Abstract: A method of validating a regulated application by generating, on a local data processing system, an automated agent to oversee a validation process of the regulated application on the local data processing system regardless of a local or web-based nature of the regulated application.

Abstract: The disclosure is directed to an antibody-drug conjugate (ADC) comprising a monoclonal antibody, or an antigen-binding fragment thereof, directed against B-cell maturation antigen (BCMA) conjugated to a cytotoxin. The disclosure also provides compositions comprising the antibody-drug conjugate and methods of killing multiple myeloma cells (including multiple myeloma stems cells) that express BCMA by contacting multiple myeloma cells with the ADC.

Abstract: A presence of a consumer transacting at a transaction terminal is detected. Content for the transaction terminal is played as media on the transaction terminal. When an identity of the consumer is resolved, the content is switched to new content that is targeted/customized to the consumer and is played as new media on the transaction terminal. When a transaction concludes, the media play is stopped. Statistics for the transaction and media play are retained for tracking and reporting.

Abstract: The present invention is to a thermosetting epoxy functional (meth)acrylate resin which when formulated into a powder coating composition, applied and cured to form a powder coating on a metal substrate, provides excellent filiform corrosion resistance, without impairing powder coating clarity or wet adhesion.

Abstract: An electronic notebook system is described comprising a housing, a computing device, wireless interfaces, antennas, sensors, a touch display configured to receive input via a stylus and/or human digit input, the stylus comprising a pressure and/or an inclination sensor, a microphone, camera, the system configured to provide a user condition interface, receive a user selection of a first user condition, provide an interface configured to receive user details, receive audible user details via the microphone, convert the audible user details received via the microphone to text, perform natural language processing to identify text keywords utilizing sentence segmentation, part-of-speech tagging, paraphrase recognition, and/or co-reference resolution, identify a condition based at least in part on the identified one or more keywords, dynamically generate an alert based at least in part on the identified condition, wirelessly transmit the alert to one or more destinations via at least a first wireless interface and

Abstract: A system for forming a deep drawn helmet and method therefor are disclosed. The system includes a forming draw ring and a non-forming draw ring and supports a prepreg stack between a forming aperture of the forming draw ring and a non-forming aperture of the non-forming draw ring. The system clamps a flange portion of the prepreg stack between a contact surface of the forming draw ring and a contact surface of the non-forming draw ring, which forms a clamped assembly of the rings and the prepreg stack. The system then forms a deep drawn helmet preform from the prepreg stack of the clamped assembly. The same system or a different forming system then consolidates one or more of the preforms into a final deep drawn helmet. The system can control sliding of the flange during forming of the helmet preform without reducing the flange clamping force.

Abstract: Systems and methods are disclosed. A digitized human vocal expression of a user and digital images are received over a network from a remote device. The digitized human vocal expression is processed to determine characteristics of the human vocal expression, including: pitch, volume, rapidity, a magnitude spectrum identify, and/or pauses in speech. Digital images are received and processed to detect characteristics of the user face, including detecting if any of the following is present: a sagging lip, a crooked smile, uneven eyebrows, and/or facial droop. Using the human vocal expression characteristics and face characteristics, a determination is made as to what action is to be taken. A cepstrum pitch may be determined using an inverse Fourier transform of a logarithm of a spectrum of a human vocal expression signal. The volume may be determined using peak heights in a power spectrum of the human vocal expression.

Abstract: The present disclosure relates to analytic mapping of metagenomic and hydrocarbon footprints of geologic subzones. A plurality of DNA profiles are generated based on a set of distinct geological specimens from each well of a plurality of wells. BioGeo markers, BioGeo signatures and a BioGeo matrix are generated based on the plurality of DNA profiles.

Abstract: Pet hair removers are disclosed herein. In some embodiments, the pet hair remover includes a handle, a collection chamber, a roller, a roller frame, a door, and a blade. In some embodiments, the pet hair remover comprises a protrusion on an exterior, planar surface of the roller, and the roller's rotation is limited by the protrusion contacting the roller frame. In some embodiments, the door is at least partially transparent to provide a view of the collection chamber. In some embodiments, the pet hair remover further comprises a spring that biases the door open, a latch that holds the door closed, and a button on the handle.

Abstract: The present invention relates to methods and compositions for producing differentiated otic cells. In particular, the invention relates to methods and compositions for the production of inner ear cells from pluripotent stem cells. The present invention also relates to methods of treating sensorineural hearing loss.

Abstract: At least one computer-readable medium on which are stored instructions that, when executed by one or more processing devices, enable the one or more processing devices to perform a method. The method includes the steps of receiving over a network a request from an employing entity to facilitate an automatic savings program including savings accounts for employees of the employing entity, receiving over the network a request from an employee to participate in the automatic savings program, automatically routing at predetermined time intervals an employee-selected amount of the employee's wages to a savings account of the employee, receiving at least one request over the network from the employee to transfer funds from the savings account of the employee to an employee-designated destination, and initiating the requested fund transfer.

Abstract: A releasable locking mechanism for a refrigerated unit. A latch plate is movable between a position that can be engaged by a deadbolt and a position clear of the deadbolt. The latch plate is moved by a door release accessible from an interior of the refrigerated unit. When the door release is activated, a pin blocks movement of the latch plate so that the refrigerated unit remains unlocked until the pin is reset.

Abstract: Apparatus for assessing medical risks of a patient includes an analytics engine and equipment that provides data to the analytics engine. The analytics engine analyzes the data from the equipment to determine a sepsis risk score, a falls risk score, and a pressure injury score. The apparatus further include displays that are communicatively coupled to the analytics engine and that display the sepsis, falls, and pressure injury risk scores. The displays include a status board display located at a master nurse station, an in-room display provided by a room station of a nurse call system, an electronic medical records (EMR) display of an EMR computer, and a mobile device display of a mobile device of a caregiver assigned to the patient.

Abstract: The present disclosure relates to: a) solid state forms of hydrobromide salts of Compound 1; b) pharmaceutical compositions comprising one or more solid state forms of hydrobromide salts of Compound 1, and, optionally, a pharmaceutically acceptable carrier; c) methods of treating tumors or cancers by administering one or more solid state forms of hydrobromide salts of Compound 1 to a subject in need thereof; and d) methods for the preparation of solid state forms of Compound 1.

Abstract: The present disclosure relates to: a) solid state forms of hydrobromide salts of Compound 1; b) pharmaceutical compositions comprising one or more solid state forms of hydrobromide salts of Compound 1, and, optionally, a pharmaceutically acceptable carrier; c) methods of treating tumors or cancers by administering one or more solid state forms of hydrobromide salts of Compound 1 to a subject in need thereof; and d) methods for the preparation of solid state forms of Compound 1.

Abstract: The present disclosure concerns combination therapy for cancer that utilizes (i) an oncolytic virus; (ii) a virus comprising nucleic acid encoding an immunomodulatory factor; and (iii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen. In particular embodiments, the virus comprises nucleic acid encoding an immunomodulatory factor comprises nucleic acid encoding IL-12 and/or antagonist anti-PD-L1 antibody.

Abstract: A method is provided, the method including receiving a test result data, wherein said test result data represents a result of a test on a physical specimen, associating said test result data with a standard-of-care data, wherein said standard-of-care data represents a recommended course of action for the condition represented by the test result data, and transforming said specimen data and said standard-of-care data into a human-readable form. A system including a processor is provided, a software adapted to be executed on said processor, said software comprising instructions for receiving a test result data, wherein said test result data represents a result of a test on a physical specimen, associating said test result data with a standard-of-care data, wherein said standard-of-care data represents a recommended course of action for the condition represented by the test result data, and transforming said specimen data and said standard-of-care data into a human-readable form.

Abstract: Provided is a method and a composition for improving behavioral performance in an individual comprising identifying an individual in need of treatment, and providing such an individual a composition comprising bacteria within the genus Bacteroides.

Abstract: Systems and Computer Readable Media for enabling methods for multi-party authorization including a security component determining that a request for the performance of an action on a computing device is from a first party. The security component initiates transmissions to the computing device of first and second information indicating knowledge of first and second secrets provisioned on the computing device. The computing device, upon verifying the knowledge of first and second secrets, then permits the requested action.

Abstract: A plunger caddy and cleaning assembly includes a housing that accommodates a plunger; a fluid reservoir mounted within the housing; tubing extending from an interior of the fluid reservoir; and a fluid dispersing assembly in connected to the fluid reservoir by way of the tubing. The fluid dispersing assembly has a spray wand with a handle and is removably mounted to the housing.