formula (I) 1
    Type: Application
    Filed: January 15, 2002
    Publication date: September 12, 2002
    Applicant: H. Lundbeck A/S
    Inventors: Ejner Knud Moltzen, Ivan Mikkelsen, Christian Krog-Jensen
  • 4,5,6 and 7-indole and indoline derivatitives, their preparation and use
    Patent number: 6391882
    Abstract: A substituted 4-, 5-, 6-, and 7-indole derivative of Formula (I) wherein A is a group having formula (IIA), (IIB), (IIC) wherein X, U, Y, R3 to R12, Z, W, n and m are as defined above. The compounds are potent serotonin reuptake inhibitors and have 5-HT1A receptor antagonistic activity.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: May 21, 2002
    Assignee: H. Lundbeck A/S
    Inventors: Ejner Knud Moltzen, Ivan Mikkelsen, Christian Korg-Jensen
  • Piperidine, tetrahydropyridine and piperazine derivatives, their preparation and use
    Publication number: 20020035113
    Abstract: A piperidine, tetrahydropyridine or piperazine derivative having formula (I), 1
    Type: Application
    Filed: July 9, 2001
    Publication date: March 21, 2002
    Applicant: H. Lundbeck A/S
    Inventors: Ejner Knud Moltzen, Christian Krog-Jensen, Berith Bjornholm
  • Phenyl indole compounds
    Patent number: 5703087
    Abstract: The present invention relates to phenylindole compounds of formula I: ##STR1## related to atypical neuroleptic sertindole.
    Type: Grant
    Filed: November 27, 1996
    Date of Patent: December 30, 1997
    Assignee: H. Lundbeck A/S
    Inventors: Jens Kristian Perregaard, Ejner Knud Moltzen, Kim Andersen, Henrik Pedersen, Klaus Peter B.o slashed.ges.o slashed., Andre Pernet, Barbara Bopp, Darcy Mulford, Kiyoshi Sakamoto
  • 1,2,3-triazole and tetrazole substituted piperidine or tetrahydropyridine compounds useful as acetylcholine agonists
    Patent number: RE36374
    Abstract: The present invention relates to novel compounds of the following formula, where the dotted line designates in optional bond: ##STR1## wherein "het" designates a five membered heterocyclic ring which may include 1 or 2 double bonds and 1-4 heteroatoms selected from nitrogen, oxygen or sulphur, provided that "het" may not designate a 1,4- or 1,3,4-oxadiazole,R.sup.1 is selected from hydrogen, lower alkyl, optionally substituted with phenyl which may be substituted with halogen, lower alkyl, or lower alkoxy, or a group R.sup.6 --CO--NH--CH.sub.2 -- or R.sup.6 --O--CO--, wherein R.sup.6 is lower alkyl, branched or unbranched, or phenyl optionally substituted with halogen, trifuoromethyl, lower alkyl, hydroxy, lower alkoxy, or lower acyloxy;R.sup.2 and R.sup.
    Type: Grant
    Filed: May 13, 1996
    Date of Patent: November 2, 1999
    Assignee: H. Lundbeck, A/S
    Inventors: Klaus Peter Bogeso, Klaus Gundertofte, Ejner Knud Moltzen, Henrik Pedersen