Patents by Inventor Eli N. Glezer

Eli N. Glezer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MANIPULATING AND DETECTING BIOLOGICAL SAMPLES
    Publication number: 20230347021
    Abstract: Disclosed herein, inter alia, are compositions and methods for efficient transfer and analyses of cellular material, tissue samples, such as tissue sections, using carrier substrates.
    Type: Application
    Filed: April 28, 2023
    Publication date: November 2, 2023
    Inventors: Jaekyung KOH, Zhenmin HONG, Weiqiao DING, Hu CANG, William DEMPSEY, Eli N. GLEZER, Yuji ISHITSUKA, Mohammad Vatankhah VARNOSFADERANI
  • Lung cancer biomarkers
    Patent number: 11802877
    Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
    Type: Grant
    Filed: May 26, 2020
    Date of Patent: October 31, 2023
    Assignee: MESO SCALE TECHNOLOGIES, LLC.
    Inventors: Anahit Aghvanyan, Eli N. Glezer, John Kenten, Sudeep Kumar, Galina Nikolenko, Martin Stengelin, Srikant Vaithilingam
  • SCAFFOLDS FOR MULTI-DIMENSIONAL ANALYSES
    Publication number: 20230340591
    Abstract: Disclosed herein, inter alia, are compositions and methods for detecting polynucleotides within a three-dimensional polymer matrix.
    Type: Application
    Filed: April 19, 2023
    Publication date: October 26, 2023
    Inventors: Eli N. GLEZER, Daan WITTERS
  • TARGETED SEQUENCING
    Publication number: 20230340592
    Abstract: Disclosed herein, inter alia, are methods of making, amplifying, and sequencing compositions, and kits useful in obtaining sequencing data.
    Type: Application
    Filed: April 19, 2023
    Publication date: October 26, 2023
    Inventor: Eli N. GLEZER
  • METHODS AND SYSTEMS FOR MULTIDIMENSIONAL IMAGING
    Publication number: 20230333361
    Abstract: A multi-depth confocal imaging system includes at least one light source configured to provide excitation beams and an objective lens. The excitation beams are focused into a sample at a first plurality of focus depths along an excitation direction through the objective lens. An image sensor receives emissions from the sample via the objective lens, wherein the emissions define foci relative to the image sensor at a second plurality of focus depths.
    Type: Application
    Filed: June 7, 2023
    Publication date: October 19, 2023
    Inventors: Hu CANG, Eli N. GLEZER
  • Methods and compositions for sequencing complementary polynucleotides
    Patent number: 11788133
    Abstract: Disclosed herein, inter alia, are substrates, kits, and efficient methods of preparing and sequencing two or more regions of a double-stranded polynucleotide.
    Type: Grant
    Filed: October 21, 2022
    Date of Patent: October 17, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Daan Witters, Eli N. Glezer, Allen Lipson
  • Nucleic acid sequencing-by-synthesis (SBS) methods that combine SBS cycle steps
    Patent number: 11773439
    Abstract: The present disclosure provides improved nucleic acid sequencing-by-synthesis (SBS) methods, related kits and reagents, and systems for performing such methods using such kits and reagents.
    Type: Grant
    Filed: November 4, 2022
    Date of Patent: October 3, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Andrew Spaventa, David Barker
  • Spatial sequencing
    Patent number: 11753678
    Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a sample comprising a cell.
    Type: Grant
    Filed: October 12, 2022
    Date of Patent: September 12, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventor: Eli N. Glezer
  • SYSTEMS AND METHODS FOR MULTICOLOR IMAGING
    Publication number: 20230280274
    Abstract: Disclosed herein, inter alia, are methods and systems of image analysis useful for rapidly identifying and/or quantifying features.
    Type: Application
    Filed: May 10, 2023
    Publication date: September 7, 2023
    Inventors: Fedor TRINTCHOUK, Eli N. GLEZER
  • Flow cell carrier and methods of use
    Patent number: 11747262
    Abstract: The present disclosure relates to a flow cell carrier. The flow cell carrier may include a flow cell and a frame. The frame may include a pocket and a handle. The pocket may have at least one spring feature and at least one banking feature. The frame may be configured to retain the flow cell within the pocket such that a maximal surface area of the flow cell is exposed to an optical lens. Related methods and kits are also disclosed.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: September 5, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Sandor Kovacs, Anson Hsu, David Baranson, John Van Doorn, Eli N. Glezer
  • PHASE PROTECTIVE REAGENT FLOW ORDERING
    Publication number: 20230265501
    Abstract: Disclosed herein, inter alia, are phase protective reagent flow orders and methods useful for improving sequencing efficiency.
    Type: Application
    Filed: December 20, 2022
    Publication date: August 24, 2023
    Inventors: Timothy LOONEY, Eli N. GLEZER, Yuji ISHITSUKA
  • MANIPULATING AND DETECTING BIOLOGICAL SAMPLES
    Publication number: 20230266209
    Abstract: Disclosed herein, inter alia, are compositions and methods for efficient transfer and analyses of cellular material, tissue samples, such as tissue sections, using carrier substrates.
    Type: Application
    Filed: April 28, 2023
    Publication date: August 24, 2023
    Inventors: Jaekyung KOH, Zhenmin HONG, Weiqiao DING, Hu CANG, William DEMPSEY, Eli N. GLEZER, Yuji ISHITSUKA, Mohammad Vatankhah VARNOSFADERANI
  • METHODS AND COMPOSITIONS FOR REDUCING NUCLEOTIDE IMPURITIES
    Publication number: 20230265505
    Abstract: Disclosed herein, inter alia, are compositions and methods for depleting nucleotide impurities in nucleotide solutions.
    Type: Application
    Filed: March 22, 2023
    Publication date: August 24, 2023
    Inventors: Abrehet ABDU, Eli N. GLEZER, Laura Ann HALE, Jiawen LI
  • NUCLEOTIDE ANALOGUES
    Publication number: 20230257414
    Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Application
    Filed: April 4, 2023
    Publication date: August 17, 2023
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • STRAND DISPLACING AMPLIFICATION ENZYMES
    Publication number: 20230257803
    Abstract: Disclosed herein, inter alia, are novel strand-displacing polymerases and methods of use thereof.
    Type: Application
    Filed: December 21, 2022
    Publication date: August 17, 2023
    Inventors: Souad NAJI, Eli N. GLEZER, Bruna Krebs KUTCHE, Ali NIKOOMANZAR, Alexander SEVY, Caleb NEWMAN, Ryan SHULTZABERGER, Abrehet ABDU, Youngjin CHO, Janell J. KOSMATKA
  • HIGH DENSITY SEQUENCING AND MULTIPLEXED PRIMING
    Publication number: 20230242904
    Abstract: Disclosed herein, inter alia, are methods and compositions for sequencing a plurality of template nucleic acids.
    Type: Application
    Filed: January 13, 2023
    Publication date: August 3, 2023
    Inventors: Eli N. GLEZER, Daan WITTERS, Niek VAN WIETMARSCHEN
  • Methods and systems for multidimensional imaging
    Patent number: 11714271
    Abstract: A multi-depth confocal imaging system includes at least one light source configured to provide excitation beams and an objective lens. The excitation beams are focused into a sample at a first plurality of focus depths along an excitation direction through the objective lens. An image sensor receives emissions from the sample via the objective lens, wherein the emissions define foci relative to the image sensor at a second plurality of focus depths.
    Type: Grant
    Filed: March 10, 2022
    Date of Patent: August 1, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Hu Cang, Eli N. Glezer
  • METHODS AND COMPOSITIONS FOR SEQUENCING COMPLEMENTARY POLYNUCLEOTIDES
    Publication number: 20230227904
    Abstract: Disclosed herein, inter alia, are substrates, kits, and efficient methods of preparing and sequencing two or more regions of a double-stranded polynucleotide.
    Type: Application
    Filed: January 13, 2023
    Publication date: July 20, 2023
    Inventors: Daan WITTERS, Eli N. GLEZER, Allen LIPSON
  • MODIFIED THERMOCCOCUS POLYMERASES
    Publication number: 20230227798
    Abstract: Provided herein are modified Archaeal family B polymerases derived from the Archaeal microorganism Thermococcus sp. EP1 that exhibit improved incorporation of nucleotide analogues utilized in DNA sequences.
    Type: Application
    Filed: October 20, 2022
    Publication date: July 20, 2023
    Inventors: Souad NAJI, Carl W. FULLER, Eli N. GLEZER, Andrew SPAVENTA
  • Strip tube for a reagent cartridge
    Patent number: D1001310
    Type: Grant
    Filed: December 30, 2022
    Date of Patent: October 10, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele Jeffrey-Coker, Eli N. Glezer, Anson Hsu, Cory Spivey